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Your search keyword '"NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU)"' showing total 4 results
Start Over Author "NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU)" Topic rheumatology
4 results on '"NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU)"'

1. Gender Equity in Academic Rheumatology, Current Status and Potential for Improvement: A Cross-Sectional Study to Inform an EULAR Task Force

Author

Pavel V Ovseiko, Laure Gossec, Laura Andreoli, Uta Kiltz, Leonieke van Mens, Neelam Hassan, Marike van der Leeden, Heidi J Siddle, Alessia Alunno, Iain B McInnes, Nemanja S Damjanov, Florence Apparailly, Caroline Ospelt, Irene E van der Horst-Bruinsma, Elena Nikiphorou, Katie L Druce, Zoltán Szekanecz, Alexandre Sepriano, Tadej Avcin, George Bertsias, Georg Schett, Anne-Maree Keenan, Linda H Pololi, Laura C Coates, University of Oxford, Service de Rhumatologie [CHU Pitié Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), University of Brescia, Ruhr University Bochum (RUB), Department of Clinical Immunology and Rheumatology [Academic Medical Center, Amsterdam], University of Amsterdam [Amsterdam] (UvA), North Bristol NHS Trust [Bristol, UK], University of Bristol [Bristol], Amsterdam UMC - Amsterdam University Medical Center, University of Leeds, University of L'Aquila [Italy] (UNIVAQ), University of Glasgow, University of Belgrade [Belgrade], Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University hospital of Zurich [Zurich], VU University Medical Center [Amsterdam], King‘s College London, University of Manchester [Manchester], University of Debrecen Egyetem [Debrecen], Leiden University Medical Center (LUMC), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), University of Crete [Heraklion] (UOC), Universitätsklinikum Erlangen [Erlangen], NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU), National Institute for Health Research (NIHR), Brandeis University, Gestionnaire, Hal Sorbonne Université, Rehabilitation medicine, AMS - Ageing & Vitality, AMS - Musculoskeletal Health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, APH - Societal Participation & Health, Rheumatology, AII - Inflammatory diseases, and AMS - Tissue Function & Regeneration

Subjects
Gender Equity, Male, [SDV]Life Sciences [q-bio], Immunology, health services research, Europe, [SDV] Life Sciences [q-bio], Cross-Sectional Studies, Rheumatology, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], Immunology and Allergy, Humans, Female, epidemiology, ddc:610, Rheumatologists, qualitative research
Abstract

ObjectivesEvidence on the current status of gender equity in academic rheumatology in Europe and potential for its improvement is limited. The EULAR convened a task force to obtain empirical evidence on the potential unmet need for support of female rheumatologists, health professionals and non-clinical scientists in academic rheumatology.MethodsThis cross-sectional study comprised three web-based surveys conducted in 2020 among: (1) EULAR scientific member society leaders, (2) EULAR and Emerging EULAR Network (EMEUNET) members and (3) EULAR Council members. Statistics were descriptive with significance testing for male/female responses assessed by χ2 test and t-test.ResultsData from EULAR scientific member societies in 13 countries indicated that there were disproportionately fewer women in academic rheumatology than in clinical rheumatology, and they tended to be under-represented in senior academic roles. From 324 responses of EULAR and EMEUNET members (24 countries), we detected no gender differences in leadership aspirations, self-efficacy in career advancement and work–life integration as well as the share of time spent on research, but there were gender differences in working hours and the levels of perceived gender discrimination and sexual harassment. There were gender differences in the ranking of 7 of 26 factors impacting career advancement and of 8 of 24 potential interventions to aid career advancement.ConclusionsThere are gender differences in career advancement in academic rheumatology. The study informs a EULAR task force developing a framework of potential interventions to accelerate gender-equitable career advancement in academic rheumatology.

Published
2022

2. Recommendations for the execution and reporting of skin ultrasound in systemic sclerosis: an international collaboration under the WSF skin ultrasound group

Author

Tânia Santiago, Eduardo José Ferreira Santos, Barbara Ruaro, Gemma Lepri, Lorraine Green, Marie Wildt, Shinji Watanabe, Alain Lescoat, Roger Hesselstrand, Francesco del Galdo, John D Pauling, Lucy Jean Reeve, Maria Antonieta D'Agostino, Marco Matucci-Cerinic, Annamaria Iagnocco, Jose Antonio Pereira da Silva, Centro Hospitalar e Universitário [Coimbra], University of Coimbra [Portugal] (UC), Health Sciences Research Unit: Nursing [Coimbra, Portugal] (UICiSA:E), Escola Superior de Enfermagem de Coimbra [Coimbra, Portugal], Università degli studi di Trieste = University of Trieste, Università degli Studi di Firenze = University of Florence (UniFI), Leeds Institute of Molecular Medicine, University of Leeds, Lund University [Lund], Nippon Medical School [Tokyo, Japon], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU Pontchaillou [Rennes], NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU), National Institute for Health Research (NIHR), Royal United Hospitals Bath (RUH), University of Bath [Bath], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Università degli studi di Torino = University of Turin (UNITO), Santiago, Tânia, Santos, Eduardo José Ferreira, Ruaro, Barbara, Lepri, Gemma, Green, Lorraine, Wildt, Marie, Watanabe, Shinji, Lescoat, Alain, Hesselstrand, Roger, Del Galdo, Francesco, Pauling, John D, Reeve, Lucy Jean, D'Agostino, Maria Antonieta, Matucci-Cerinic, Marco, Iagnocco, Annamaria, and da Silva, Jose Antonio Pereira

Subjects
Scleroderma, Systemic, Outcome and Process Assessment, Health Care, Ultrasonography, Consensus, Humans, Reproducibility of Results, Skin, Rheumatology, [SDV]Life Sciences [q-bio], Immunology, Systemic, Reproducibility of Result, Consensu, Outcome and Process Assessment, Scleroderma, Health Care, Immunology and Allergy, Human
Abstract

ObjectiveUltrasound is a promising tool to foster much-needed improvement of skin assessment in systemic sclerosis (SSc). Our aim was to develop evidence and expert opinion-based recommendations to promote the standardisation and harmonisation of technical execution and reporting of skin ultrasound studies in SSc.MethodsA multidisciplinary task force of 16 members from five European countries and Japan was convened under the auspices of World Scleroderma Foundation. First, a systematic literature review (SLR) was performed. Then, each member proposed and formulated items to the overarching principles, recommendations and research agenda. Two rounds of mails exchange for consensus as well as an on-line meeting were performed to debate and refine the proposals. Two Delphi rounds of voting resulted in the final recommendations. Levels of evidence and strengths of recommendations were assigned, and task force members voted anonymously on the level of agreement with each of the items.ResultsFive overarching principles and seven recommendations were developed, based on an SLR and expert opinion, through consensus procedures. The overarching principles highlight the promising role of skin ultrasound in SSc assessment, the need for standardisation of technical aspects, sufficient training and adequate equipment. The recommendations provide standards for the execution and reporting of skin ultrasound in SSc. The research agenda includes the need for more research into unmet needs according to Outcome Measures in Rheumatology Algorithm requirements.ConclusionThese are the first recommendations providing guidance on the execution and reporting of skin ultrasound in SSc patients, aiming at improving the interpretability, reliability and generalisability of skin ultrasound, thus consolidating its role in research and practice.

Published
2022

3. Development of patient-centred standards of care for osteoarthritis in Europe: the eumusc.net-project

Author

Michaela A, Stoffer, Josef S, Smolen, Anthony, Woolf, Ales, Ambrozic, Florian, Berghea, Annelies, Boonen, Ailsa, Bosworth, Loreto, Carmona, Maxime, Dougados, Maarten, de Wit, Josephine, Erwin, Veronika, Fialka-Moser, Ruxandra, Ionescu, Anne-Maree, Keenan, Estibaliz, Loza, Rikke H, Moe, Rolf, Greiff, Pawel, Olejnik, Ingemar F, Petersson, Anne-Christine, Rat, Blaz, Rozman, Britta, Strömbeck, Lorraine, Tanner, Till, Uhlig, Theodora P M Vliet, Vlieland, Tanja A, Stamm, Medizinische Universität Wien = Medical University of Vienna, Royal Cornwall Hospital, University Medical Centre Ljubljana (UMCL), Universitatea de Medicina si Farmacie Carol Davila = Université de médecine et pharmacie Carol Davila (UMFCD), Maastricht University Medical Center (MUMC), Maastricht University [Maastricht], National Rheumatoid Arthritis Society (NRAS), Instituto de Salud Musculoesqueletica (InMusc), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Reumapatientenbond, NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU), National Institute for Health Research (NIHR), University of Leeds, National Advisory Unit on Rehabilitation in Rheumatology (NKRR ), Rheumatikerförbundet = Swedish Rheumatism Association, Instytut Reumatologii, Lund University [Lund], Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Leiden University Medical Center (LUMC), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Maastricht University Medical Centre (MUMC), Interne Geneeskunde, RS: CAPHRI School for Public Health and Primary Care, and RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation

Subjects
Delphi Technique, Delphi method, Psychological intervention, Alternative medicine, Osteoarthritis, GUIDELINES, MESH: Delphi Technique, 0302 clinical medicine, MESH: Osteoarthritis, Multidisciplinary approach, Patient-Centered Care, Immunology and Allergy, Orthopedics and Sports Medicine, computer.programming_language, Evidence-Based Medicine, 030503 health policy & services, Health services research, Standard of Care, Checklist, 3. Good health, Europe, EULAR RECOMMENDATIONS, 0305 other medical science, MESH: Pain Management, medicine.medical_specialty, Immunology, Biomedical Engineering, KNEE OSTEOARTHRITIS, General Biochemistry, Genetics and Molecular Biology, MESH: Patient-Centered Care, Patient perspective, 03 medical and health sciences, Nursing, Rheumatology, ESCISIT, medicine, MANAGEMENT, Humans, Pain Management, QUALITY, MESH: Standard of Care, 030203 arthritis & rheumatology, HIP, MESH: Humans, business.industry, Evidence-based medicine, Clinical and Epidemiological Research, medicine.disease, RHEUMATOID-ARTHRITIS, Family medicine, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, computer, Patient centred, Delphi, STANDING-COMMITTEE, MESH: Evidence-Based Medicine, TASK-FORCE
Abstract

ObjectiveThe eumusc.net project is an initiative founded by the European Community and the European League Against Rheumatism. One aim of the project was to facilitate equal standards for musculoskeletal health across Europe. The aim of this work-package was to develop patient-centred and consensus based standards of care (SOC) for osteoarthritis (OA), which should be available in a professional and a patient version.MethodsA systematic review concerning guidelines dealing with OA was conducted. Furthermore, experts in musculoskeletal diseases were contacted to ensure that ‘grey’ literature was not excluded. Documents that fulfilled predefined inclusion/exclusion criteria were included and all interventions for OA were extracted and categorised. Based on this list of interventions, a three round Delphi exercise with an international and multidisciplinary expert panel, including patient research partners, was performed to achieve expert consensus.ResultsSix documents were included and used for further analysis. Out of them, 46 interventions have been extracted and 10 consensus based SOC were formulated. In addition, a patient version, written in a lay-understandable wording and in the format of checklist questions was developed. An example is SOC 5: “People with OA should achieve optimal pain control using pharmacological and non-pharmacological means.” The matching patient-centred checklist question reads: “Do I know how to control pain associated with OA?”ConclusionsThe SOC for OA will be available in the 23 languages of the European Union to enhance unified information to patients and professionals and to further harmonise the treatment/care of OA within Europe.

Published
2015

4. OR10-002 - A novel TNFR1 transcript of TRAPS gene

Author

Elodie Sanchez, Stephan Soler, Michael F. McDermott, M Albers, Isabelle Touitou, Sylvie Grandemange, Laura Obici, Cécile Rittore, Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques (LGMR), IFR3, Université Montpellier 1 (UM1)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Medical Practice, University Medical Center [Utrecht], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione 'Istituto Neurologico Nazionale C. Mondino', NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU), National Institute for Health Research (NIHR), Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and BMC, Ed.

Subjects
TNFRSF1A gene, medicine.medical_specialty, Bioinformatics, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, 0302 clinical medicine, Text mining, Rheumatology, Cell surface receptor, Internal medicine, medicine, Immunology and Allergy, 030212 general & internal medicine, Pediatrics, Perinatology, and Child Health, Gene, ComputingMilieux_MISCELLANEOUS, 030203 arthritis & rheumatology, Genetics, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Transcriptional activity, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, 3. Good health, Periodic syndrome, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Pediatrics, Perinatology and Child Health, Meeting Abstract, Tumor necrosis factor alpha, business
Abstract

Mutations in the TNFRSF1A gene encoding the TNF cell surface receptor, TNFR1, cause TNFR-associated periodic syndrome (TRAPS) and polymorphisms in TNFRSF1A, including rs4149570, rs767455 and rs1800692, are associated with inflammatory diseases.

Published
2013

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