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The presence of antibodies to rifampin was determined in sera of patients with tuberculosis on daily treatment one day after discontinuation of treatment, one week later, 3 weeks later, and 8 weeks later. The highest number of positive patients was found in the third week.

In sera of patients treated with rifampicin, who had episodes ascribable to rifampicin sensitization, IgE antibodies were found. These antibodies cross-react with rifamycin SV and with the chromophoric moiety of rifamycins, but not with the side chain of rifampicin.