1. Boosting with an aerosolized Ad5-nCoV elicited robust immune responses in inactivated COVID-19 vaccines recipients.
- Author
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Zhe Zhang, Shipo Wu, Yawei Liu, Kailiang Li, Pengfei Fan, Xiaohong Song, Yudong Wang, Zhenghao Zhao, Xianwei Zhang, Jin Shang, Jinlong Zhang, Jinghan Xu, Yao Li, Yaohui Li, Jipeng Zhang, Kefan Fu, Busen Wang, Meng Hao, Guanying Zhang, and Pengwei Long
- Subjects
SARS-CoV-2 Omicron variant ,COVID-19 vaccines ,COVID-19 pandemic ,BOOSTER vaccines ,IMMUNE response - Abstract
Introduction: The SARS-CoV-2 Omicron variant has become the dominant SARS-CoV-2 variant and exhibits immune escape to current COVID-19 vaccines, the further boosting strategies are required. Methods: We have conducted a non-randomized, open-label and parallelcontrolled phase 4 trial to evaluate the magnitude and longevity of immune responses to booster vaccination with intramuscular adenovirus vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, a recombinant protein subunit vaccine (ZF2001) or homologous inactivated vaccine (CoronaVac) in those who received two doses of inactivated COVID-19 vaccines. Results: The aerosolized Ad5-nCoV induced the most robust and long-lasting neutralizing activity against Omicron variant and IFNg T-cell response among all the boosters, with a distinct mucosal immune response. SARS-CoV-2-specific mucosal IgA response was substantially generated in subjects boosted with the aerosolized Ad5-nCoV at day 14 post-vaccination. At month 6, participants boosted with the aerosolized Ad5-nCoV had remarkably higher median titer and seroconversion of the Omicron BA.4/5-specific neutralizing antibody than those who received other boosters. Discussion: Our findings suggest that aerosolized Ad5-nCoV may provide an efficient alternative in response to the spread of the Omicron BA.4/5 variant. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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