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Your search keyword '"Cantacuzene, D."' showing total 3 results
Start Over Author "Cantacuzene, D." Topic receptors, adrenergic, beta
3 results on '"Cantacuzene, D."'

1. Effect of fluorine substitution on the agonist specificity of norepinephrine.

Author

Cantacuzene D, Kirk KL, McCulloh DH, and Creveling CR

Subjects
Animals, Aorta, Fluorine, Guinea Pigs, Hydrogen Bonding, In Vitro Techniques, Norepinephrine chemical synthesis, Norepinephrine pharmacology, Structure-Activity Relationship, Norepinephrine analogs & derivatives, Receptors, Adrenergic drug effects, Receptors, Adrenergic, alpha drug effects, Receptors, Adrenergic, beta drug effects
Abstract

Substitution of fluorine for hydrogen in position 2, 5, or 6 of the aromatic ring of norepinephrine markedly alters the alpha- and beta-adrenergic agonist properties of norephinephrine. The 6-fluoro isomer is an beta-adrenergic agonist with virtually no beta agonist activity, while the 2-fluoro isomer is a beta-adrenergic agonist with little alpha activity. The 5-fluoro isomer is equipotent with norepinephrine as an alpha agonist and significantly more potent as a beta agonist. The possible physiochemical basis for these differences is discussed.

Published
1979
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2. Effects on fluorine analogs of norepinephrine on stimulation of cyclic adenosine 3',5'-monophosphate and binding to beta-adrenergic receptors in intact pinealocytes.

Author

Auerbach DA, Klein DC, Kirk KL, Cantacuzene D, and Creveling CR

Subjects
Animals, Animals, Newborn, Binding, Competitive, Cells, Cultured, Kinetics, Norepinephrine pharmacology, Pindolol analogs & derivatives, Pindolol metabolism, Pineal Gland drug effects, Rats, Receptors, Adrenergic, beta drug effects, Cyclic AMP metabolism, Norepinephrine analogs & derivatives, Pineal Gland metabolism, Receptors, Adrenergic metabolism, Receptors, Adrenergic, beta metabolism
Published
1981
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3. The binding of fluorocatecholamines to adrenergic and dopaminergic receptors in rat brain membranes.

Author

Nimit Y, Cantacuzene D, Kirk KL, Creveling CR, and Daly JW

Subjects
Animals, Cerebellum metabolism, Clonidine antagonists & inhibitors, Corpus Striatum metabolism, Dioxanes metabolism, Dopamine analogs & derivatives, Dopamine metabolism, Male, Membranes metabolism, Norepinephrine analogs & derivatives, Norepinephrine metabolism, Rats, Cerebral Cortex metabolism, Receptors, Adrenergic metabolism, Receptors, Adrenergic, alpha metabolism, Receptors, Adrenergic, beta metabolism, Receptors, Dopamine administration & dosage
Published
1980
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