13 results on '"Sadeghi, Hossein"'
Search Results
2. Renoprotective effect of Otostegia persica on vancomycin-induced nephrotoxicity in rats.
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Sadeghi, Heibatollah, Soltani, Mitra, Kokhdan, Esmaeel Panahi, Abbasi, Reza, Sadeghi, Hossein, Mostafazade, Mostafa, and Mehraban, Fouad
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RATS ,NEPHROTOXICOLOGY ,LABORATORY rats ,VITAMIN E ,GLYCOPEPTIDE antibiotics ,ERYTHROCYTES ,VITAMINS - Abstract
Vancomycin (VCM), as a glycopeptide antibiotic, is commonly used against serious and life-threatening bacterial infections. Nephrotoxicity is the most important complication of VCM in which free radicals play an important role in its pathophysiology. Thus, the aim of this research was to examine effects of hydro-alcoholic extract of Otostegia persica on nephrotoxicity of VCM in rats. Thirty male Wistar rats were at random divided into 5 groups. The control group was given normal saline. The other groups were treated every 12 h for 7 consecutive days with VCM (200 mg/kg i.p.) alone, VCM (200 mg/kg i.p.) plus Otostegia persica (250 mg/kg), VCM (200 mg/kg i.p.) plus Otostegia persica (500 mg/kg) and VCM (200 mg/kg i.p.) plus vitamin E (250 mg/kg). The extract and vitamin E were administered 30 min prior to VCM. Nephrotoxicity was evaluated biochemically and histopathologically. The results showed that VCM significantly increased excretion of red blood cell (RBC) in urine, serum levels of urea, creatinine, and MDA, and the ratio of weight kidney to body weight (p <.05). Creatinine clearance also markedly decreased compared to the normal group (p <.01), whereas the serum levels of sodium and potassium remain unchanged. Otostegia persica (500 mg/kg) similar to vitamin E significantly attenuated elevation in the serum levels of urea, creatinine, and MDA (p < 0.01). The extract and vitamin E also improved creatinine clearance and the proportion of weight kidneys to body weight (p <.01). The pathological finding confirmed the biochemical findings. The present data confirmed that Otostegia persica has beneficial effects to ameliorate VCM-induced nephrotoxicity in rats, which may be attributable to its antioxidant properties. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. Protective and therapeutic effects of ethanolic extract of Nasturtium officinale (watercress) and vitamin E against bleomycin-induced pulmonary fibrosis in rats.
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Ramezani, Sanaz, Javadi, Iraj, Kokhdan, Esmaeel, Omidifar, Navid, Nikbakht, Jafar, Sadeghi, Heibatollah, Doustimotlagh, Amir, Danaei, Nazanin, Abbasi, Reza, and Sadeghi, Hossein
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WATERCRESS ,PULMONARY fibrosis ,VITAMIN E ,MALONDIALDEHYDE ,LUNG diseases ,TREATMENT effectiveness ,RATS - Abstract
Background and purpose: Pulmonary fibrosis is a chronic disease of the lungs caused by inflammation, species of reactive oxygen, and immune defects. Antioxidant properties of Nasturtium officinale has been reported in some studies. Therefore, the objective of the current study was to evaluate the effect of ethanolic extract of Nasturtium officinale (EENO) on bleomycin (BLM)-induced lung fibrosis in rats. Experimental approach: Forty adult male Wistar rats (180-220 g) were randomly divided into 5 experimental groups. Normal control, BLM control received a single dose of BLM (6 IU/kg) intratracheally only on the first day, EENO + BLM group received EENO (500 mg/kg) one week before intratracheal BLM instillation and two weeks afterward, BLM + EENO group and BML + vitamin E group received EENO (500 mg/kg) and vitamin E (500 mg/kg) half-hour after BLM installation, respectively. The animals were sacrificed on day 22. Change in body weight, lung index, serum level of malondialdehyde (MDA) and nitric oxide (NO) metabolite, lung tissue hydroxyproline content and lung pathology were assessed. Findings/Results: Pre- or post-treatment with EENO attenuated pulmonary fibrosis as evidenced by normalized lung index, improved histological changes and inhibited collagen deposition (hydroxyproline) in the animal lung. EENO also decreased MDA and NO metabolite release in comparison to the BLM control. vitamin E (500 mg/ kg) also significantly inhibited the BLM-induced lung toxicity. Conclusions and implications: EENO can prevent BLM-induced lung fibrosis in rats via antioxidant activities. However, more studies are needed to elicit the exact mechanism of this effect. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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4. Nephroprotective Effects of Zataria multiflora Boiss. Hydroalcoholic Extract, Carvacrol, and Thymol on Kidney Toxicity Induced by Cisplatin in Rats.
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Panahi kokhdan, Esmaeel, Sadeghi, Hossein, Kazemi, Shima, and Doustimotlagh, Amir Hossein
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NEPHROTOXICOLOGY , *ANALYSIS of variance , *ANIMAL experimentation , *CISPLATIN , *MEDICINAL plants , *RATS , *STATISTICS , *PLANT extracts , *DATA analysis , *OXIDATIVE stress , *DATA analysis software , *DESCRIPTIVE statistics ,RISK factors ,THERAPEUTIC use of plant extracts - Abstract
Background. Cisplatin (Cis) is an anticancer drug; however, it has dose-dependent renal toxicity. The current study aims to investigate the protective effects of Zataria multiflora Boiss. hydroalcoholic extract (Z.M.B), carvacrol, and thymol on cisplatin-induced nephrotoxicity in rats. Materials and Methods. Forty-two Wistar male rats were randomly allocated into six groups (n = 7). Group I received normal saline; group II received Cis (7 mg/kg. ip); group III received the Z.M.B extract only (500 mg/kg/d, po); group IV received Z.M.B extract (500 mg/kg/d, po) + Cis; group V received carvacrol (50 mg/kg/d, po) + Cis; and group VI received thymol (50 mg/kg/d, po) + Cis. The levels of biochemical markers, oxidative stress parameters, and histopathological staining were determined in serum and renal tissues. Also, the chemical compositions (carvacrol and thymol) of the Z.M.B extract were assayed by HPLC analysis. Result. The results revealed that Z.M.B extract, carvacrol, and thymol markedly decreased the renal index as compared with the Cis-only group. Also, carvacrol and thymol significantly reduced the blood urea nitrogen level as compared with the Cis-only group. Furthermore, Z.M.B extract, carvacrol, and thymol significantly attenuated the Cis-induced increase in malondialdehyde and nitric oxide metabolite. Additionally, histopathological examination showed that Z.M.B extract, carvacrol, and thymol markedly ameliorated Cis-induced renal tubular necrosis. Conclusion. The results showed renoprotective effects of Z.M.B extract, carvacrol, and thymol in Cis-induced nephrotoxicity in rats. Therefore, Z.M.B extract can be considered as a potential candidate for the protection of nephrotoxicity induced by Cis. [ABSTRACT FROM AUTHOR]
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- 2021
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5. Anticancer activity of Astragalus ovinus against 7, 12 dimethyl benz (a) anthracene (DMBA)-induced breast cancer in rats.
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Mehraban, Fouad, Mostafazadeh, Mostafa, Sadeghi, Hossein, Azizi, Arsalan, Toori, Mehdi Akbartabar, Gramizadeh, Bita, Barati, Vahid, and Sadeghi, Heibatollah
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ASTRAGALUS (Plants) ,BREAST cancer ,ANTHRACENE ,RATS ,OLIVE oil ,PHENOLS - Abstract
Objective: Some species of Astragalus are used for the treatment of various types of cancer. The present study was designed to evaluate the anticancer potential of Astragalus ovinus extract (AOE) against DMBA-induced breast carcinoma in rats. Materials and Methods: The anti-tumor and antioxidant effects of AOE were evaluated against DMBA-induced breast carcinoma in rats using DPPH, FRAP and ABTS technique, respectively. Forty adult female Sprague-Dawley rats were randomly divided into four groups including the control group received a single dose of DMBA solvent orally, and groups II, III and IV received a single dose of DMBA (40 mg/kg) dissolved in olive oil. Groups I and II received normal saline and groups III and IV were treated with AOE orally (120 and 240 mg/kg respectively) for 60 consecutive days. Chemopreventive effects were assessed in terms of diameter and volume of tumors, expression levels of PCNA, and serum levels of CA15.3, p53, MDA, CAT, and calcium, and histopathological features. Results: AOE contained a noticeable amount of phenolic and flavonoids compounds. This extract showed a potent antioxidant activity both in vitro and in vivo. AOE significantly decreased the diameter and volume of tumors (p<0.01) and reduced the serum levels of CA15.3 (p<0.001), p53 (p<0.01), MDA (p<0.001), and calcium (p<0.01). AOE also decreased the expression of PCNA in cancerous tissues and reduced the histopathological deformity. Conclusion: According to the data, AOE produced a significant chemopreventive activity in DMBA-induced breast tumors in rats, probably due to its antioxidant and its inhibitory effect on some tumorigenicity markers such as CA15.3, p53 and PCNA activity. [ABSTRACT FROM AUTHOR]
- Published
- 2020
6. Metformin attenuates oxidative stress and liver damage after bile duct ligation in rats.
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Sadeghi, Heibatollah, Jahanbazi, Fatemeh, Sadeghi, Hossein, Omidifar, Navid, Alipoor, Behnam, Kokhdan, Esmaeel, Mousavipoor, Seyed, Mousavi-Fard, Seyed, and Doustimotlagh, Amir
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LIVER analysis ,OXIDATIVE stress ,BILE ducts ,RATS ,LIVER - Abstract
The aim of the current study was to investigate the antioxidative effect of metformin (MTF) on bile duct ligation (BDL)-induced hepatic disorder and histological damage in rats. The rats were divided into 4 groups including sham control (SC), BDL alone (BDL surgery), MTF1 (BDL surgery and administration of 250 mg/kg of MFM) and MTF2 (BDL surgery and administration of 500 mg/kg of MTF). After BDL, the animals treated with MTF by gavage for 10 days. Hematoxylin and eosin staining, biochemical analysis and oxidative stress markers were assayed to determine histological alterations, liver functions, and oxidant/antioxidant status. Hepatotoxicity was verified by remarkable increase in plasma levels of aminotransferases and alkaline phosphatase activity and liver histology 10 days after the BDL surgery. Our finding showed that treatment with MTF markedly reduced plasma alkaline phosphatase and alleviated liver injury indices (P ≤ 0.05). Furthermore, BDL caused a considerable increase in the protein carbonyl and malondialdehyde content (P ≤ 0.05). However, MTF reduces oxidative stress by constraining the protein oxidation and lipid peroxidation, and increases antioxidant reserve by increasing the ferric reducing ability of plasma and reducing glutathione levels. MTF exerts antioxidative effects in the liver fibrosis and may represent a hepato-protective effect when given to rats with BDL-induced hepatic injury. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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7. The use of 99mTc-phytate for assessment the protective effect of vitamin E against hepatotoxicity induced by methotrexat in rat.
- Author
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Amirfakhrian, Hossein, Abedi, Seyed Mohammad, Sadeghi, Hossein, Azizi, Soheil, and Hosseinimehr, Seyed Jalal
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ANIMAL experimentation ,HEPATOTOXICOLOGY ,HISTOLOGICAL techniques ,INTRAPERITONEAL injections ,LIVER failure ,METHOTREXATE ,RADIONUCLIDE imaging ,RADIOISOTOPES ,RATS ,TECHNETIUM ,VITAMIN E - Abstract
Hepatotoxicity is one of the most common side effects of methotrexate (MTX) therapy in patients. The aim of this study was to evaluate the protective effect of vitamin E against MTX-induced hepatotoxicity using
99m Tc-phytate as a radiopharmaceutical agent in animals. Rats were divided into five groups as follows: control, solvent, Vit E (100 mg/kg), MTX (20 mg/kg) and Vit E + MTX. Animals were intraperitoneally injected with Vit E for 17 days before MTX injection and continued for 4 days.99m Tc-phytate was injected into the tail of rats after the 21 days of Vit E administration. Percentage of the injected dose per gram of liver and spleen tissues (%ID/g) was calculated in treated rats. Liver imaging was obtained with gamma camera. In other experiment, liver of treated rats was assessed for histopathology.99m Tc-phytate uptake (%ID/g) of livers in control, solvent, Vit E, MTX and Vit E + MTX groups were 8.99% ± 1.37, 8.53% ± 2.91, 8.65% ± 3.84, 3.22% ± 1.09 and 8.38% ± 2.68. Vit E administration resulted in a significant increase of the level of %ID/g in MTX-injected animal. Vit E pre-treatment improved the shape of liver in MTX-treated rat which was seen abnormal view in planar imaging. Histophatological examinations approved the protective effect of Vit E against MTX-induced hepatotoxicity in rats. The results of this study show that Vit E significantly attenuates the MTX-induced hepatotoxicity in rats, and99m Tc-phytate is an acceptable radiopharmaceutical agent for assessment of liver and spleen damages in the animal model. [ABSTRACT FROM AUTHOR]- Published
- 2018
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8. Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat.
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Sadeghi, Heibatollah, Hosseinzadeh, Saleh, Touri, Mehdi Akbartabar, Ghavamzadeh, Mehdi, Barmak, Mehrzad Jafari, sayahi, Moslem, and Sadeghi, Hossein
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ROSES ,HEPATOTOXICOLOGY ,THERAPEUTIC use of plant extracts - Abstract
Objective: The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl
4 )-induced hepatotoxicity in rats. Materials and Methods: Male Wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4 ), R. canina 250, 500, and 750 mg/kg + CCl4 and R. canina 750 mg/kg alone. R. canina (p.o., daily) and CCl4 (1 ml/kg twice a week, 50% v/v in olive oil, i.p.) were administered to animals for six weeks. Serum analysis was performed to assay the levels of aspartate aminotransferase (AST), alanine amino transaminase (ALT), alkaline phosphatase (ALP), albumin (ALB), total protein (TP) and malondialdehyde (MDA). Biochemical observations were also supplemented with histopathological examination (haematoxylin and eosin staining) of liver section. Results: Hepatotoxicity was evidenced by considerable increase in serum levels of AST, ALT, ALP, and lipid peroxidation (MDA) and decrease in levels of ALB and TP. Injection of CCL4 also induced congestion in central vein, and lymphocyte infiltration. Treatment with hydro-alcoholic fruit extract of R. canina at doses of 500 and 750 mg/kg significantly reduced CCl4 -elevated levels of ALT, AST, ALP and MDA (p<0.01). The extract also increased the serum levels of ALB and TP compared to CCl4 group (p<0.01) at the indicated dose Histopathological studies supported the biochemical finding. Conclusion: Our finding indicated hepatoprotective effects of the hydro-alcoholic fruit extract of R. canina on CCl4 -induced hepatic damage in rats and suggested that these effects may be produced through reducing oxidative stress. [ABSTRACT FROM AUTHOR]- Published
- 2016
9. Further studies on anti-inflammatory activity of maprotiline in carrageenan-induced paw edema in rat
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Sadeghi, Hossein, Hajhashemi, Valiolla, Minaiyan, Mohsen, Movahedian, Ahmad, and Talebi, Ardeshir
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ANTHRACENE , *CARRAGEENANS , *MAPROTILINE , *EDEMA , *LABORATORY rats , *MENTAL illness treatment , *PHARMACODYNAMICS - Abstract
Abstract: Antidepressant drugs are commonly used for treatment of different medical disorders besides of psychiatric diseases. Accumulating evidence suggests that antidepressants exhibit anti-inflammatory activity in vivo and in vitro conditions, but the mechanisms of this property are not clear very well. In our earlier work, we demonstrated that i.c.v. and i.p. injection of maprotiline, as an antidepressant, decreased paw edema at the fourth hour after subplantar injection of carrageenan. Therefore, this work was undertaken to investigate anti-inflammatory effects of maprotiline in more details. Our results verified that i.p. (25 and 50mg/kg) and i.c.v. (100μg/rat) application of maprotiline significantly reduced paw edema at 1, 2, 3 and 4h intervals after carrageenan challenge. Pathological examinations and MPO activity also showed that both i.p. and i.c.v. maprotiline considerably inhibited infiltration of PMN leucocytes into the inflamed paws. Additionally, i.p. and i.c.v. maprotiline at all applied doses noticeably declined levels of IL-1β into the site of inflammation, while only i.p. maprotiline at a dose of 50mg/kg significantly decreased TNF-α levels in the carrageenan-injected paws. These results confirmed anti-edematogenic activity of i.p. and i.c.v. maprotiline in the carrageenan induced paw edema model and showed that these properties of maprotiline might be mediated through inhibition of PMN infiltration and release of IL-1β and TNF-α. [Copyright &y& Elsevier]
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- 2013
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10. Stachys pilifera Benth. Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through the Antioxidant Pathways.
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Danaei, Nazanin, Panahi kokhdan, Esmaeel, Sadeghi, Hossein, Sadeghi, Heibatollah, Hassanzadeh, Sajad, Rostamzadeh, Davuod, Azarmehr, Nahid, and Hafez Ghoran, Salar
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THERAPEUTIC use of antioxidants , *EXPERIMENTAL design , *DISEASE progression , *FIBROBLASTS , *INTRATRACHEAL drug administration , *ANIMAL experimentation , *VITAMIN E , *LUNGS , *CELLULAR signal transduction , *TREATMENT effectiveness , *RATS , *CELL proliferation , *BLEOMYCIN , *PULMONARY fibrosis , *PLANT extracts , *EVALUATION - Abstract
Background and Aim. Fibrosis of the lungs is an interstitial lung disease whose diagnosis and treatment are not well-established. Stachys pilifera Benth. (Lamiaceae) has been proven to have antioxidant and anti-inflammatory properties. This study was performed to determine the effect of S. pilifera extract on bleomycin-induced pulmonary fibrosis in rats. Methods. In this experimental study, 35 male Wistar rats (120–180 g) were divided into five groups (n = 7) as follows: intratracheal instillation of bleomycin (BLM, 7.5 IU/kg) was administered to group II. The third and fourth groups received BLM plus Stachys pilifera hydroalcoholic extract (SPHE) (300 mg/kg/day, gavage). Vitamin E (500 mg/kg/day, gavage) was given to group V in addition to BLM. After 14 days, the animals were euthanized to assess biochemical parameters and lung histopathology. Malondialdehyde (MDA), nitric oxide (NO), total thiol (TSH), and glutathione (GSH) levels were measured. In addition, hydroxyproline (HYP) levels along with histological changes in lung tissue were also assessed. Results. MDA, NO, and HYP elevations induced by BLM toxicity were significantly inhibited by SPHE (300 and 600 mg/kg), and Vit E. SPHE also significantly increased GSH and TSH levels in comparison to the BLM group.HPLC analyses showed the presence of thymol (55.47 ng/mL) and carvacrol (109.91 ng/mL) in SPHE as potential bioactive phenolic compounds. Conclusion. The results suggest that SPHE alleviates the development of BLM-induced pulmonary fibrosis by inhibiting the proliferation of fibroblasts mediated by antioxidant pathways. Other mechanisms underlying this Effect of SPHE need to be clarified through further research. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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11. Antioxidant and Anti-Inflammatory Effects of Origanum majorana L. Methanolic Extract on Bile Duct Ligation in Male Rats.
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Gheitasi, Izadpanah, Motaghi, Nikta, Sadeghi, Hossein, Sadeghi, Heibatollah, Moslemi, Zahra, Eftekhari, Mahdieh, Shakerinasab, Nasrin, and Doustimotlagh, Amir Hossein
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BIOMARKERS , *INTERLEUKINS , *TRANSFORMING growth factors-beta , *MEDICINAL plants , *CHOLESTASIS , *INFLAMMATION , *ANIMAL experimentation , *ORAL drug administration , *OXIDATIVE stress , *RATS , *GENE expression , *TUMOR necrosis factors , *MESSENGER RNA , *PLANT extracts , *LIGATURE (Surgery) , *ALANINE aminotransferase , *ASPARTATE aminotransferase , *BILIRUBIN , *BLOOD ,BILE duct surgery - Abstract
Introduction. Cholestasis is caused by malfunction of the hepatobiliary system. This disorder is the result of the accumulation of bile fatty acids and other toxins in the liver. The aim of the current study was to investigate the antioxidative and hepatoprotective effects of methanolic extract of Origanum majorana L. (OM) on hepatic disorder and tissue damage induced by bile duct ligation (BDL) in rats. Materials and methods. Twenty-eight male Wistar rats were randomly divided into 4 groups including sham control group received vehicle (SC-V), bile duct ligation received vehicle (BDL-V), bile duct ligation group received OM extract (BDL + OM), and sham control group received OM extract (SC + OM). One day after surgery, the animals received vehicle or methanolic extract of OM 300 mg/kg/day for 7 consecutive days by oral gavage. Finally, the animals were anesthetized and the blood samples were collected from each animal. After sacrificing of animals, liver tissue from each rat was removed and divided into three parts: one part was used for preparing of homogenized tissue, one part was fixed in 10% neutral formalin for histopathology examination, and the third part was kept in liquid nitrogen for gene expression analysis. Biomarkers of oxidative stress in the liver tissue and serum, as well as histopathological changes of the liver, were assessed. Also, the gene expression of IL-1, TNF-α, TGF-β, and α-SMA has been measured. Results. The results showed that BDL-V significantly increased the activity of ALT, AST, ALP, and total bilirubin compared to the SC-V group. The oxidative stress markers such as MDA and FRAP significantly increased due to BDL, while the CAT activity reduced in the BDL-V group compared to SC-V group. Oral treatment with OM reduced ALT and AST activity, although it was not statistically significant. OM treatment considerably increased the activity of CAT compared to BDL group. BDL-V induced a significant histological change in the liver, while treatment with OM at a dose of 300 mg/kg showed a minor effect on histopathological changes. In addition, the mRNA of IL-1, TNF-α, TGF-β, and α-SMA significantly increased in the BDL-V group, while treatment with OM only significantly reduced TGF-β in comparison with BDL-V rats. Conclusions. The results of the present study showed that oral administration of OM extract had a moderate protective effect on cholestasis due to BDL. Indeed, more studies with different doses of extract are needed to confirm this finding. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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12. The hydroalcoholic extract of Nasturtium officinale reduces oxidative stress markers and increases total antioxidant capacity in patients with asthma.
- Author
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Shakerinasab, Nasrin, Mottaghipisheh, Javad, Eftekhari, Mahdieh, Sadeghi, Hossein, Bazarganipour, Fatemeh, Abbasi, Reza, Doustimotlagh, Amir Hossein, and Iriti, Marcello
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ASTHMA , *IN vivo studies , *INFLAMMATION , *ANIMAL experimentation , *ANTIOXIDANTS , *OXIDATIVE stress , *RATS , *PLACEBOS , *TREATMENT effectiveness , *WATERCRESS , *PLANT extracts , *REACTIVE oxygen species , *METABOLITES - Abstract
Asthma is a common chronic disease characterized by inflammation of the airways. One of the most devastating consequences of this inflammatory process is the production of reactive oxygen species responsible for oxidative stress. Nasturtium officinale commonly known as watercress has traditionally been applied in Iranian folk medicine to treat respiratory disorders and diseases mainly bronchitis and asthma. In accordance with these ethnopharmacological reports, through our previous in vivo experiment, we have confirmed significant effect of its hydroalcoholic extract in reducing lung inflammation and oxidative stress in an ovalbumin-induced asthmatic rat model. Aim of the study: The aim of the present study was to investigate the anti-inflammatory and antioxidant effects of N. officinale hydroalcoholic extract (NOE) in patients with asthma, in order to confirm our findings of the previous performed in vivo study. The NOE capsules (500 mg) were treated twice daily for 4 weeks as a supplementary treatment in a randomized, double-blind, and placebo-controlled trial in asthmatics. The primary outcome was Asthma Control Test score. The blood samples were taken at the beginning and end of the study. Then, the level of inflammatory markers, oxidative stress markers and antioxidant enzyme activity were measured. Treatment with NOE for one month caused a reduction in the levels of MDA, PCO and NO metabolite markers compared to the placebo group. In addition, FRAP levels as an indicator of total antioxidant capacity in the intervention group was significantly increased at the end of the treatment period compared to pre-treatment values. Findings demonstrated that NOE may have a therapeutic effect on asthma by improving oxidative stress. However, more studies are required to support these results. Moreover, bio-assay guided fractionation and isolation approach can be conducted to identify major bioactive compound/s. [Display omitted] • Nasturtium officinale has been well-known in Iranian folk medicine to treat respiratory disorders and ailments. • The efficacy of N. officinale on asthmatic patients was assessed through a randomized, double-blind, and placebo-controlled trial. • The hydroalcoholic extract of N. officinale reduced the levels of inflammatory markers and enhanced antioxidant enzyme. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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13. Effects of date palm pollen (Phoenix dactylifera L.) and Astragalus ovinus on sperm parameters and sex hormones in adult male rats.
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Mehraban, Fouad, Jafari, Mehrzad, Toori, Mehdi Akbartabar, Sadeghi, Hossein, Joodi, Behzad, Mostafazade, Mostafa, and Sadeghi, Heibatollah
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DATE palm , *ASTRAGALUS membranaceus , *SEX hormones , *ESTRADIOL ,GONADAL diseases - Abstract
Background: Date Palm Pollen (DPP) and Astragalus genus are used in some countries for the treatment of infertility. Objective: This study was designed to investigate effects of DPP and Astragalus ovinus {A.Ovinus) on fertility in healthy adult male rats. Materials and Methods: Thirty-six rats were divided into six groups (n=6) including control and five treatment groups. DPP (120, 240 and 360 mg/kg) and A.ovinus (100, 500 mg/ kg) were orally given to the treatment groups. After thirtyfive days, blood samples were taken to determine serum levels of FSH, LH, testosterone and estradiol. Weight of testis and epididymis, sperm count, sperm motility, seminiferous tubules diameter (STD), germinal cell layer thickness (GCLT), sertoli, leydig and spermatogonia cells were also evaluated. Results: DPP at the of 120 and 240 mg/kg doses significantly raised the ratio of testis or epididymis to body weight, sperm count, sperm motility , and estradiol level compared to the control group (p<0.05). LH and testosterone levels only noticeably increased at 120 mg/kg of DPP (p<0.01 and p<0.001 respectively). STD increased in the three applied doses (p=0.001). A. ovinus extract at the indicated doses produced a significant reduction in the ratio of testis or epididymis to body weight and sperm motility (p<0.05). Sperm count, spermatogonia, leydig cells and FSH level decreased at dose of 500 mg/kg. Furthermore, GCLT, spermatogonia cells, and serum estradiol level increased at 100 mg/kg dose of A. ovinus. Conclusion: Our findings indicate that DPP could improve fertility factors, while A.ovinus can exhibit deleterious effects on gonad and sperm parameters in rats. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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