1. In vivo human retinal swept source optical coherence tomography and angiography at 830 nm with a CMOS compatible photonic integrated circuit.
- Author
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Rank, Elisabet A., Nevlacsil, Stefan, Muellner, Paul, Hainberger, Rainer, Salas, Matthias, Gloor, Stefan, Duelk, Marcus, Sagmeister, Martin, Kraft, Jochen, Leitgeb, Rainer A., and Drexler, Wolfgang
- Subjects
OPTICAL coherence tomography ,INTEGRATED circuits ,ANGIOGRAPHY ,BEAM splitters ,RETINAL imaging ,INTEGRATING circuits - Abstract
Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only (12 × 5) mm 2 . The system achieves 94 dB imaging sensitivity with 750 μ W on the sample, 50 kHz imaging speed and 5.5 μ m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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