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Purpose: To determine the distribution of central corneal thickness (CCT) and its determinants in an Iranian geriatric population., Methods: This population-based study was conducted in 2019 in Tehran, the capital of Iran, using stratified multistage random cluster sampling. The study population was all residents ≥60 years of age. First, preliminary optometric and ocular health examinations were performed including the measurement of uncorrected and best-corrected visual acuity, objective and subjective refraction, anterior and posterior segment examination. The study participants then underwent corneal imaging using Pentacam HR., Results: Out of 3791 invitees, 3310 participated in this study (response rate: 87.3%). The mean CCT and apex corneal thicknesses were 528 µ (95% CI: 526-529) and 529 µ (95% CI: 527-530), respectively. The highest and lowest mean corneal thickness was related to the superior (620 µ: 95% CI: 618-622) and the temporal (591 µ: 95% CI: 590-592) paracentral points, respectively. According to the multiple linear regression model, the CCT was significantly inversely related to keratometry readings (K1 and K2) and had a statistically significant direct relationship with intraocular pressure (IOP), corneal eccentricity (ECC), and corneal volume (CV) (all p values <0.05). The CCT was significantly higher in diabetic patients (p = 0.043)., Conclusion: The CCT values in the geriatric Iranian population were lower than the values reported in most previous studies. The CCT is mostly influenced by IOP and corneal parameters (curvature, shape factor, and volume) and is not affected by demographic factors, refractive error, and ocular biometric components., (© 2022. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.)

Purpose: To determine the age-sex-standardized prevalence of uncorrected refractive error and its determinants., Methods: This population-based cross-sectional study was conducted on 3310 people aged≥ 60 years in Tehran, Iran in 2019. Need for spectacles was defined as uncorrected visual acuity worse than 20/40 in better eye that could be corrected to more than 20/40 with suitable spectacles. Met need was defined as proportion of individuals with need for spectacles whose visual acuity was 20/40 or better with current spectacles. Unmet need was defined as proportion of individuals with need for spectacles who needed but did not have spectacles or their visual acuity was worse than 20/40 with current spectacles while suitable spectacles improved their visual acuity to 20/40 or better., Results: The age-sex-standardized prevalence of need for spectacles, met need, and unmet need was 16.67% (95% CI: 15.33-18.09), 7.81% (95% CI: 6.95-8.78), and 8.85% (95% CI: 7.77-10.07), respectively. Myopic subjects had the highest prevalence of need for spectacles (24.06%, 95% CI: 21.47-26.87). The odds ratio of met and unmet need in subjects≥ 80 years versus those aged 60-65 years was 0.36 ( p -value: 0.009) and 2.34 ( p -value: <0.001), respectively. The odds ratio of met and unmet need in subjects with a university education versus illiterate subjects was 1.72 ( p -value: 0.045) and 0.42 ( p -value: 0.007), respectively., Conclusion: The prevalence of uncorrected refractive error was lower in this study compared to previous studies. The met need rate was lower in subjects with older age and lower education levels.

Purpose: The purpose of the present study was to evaluate the prevalence of refractive errors in the Middle East region., Methods: In this meta-analysis, a structured strategy was applied to search databases PubMed, Web of Science, Scopus, and Google Scholar, databases as well as the reference lists of the selected articles to identify cross-sectional studies assessing the prevalence of refractive errors in the Middle East region until September 2019. The outcome measure was the prevalence of refractive errors, including myopia, hyperopia, and astigmatism, in two age groups of ≤ 15 years and > 15 years. The study results were combined using a random effects model at a confidence level of 95%., Results: The prevalence of myopia, hyperopia, and astigmatism was 4% (95% CI 4, 5), 8% (95% CI 6, 10), and 15% (95% CI 10, 19) in people less than or equal to 15 years and 30% (95% CI 25, 34), 21% (95% CI 15, 28), and 24% (95% CI 16, 31) in subjects over 15 years, respectively. The prevalence of myopia, hyperopia, and astigmatism was 3.5%, 12.4%, and 9.0% in male and 4.2%, 13.1%, and 9.9% in female subjects aged ≤ 15 years, respectively. In subjects aged > 15 years, the prevalence was 31.7%, 14.5%, and 31.5% in males and 31.9%, 11.2%, and 31% in females, respectively., Conclusion: The prevalence of hyperopia is relatively high in Middle Eastern children, while the prevalence of myopia is higher in adults in this region. It seems that astigmatism is not a serious refractive problem in this region compared to the rest of the world.

Purpose: To determine the distribution of anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) values in a rural population over 5 years of age using the Pentacam., Methods: In this cross-sectional study, samples were selected from over 1-year-old inhabitants of two villages in Iran using a multistage cluster sampling approach. All participants underwent the measurement of uncorrected and corrected visual acuity and auto-refraction, retinoscopy, subjective refraction, and slit lamp examination. Finally, corneal imaging was done for all subjects over 5 years of age using the Pentacam., Results: Of 3851 selected individuals, 3314 participated in the study, of whom 2681 met the inclusion criteria. The mean age of the sample was 36.03 ± 18.5 years (range 6-90 years). The mean ACD, ACA, and ACV values were 3.37 mm (95% CI: 3.37-3.39), 34.82° (95% CI: 34.45-35.2), and 159.17 µL (95% CI: 156-161.36), respectively. The results of multiple linear regression models showed that ACD, ACA, and ACV values reduced with age, and ACD and ACV values were significantly higher in males. ACA and ACV values correlated inversely with central corneal thickness, while the ACA value correlated directly with keratometry and inversely with the ACV value., Conclusion: This study is one of the few studies in the world showing changes in ACD values in different age groups using the Pentacam. According to the results, aging was associated with a decline in the mean ACD, ACA, and ACV values. These parameters were the largest in patients with emmetropia and smallest in hyperopic subjects.