1. The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce.
- Author
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Liu F, Cai XL, Yang H, Xia XK, Guo ZY, Yuan J, Li MF, She ZG, and Lin YC
- Subjects
- Anthracenes chemistry, Anthracenes isolation & purification, Anthracenes pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Benzopyrans chemistry, Benzopyrans pharmacology, Cell Line, Tumor drug effects, Crystallography, X-Ray, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Mycorrhizae metabolism, Plant Bark, Plant Stems, X-Ray Diffraction, Antineoplastic Agents isolation & purification, Benzopyrans isolation & purification, Rhizophoraceae chemistry, Talaromyces metabolism
- Abstract
Bioactivity-directed fractionation of the extract of the mangrove endophytic fungus Talaromyces sp. ZH-154, which was isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae, afforded two new metabolites, 7-epiaustdiol ( 1) and 8-O-methylepiaustdiol ( 2), together with the known compounds, stemphyperylenol ( 3), skyrin ( 4), secalonic acid A ( 5), emodin ( 6), and norlichexanthone ( 7). Their structures were elucidated on the basis of spectroscopic evidences including CD, MS, and 1D, 2D NMR techniques. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction. All isolated compounds were evaluated for their antimicrobial and in vitro cytotoxic activities., (Georg Thieme Verlag KG Stuttgart . New York.)
- Published
- 2010
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