7 results on '"You, Y."'
Search Results
2. Perioperative and oncological outcomes following robotic en bloc multivisceral resection for colorectal cancer.
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DiBrito, Sandra R., Manisundaram, Naveen, Kim, Youngwan, Peacock, Oliver, Hu, Chung‐Yuan, Bednarski, Brian, You, Y. Nancy, Uppal, Abhineet, Tillman, Matthew, Konishi, Tsuyoshi, Kaur, Harmeet, Palmquist, Sarah, Holliday, Emma, Dasari, Arvind, and Chang, George J.
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COLORECTAL cancer ,RECTAL surgery ,ONCOLOGIC surgery ,VAS deferens ,MINIMALLY invasive procedures ,SEMINAL vesicles - Abstract
Aim: As multidisciplinary treatment strategies for colorectal cancer have improved, aggressive surgical resection has become commonplace. Multivisceral and extended resections offer curative‐intent resection with significant survival benefit. However, limited data exist regarding the feasibility and oncological efficacy of performing extended resection via a minimally invasive approach. The aim of this study was to determine the perioperative and long‐term outcomes following robotic extended resection for colorectal cancer. Method: We describe the population of patients undergoing robotic multivisceral resection for colorectal cancer at our single institution. We evaluated perioperative details and investigated short‐ and long‐term outcomes, using the Kaplan–Meier method to analyse overall and recurrence‐free survival. Results: Among the 86 patients most tumours were T3 (47%) or T4 (47%) lesions in the rectum (78%). Most resections involved the anterior compartment (72%): bladder (n = 13), seminal vesicle/vas deferens (n = 27), ureter (n = 6), prostate (n = 15) and uterus/vagina/adnexa (n = 27). Three cases required conversion to open surgery; 10 patients had grade 3 complications. The median hospital stay was 4 days. Resections were R0 (>1 mm) in 78 and R1 (0 to ≤1 mm) in 8, with none being R2. The average nodal yield was 26 and 48 (55.8%) were pN0. Three‐year overall survival was 88% and median progression‐free survival was 19.4 months. Local recurrence was 6.1% and distant recurrence was 26.1% at 3 years. Conclusion: Performance of multivisceral and extended resection on the robotic platform allows patients the benefit of minimally invasive surgery while achieving oncologically sound resection of colorectal cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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3. Robotic lateral pelvic lymph node dissection after chemoradiation for rectal cancer: a Western perspective.
- Author
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Peacock, O., Limvorapitak, T., Bednarski, B. K., Kaur, H., Taggart, M. W., Dasari, A., Holliday, E. B., Minsky, B. D., You, Y. N., and Chang, G. J.
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LYMPHADENECTOMY ,RECTAL cancer ,SURGICAL robots ,RECTAL surgery ,BODY mass index ,CHEMORADIOTHERAPY ,LENGTH of stay in hospitals - Abstract
Aim: There are limited outcome data for lateral pelvic lymph node dissection (LPLND) following neoadjuvant chemoradiotherapy (nCRT), particularly in the West. Our aim was to evaluate the short‐term perioperative and oncological outcomes of robotic LPLND at a single cancer centre. Method: A retrospective analysis of a prospective database of consecutive patients undergoing robotic LPLND for rectal cancer between November 2012 and February 2020 was performed. The main outcomes were short‐term perioperative and oncological outcomes. Major morbidity was defined as Clavien–Dindo grade 3 or above. Results: Forty patients underwent robotic LPLND during the study period. The mean age was 54 years (SD ± 15 years) and 13 (31.0%) were female. The median body mass index was 28.6 kg/m2 (IQR 25.5–32.6 kg/m2). Neoadjuvant CRT was performed in all patients. Resection of the primary rectal cancer and concurrent LPLND occurred in 36 (90.0%) patients, whilst the remaining 4 (10.0%) patients had subsequent LPLND after prior rectal resection. The median operating time was 420 min (IQR 313–540 min), estimated blood loss was 150 ml (IQR 55–200 ml) and length of hospital stay was 4 days (IQR 3–6 days). The major morbidity rate was 10.0% (n = 4). The median lymph node harvest from the LPLND was 6 (IQR 3–9) and 13 (32.5%) patients had one or more positive LPLNs. The median follow‐up was 16 months (IQR 5–33 months), with 1 (2.5%) local central recurrence and 7 (17.5%) patients developing distant disease, resulting in 3 (7.5%) deaths. Conclusion: Robotic LPLND for rectal cancer can be performed in Western patients to completely resect extra‐mesorectal LPLNs and is associated with acceptable perioperative morbidity. [ABSTRACT FROM AUTHOR]
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- 2020
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4. Robotic rectal cancer surgery: comparative study of the impact of obesity on early outcomes.
- Author
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Peacock, O., Limvorapitak, T., Hu, C.‐Y., Bednarski, B. K., Tillman, M. M., Kaur, H., Taggart, M. W., Dasari, A., Holliday, E. B., You, Y. N., and Chang, G. J.
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RECTAL surgery ,RECTAL cancer ,ONCOLOGIC surgery ,MINIMALLY invasive procedures ,SURGICAL excision ,ROBOTICS - Published
- 2020
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5. Ileorectal Anastomosis for Slow Transit Constipation: Long-Term Functional and Quality of Life Results
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Hassan, Imran, Pemberton, John H., Young-Fadok, Tonia M., You, Y. Nancy, Drelichman, Ernesto R., Rath-Harvey, Doris, Schleck, Cathy D., Larson, Dirk R., and Drelichman, Ernesto R
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COLECTOMY ,CONSTIPATION ,PATIENTS ,QUALITY of life ,QUESTIONNAIRES ,INTESTINAL diseases ,ILEUM surgery ,RECTAL surgery ,CONVALESCENCE ,DIGESTIVE organ surgery ,GASTROINTESTINAL motility ,HEALTH status indicators ,PSYCHOMETRICS ,SURGICAL anastomosis - Abstract
The results of colectomy and ileorectal anastomosis (IRA) in patients diagnosed by physiologic testing as having slow transit constipation (STC) have been reported. The durability of functional results and long-term quality of life (QoL) in these patients, however, has not been established. Between 1987 and 2002, 3670 patients were evaluated for constipation at our institution; 110 (3%) fulfilled the criteria for STC and underwent an IRA. Patients were prospectively followed and functional outcomes assessed annually by standardized questionnaires. After a median follow-up of 11 years, 104 eligible patients were mailed validated questionnaires to assess functional outcomes and QoL (Knowles-Eccersley-Scott Symptom [KESS] score, the Irritable Bowel Syndrome Quality of Life [IBS-QOL], and the SF-12 health survey). Prospectively assessed functional data was available on 85 of 104 (82%) eligible patients. At last follow-up, improvement of constipation and satisfaction with bowel function was reported by 98% and 85% of patients, respectively. Performance measures including social activity, household work, sexual life, and family relationships were reported to have improved or were not affected as a result of surgery by 75%, 86%, 81%, and 86% of the patients respectively. Fifty-nine patients (57%) responded to the study questionnaires. All 59 patients reported their constipation to be better since IRA, 83% did not require any medication, and 85% reported being satisfied with bowel function. The KESS scores of patients undergoing IRA for STC (median 6, range 0−35) were lower than reported scores of STC patients not operated upon (median 21, range 11−35, P < 0.001) indicating symptomatic improvement after surgery. Mean IBS-QOL scores were similar to reported scores of patients undergoing IRA for other conditions [80 (23) versus 84 (16)], P = 0.7). Mean SF-12 physical and mental summary scores were similar to reported SF-12 scores of the normal population (49.5 versus 50 and P = 0.70, 48.7 versus 50, P = 0.42, respectively). Ileorectal anastomosis in appropriately selected patients with slow transit constipation results in durable symptomatic relief and a long-term quality of life indistinguishable from the general population. [Copyright &y& Elsevier]
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- 2006
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6. Nongastrointestinal Stromal Tumor Spindle Cell Sarcomas of the Colon or Rectum.
- Author
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IKOMA, NARUHIKO, ROLAND, CHRISTINA L., CORMIER, JANICE N., YI-JU CHIANG, TORRES, KEILA E., HUNT, KELLY K., YOU, Y. NANCY, FEIG, BARRY W., and Chiang, Yi-Ju
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COLON cancer , *RECTAL cancer , *ONCOLOGIC surgery , *SURGICAL excision , *GASTROINTESTINAL stromal tumors , *RECTAL surgery , *COLECTOMY , *COLON tumors , *DATABASES , *RESEARCH funding , *SARCOMA , *SURVIVAL analysis (Biometry) , *TREATMENT effectiveness , *RETROSPECTIVE studies , *DIAGNOSIS ,RECTUM tumors - Abstract
Because of the low incidence of nongastrointestinal stromal tumor (non-GIST) spindle cell sarcomas of the colon or rectum, the clinical behavior and ideal surgical treatment of these tumors and patient outcomes are poorly defined. The purpose of this study was to characterize these tumors and to determine the best surgical approach. We identified 1056 patients with non-GIST spindle cell sarcomas of the colon or rectum (1998-2010) in the National Cancer Database and collected data for each patient that included patient and tumor characteristics, tumor site (colon vs rectum), surgery type, and outcomes. The median overall survival was significantly longer in patients with rectal tumors than in those with colon tumors (P < 0.01). Patients with colon tumors who underwent anatomic surgical resection showed a trend toward longer median survival than those with no surgical treatment [hazard ratio (HR), 1.94; P = 0.09] or who underwent local excision (HR, 1.74; P = 0.09). Patients with rectal tumors did not benefit from anatomic surgical resection, but there was a trend favoring local excision (HR, 0.55; P = 0.06). Local sphincter-sparing procedures should be considered for rectal non-GIST tumors whenever technically feasible. [ABSTRACT FROM AUTHOR]
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- 2018
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7. Circumferential Resection Margin as a Hospital Quality Assessment Tool for Rectal Cancer Surgery.
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Patel, Sameer H., Hu, Chung-Yuan, Massarweh, Nader N., You, Y. Nancy, McCabe, Ryan, Dietz, David, Facktor, Matthew A., and Chang, George J.
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RECTAL cancer , *RECTAL surgery , *ONCOLOGIC surgery , *ABDOMINOPERINEAL resection , *HOSPITALS , *ACQUISITION of data - Abstract
Background: Circumferential resection margin (CRM) status is an important predictor of outcomes after rectal cancer operation, and is influenced not only by operative technique, but also by incorporation of a multidisciplinary treatment strategy. This study sought to develop a risk-adjusted quality metric based on CRM status to assess hospital-level performance for rectal cancer operation.Study Design: We conducted a retrospective observational cohort study of 58,374 patients with resected stage I to III rectal cancer within 1,303 hospitals who were identified from the National Cancer Database (2010 to 2015). The number of observed cases with a positive CRM (≤ 1 mm) was divided by the risk-adjusted expected number of cases with positive CRM to form the observed-to-expected (O/E) ratio. Secondary endpoint was overall survival.Results: The overall rate of CRM positivity was 15.9%. Based on the O/E ratio for 1,139 hospitals, 147 (12.9%) and 103 (9.0%) were significantly worse and better performers, respectively. The majority of hospitals (n = 570) performed as expected. Positive CRMs using criteria of 0 mm and 0.1 to 1 mm were associated with a significantly shorter 5-year overall survival of 49% and 63.5% (hazard ratio 1.67; 95% CI, 1.57 to 1.76 and hazard ratio 1.19; 95% CI, 1.12 to 1.26) than negative CRM > 1 mm of 74.1% (all p < 0.001).Conclusions: CRM-based O/E ratio is a robust hospital-based quality measure for rectal cancer operation. It allows facilities to compare their performance with that of centers of similar characteristics and helps identify underperforming, at-risk, and high-performing centers. National quality-improvement initiatives for rectal cancer should focus on ensuring high-quality data collection and providing ready access to risk-adjusted comparative metrics. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
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