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The aim of this study was to investigate the effectiveness of 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD). Rats (n=30) were randomly and equally divided into three groups, 1st group considered control, 2nd group orally administered for 30 day 125 ng/kg/day TCDD, and 3rd group orally administered for 90 day 125 ng/kg/day TCDD respectively by stomach tube, TCDD dissolved in corn oil. Liver samples were taken from half of rats on day 30 and 90 and biochemical assay of fasting serum peroxynitrate radical, TG-HDL, LDL and VLDL cholesterol and serum catalase activity. Results indicated that TCDD significantly (P<0.05) increased in lipid profile and decrease catalase and peroxynitrate radical. Pathological examination showed liver damage, abscess, centrilobular necrosis with massive calcified giant cells (epithelioid and macrophage) extensive granuloma, In conclusion the TCDD showed intoxicant and early carcinogenesis in rats and it's time and dose depended manner. [ABSTRACT FROM AUTHOR]

Diabetes mellitus is associated with importance of rat model. The chronic complication of (D.M) type 2 is coronary artery atherosclerosis caused by reactive oxygen species (ROS) by causing hyperlipidemia. Alpha-lipoic acid (ALA) is prevention complication of diabetes mellitus its potent antioxidant by prevention diabetic atherosclerosis and vascular disease. 30 Sprague-Dawley rats randomly equally divided into 3 groups 1st group (control), 2nd group daily injected for 3 days I/P with (40-45 mg/kg) streptozotocin, 3rd group daily injected I/P with (40-45 mg/kg) streptozotocin for 3 days daily supplement with ALA (300 mg/kg) for 60 day. Glucose concentration and lipid profile increased with concentration of insulin resistance IR and GH-PX mg/Hb/min at 2nd group mostly at 60 days with atherosclerotic plaque in the coronary artery, while 3rd group showed decreased in glucose and lipid profile and decrease IR with GH-Hb at 60 day without pathological atherosclerotic plaque in coronary artery. [ABSTRACT FROM AUTHOR]