1. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.
- Author
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Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, and Zinn AR
- Subjects
- Basic Helix-Loop-Helix Transcription Factors metabolism, Behavior, Addictive, Craniopharyngioma complications, Craniopharyngioma therapy, Eating, Feeding Behavior, Female, Humans, Hyperphagia etiology, Hyperphagia therapy, Male, Models, Animal, Obesity complications, Odds Ratio, Phenotype, Prader-Willi Syndrome complications, Prader-Willi Syndrome therapy, Repressor Proteins metabolism, Satiety Response, Craniopharyngioma diagnosis, Hyperphagia diagnosis, Obesity prevention & control, Prader-Willi Syndrome diagnosis, Research
- Abstract
Objective: Hyperphagia is a central feature of inherited disorders (e.g., Prader-Willi Syndrome) in which obesity is a primary phenotypic component. Hyperphagia may also contribute to obesity as observed in the general population, thus raising the potential importance of common underlying mechanisms and treatments. Substantial gaps in understanding the molecular basis of inherited hyperphagia syndromes are present as are a lack of mechanistic of mechanistic targets that can serve as a basis for pharmacologic and behavioral treatments., Design and Methods: International conference with 28 experts, including scientists and caregivers, providing presentations, panel discussions, and debates., Results: The reviewed collective research and clinical experience provides a critical body of new and novel information on hyperphagia at levels ranging from molecular to population. Gaps in understanding and tools needed for additional research were identified., Conclusions: This report documents the full scope of important topics reviewed at a comprehensive international meeting devoted to the topic of hyperphagia and identifies key areas for future funding and research., (Copyright © 2013 The Obesity Society.)
- Published
- 2014
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