5 results on '"Mulvihill, Alan O."'
Search Results
2. Raised intracranial pressure and retinal haemorrhages in childhood encephalopathies.
- Author
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Minns RA, Jones PA, Tandon A, Fleck BW, Mulvihill AO, and Minns FC
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Logistic Models, Male, Prospective Studies, Retina diagnostic imaging, Retinal Hemorrhage diagnostic imaging, Brain Diseases complications, Brain Diseases physiopathology, Intracranial Pressure, Retinal Hemorrhage complications, Retinal Hemorrhage physiopathology
- Abstract
Aim: To explore the relationship between raised intracranial pressure (RICP) and retinal haemorrhages in traumatic and non-traumatic childhood encephalopathies., Method: A prospective study of 112 children (35 females and 77 males, age range 0.01mo-17y 8.3mo; mean 5y 8.6mo, median 4y 5.6mo) included 57 accidental traumatic brain injuries (ATBIs), 21 inflicted traumatic brain injuries (ITBIs), and 34 non-traumatic encephalopathy cases. Measurements included intracranial pressure (ICP), cerebral perfusion pressure, pressure-time index of ICP, and number, zone, and layer of retinal haemorrhages on retinal imaging., Results: Group I had measured elevated ICP (n=42), Group II had clinical and/or radiological signs of RICP (n=21), and Group III had normal ICP (n=49). In the combined Groups I and II, 38% had retinal haemorrhages. Multiple logistic regression confirmed that the presence of retinal haemorrhages was significantly related to the presence of RICP independent of age and aetiology; however, the occurrence and overall numbers were not significantly related to the specific ICP level. The numbers of intraretinal (nerve-fibre layer and dot blot) retinal haemorrhages were significantly greater in those with RICP. The ITBI population was significantly different from the other combined aetiological categories., Interpretation: The study results indicate a complex RICP/retinal haemorrhage relationship. There was no evidence of existing retinal haemorrhages being exacerbated or new retinal haemorrhages developing during periods of confirmed RICP., (© 2017 Mac Keith Press.)
- Published
- 2017
- Full Text
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3. Prediction of inflicted brain injury in infants and children using retinal imaging.
- Author
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Minns RA, Jones PA, Tandon A, Fleck BW, Mulvihill AO, and Elton RA
- Subjects
- Adolescent, Brain Injuries complications, Child, Child, Preschool, Diagnostic Techniques, Ophthalmological, Female, Humans, Infant, Male, Photography, Predictive Value of Tests, Prospective Studies, Retinal Hemorrhage etiology, Brain Injuries pathology, Retinal Hemorrhage pathology
- Abstract
Background: Retinal hemorrhages (RHs) occur in inflicted traumatic brain injury (ITBI), accidental traumatic brain injury (ATBI), and some medical conditions, although the reported number, distribution, type, and frequency vary greatly between these different etiologies. We hypothesize that these RH characteristics reliably help to distinguish ITBI from ATBI and nontraumatic etiologies., Methods: A 6-year prospective observational study using wide-field retinal imaging (RetCam) was conducted within 24 hours of admission to PICU, on serially recruited children with traumatic and nontraumatic encephalopathies. "Definite" and "probable" ITBI cases were confirmed by multiagency child protection case conferences. Image analysis used digital color and grayscale images for retinal "zoning" and "layering" of hemorrhages., Results: Significant differences were found between the mean numbers of hemorrhages in ATBI/ITBI, and ITBI/nontraumatic etiologies for the 3 retinal zones (range, P = .003-.009) and for the dot-blot hemorrhages (range P = .001-.002). The mean numbers of RHs per ITBI patient in the peripapillary, macula, and peripheral zones were 14, 28, and 31 respectively. RHs in ATBI were near the optic disc and more superficial than in ITBI, where hemorrhages involved deeper layers (range, P = .003-.039) and were more peripheral (P = .03). The positive predictive value for ITBI in children <3 years with >25 dot-blot (intraretinal) hemorrhages was 93%., Conclusions: This prospective study, which included all potential causes of RHs, with objective retinal methodology, has confirmed that a young age and a high dot-blot count are strong predictors of ITBI. This high predictive value may support medicolegal deliberations.
- Published
- 2012
- Full Text
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4. An inter-observer and intra-observer study of a classification of RetCam images of retinal haemorrhages in children.
- Author
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Mulvihill AO, Jones P, Tandon A, Fleck BW, and Minns RA
- Subjects
- Child, Child, Preschool, Craniocerebral Trauma diagnosis, Diagnosis, Differential, Female, Humans, Infant, Male, Observer Variation, Retinal Hemorrhage diagnosis, Craniocerebral Trauma classification, Diagnostic Techniques, Ophthalmological standards, Retinal Hemorrhage classification
- Abstract
Background: There is currently no universally accepted classification of childhood retinal haemorrhages., Aim: To measure the inter- and intra-observer agreement of clinical classifications of retinal haemorrhages in children., Methods: Four examiners (two consultant ophthalmologists and two other clinicians) were shown 142 retinal haemorrhages on 31 RetCam photographs. The retinal haemorrhages were from children with accidental or abusive head injury, or other encephalopathies, and included retinal haemorrhages of different ages. Specified haemorrhages were initially classified by each examiner according to their clinical understanding. Altogether, 26 haemorrhages were re-presented to test intra-observer consistency. Examiners then agreed a common description for each haemorrhage type and five categories were described (vitreous, pre-retinal, nerve fibre layer, intra-retinal/sub-retinal or indeterminate) and the study repeated., Results: There was 'fair agreement' initially (Fleiss' unweighted κ=0.219) and, with the agreed classification, slight improvement (0.356). Intra-observer agreement marginally improved on re-test. The two consultant ophthalmologists showed 'fair' agreement on both occasions (paired κ statistic). The other rater pair improved from 'fair' to 'substantial' agreement with the new classification., Conclusions: The classification of retinal haemorrhage in children by appearance alone shows only fair agreement between examiners. Clinicians who are not consultant ophthalmologists appear to benefit from the new succinct classification.
- Published
- 2011
- Full Text
- View/download PDF
5. An interrater reliability study of a new 'zonal' classification for reporting the location of retinal haemorrhages in childhood for clinical, legal and research purposes.
- Author
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Fleck BW, Tandon A, Jones PA, Mulvihill AO, and Minns RA
- Subjects
- Child, Child Abuse diagnosis, Craniocerebral Trauma complications, Diagnosis, Differential, Diagnostic Techniques, Ophthalmological, Forensic Medicine methods, Humans, Observer Variation, Optic Disk pathology, Retinal Hemorrhage etiology, Retinal Hemorrhage pathology, Retinal Hemorrhage classification
- Abstract
Background/aims: To develop and assess a zonal classification of the retina to facilitate description of the location of retinal haemorrhages in children., Methods: A novel zonal classification of the retina was devised based on the anatomical landmarks of the optic disc and vascular arcades, by reviewing a large number of wide field digital retinal images drawn from our database of children with accidental and non-accidental head injury and other encepthalopathies. Four expert examiners then independently 'located' 142 retinal haemorrhages by zone, from 31 high quality photographs., Results: Cohen's unweighted kappa scores for all possible pairs of the four raters (ie, six pairs) ranged from 0.86 to 0.92, that is 'almost perfect' agreement. Fleiss' kappa for agreement between multiple raters (four) and for multiple categories (three) was 0.8841, that is 'almost perfect' agreement. Cohen's unweighted kappa statistic for intrarater reliability gave an overall concordance that ranged from 'substantial' to 'perfect' agreement., Conclusion: This new retinal zone classification and the use of photographs and templates is a very reliable tool for reporting the location of retinal haemorrhages from multiple aetiologies in children, and may be useful for research and medico-legal reports.
- Published
- 2010
- Full Text
- View/download PDF
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