1. Cytokine gene expression following RSV-A infection.
- Author
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Khare VM, Saxena VK, Tomar A, Nyinawabera A, Singh KB, Ashby CR Jr, and Tiwari AK
- Subjects
- Animals, Chickens, Cytokines genetics, Gene Expression immunology, Host-Pathogen Interactions immunology, Inflammation Mediators immunology, Inflammation Mediators metabolism, Rous sarcoma virus physiology, Sarcoma, Avian genetics, Sarcoma, Avian virology, Th1 Cells metabolism, Th1 Cells virology, Th2 Cells metabolism, Th2 Cells virology, Up-Regulation immunology, Cytokines immunology, Rous sarcoma virus immunology, Sarcoma, Avian immunology, Th1 Cells immunology, Th2 Cells immunology
- Abstract
The present study determines the cytokine gene expression in chickens following RSV-A infection, using RT-qPCR. In susceptible chickens tumors progressed to fulminating metastatic tumors while it regressed in regressors chickens and some resistant non-responder chickens did not respond to RSV-A infection and thus did not develop tumors at all. The in vivo expression of pro-inflammatory cytokines, Th1 cytokines and Th2 cytokines was determined at the primary site of infection, as well as in different organs of progressor, regressor and non-responder chicks at different time intervals. Our results indicated a significant upregulation of the pro-inflammatory cytokines, IL-6 and IL-8, in all the organs of progressor chicks, while they were significantly lower in regressor and non-responder chicks. The expression of the Th1 cytokines IFN-γ and TNF-α was low in all of the organs of the progressor group, except that in spleen. In contrast, regressor and non-responder groups showed high expression of IFN-γ and TNF-α. Further, there was an early upregulation of the expression of the Th2 cytokine, IL-10, TGF-β and GM-CSF, in all of the organs of progressors as compared to uninfected control.
- Published
- 2019
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