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Your search keyword '"Lane, Stephen M."' showing total 2 results
Start Over Author "Lane, Stephen M." Topic retina
2 results on '"Lane, Stephen M."'

1. Optical coherence tomography and Raman spectroscopy of the ex-vivo retina.

Author

Evans JW, Zawadzki RJ, Liu R, Chan JW, Lane SM, and Werner JS

Subjects
Animals, Feasibility Studies, Humans, Image Processing, Computer-Assisted, In Vitro Techniques, Phantoms, Imaging, Spectrum Analysis, Raman methods, Systems Integration, Time Factors, Tomography, Optical Coherence methods, Retina anatomy & histology, Spectrum Analysis, Raman instrumentation, Tomography, Optical Coherence instrumentation
Abstract

Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combine these imaging modalities. We describe an OCT microscope for ex-vivo imaging combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. We present our first results and discuss the challenges to further development of this dual-mode instrument and limitations for future in-vivo retinal imaging.

Published
2009
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2. Optical coherence tomography and Raman spectroscopy of the ex-vivo retina

Author

Evans, Julia W, Zawadzki, Robert J, Liu, Rui, Chan, James W, Lane, Stephen M, and Werner, John S

Subjects
Time Factors, Image Processing, Medical Biotechnology, Bioengineering, Optical Physics, In Vitro Techniques, Eye, Retina, Phantoms, Imaging, Medicinal and Biomolecular Chemistry, Computer-Assisted, Animals, Humans, Tomography, Raman, Eye Disease and Disorders of Vision, screening and diagnosis, optical coherence tomography, Spectrum Analysis, 4.1 Discovery and preclinical testing of markers and technologies, Optoelectronics & Photonics, Systems Integration, Detection, Optical Coherence, retinal imaging, Raman spectroscopy, Feasibility Studies, Biomedical Imaging
Abstract

Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combine these imaging modalities. We describe an OCT microscope for ex-vivo imaging combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. We present our first results and discuss the challenges to further development of this dual-mode instrument and limitations for future in-vivo retinal imaging.

Published
2009

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