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1. Validating regional Hospital Information System data through comparison with a local cancer register to identify interval cancers of a breast screening program.

Author

Sperati A, Pannozzo F, Giorgi Rossi P, Baiocchi D, Barca A, and Borgia P

Subjects
Aged, Female, Humans, Mass Screening methods, Middle Aged, Neoplasm Invasiveness, Predictive Value of Tests, Program Evaluation, Sensitivity and Specificity, Breast Neoplasms diagnostic imaging, Breast Neoplasms epidemiology, Hospital Information Systems, Mammography standards, Mass Screening standards, Registries
Abstract

The objective of this study was to evaluate the accuracy of the Hospital Information System (HIS) in monitoring the breast cancer incidence and interval cancers compared with the cancer registry (CR). The HIS data linked with CR and Mammographic Screening Information System data for breast cancer cases diagnosed in the period 1999-2003. The sensitivity and positive predictive value of the HIS data were calculated using the CR as a gold standard. One thousand two hundred and thirty-six breast cancers were registered by the CR and 1028 were reported in the HIS. The sensitivity rate was 83.2% and the positive predictive value was 83.0%; similar results were obtained in the screening target population (50-69 years old). Fifteen invasive breast cancers occurred among screened women identified by HIS (four interval cancers and 11 screen-detected), two were registered as in situ in the CR. The HIS seems to have the potential to identify interval breast cancers, but the low accuracy of information does not permit an exact measure of the incidence.

Published
2009
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2. The risk of developing a second, different, cancer among 14 560 survivors of malignant cutaneous melanoma: a study by AIRTUM (the Italian Network of Cancer Registries).

Author

Crocetti E, Guzzinati S, Paci E, Falcini F, Zanetti R, Vercelli M, Rashid I, De Lisi V, Russo A, Vitarelli S, Ferretti S, Mangone L, Cesaraccio R, Tumino R, and Pannozzo F

Subjects
Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Follow-Up Studies, Humans, Italy epidemiology, Male, Middle Aged, Neoplasms, Second Primary epidemiology, Risk Factors, Melanoma epidemiology, Neoplasms, Second Primary etiology, Registries, Skin Neoplasms epidemiology, Survivors statistics & numerical data
Abstract

The aim of this study was to provide further quantitative data on the risk of second nonmelanoma cancers in patients with cutaneous malignant melanoma (CMM). A cohort of 14 560 population-based patients from the Italian Network of Cancer Registries incident during 1985-2002 were included and followed up for further incident cases and vital status. Standardized incidence ratios (SIR) were used to compare the number of observed second cancers with expected cancers. In a total of 69 581 person-years, 1020 second cancers were registered, of which 804.6 were expected (SIR=1.27; 95% confidence interval 1.19-1.35). The risk was similar for males and females, (SIR=1.27 and 1.26, respectively). The risk was slightly higher among younger (<60 years; SIR=1.44) than older (60+ years; SIR=1.19) patients. The overall risk in the period after CMM diagnosis did not change significantly (SIR=1.34 during the first 5 years and 1.12 afterwards). No differences in the overall risk were evident in different years of diagnosis, for different melanoma morphology types or for different geographical areas within Italy. Statistically significantly increased risks were found for nonmelanoma skin cancers [observed number (n)=362, SIR=3.12], for bone (n=5, SIR=6.08) and for kidney cancers (n=39, SIR=1.95) and lower than expected risks were found for liver (SIR=0.46) and lung cancers (SIR=0.71). We confirm that CMM patients are at high risk for nonmelanoma skin cancers. The reasons for the increased risk of kidney and bone cancers are not yet clear.

Published
2008
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3. An estimate of the number of people in Italy living after a childhood cancer

Author

Francisci, Silvia, Guzzinati, Stefano, Dal Maso, Luigino, Sacerdote, Carlotta, Buzzoni, Carlotta, Gigli, Anna, Rugge, Massimo, Bidoli, Ettore, Bucchi, Dania, Tagliabue, Giovanna, Fusco, Mario, Falcini, Fabio, Marani, Enza, Pannozzo, Fabio, Carrozzi, Giuliano, Mangone, Lucia, Sechi, Ornelia, Michiara, Maria, Spata, Eugenia, Ferretti, Stefano, Giacomin, Adriano, Maule, Milena, Gatta, Gemma, and Capocaccia, Riccardo

Subjects
Male, Cancer Research, childhood cancer, incidence, Italy, prevalence, survival, Adolescent, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Neoplasms, Prevalence, Registries, Survival Rate, Medicine (all), Oncology, Socio-culturale, Newborn, Preschool
Abstract

Cancers diagnosed in children below the age of 15 years represent 1.2% of all cancer cases, and survival after a childhood cancer has greatly improved over the past 40 years in all high income countries. This study aims to estimate the number of people living in Italy after a childhood cancer for all cancers combined and for a selection of cancer types. We computed 15-year prevalence using data from 15 Italian population-based cancer registries (covering 19% of Italian population) and estimated complete prevalence for Italy by using the CHILDPREV method, implemented in the COMPREV software. A total of 44,135 persons were alive at January 1st, 2010 after a cancer diagnosed during childhood. This number corresponds to a proportion of 73 per 100,000 Italians and to about 2% of all prevalent cases. Among them, 54% were males and 64% had survived after being diagnosed before 1995, the start of the observation period. A quarter of all childhood prevalent cases were diagnosed with brain and central nervous system tumors, a quarter with acute lymphoid leukemia, and 7% with Hodgkin lymphoma. Nearly a quarter of prevalent patients were aged 40 years and older. Information about the number of people living after a childhood cancer in Italy by cancer type and their specific health care needs may be helpful to health-care planners and clinicians in the development of guidelines aimed to reduce the burden of late effect of treatments during childhood.

Published
2017

4. Italian cancer figures, report 2011: Survival of cancer patients in Italy

Author

Airtum, Working Group, Fusco, Mario, Buzzoni, Carlotta, Coviello, Enzo, Rashid, Ivan, Bianconi, Fortunato, Cuccaro, Francesco, Castaing, Marine, Angelis, Roberta, Giacomin, Adriano, Guzzinati, Stefano, Mosso, Maria Luisa, Pisani, Paola, Quaglia, Alberto, Randi, Giorgia, Ramazzotti, Valerio, Russo, Antonio, Senatore, Gennaro, Stracci, Fabrizio, Traina, Adele, Vercelli, Marina, Zarcone, Maurizio, Ferretti, Stefano, Mazzoleni, Guido, Bellu, Francesco, Tschugguel, Birgit, Valiere, Elena, Facchinelli, Gerlinde, Falk, Markus, Dal Cappello, Tomas, Vercellino, Pier Carlo, Andreone, Simona, Busato, Anna, Marzola, Laura, Migliari, Elena, Carletti, Nada, Nenci, Italo, Crocetti, Emanuele, Caldarella, Adele, Corbinelli, Antonella, Giusti, Francesco, Intrieri, Teresa, Manneschi, Gianfranco, Nemcova, Libuse, Romeo, Gianpaolo, Sacchettini, Claudio, Zappa, Marco, Paci, Eugenio, Serraino, Diego, Angelin, Tiziana, Bidoli, Ettore, Dal Maso, Luigino, Dottori, Margherita, Paoli, Angela, Santis, Emilia, Forgiarini, Ornella, Lise, Mauro, Zucchetto, Antonella, Zanier, Loris, Orengo, Maria Antonietta, Casella, Claudia, Marani, Enza, Puppo, Antonella, Celesia, Maria Vittoria, Cogno, Roberta, Manenti, Simone, Garrone, Elsa, Pannozzo, Fabio, Busco, Susanna, Maria Cecilia Cercato, Battisti, Walter, Sperduti, Isabella, Macci, Leonarda, Bugliarello, Ester, Bernazza, Edvige, Tamburo, Lucilla, Rossi, Miriana, Curatella, Simonetta, Francesco, Carla, Tamburrino, Silvana, Bisanti, Luigi, Autelitano, Mariangela, Ghilardi, Simona, Leone, Rosanna, Filipazzi, Luisa, Bonini, Annamaria, Giubelli, Cinzia, Federico, Massimo, Artioli, Maria Elisa, Valla, Katia, Braghiroli, Barbara, Cirilli, Claudia, Luminari, Stefano, Pirani, Monica, Ferrari, Lorenza, Bellatalla, Caterina, Fusco, Maria, Panico, Margherita, Perrotta, Carmela, Vassante, Biagio, Vitale, Maria Francesca, Michiara, Maria, Bozzani, Francesco, Sgargi, Paolo, Tumino, Rosario, La Rosa, Maria Guglielmina, Cascone, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Morana, Gabriele, Nicita, Carmela, Rollo, Patrizia Concetta, Ruggeri, Maria Grazia, Sigona, Aurora, Spata, Eugenia, Vacirca, Stefania, Mangone, Lucia, Di Felice, Enza, Pezzarossi, Annamaria, Caroli, Stefania, Pellegri, Carlotta, Vicentini, Massimo, Storchi, Cinzia, Cavuto, Silvio, Costa, Jaqueline, Falcini, Fabio, Colamartini, Americo, Bucchi, Lauro, Balducci, Chiara, Ravegnani, Mila, Vitali, Benedetta, Cordaro, Carlo, Caprara, Licia, Giuliani, Orietta, Giorgetti, Stefania, Salvatore, Silvia, Palumbo, Monica, Vattiato, Rosa, Ravaioli, Alessandra, Foca, Flavia, Rinaldi, Elisa, Mancini, Silvia, Tonelli, Chiara, Amadori, Marinella, Cremone, Luigi, Iannelli, Arturo, Zevola, Arrigo, Budroni, Mario, Cesaraccio, Rosaria, Pirino, Daniela, Carboni, Donatella, Fiori, Giovanna, Soddu, Marcella, Mameli, Gianpaolo, Mura, Francesco, Contrino, Maria Lia, Madeddu, Anselmo, Tisano, Francesco, Sciacca, Salvatore, Muni, Angela, Mizzi, Margherita, Russo, Maria, Sacco, Giorgio, Aletta, Paoletta, Colanino Ziino, Antonio, Tessandori, Roberto, Fanetti, Anna Clara, Maspero, Sergio, Annulli, Monica Lucia, Moroni, Elena, Sanoja Gonzalez, Maria Eugenia, Zanetti, Roberto, Rosso, Stefano, Patriarca, Silvia, Prandi, Rossana, Sobrato, Irene, Gilardi, Franca, Busso, Paola, Piffer, Silvano, Gentilini, Maria A., Battisti, Laura, Rizzello, Roberto, Cappelletti, Maddalena, Moser, Marilena, La Rosa, Francesco, D Alo, Daniela, Scheibel, Massimo, Costarelli, Daniela, Spano, Francesco, Rossini, Stefania, Santucci, Cinzia, Petrinelli, Anna Maria, Solimene, Clotilde, Brunori, Valerio, Crosignani, Paolo, Tagliabue, Giovanna, Contiero, Paolo, Preto, Lucia, Tittarelli, Andrea, Maghini, Anna, Codazzi, Tiziana, Frassoldi, Emanuela, Gada, Daniela, Costa, Enrica, Di Grazia, Laura, Zambon, Paola, Baracco, Maddalena, Bovo, Emanuela, Dal Cin, Antonella, Fiore, Anna Rita, Greco, Alessandra, Monetti, Daniele, Rosano, Alberto, Stocco, Carmen, Tognazzo, Sandro, Donato, Francesco, Limina, Rosa Maria, Adorni, Anna, Andreis, Paolo, Zani, Giuseppe, Piovani, Francesco, Salvi, Ornella, Puleio, Maria, Vitarelli, Susanna, Antonini, Silvia, Candela, Giuseppina, Pappalardo, Giuseppe, Scuderi, Tiziana, Lottero, Barbara, Ribaudo, Michele, Ricci, Paolo, Guarda, Linda, Gatti, Luciana, Bozzeda, Annalaura, Dall Acqua, Maria, Pironi, Vanda, Sutera Sardo, Antonella, Mazzei, Adriana, Sirianni, Nicola, Lavecchia, Anna Maria, Mancuso, Pierina, Usala, Mario, Pala, Filomena, Sini, Giovanna Maria, Pintori, Nicolina, Canu, Luisa, Demurtas, Giuliana, Doa, Nina, Ponz Leon, Maurizio, Domati, Federica, Rossi, Giuseppina, Goldoni, Carlo Alberto, Rossi, Federica, Gaetani, Carmela, Benatti, Piero, Roncucci, Luca, Di Gregorio, Carmela, Pedroni, Monica, Pezzi, Annalisa, Maffei, Stefania, Mariani, Francesco, Borsi, Enrica, Carruba, Giuseppe, Cusimano, Rosanna, Amodio, Rosalba, Dolcemascolo, Cecilia, Staiti, Rosalba, Pastore, Guido, Magnani, Corrado, Terracini, Benedetto, Cena, Tiziana, Alessi, Daniela, Baussano, Iacopo, Merletti, Franco, Maule, Milena, Macerata, Vanda, Cocchioni, Mario, Pascucci, Cristiana, Gennaro, Valerio, Lazzarotto, Anna, Benfatto, Lucia, Mazzucco, Giovanna, Montanaro, Fabio, AIRTUM Working Group: [.., Enrica Borsi, and ]

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Age Factors, Infant, Newborn, Infant, Middle Aged, Survival Analysis, CANCER, Survival Rate, Young Adult, Italy, Organ Specificity, Child, Preschool, Neoplasms, Humans, Female, Registries, Child, Aged
Abstract

INTRODUCTION: population-based survival analyses are fundamental to assess the impact of public health interventions and new therapies in cancer control. This monograph updates previous reports on cancer patient survival in Italy up to the year 2007. MATERIAL AND METHODS: we extracted from the Network of Italian Cancer Registries (AIRTUM) database over 1,490,000 records of tumours diagnosed during 1990-2007 and followed up to the end of 2008, including all multiple tumours. We used the Ederer II method to estimate relative survival (RS) for 29 different types of neoplasm. Five-year relative survival rates were analysed by gender and macroarea. Trends in 5-, 10- and 15-year RS were studied by gender over six 3-year diagnostic periods, from 1990 to 2007. Conditional 5-year RS was also computed by gender and macroarea. Hybrid approaches were applied to exploit the recent survival experiences of cases diagnosed up to 2007. Adjustment for age was performed using EUROCARE weights. Additional sections describe cancer patient survival in childhood and in elderly patients and provide a comparison of cancer patient survival rates in Italy with those of other countries. RESULTS: Standardized 5-year RS for all tumours but skin in 52% for men and 61% for women. Patient survival has improved for almost all types of cancer: from 1990 to 2007 5-year RS has increased by 15% for all cancers but skin; the exceptions are some cancers with poor prognosis, where patient survival has remained basically unchanged. In males, RS was usually lower than in females, but trend analysis shows that the gap is narrowing. We also report persisting lower RS in southern Italy: 5-year RS in the South is usually from 4% to 10% lower than in the North and Centre. CONCLUSION: this study provides valuable information for all stakeholders in cancer control, both in Italy and elsewhere. Increasing survival reflects improvements in various areas of cancer control. On the other hand, delayed diagnosis and suboptimal management are consistent with the reported differences in survival within the country.

Published
2011

5. [Italian cancer figures, report 2010: Cancer prevalence in Italy. Patients living with cancer, long-term survivors and cured patients]

Author

Airtum, Working Group, Guzzinati, Stefano, Dal Maso, Luigino, Angelis, Roberta, Paoli, Angela, Buzzoni, Carlotta, Crocetti, Emanuele, Bucchi, Lauro, Casella, Claudia, Cuccaro, Francesco, Fusco, Mario, Luminari, Stefano, Madeddu, Anselmo, Mangone, Lucia, Patriarca, Silvia, Piffer, Silvano, Stracci, Fabrizio, Tagliabue, Giovanna, Tumino, Rosario, Zappa, Marco, Capocaccia, Riccardo, Ferretti, Stefano, Mazzoleni, Guido, Bellu, Francesco, Tschugguel, Birgit, Valiere, Elena, Facchinelli, Gerlinde, Falk, Markus, Dal Cappello, Tomas, Giacomin, Adriano, Vercellino, Pier Carlo, Andreone, Simona, Busato, Anna, Marzola, Laura, Migliari, Elena, Carletti, Nada, Nenci, Italo, Caldarella, Adele, Corbinelli, Antonella, Giusti, Francesco, Intrieri, Teresa, Manneschi, Gianfranco, Nemcova, Libuse, Romeo, Gianpaolo, Sacchettini, Claudio, Paci, Eugenio, Serraino, Diego, Angelin, Tiziana, Bidoli, Ettore, Dottori, Margherita, Santis, Emilia, Forgiarini, Ornella, Zucchetto, Antonella, Zanier, Loris, Vercelli, Marina, Orengo, Maria Antonietta, Marani, Enza, Puppo, Antonella, Celesia, Maria Vittoria, Cogno, Roberta, Manenti, Simone, Garrone, Elsa, Quaglia, Alberto, Pannozzo, Fabio, Busco, Susanna, Rashid, Ivan, Ramazzotti, Valerio, Cercato, M. Cecilia, Battisti, Walter, Sperduti, Isabella, Macci, Leonarda, Bugliarello, Ester, Bernazza, Edvige, Tamburo, Lucilla, Rossi, Miriana, Curatella, Simonetta, Francesco, Carla, Tamburrino, Silvana, Bisanti, Luigi, Autelitano, Mariangela, Randi, Giorgia, Ghilardi, Simona, Leone, Rosanna, Filipazzi, Luisa, Bonini, Annamaria, Giubelli, Cinzia, Federico, Massimo, Artioli, Maria Elisa, Valla, Katia, Braghiroli, Barbara, Cirilli, Claudia, Pirani, Monica, Ferrari, Lorenza, Bellatalla, Caterina, Fusco, Maria, Panico, Margherita, Perrotta, Carmela, Vassante, Biagio, Traina, Adele, Carruba, Giuseppe, Cusimano, Rosanna, Amodio, Rosalba, Dolcemascolo, Cecilia, Staiti, Rosalba, Zarcone, Maurizio, Michiara, Maria, Bozzani, Francesco, Sgargi, Paolo, Cilia, Sonia, La Rosa, Maria Guglielmina, Cascone, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Morana, Gabriele, Nicita, Carmela, Rollo, Patrizia, Ruggeri, Maria Grazia, Sigona, Aurora, Spata, Eugenia, Vacirca, Stefania, Di Felice, Enza, Pezzarossi, Annamaria, Caroli, Stefania, Pellegri, Carlotta, Vicentini, Massimo, Storchi, Cinzia, Cavuto, Silvio, Costa, Jaqueline, Falcini, Fabio, Colamartini, Americo, Balducci, Chiara, Ravegnani, Mila, Vitali, Benedetta, Cordaro, Carlo, Caprara, Licia, Giuliani, Orietta, Giorgetti, Stefania, Salvatore, Silvia, Palumbo, Monica, Vattiato, Rosa, Ravaioli, Alessandra, Foca, Flavia, Rinaldi, Elisa, Donato, Andrea, Iannelli, Arturo, Senatore, Gennaro, Zevola, Arrigo, Budroni, Mario, Cesaraccio, Rosaria, Pirino, Daniela, Carboni, Donatella, Fiori, Giovanna, Soddu, Marcella, Mameli, Gianpaolo, Mura, Francesco, Contrino, Maria Lia, Tisano, Francesco, Sciacca, Salvatore, Muni, Angela, Mizzi, Margherita, Russo, Maria, Tessandori, Roberto, Ardemagni, Giuseppina, Gianola, Luigi, Maspero, Sergio, Annulli, Monica Lucia, Moroni, Elena, Roberto, Guglielmana, Zanetti, Roberto, Rosso, Stefano, Prandi, Rossana, Sobrato, Irene, Gilardi, Franca, Busso, Paola, Franchini, Silva, Gentilini, Maria A., Battisti, Laura, Cappelletti, Maddalena, Moser, Marilena, La Rosa, Francesco, D Alo, Daniela, Scheibel, Massimo, Costarelli, Daniela, Spano, Francesco, Rossini, Stefania, Santucci, Cinzia, Petrinelli, Anna Maria, Solimene, Clotilde, Bianconi, Fortunato, Brunori, Valerio, Crosignani, Paolo, Contiero, Paolo, Preto, Lucia, Tittarelli, Andrea, Maghini, Anna, Codazzi, Tiziana, Frassoldi, Emanuela, Gada, Daniela, Costa, Enrica, Di Grazia, Laura, Zambon, Paola, Baracco, Maddalena, Bovo, Emanuela, Dal Cin, Antonella, Fiore, Anna Rita, Greco, Alessandra, Monetti, Daniele, Rosano, Alberto, Stocco, Carmen, Tognazzo, Sandro, Donato, Francesco, Limina, Rosa Maria, Adorni, Anna, Andreis, Paolo, Zani, Giuseppe, Piovani, Francesco, Salvi, Ornella, Puleio, Maria, Vitarelli, Susanna, Antonini, Silvia, Candela, Giuseppina, Pappalardo, Giuseppe, Scuderi, Tiziana, Lottero, Barbara, Ribaudo, Michele, Ricci, Paolo, Guarda, Linda, Gatti, Luciana, Bozzeda, Annalaura, Dall Acqua, Maria, Pironi, Vanda, Sutera Sardo, Antonella, Mazzei, Adriana, Sirianni, Nicola, Lavecchia, Anna Maria, Mancuso, Pierina, Usala, Mario, Pala, Filomena, Sini, Giovanna Maria, Pintori, Nicolina, Canu, Luisa, Demurtas, Giuliana, Doa, Nina, Pisani, Paola, Pastore, Guido, Magnani, Corrado, Terracini, Benedetto, Cena, Tiziana, Alessi, Daniela, Baussano, Iacopo, Merletti, Franco, Maule, Milena, Mosso, Maria Luisa, Nonnato, Marinella, Rasulo, Assunta, Richiardi, Lorenzo, Zuccolo, Luisa, Pivetta, Emanuele, Dalmasso, Paola, Macerata, Vanda, Ponz Leon, Maurizio, Domati, Federica, Rossi, Giuseppina, Goldoni, Carlo Alberto, Rossi, Federica, Gaetani, Carmela, Benatti, Piero, Roncucci, Luca, Di Gregorio, Carmela, Pedroni, Monica, Pezzi, Annalisa, Maffei, Stefania, Mariani, Francesco, Enrica Borsi, Cocchioni, Mario, Pascucci, Cristiana, Gennaro, Valerio, Lazzarotto, Anna, Benfatto, Lucia, Mazzucco, Giovanna, Montanaro, Fabio, AIRTUM Working Group […, Enrica, Borsi, and …]

Subjects
Adult, Male, Time Factors, Adolescent, Databases, Factual, Remission Induction, Infant, Middle Aged, CANCER, Cancer prevalence, Italy, Epidemiologic Studies, Young Adult, Child, Preschool, Neoplasms, Prevalence, Humans, Long-term survivors, Female, Registries, Survivors, Child, Aged
Abstract

OBJECTIVES: the aim of the present monograph is to update the estimation of the number of people living with cancer in Italy, to describe geographic variability, and estimate the number of long-term survivors, i.e., people living five years or more after a cancer diagnosis. MATERIALS AND METHODS: the study included the data of the AIRTUMdatabase. Twenty-four Cancer Registries (CRs) (covering 27% of the Italian population) collected information on the incidence and vital status of 1,275,353 cases diagnosed between 1978 and 2005. For each CR, the observed prevalence was calculated up to the maximum observable duration. To estimate the complete prevalence (all living patients, independently from time since diagnosis) and the prevalence for lengths of time exceeding the CR maximum duration of registration, the observed prevalence was corrected through a completeness index. Completeness indices, gender, age and site specific, were estimated by means of statistical regression models using cancer incidence and survival data available from CRs with more than 15 years of observation. As of 1 January 2006, the prevalence was estimated (as absolute numbers and as a proportion per 100,000 inhabitants) for 46 cancer sites, by gender, age class, years since diagnosis and geographic areas. RESULTS: as of 2006, 2,244,000 persons (4%of the Italian population) were alive with a cancer diagnosis. A relevant geographic variability emerged, with proportions between 4%-5% among CRs in the Centre and North of Italy, and proportions between 2%-3% in the South. Forty-four percent of prevalent subjects (988,000) were males and 56% (1,256,000) females. Fifty-seven percent (1,285,680 people, 2.2% of total population) of these patients was represented by long-term survivors. In patients aged 75 years or more, the proportions of prevalent cases were 19%in males and 13%in females, and 10%between 60 and 75 years of age in both genders.More than half a million Italian women were alive with a breast cancer diagnosis (42%of women with a neoplasm), followed by women with cancers of the colonrectum (12%), corpus uteri (7%), thyroid (5%), and cervix uteri (4%). In men, 22%of prevalent cases (216,716) included patients with prostate cancer, 18% with bladder cancer, and 15%with colon-rectum cancer. Percentages of long-term survivors higher than 70% were reported for cancers of the cervix uteri (82% at five years, and 55% at 15 years from diagnosis), Hodgkin lymphoma, testis, brain and central nervous system, bone and connective tissue. Many patients with these types of cancers (often occurring in young people) can be considered "cured", i.e., with a life expectancy overlapping that of the general population.The estimated proportions of prevalent cases emerging from this study in Italy were quite similar to those reported in Northern Europe, but at least 15%lower than those in the United States. CONCLUSIONS: in 2006, the number of prevalent cases nearly doubled compared to 1992. The increase over time in the proportion of elderly patients, related to population ageing, requires adequate health policies. Knowing the number of people alive many years after cancer diagnosis (either cured or long-term survivors) provides the scientific bases for the definition of health policies focusing on them. Furthermore, it promotes the conduction of studies aimed at improving the present knowledge on the quality of life of these patients during and after the active phase of treatments, in addition to studies on the long-term effects of treatments.

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