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2 results on '"EEM VANESSENZANDVLIET"'

1. IMPORTANCE OF TOTAL SERUM IGE FOR IMPROVEMENT IN AIRWAYS HYPERRESPONSIVENESS WITH INHALED CORTICOSTEROIDS IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY-DISEASE

Author

Huib Kerstjens, Jan Schouten, Paul Brand, DFME SCHOONBROOD, PJ STERK, Dirkje Postma, KF KERREBIJN, PH QUANJER, HJ SLUITER, EM POUW, CM ROOS, HM JANSEN, Degooyer, A., TW VANDERMARK, GH KOETER, PM DELONG, AMJ WEVER, JH DIJKMAN, PNR DEKHUIJZEN, HTM FOLGERING, CLA VANHERWAARDEN, SE OVERBEEK, JM BOGAARD, Hilvering, C., SJ GANS, HJJ MENGELEERS, BAHA VANDERBRUGGENBOGAARTS, Kreukniet, J., EEM VANESSENZANDVLIET, EJ DUIVERMAN, JM KOUWENBERG, JE PRINSEN, HJ WAALKENS, Gerritsen, J., Knol, K., JGR DEMONCHY, FW DEKKER, AA KAPTEIN, PJFM MERKUS, SJ POCOCK, MD HUGHES, NJ ROBINSON, ER BLEECKER, DA MEYERS, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
LUNG-FUNCTION, ALLERGY, SKIN-TEST REACTIVITY, INFLAMMATION, BUDESONIDE, HYPERREACTIVITY, REVERSIBILITY, AIR-FLOW LIMITATION, respiratory system, BRONCHODILATOR RESPONSE, respiratory tract diseases, RESPONSIVENESS
Abstract

Airways hyperresponsiveness is a hallmark of asthma, and many patients with COPD also demonstrate hyperresponsiveness. Inhaled corticosteroids improve hyperresponsiveness, but the extent of improvement may vary considerably between patients. This study was designed to determine which patient characteristics predict these differences in response. Patients with mild to moderately severe obstructive airways disease (asthma and COPD) were selected if PC20 less than or equal to 8 mg/ml and FEV(1)

Published
1995

2. INFLUENCE OF TREATMENT ON PEAK EXPIRATORY FLOW ACID ITS RELATION TO AIRWAY HYPERRESPONSIVENESS AND SYMPTOMS

Author

Huib Kerstjens, Paul Brand, PM DEJONG, GH KOETER, Dirkje Postma, PH QUANJER, HJ SLUITER, EM POUW, DFME SCHOONBROOD, CM ROOS, HM JANSEN, Degooyer, A., TW VANDERMARK, PJ STERK, AMJ WEVER, JH DIJKMAN, PNR DEKHUIJZEN, HTM FOLGERING, CLA VANHERWAARDEN, SE OVERBEEK, JM BOGAARD, Hilvering, C., SJ GANS, HJJ MENGELERS, BAHA VANDERBRUGGENBOGAARTS, Kreukniet, J., EEM VANESSENZANDVLIET, KF KERREBIJN, EJ DUIVERMAN, JM KOUWENBERG, JE PRINSEN, HJ WAALKENS, Gerritsen, J., Knol, K., JGR DEMONCHY, FW DEKKER, AA KAPTEIN, PJFM MERKUS, SJ POCOCK, MD HUGHES, ER BLEECKER, DA MEYERS, Faculteit Medische Wetenschappen/UMCG, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
DIURNAL-VARIATION, respiratory system, DISEASE, respiratory tract diseases, RESPONSIVENESS, LUNG-FUNCTION, VARIABILITY, immune system diseases, BUDESONIDE, BRONCHIAL HYPERRESPONSIVENESS, ASTHMA, GLUCOCORTICOID RECEPTOR CHARACTERISTICS, circulatory and respiratory physiology, BRONCHODILATOR
Abstract

Background - Despite effective treatments, the morbidity and mortality of obstructive airways disease (asthma and COPD) remains high. Home monitoring of peak expiratory dow (PEF) is increasingly being advocated as an aid to better management of obstructive airways disease. The few available studies describing effects of treatment on the level and variation of PEF have involved relatively small numbers of subjects and did not use control groups. Methods - Patients aged 18-60 years were selected with PC20 less than or equal to 8 mg/ml and FEV(1) Results - Improvements in PEF occurred within the first three months of treatment with BA + CS and was subsequently maintained: the mean (SE) increase in morning PEF was 51 (8) l/min in the BA + CS group compared with no change in the other two groups. Similarly, afternoon PEF increased by 22 (7) l/min. Diurnal variation in PEF (amplitude %mean) decreased from 18.0% to 10.2% in the first three months of treatment with BA + CS. Within-subject relations between changes in diurnal variation in PEF and changes in PC20 were found to be predominantly negative (median rho-0.40) but with a large scatter. Relations between diurnal variation ation in PEF and changes in symptom scores, FEV(1), and bronchodilator response were even weaker. Conclusions - In patients with moderately severe obstructive airways disease, PEF rates and variation are greatly improved by inhaled corticosteroids. Since the relation of diurnal PEF variation with PC20 symptoms, FEV(1), and bronchodilator response were all weak, these markers of disease severity may all provide different information on the actual disease state. PEF measurements should be used in addition to the other markers but not instead of them.

Published
1994

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