1. 4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel.
- Author
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Lahm GP, Cordova D, Barry JD, Pahutski TF, Smith BK, Long JK, Benner EA, Holyoke CW, Joraski K, Xu M, Schroeder ME, Wagerle T, Mahaffey MJ, Smith RM, and Tong MH
- Subjects
- Animals, Chloride Channels metabolism, Dose-Response Relationship, Drug, Insecta, Insecticides chemical synthesis, Insecticides chemistry, Isoxazoles chemical synthesis, Isoxazoles chemistry, Molecular Structure, Structure-Activity Relationship, Chloride Channels antagonists & inhibitors, Insecticides pharmacology, Isoxazoles pharmacology, Receptors, GABA metabolism
- Abstract
Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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