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Start Over Author "Shikun Fang" Topic rc254-282
3 results on '"Shikun Fang"'

1. Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Author

Yue Zhang, Xinyi Zhang, Yumeng Xu, Shikun Fang, Ying Ji, Ling Lu, Wenrong Xu, Hui Qian, and Zhao Feng Liang

Subjects
circRNAs, biogenesis, cancer, biomarkers, mechanisms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studies have reported its various functions and mechanisms in biological events, such as the occurrence and development of cancer. In this review, we focus on the classification, characterization, biogenesis, functions of circRNAs, and the latest advances in cancer research. The development of circRNAs as biomarkers in cancer diagnosis and treatment also provides new ideas for studying circRNAs research.

Published
2022
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2. CircRNAs: Emerging Bladder Cancer Biomarkers and Targets

Author

Zhaofeng Liang, Wenhao Guo, Shikun Fang, Yue Zhang, Ling Lu, Wenrong Xu, and Hui Qian

Subjects
CircRNAs, bladder cancer, functions, biomarker, targets, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Circular RNAs (circRNAs) are newly discovered intriguing RNAs due to the covalently closed loop structure, high stability, tissue specificity, and functional diversity. In recent years, a large number of circRNAs have been identified through high-throughput sequencing technology and bioinformatics methods, the abnormal expression of circRNAs are closely related to many diseases including bladder cancer (BC). CircRNAs have been proven to have several functions, such as acting as a regulator of parental gene transcription, miRNA sponge and interacting with proteins to regulate its expression. In addition, some circRNAs have been identified to encode proteins. CircRNAs have the characteristics of high abundance, high stability, wide distribution in body fluids, tissue specificity, and developmental stage specificity, which determine that circRNAs has great potential to be utilized as biomarkers for BC. Herein, we briefly summarize the biogenesis, functions and roles, and the current research progress of circRNAs in BC with a focus on the potential application for BC diagnosis, treatment, and prognosis.

Published
2021
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3. Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

Author

Longtao Jin, Zhaofeng Liang, Wenrong Xu, Yue Zhang, Shikun Fang, and Ling Lu

Subjects
Poor prognosis, function, gastric cancer, Active components, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, Abnormal expression, Review, exosomes, Biology, medicine.disease, Extracellular vesicles, Microvesicles, Human health, Oncology, medicine, Cancer research, circRNAs, RC254-282, Function (biology)
Abstract

Ling Lu,1,* Shikun Fang,2,* Yue Zhang,2 Longtao Jin,1 Wenrong Xu,2 Zhaofeng Liang2 1Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People’s Republic of China; 2Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaofeng LiangJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People’s Republic of ChinaEmail liangzhaofeng@ujs.edu.cnAbstract: Gastric cancer (GC) is a common malignant tumor affecting human health, with occult onset and poor prognosis. Exosomes are extracellular vesicles secreted by almost all cells, which can reflect the state of source cells or tissues. It is reported that exosomes are involved in almost all processes of GC. Exosomes provided a window to understand changes in cell or tissue states by carrying active components such as circular RNAs (circRNAs). CircRNAs are a naturally occurring class of endogenous noncoding RNAs and abnormal expression during the occurrence and development of GC. Exosomal circRNAs are those circRNAs stably existing in exosomes and having high clinical values as novel potential diagnosis and prognosis biomarkers of GC, which have the characteristics of abnormal expression, tissue specificity and development stage specificity. Herein, we briefly summarize the functions and roles and the current research progress of exosomes and exosomal circRNAs in GC with a focus on the potential application for GC progression, diagnosis and prognosis. We also prospected the clinical application of exosomes and exosomal circRNAs in the future.Keywords: gastric cancer, exosomes, circRNAs, function

Published
2021

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