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4 results on '"Denton MJ"'

4. No evidence of linkage between the locus for autosomal dominant retinitis pigmentosa and D3S47 (C17) in three Australian families.

Author

Jiménez JB, Samanns C, Watty A, Pongratz J, Olsson JE, Dickinson P, Buttery R, Gal A, and Denton MJ

Subjects
Adolescent, Adult, Australia, Child, Child, Preschool, Female, Genetic Markers, Genotype, Humans, Male, Pedigree, Recombination, Genetic, Genes, Dominant, Genetic Linkage, Retinitis Pigmentosa genetics, Rhodopsin genetics
Abstract

A linkage analysis has been performed on three Australian families segregating for autosomal dominant retinitis pigmentosa (ADRP). No evidence of linkage has been found in any of the pedigrees studied between the locus D3S47 and the gene for ADRP. The D3S47 locus was found to show very close linkage with the ADRP gene in a large Irish pedigree. Our study together with a similar report on a British family indicates that there is genetic heterogeneity in this disease.

Published
1991
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