1. Histological effects of a combined collagen stimulation procedure consisting of microfocused ultrasound, soft tissue filler, and Ca-HA injections.
- Author
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Casabona G, Kaye K, Cotofana S, Davidovic K, Alfertshofer M, and Freytag L
- Subjects
- Humans, Middle Aged, Durapatite, Calcium pharmacology, Skin, Collagen pharmacology, Hyaluronic Acid, Rhytidoplasty, Dermal Fillers, Skin Aging, Cosmetic Techniques
- Abstract
Background: An increasing demand for in-office aesthetic procedures aiming to improve collagen stimulation has been reported., Objective: To analyze the effects of combinations of different aesthetic collagen stimulation procedures using histological analysis., Methods: Histological analysis was performed on skin samples of the excess skin of a 60-year-old patient after sub-superficial musculo-aponeurotic system facelift surgery. The excess skin before facelift surgery was divided into three areas per hemiface. Each area-with exception of area A as a control-received an isolated or combined treatment of microfocused ultrasound (MFU), injections of calcium-hydroxylapatite/hyaluronic-acid-based soft tissue filler, and microneedling. The effect of the treatments was analyzed using histological analysis with H&E coloration and PAS staining., Results: A threefold increase of epidermal and dermal thickness was achieved by treating the skin with the proposed combined treatment comprising MFU and injections of calcium-hydroxylapatite- and hyaluronic-acid-based soft tissue fillers., Conclusion: The investigated treatments act synergistically in the production of collagen and combining these treatments allows for an increase in collagen production., (© 2023 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
- Published
- 2023
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