1. Associations between red blood cell and platelet transfusions and retinopathy of prematurity
- Author
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Hengartner, Tobias, Adams, Mark, Pfister, Riccardo, Snyers, Diane, McDougall, Jane, Waldvogel, Salome, Held-Egli, Katrin, Spring, Lea, Rogdo, Bjarte, Riedel, Thomas, Arlettaz Mieth, Romaine, Swiss Neonatal Network, University of Zurich, and Hengartner, Tobias
- Subjects
medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,610 Medicine & health ,Red blood cell transfusion ,Logistic regression ,Retinopathy of prematurity ,1309 Developmental Biology ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Medicine ,Platelet ,2735 Pediatrics, Perinatology and Child Health ,030212 general & internal medicine ,Prospective cohort study ,Platelet transfusion ,Original Paper ,ddc:618 ,business.industry ,Obstetrics ,Gestational age ,Odds ratio ,10027 Clinic for Neonatology ,medicine.disease ,Confidence interval ,eye diseases ,Pediatrics, Perinatology and Child Health ,business ,Developmental Biology - Abstract
Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). Results: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development. Conclusions: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.
- Published
- 2020