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Background: Aging is associated with a health impairment and an increase of the vulnerability of the older people. Strength training under intermittent hypoxic conditions has been shown to have therapeutic effects on individual's health., Aims: The aim of this study was to investigate the effects of a combined intermittent hypoxia (IH) and whole-body vibration (WBV) training program on health-related outcomes in older people., Methods: A total of 60 adults (over the age of 65) voluntarily participated in an intervention that lasted 20 weeks (three 30-min sessions per week). The participants were divided into four experimental groups subjected to different environmental conditions (IH vs normoxia) and exercise (non-exercise vs WBV). Functional fitness, body composition, metabolic parameters, inflammatory biomarkers, and bone turnover were evaluated before and after the intervention. A multifactorial ANOVA with repeated measures was performed to explore differences within and between groups., Results: The results showed that IH and WBV had a positive synergistic effect on inflammatory parameters (CRP and IL-10), bone formation biomarker (PINP), and body composition (muscle and bone mass)., Conclusion: In conclusion, a combined IH and WVB training could be a useful tool to prevent the deterioration of health-related outcomes associated with aging. Clinical trial registration NCT04281264. https://clinicaltrials.gov/ ., (© 2024. The Author(s).)

Background: Metabolic stress is considered a key factor in the activation of hypertrophy mechanisms which seems to be potentiated under hypoxic conditions.This study aimed to analyze the combined effect of the type of acute hypoxia (terrestrial vs simulated) and of the inter-set rest configuration (60 vs 120 s) during a hypertrophic resistance training (R T ) session on physiological, perceptual and muscle performance markers., Methods: Sixteen active men were randomized into two groups based on the type of hypoxia (hypobaric hypoxia, HH: 2,320 m asl; vs normobaric hypoxia, NH: FiO 2 of 15.9%). Each participant completed in a randomly counterbalanced order the same R T session in four separated occasions: two under normoxia and two under the corresponding hypoxia condition at each prescribed inter-set rest period. Volume-load (load × set × repetition) was calculated for each training session. Muscle oxygenation (SmO 2 ) of the vastus lateralis was quantified during the back squat exercise. Heart rate (HR) was monitored during training and over the ensuing 30-min post-exercise period. Maximal blood lactate concentration (maxLac) and rating of perceived exertion (RPE) were determined after the exercise and at the end of the recovery period., Results: Volume-load achieved was similar in all environmental conditions and inter-set rest period length did not appreciably affect it. Shorter inter-set rest periods displayed moderate increases in maxLac, HR and RPE responses in all conditions. Compared to HH, NH showed a moderate reduction in the inter-set rest-HR (ES > 0.80), maxLac (ES > 1.01) and SmO 2 (ES > 0.79) at both rest intervals., Conclusions: Results suggest that the reduction in inter-set rest intervals from 120 s to 60 s provide a more potent perceptual, cardiovascular and metabolic stimulus in all environmental conditions, which could maximize hypertrophic adaptations in longer periods of training. The abrupt exposure to a reduced FiO 2 at NH seems to reduce the inter-set recovery capacity during a traditional hypertrophy R T session, at least during a single acute exposition. These results cannot be extrapolated to longer training periods., Competing Interests: Brad J. Schoenfeld serves on the scientific advisory board to Tonal Corporation, a manufacturer of exercise equipment., (©2022 Benavente et al.)

Hypobaric hypoxia (HH) seems to lead to different responses compared to normobaric hypoxia (NH) during physical conditioning. The aim of the study was to analyze the hormonal and circulating ion responses after performing high-intensity resistance training with different inter-set rest under HH and NH condition. Sixteen male volunteers were randomly divided into two training groups. Each group completed two counterbalanced resistance training sessions (three sets × ten repetitions, remaining two repetitions in reserve), with both one- and two-minute inter-set rest, under HH and NH. Blood samples were obtained to determine hormones and circulating ions (Ca 2+ , Pi, and HCO 3 ) at baseline and after training sessions (5, 10, and 30 min). Resistance training with one-minute rest caused greater hormonal stress than with two-minute rest in cortisol and growth hormone, although the hypoxic environmental condition did not cause any significant alterations in these hormones. The short inter-set rest also caused greater alterations in HCO - ) at baseline and after training sessions (5, 10, and 30 min). Resistance training with one-minute rest caused greater hormonal stress than with two-minute rest in cortisol and growth hormone, although the hypoxic environmental condition did not cause any significant alterations in these hormones. The short inter-set rest also caused greater alterations in HCO 3 - , were observed after training in HH compared to NH. Metabolic and physiological responses after resistance training are mediated by inter-set rest intervals and hypoxic environmental condition. According to the alterations observed in the circulating ions, HH could cause greater muscular fatigue and metabolic stress than NH.2+ and Pi, and lower levels of HCO 3 - , were observed after training in HH compared to NH. Metabolic and physiological responses after resistance training are mediated by inter-set rest intervals and hypoxic environmental condition. According to the alterations observed in the circulating ions, HH could cause greater muscular fatigue and metabolic stress than NH.

Ageing is associated with chronic low-grade inflammation and with a decrease in muscle mass and strength. The aim of the study was to evaluate the effect of a resistance training programme in conditions of intermittent hypoxia on inflammatory biomarkers in older people. A total of 54 older adults (aged 65-75 years), who voluntarily participated in the study, were randomly divided into three groups: the control (CON) group, the resistance training normoxia (RTN) group that performed resistance training in normoxia and resistance training hypoxia (RTH) group that trained under hypoxic conditions at a simulated altitude of 2500 m above sea level. The training programme that was carried out during 24 weeks was similar in both experimental groups and consisted of a full-body workout with elastic bands and kettlebells (three sets x 12-15 reps). Blood inflammatory parameters (CRP, VCAM-1, IL-6, IL-8 and IL-10) were analysed before and after the intervention. After the resistance training programme, a significant decrease in CRP and IL-8 levels was observed, as well as an increase in IL-10 levels, both in normoxia and hypoxia. These results show that resistance training, either in conditions of normoxia or hypoxia, is useful to deal with the chronic inflammation associated with ageing., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)

Hypoxic training methods are increasingly being used by researchers in an attempt to improve performance in normoxic ambients. Moreover, previous research suggests that resistance training in hypoxia can cause physiological and muscle adaptations. The primary aim of this study was to compare the effects of 8 weeks of high-intensity resistance circuit-based (HRC) training in hypoxia on body composition and strength performance. The secondary aim was to examine the effects of HRC on metabolic parameters. Twenty-eight male participants were randomly assigned to either hypoxia (Fraction of inspired oxygen [F I O 2 ] = 15%; HRC hyp : n  = 15; age: 24.6 ± 6.8 years; height: 177.4 ± 5.9 cm; weight: 74.9 ± 11.5 kg) or normoxia [F I O 2 ] = 20.9%; HRC norm : n  = 13; age: 23.2 ± 5.2 years; height: 173.4 ± 6.2 cm; weight: 69.4 ± 7.4 kg) groups. Training sessions consisted of two blocks of three exercises (Block 1: bench press, leg extension and front pull down; Block 2: deadlift, elbow flexion and ankle extension). Each exercise was performed at six repetition maximum. Rest periods lasted for 35-s between exercises, 3-min between sets and 5-min between blocks. Participants exercised twice weekly for 8 weeks, and body composition, strength and blood tests were performed before and after the training program. Lean body mass and bone mineral density significantly increased over time in the HRC hyp ( p  < .005; ES = 0.14 and p  < .014; ES = 0.19, respectively) but not in the HRC norm after training. Both groups improved their strength performance over time ( p  < .001), but without group effect differences. These results indicate that simulated hypoxia during HRC exercise produced trivial effects on lean body mass and bone mineral density compared to normoxia.

Background: Resistance training performed under hypoxia conditions has been shown to cause major metabolic and hormonal responses. However, the influence of hypoxia on an acute session has been barely studied. The aim of this study was to evaluate the acute effects of an intermittent hypoxic resistance training (IHRT) to muscle failure on bench press performance., Methods: A randomized crossover design was performed, and 25 untrained men performed a resistance training under two different conditions: normoxia (FIO2=21%) and high-level hypoxia (FIO2=13%). Resistance training consisted of 3 sets of 75% 1RM to muscle failure, with a 2-minute rest between sets. Physical performance was assessed by quantifying total repetitions, concentric velocity and power variable during all sets. Arterial oxygen saturation, heart rate, rating of perceived exertion (RPE), capillary blood lactate and muscle soreness were also assessed after training., Results: Physical performance during bench press did not differ under hypoxic conditions (P>0.05). However, there were significant increases (P<0.05) of RPE (from 7.5±0.8 to 7.9±0.8) and blood lactate concentrations (from 5.5±1.2 to 6.2±1.5 mmol/L) in the hypoxia group., Conclusions: These findings suggest that hypoxic resistance exercise does not affect exercise performance during bench press exercise. However, influence to perceived exercise intensity and blood lactate concentrations, suggesting that hypoxic resistance training may add substantially to the training dose experienced.

Background: The inertial flywheel device causes an increase in eccentric overload during training. The aim was to study muscle oxygen saturation produced during an inertial flywheel squat training, comparing it with a barbell squat training., Methods: Twelve male adults performed a barbell squat training (3×8 reps, 75-80% 1RM) and a flywheel squat training (3×8 reps, all-out). Muscle oxygen saturation (%SmO2), total hemoglobin (tHb), reoxygenation, heart rate (HR), lactate, vertical jumps, maximal voluntary isometric contraction and rated perceived exertion (RPE) were studied., Results: Both protocols produced a significant decrease in %SmO2 and tHB during the sets of squats, and a significant increase in HR, lactates dand RPE after training. The flywheel squat protocol caused a greater decrease in %SmO2 than the barbell squat protocol in each of the sets of exercises (1st set: -67.5±7.2% vs. -53.7±16.2%; 2nd set: -67.2±13.5% vs. -53.6±15.4%; 3rd set: -68.1±13.0% vs. -55.0±17.0%), as well as a longer reoxygenation after finishing the training (61.7±12.6 vs. 55.7±13.7 s)., Conclusions: Although no differences were found on a muscle fatigue level, the flywheel training brought on greater physiological stress than the barbell squat training, observing a greater decrease in muscle oxygen saturation and a longer reoxygenation.

Background: Previous studies have demonstrated positive effects of acute vibration exercise on concentric strength and power, but few have observed the effects of vibration exposure on resistance training. The aim of this study was to verify the effects of whole body vibration applied to the chest via hands on bench press resistance training in trained and untrained individuals., Methods: Nineteen participants (10 recreationally trained bodybuilders and 9 untrained students) performed two randomized sessions of resistance training on separate days. Each strength session consisted of 3 bench press sets with a load of 75% 1RM to failure in each set, with 2 minutes' rest between sets. All subjects performed the same strength training with either, vibration exposure (12 Hz, 4 mm) of 30 seconds immediately before each bench press set or without vibration. Number of total repetitions, kinematic parameters, blood lactate and perceived exertion were analyzed., Results: In the untrained group, vibration exposure caused a significant increase in the mean velocity (from 0.36±0.02 to 0.39±0.03 m/s) and acceleration (from 0.75±0.10 to 0.86±0.09 m/s2), as well as a decrease in perceived effort (from 8±0.57 to 7.35±0.47) in the first bench press set, but no change was observed in the third bench press set. In the recreationally trained bodybuilders, vibration exposure did not cause any improvement on the performance of bench press resistance training., Conclusions: These results suggest that vibration exposure applied just before the bench press exercise could be a good practice to be implemented by untrained individuals in resistance training.

Currently, the use of accelerometers in sport is increasing, and thus, the devices are required to be valid and reliable. This study tested (a) the reliability and validity of WIMU PRO accelerometers to measure PlayerLoad (PL) and (b) the influence of speed, inertial device location, and type of surface where the incremental test is performed. Twenty resistance-trained men (age: 27.32±6.6= years; height: 1.74±0.03 m; body mass: 68.96±4.37 kg; and body mass index: 22.76 ± 1.11 kgm22) volunteered to participate in the study that lasted = weeks. Four progressive incremental tests were performed in treadmill and athletic track conditions. External load variable (PL) and physiological variables (heart rate [HR] and SmO2) were recorded by 4 WIMU PRO inertial devices (scapulae, center of mass, knee, and ankle), a GARMIN HR band, and a MOXY nearinfrared spectroscopy device, respectively. High reliability was found on both types of surface, showing the best values at the ankle (treadmill: intraclass correlation coefficient [ICC] = 0.99, coefficient of variation [CV] = 4.6=%; track: ICC = 0.96, CV = 6.=4%). A nearly perfect convergent validity was shown with HRAVG (r = 0.99) and a moderate one with SmO2 (r = −0.69). Significant differences in the PL variable between surfaces were reported in all locations except the scapulae (p=0.173), and the higher values were found on the track. In the analysis per location, the ankle location reported the highest values at all speeds and on the 2 surfaces analyzed. Assessment needs to be individualized, due to the great variability of gait biomechanics among subjects. The accelerometer location should be chosen according to the purpose of the measurement, with the ankle location being recommended for neuromuscular load analysis in running. [ABSTRACT FROM AUTHOR]

Purpose: Promising benefits on fat mass and biochemical components may be reported after applying programs of cyclic hypoxia and HIIT. Aim: To investigate the effect of a month of detraining on cardiometabolic risk markers after active hypoxia exposure. Methods: Participants included 59 overweight/obese women, who started a 12‐week program of 36 sessions, and were randomly divided into four groups: (a) aerobic interval training in hypoxia (AitH; FiO2 = 17.2%; n = 13), (b) aerobic interval training in normoxia (AitN; n = 15), (c) sprint interval training in hypoxia (SitH; FiO2 = 17.2%; n = 15), and (d) sprint interval training in normoxia (SitN; n = 18). Body composition, anthropometric, and biochemical parameters were assessed at baseline (A), after 36 training sessions (B) and after 4 weeks of detraining (C). Results: Hypoxia conditions showed a significant positive effect on waist circumference (P = 0.01), WHR (P = 0.04), and percentage of trunk fat mass (P < 0.001). The percentage of trunk fat continued to decrease significantly after training cessation in both AitH and SitH groups. Conclusion: After 4 weeks of detraining with a previous 12 weeks of high‐intensity interval training under cyclic normobaric hypoxia, the percentage of fat mass located in the trunk decreases significantly and this effect was not observed in the normoxia groups. [ABSTRACT FROM AUTHOR]