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Objective The relationship between the estrogen receptor（ER）gene and the incidence of tenosynovitis was studied by analyzing the distribution of the ER genotypes in women with menopause tenosynovitis，menopause healthy women and non menopause healthy women.Methods A total of 111 cases of menopause women in the Eighth Affiliated Hospital of Yat⁃sen Universtity were selected from August 2012 to December 2015，which 48 cases were tenosynovitis（group A），63 cases menopause healthy women（group B），and 63 non menopause healthy women as control（group C）.Collected three groups of subjects in the morning，and the distribution of ER genotype was detected by polymerase chain reaction，and correlation analysis was performed.Results There were no significant differences in ER genotype distribution and ER gene polymorphism between group A and group B and C（P>0.05）.Conclusion ER genetic polymorphism in postmenopausal women has no obvious relationship of tenosynovitis. [ABSTRACT FROM AUTHOR]