1. The Efficacy of Exercise Training for Cutaneous Microvascular Reactivity in the Foot in People with Diabetes and Obesity: Secondary Analyses from a Randomized Controlled Trial.
- Author
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Lanting, Sean, Way, Kimberley, Sabag, Angelo, Sultana, Rachelle, Gerofi, James, Johnson, Nathan, Baker, Michael, Keating, Shelley, Caterson, Ian, Twigg, Stephen, and Chuter, Vivienne
- Subjects
PEOPLE with diabetes ,EXERCISE therapy ,RANDOMIZED controlled trials ,HIGH-intensity interval training ,TYPE 2 diabetes - Abstract
It is unclear if cutaneous microvascular dysfunction associated with diabetes and obesity can be ameliorated with exercise. We investigated the effect of 12-weeks of exercise training on cutaneous microvascular reactivity in the foot. Thirty-three inactive adults with type 2 diabetes and obesity (55% male, 56.1 ± 7.9 years, BMI: 35.8 ± 5, diabetes duration: 7.9 ± 6.3 years) were randomly allocated to 12-weeks of either (i) moderate-intensity continuous training [50–60% peak oxygen consumption (VO
2peak ), 30–45 min, 3 d/week], (ii) low-volume high-intensity interval training (90% VO2peak , 1–4 min, 3 d/week) or (iii) sham exercise placebo. Post-occlusive reactive hyperaemia at the hallux was determined by laser-Doppler fluxmetry. Though time to peak flux post-occlusion almost halved following moderate intensity exercise, no outcome measure reached statistical significance (p > 0.05). These secondary findings from a randomised controlled trial are the first data reporting the effect of exercise interventions on cutaneous microvascular reactivity in the foot in people with diabetes. A period of 12 weeks of moderate-intensity or low-volume high-intensity exercise may not be enough to elicit functional improvements in foot microvascular reactivity in adults with type 2 diabetes and obesity. Larger, sufficiently powered, prospective studies are necessary to determine if additional weight loss and/or higher exercise volume is required. [ABSTRACT FROM AUTHOR]- Published
- 2022
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