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6 results on '"De Martinis, C."'

1. [Distribution and metabolism of testosterone in rats].

Author

Fonzo D, Lauro R, Dogliotti L, Veglio V, and De Martinis C

Subjects
Adipose Tissue metabolism, Adrenal Glands metabolism, Animals, Brain metabolism, Female, Hydroxytestosterones analysis, Kidney metabolism, Kidney ultrastructure, Liver metabolism, Liver ultrastructure, Male, Muscle, Skeletal metabolism, Myocardium metabolism, Organ Specificity, Rats, Wistar, Sex Characteristics, Spleen metabolism, Subcellular Fractions metabolism, Rats metabolism, Testosterone metabolism
Abstract

Distribution and metabolism of testosterone were studied in male and female rats. While no differences between sexes were observed in the hormone distribution to liver, kidney, spleen, heart, adipose tissue, muscle, brain and adrenal, male liver was found to metabolize testosterone mainly to polar compounds; female liver mainly to A-ring reduced compounds.

Published
1972

2. [Oestrogens in the stimulation of adrenal steroid production in the rat].

Author

Lauro R, Fonzo D, Dogliotti L, and De Martinis C

Subjects
Adrenal Cortex drug effects, Adrenocorticotropic Hormone deficiency, Adrenocorticotropic Hormone physiology, Animals, Desoxycorticosterone metabolism, Estradiol pharmacology, Female, Hydroxylation drug effects, Hypophysectomy, Pituitary-Adrenal System physiology, Adrenal Cortex metabolism, Adrenal Cortex Hormones biosynthesis, Estrogens physiology, Rats physiology
Abstract

Chronic administration of oestradiol has several times been reported as leading to stimulation of in vitro adrenal hydroxylative activity in the rat. It is now shown that acute stimulation is also possible, provided ACTH is present in the system. Synthetic oestrogens with metabolic activity equivalent to that of oestradiol, however, are incapable of stimulating steroid production. It is clear that the mechanism of action of oestrogens is extremely complicated as far as the adrenal glands are concerned.

Published
1973

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