1. RNA as a drug target.
- Author
-
Drysdale MJ, Lentzen G, Matassova N, Murchie AI, Aboul-Ela F, and Afshar M
- Subjects
- Animals, Anti-Bacterial Agents chemistry, Anti-HIV Agents chemistry, Drug Design, Humans, Nucleic Acid Conformation, Protein Synthesis Inhibitors chemistry, RNA, Bacterial drug effects, RNA, Viral drug effects, Ribosomes drug effects, Structure-Activity Relationship, Anti-Bacterial Agents pharmacology, Anti-HIV Agents pharmacology, Protein Synthesis Inhibitors pharmacology, RNA, Ribosomal drug effects
- Abstract
In the antiviral and antibacterial area, increasing drug resistance means that there is an ever growing need for novel approaches towards structures and mechanisms which avoid the current problems. The huge increase in high resolution structural data is set to make a dramatic impact on targeting RNA as a drug target. The examples of the RNA binding antibiotics, particularly, the totally synthetic oxazolidinones, should help persuade the skceptics that clinically useful, selective drugs can be obtained from targeting RNA directly.
- Published
- 2002
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