Search

Your search keyword '"Spatola M"' showing total 3 results
Start Over Author "Spatola M" Topic receptors, gaba-a
3 results on '"Spatola M"'

1. GABA A receptor autoimmunity after alemtuzumab treatment for multiple sclerosis.

Author

Maniscalco GT, Mariotto S, Höftberger R, Capra R, Servillo G, Manzo V, Napolitano M, Candelaresi P, Gerevini S, Ferrari S, Bozzetti S, Spatola M, and Florio C

Subjects
Aged, Autoimmune Diseases of the Nervous System immunology, Autoimmune Diseases of the Nervous System physiopathology, Autoimmune Diseases of the Nervous System therapy, Autoimmunity immunology, B-Lymphocytes, Electroencephalography, Encephalitis immunology, Encephalitis physiopathology, Encephalitis therapy, Epilepsia Partialis Continua chemically induced, Epilepsia Partialis Continua immunology, Epilepsia Partialis Continua physiopathology, Epilepsia Partialis Continua therapy, Glucocorticoids therapeutic use, Humans, Immunoglobulins, Intravenous therapeutic use, Immunologic Factors therapeutic use, Lymphocyte Activation, Magnetic Resonance Imaging, Male, Methylprednisolone therapeutic use, Seizures immunology, Seizures physiopathology, Seizures therapy, Status Epilepticus chemically induced, Status Epilepticus immunology, Status Epilepticus physiopathology, Status Epilepticus therapy, T-Lymphocytes, Alemtuzumab adverse effects, Autoantibodies immunology, Autoimmune Diseases of the Nervous System chemically induced, Encephalitis chemically induced, Multiple Sclerosis, Relapsing-Remitting drug therapy, Receptors, GABA-A immunology, Seizures chemically induced
Published
2020
Full Text
View/download PDF

2. Investigations in GABA A receptor antibody-associated encephalitis.

Author

Spatola M, Petit-Pedrol M, Simabukuro MM, Armangue T, Castro FJ, Barcelo Artigues MI, Julià Benique MR, Benson L, Gorman M, Felipe A, Caparó Oblitas RL, Rosenfeld MR, Graus F, and Dalmau J

Subjects
Adolescent, Adult, Animals, Brain metabolism, Cognition Disorders etiology, Consciousness, Encephalitis metabolism, Encephalitis therapy, Female, HEK293 Cells, Humans, Immunotherapy, Magnetic Resonance Imaging, Male, Middle Aged, Movement Disorders etiology, Rats, Receptors, GABA-A genetics, Receptors, GABA-A metabolism, Retrospective Studies, Seizures etiology, Transfection, Young Adult, Antibodies blood, Antibodies cerebrospinal fluid, Encephalitis immunology, Receptors, GABA-A immunology
Abstract

Objective: To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABA A receptor (GABA A R) encephalitis., Methods: Clinical study of 26 patients, including 17 new (April 2013-January 2016) and 9 previously reported patients. Antibodies to α1, β3, and γ2 subunits of the GABA A R were determined using reported techniques., Results: Patients' median age was 40.5 years (interquartile range 48.5 [13.75-62.35] years; the youngest 2.5 months old; 13 female). Symptoms included seizures (88%), alteration of cognition (67%), behavior (46%), consciousness (42%), or abnormal movements (35%). Comorbidities were identified in 11 (42%) patients, including 7 tumors (mostly thymomas), 2 herpesvirus encephalitis (herpes simplex virus 1, human herpesvirus 6; coexisting with NMDAR antibodies), and 2 myasthenia without thymoma. Brain MRI was abnormal in 23 (88%) patients, showing in 20 (77%) multifocal, asynchronous, cortical-subcortical T2/fluid-attenuated inversion recovery abnormalities predominantly involving temporal (95%) and frontal (65%) lobes, but also basal ganglia and other regions. Immunologic or tumor therapy resulted in substantial improvement in 18/21 (86%) assessable patients; the other 3 (14%) died (2 status epilepticus, 1 sepsis). Compared with adults, children were more likely to have generalized seizures ( p = 0.007) and movement disorders ( p = 0.01) and less likely to have a tumor ( p = 0.01). The main epitope targets were in the α1/β3 subunits of the GABA A R., Conclusions: Anti-GABA A R encephalitis is characterized by frequent seizures and distinctive multifocal cortical-subcortical MRI abnormalities that provide an important clue to the diagnosis. The frequency of symptoms and comorbidities differ between children (more viral-related) and adults (more tumor-related). The disorder is severe but most patients respond to treatment., (© 2017 American Academy of Neurology.)

Published
2017
Full Text
View/download PDF

3. Investigations in GABAA receptor antibody-associated encephalitis

Author

Marianna Spatola, Ruben L. Caparó Oblitas, Leslie Benson, Josep Dalmau, Ana Felipe, Thaís Armangue, Francesc Graus, Mark P. Gorman, Mar Petit-Pedrol, Maria I. Barcelo Artigues, Fernanda J. Castro, Mateus Mistieri Simabukuro, Maria R. Julià Benique, Myrna R. Rosenfeld, Institut Català de la Salut, [Spatola M] Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. University of Lausanne, Lausanne, Switzerland. [Petit-Pedrol M] Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Raras Madrid, Spain. [Simabukuro MM] Neurology Division, Hospital das Clínicas, São Paulo, Brazil. São Paulo University, São Paulo, Brazil. [Armangue T] Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Raras Madrid, Spain. Neurology Service, Hospital Sant Joan de Déu, Barcelona, Spain. [Castro FJ] Hospital de Base, Brasília, Brazil. [Barcelo Artigues MI] Service of Neurology, University Hospital of Son Espases, Mallorca, Spain. [Felipe A] Hospital Universitari Vall d'Hebron, Barcelona, Spain., and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Male, Pathology, Movement disorders, Antígens, Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Chloride Channels::Receptors, GABA-A [CHEMICALS AND DRUGS], medicine.disease_cause, 0302 clinical medicine, Interquartile range, Otros calificadores::Otros calificadores::/inmunología [Otros calificadores], Young adult, Movement Disorders, biology, GABA - Receptors, Brain, Middle Aged, Magnetic Resonance Imaging, Encephalitis, Human herpesvirus 6, Female, Immunotherapy, medicine.symptom, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::encefalitis [ENFERMEDADES], Adult, medicine.medical_specialty, Thymoma, Adolescent, Consciousness, Status epilepticus, Transfection, Article, Antibodies, 03 medical and health sciences, Young Adult, Seizures, Other subheadings::Other subheadings::/immunology [Other subheadings], medicine, Animals, Humans, Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Encephalitis [DISEASES], Retrospective Studies, business.industry, Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies [CHEMICALS AND DRUGS], aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos [COMPUESTOS QUÍMICOS Y DROGAS], aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de transporte de membrana::canales iónicos::canales del cloro::receptores de GABA-A [COMPUESTOS QUÍMICOS Y DROGAS], Encefalitis, medicine.disease, biology.organism_classification, Receptors, GABA-A, Rats, 030104 developmental biology, Herpes simplex virus, HEK293 Cells, Neurology (clinical), business, Cognition Disorders, 030217 neurology & neurosurgery
Abstract

Objective:To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA receptor (GABAAR) encephalitis.Methods:Clinical study of 26 patients, including 17 new (April 2013–January 2016) and 9 previously reported patients. Antibodies to α1, β3, and γ2 subunits of the GABAAR were determined using reported techniques.Results:Patients' median age was 40.5 years (interquartile range 48.5 [13.75–62.35] years; the youngest 2.5 months old; 13 female). Symptoms included seizures (88%), alteration of cognition (67%), behavior (46%), consciousness (42%), or abnormal movements (35%). Comorbidities were identified in 11 (42%) patients, including 7 tumors (mostly thymomas), 2 herpesvirus encephalitis (herpes simplex virus 1, human herpesvirus 6; coexisting with NMDAR antibodies), and 2 myasthenia without thymoma. Brain MRI was abnormal in 23 (88%) patients, showing in 20 (77%) multifocal, asynchronous, cortical-subcortical T2/fluid-attenuated inversion recovery abnormalities predominantly involving temporal (95%) and frontal (65%) lobes, but also basal ganglia and other regions. Immunologic or tumor therapy resulted in substantial improvement in 18/21 (86%) assessable patients; the other 3 (14%) died (2 status epilepticus, 1 sepsis). Compared with adults, children were more likely to have generalized seizures (p = 0.007) and movement disorders (p = 0.01) and less likely to have a tumor (p = 0.01). The main epitope targets were in the α1/β3 subunits of the GABAAR.Conclusions:Anti-GABAAR encephalitis is characterized by frequent seizures and distinctive multifocal cortical-subcortical MRI abnormalities that provide an important clue to the diagnosis. The frequency of symptoms and comorbidities differ between children (more viral-related) and adults (more tumor-related). The disorder is severe but most patients respond to treatment.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results