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Photodynamic therapy (PDT) involves the topical application of a photosensitizer and its activation by visible light, leading to the generation of protoporphyrin IX (PpIX) and reactive oxygen species. Daylight photodynamic therapy (dPDT), a variant utilizing natural sunlight as the energy source, enhances procedural flexibility by eliminating the need for specialized equipment. dPDT has been effectively used in dermatology to treat various cutaneous disorders, including neoplastic and infectious diseases. Traditionally, skin preparation and photosensitizer application are performed by trained practitioners, limiting the accessibility of dPDT for broader populations. However, recent studies suggest that these preparatory steps can be managed by patients or caregivers, enabling fully self-applied, home-based dPDT protocols. This review systematically examines the current evidence on self-applied dPDT (SA-dPDT), emphasizing molecular mechanisms and its efficacy in managing premalignant and other cutaneous conditions. [ABSTRACT FROM AUTHOR]

The article discusses the efficacy of BF‐200 ALA PDT with half‐ versus full‐light dose in treating actinic keratosis with large field cancerization. A study was conducted on 15 male patients with severe scalp field cancerization, showing comparable lesion clearance rates between the two illumination protocols. Adverse effects were similar between the treatment arms, and the study suggests the potential for a half‐light dose protocol to reduce pain duration while maintaining efficacy in PDT treatment. Further research with larger sample sizes is recommended for broader clinical application. [Extracted from the article]