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Background Neonatal sepsis is a major cause of neonatal morbidity and mortality, especially in developing countries. Atypical clinical symptoms lead to delays in diagnosis and treatment. Scoring a combination of routine hematology parameters may be able to predict the occurrence of sepsis in preterm neonates. Objective To formulate a new model for neonatal sepsis scoring from various complete blood count parameters to predict sepsis in preterm neonates. Methods This analytical cross sectional study using secondary data from the Registry of the Neonatology Division was conducted at the RSUP Dr. Hasan Sadikin, Bandung, West Java. Subjects were neonates diagnosed with sepsis, of gestational age 28–36 weeks, who were born at the RSUP Dr. Hasan Sadikin from January to December 2021. Laboratory results of patients who met the inclusion criteria were recorded. Subjects were divided into either proven sepsis and probable sepsis groups, based on blood culture results. Results Of 112 subjects, 35.7% had proven sepsis and 64.3% probable sepsis. In the proven sepsis group, 52.5% of subjects were male, median birth weight was 1,490 grams, median gestational age was 32 weeks, 90% were small for gestational age, and 60% were delivered normally. Multivariable analysis by multiple logistic regression revealed that the parameters associated with the incidence of neonatal sepsis were c-reactive protein (CRP) > 0.18 mg/dL (score 6), hematocrit 10 (score 2). Score >8 had a sensitivity of 85% and specificity of 70.8%, with area under the ROC curve of 0.865 (P8 can be used as a predictor of sepsis in preterm neonates.

Latar belakang. Respiratory Distress Syndrome adalah masalah serius yang menyebabkan morbiditas dan mortalitas tinggi pada bayi prematur. Beberapa faktor risiko, antara lain, jenis kelamin laki-laki, ibu dengan diabetes melitus, ketuban pecah dini, hipertensi, usia ibu

Background: Myelomeningocele (MMC) is a congenital malformation affecting the central nervous system, categorized as a neural tube defect (NTDs). In untreated cases, the mortality rate within the first six months of life ranges from 35% to 70%. Globally, its incidence is estimated 0.8 to 1 per 1000 live births, and rates are higher in Asia and lower socioeconomic groups. This disease imposes a significant treatment cost and burden due to life-long disabilities. In less developed or developing countries, delays in diagnosis can lead to complications such as infection and rupture. Although rupture is a rare complication in MMC, there are limited studies that have reported it. This study aims to discuss the perioperative management and potential complications of ruptured MMC. Method: This study presents four cases of ruptured MMC that were referred from private hospitals and managed by Hasan Sadikin General Hospital in West Java, Indonesia. Each patiens underwent a clinical assessment and diagnostic evaluation upon arrival, followed by perioperative theraphy and management of any complications that emerged during treatment. Result: In three of the four cases, the children were over 24 h old when they were admitted to the hospital. Three cases were located in the lumbosacral region while one case was located in the thoracic region. Upon arrival, the clinical presentations we observed included microcephaly, small for gestational age (SGA) and congenital talipes equionavrus (CTEV). And we found several complications included wound dehisence, respiratiory failure, hydrocephalus, leg weakness, menigitis and sepsis after surgery. Conclusions: Perioperative management is highlighted as vital, necessitating a multidisciplinary approach and precise surgical techniques to mitigate severe complications.

Latar belakang. Enterokolitis nekrotikans merupakan penyakit yang dapat terjadi pada neonatus kurang bulan kecil masa kehamilan. Prevalensi neonatus kecil masa kehamilan di Indonesia tahun 2012 mencapai 18% dengan neonatus kurang bulan sejumlah 8800. Penelitian sebelumnya menyatakan insidensi enterokolitis nekrotikans pada neonatus kurang bulan kecil masa kehamilan sebesar 3,2%. Hipoksia kronis menyebabkan hipoksia perinatal sehingga didapatkan Skor Apgar yang rendah saat lahir. Skor Apgar rendah diduga dapat menyebabkan hipoperfusi splanknik yang memicu peningkatan derajat keparahan enterokolitis nekrotikans. Tujuan. Mengetahui korelasi antara Skor Apgar dengan derajat keparahan enterokolitis nekrotikans pada neonatus kurang bulan kecil masa kehamilan. Metode. Studi potong lintang ini melibatkan neonatus kurang bulan kecil masa kehamilan yang terdiagnosis enterokolitis nekrotikans dan tidak enterokolitis nekrotikans. Data berasal dari rekam medis pasien yang dirawat pada tahun 2018-2022 di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung. Hasil. Terdapat 55 neonatus kurang bulan kecil masa kehamilan yang terdiagnosis enterokolitis nekrotikans dan 55 neonatus kurang bulan kecil masa kehamilan tidak enterokolitis nekrotikans. Hasil riset didapatkan korelasi yang signifikan antara Skor Apgar menit ke-1 (p

Background Early onset neonatal sepsis is a potential life-threatening problem for preterm infant. Diagnosing early onset neonatal sepsis is challenging. Difficulties in establishing diagnosis might cause delay definitive treatment. Objective To analyze for potential associations between early onset neonatal sepsis (EONS) risk and mean platelet volume (MPV) as well as immature platelet fraction (IPF) in neonates of 28-36 weeks gestational age. Methods A prospective cohort study was conducted at Dr. Hasan Sadikin General Hospital, Bandung, West Java. Mean platelet volume (MPV) and IPF were evaluated in the first ?6 hours of life and during the 48-72 hours after the first examination. This examination was followed by observation for sepsis development. Double logistic regression analysis was used. Results Of 115 subjects, 45 preterm infants (39.1%) developed early onset neonatal sepsis. The increase in both mean MPV and mean IPF were significantly different (P

Latar belakang. Pada bayi baru lahir, anemia dapat mengganggu tumbuh kembang bayi dan memengaruhi sistem kardiorespiratori sehingga dapat menyebabkan kematian. Di Indonesia, penelitian prevalensi anemia bayi baru lahir berdasarkan berat lahir dan usia kehamilan masih sangat jarang. Tujuan. Mengetahui prevalensi anemia pada bayi baru lahir berdasarkan berat lahir dan usia kehamilan. Metode. Penelitian deskriptif dengan metode potong lintang menggunakan data sekunder dari Sistem Registrasi Divisi Neonatalogi Departemen Ilmu Kesehatan Anak RSUP DR. Hasan Sadikin Bandung. Kriteria inklusi adalah bayi yang lahir hidup di periode 1 Januari 2018 hingga 31 Desember 2018. Kriteria eksklusi adalah data rekam medis yang tidak lengkap, hilang atau tidak dapat diakses. Usia kehamilan, berat lahir bayi, dan status anemia dinilai dengan melihat kadar hemoglobin yang tercantum dalam rekam medis. Hasil. Sebanyak 1494 bayi baru lahir sesuai dengan kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan bahwa 14,5% bayi baru lahir mengalami anemia. Hasil analisis status anemia berdasarkan berat lahir dan usia kehamilan menunjukkan bahwa 79,2% pasien lahir dengan berat lahir rendah dan 75,9% pasien lahir kurang bulan. Kesimpulan. Prevalensi anemia pada bayi berat lahir rendah dan kurang bulan lebih tinggi dibandingkan dengan bayi berat lahir normal dan cukup bulan.

Latar belakang. Interleukin-1β berperan dalam kejadian infeksi/inflamasi pada bayi prematur yang dapat menyebabkan gejala klinis berat. Imaturitas organ dapat menyebabkan kejadian inflamasi yang dapat merangsang pembentukan sitokin, salah satunya Interleukin-1β. Belum ada penelitian yang menghubungkan marker tersebut terhadap sepsis dan gangguan ginjal akut pada bayi prematur. Tujuan. Melihat peran Interleukin-1β pada kejadian sepsis dan gangguan ginjal akut bayi prematur. Metode. Studi analitik komparatif kohort pada bayi lahir prematur usia kehamilan ≤36 minggu dan berat lahir