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Your search keyword '"rs2383206"' showing total 5 results
Start Over Descriptor "rs2383206" Topic rs10757278
5 results on '"rs2383206"'

2. Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis.

Author

Hu, Xuemei, Wang, Dongsen, Cui, Chunying, and Wu, Qingjian

Subjects
SINGLE nucleotide polymorphisms, CHINESE people, LINKAGE disequilibrium, ISCHEMIC stroke, CHI-squared test
Abstract

Several studies have reported that chromosome 9p21 is significantly associated with ischemic stroke (IS) risk, with the G allele associated with increased risk. However, controversial results have been reported in the literature. We systematically assessed the relationship between stroke and three 9p21 loci (rs2303206, rs2383207, and rs10757278) in this meta-analysis. First, we searched the PubMed and Embase databases for relevant studies. We then calculated odds ratios using the chi-squared test. The evaluation of experimental data was performed using bias tests and sensitivity analyses. We analyzed data from 16 studies involving 18,584 individuals of Chinese ancestry, including 14,033 cases and 14,656 controls. Our results indicated that chromosome 9p21 is significantly associated with IS (odds ratio: 1.15, 95% confidence interval: 1.1–1.20, p < 0.0001). Because the three single-nucleotide polymorphisms (rs2383206, rs2383207, and 10757278) have a linkage disequilibrium relationship, all three may increase the risk of IS. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis

Author

Xuemei Hu, Dongsen Wang, Chunying Cui, and Qingjian Wu

Subjects
ischemic stroke, chromosome 9p21, rs2383206, rs2383207, rs10757278, Chinese, Genetics, QH426-470
Abstract

Several studies have reported that chromosome 9p21 is significantly associated with ischemic stroke (IS) risk, with the G allele associated with increased risk. However, controversial results have been reported in the literature. We systematically assessed the relationship between stroke and three 9p21 loci (rs2383206, rs2383207, and rs10757278) in this meta-analysis. First, we searched the PubMed and Embase databases for relevant studies. We then calculated odds ratios using the chi-squared test. The evaluation of experimental data was performed using bias tests and sensitivity analyses. We analyzed data from 16 studies involving 18,584 individuals of Chinese ancestry, including 14,033 cases and 14,656 controls. Our results indicated that chromosome 9p21 is significantly associated with IS (odds ratio: 1.15, 95% confidence interval: 1.1–1.20, p < 0.0001). Because the three single-nucleotide polymorphisms (rs2383206, rs2383207, and 10757278) have a linkage disequilibrium relationship, all three may increase the risk of IS.

Published
2022
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5. Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis

Author

Ying Bi, Man Li, Lei Zhao, Jing Liu, Jixiang Chen, and Feng Hu

Subjects
Immunology, Disease, 030204 cardiovascular system & hematology, rs2383207, Bioinformatics, rs2383206, Polymorphism, Single Nucleotide, chromosome 9p21, 03 medical and health sciences, rs10757278, 0302 clinical medicine, Asian People, Risk Factors, ischemic stroke, Odds Ratio, medicine, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Letter to the Editor, Pharmacology, Chinese population, Chinese, Cerebral infarction, business.industry, Genetic variants, Cerebral Infarction, medicine.disease, rs10757274, Meta-analysis, Ischemic stroke, Chromosomes, Human, Pair 9, business, 030217 neurology & neurosurgery
Abstract

Ischemic stroke (IS) is the leading cause of disability. Researchers have demonstrated that IS is more a multifactorial disorder than a single-factor disease. At present, no consistent conclusions have been reached on susceptibility loci for IS on chromosome 9p21. We conducted this meta-analysis to verify whether genetic loci on chromosome 9p21 reported domestically and abroad could be responsible for IS in Chinese populations. We analyzed data from eight studies that covered a total of 9756 individuals with Chinese ancestry comprising 4254 cases and 5502 controls. Each of the four reported susceptibility loci (rs2383206, rs2383207, rs10757274, and rs10757278) was analyzed separately. The odds ratios (ORs) of rs2383206 and rs10757274 were 1.09 (95% confidence interval (CI): 1.02–1.06, P = 0.01) and 1.09 (95% CI: 1.01–1.17, P = 0.03), respectively. For rs2383207, OR value was 0.91 (95% CI: 0.84–0.98, P = 0.01). No statistical association was identified for rs10757278. We have verified previous associations for IS in Chinese populations on chromosome 9p21. Loci rs2383206 and rs10757274 may increase susceptibility to IS. Mutation at locus rs2383207 may be beneficial. However, we are unable to identify any association between rs10757278 and IS.

Published
2019
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