1. Investigation Into the Effects of Intra-Articular Steroid on Post-Traumatic Osteoarthritis in Distal Radius Fractures: A Randomized Controlled Pilot Study.
- Author
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Logli AL, Evans CH, Duryea J, Larson DR, Bakri K, Carlsen BT, Dennison DG, Karim KE, Pulos NA, Rhee PC, Rizzo M, Shin AY, Elhassan BT, and Kakar S
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Double-Blind Method, Hand Strength, Injections, Intra-Articular, Intra-Articular Fractures complications, Intra-Articular Fractures diagnostic imaging, Intra-Articular Fractures drug therapy, Pilot Projects, Prospective Studies, Range of Motion, Articular, Tomography, X-Ray Computed, Treatment Outcome, Wrist Joint, Dexamethasone administration & dosage, Dexamethasone therapeutic use, Glucocorticoids administration & dosage, Osteoarthritis etiology, Osteoarthritis prevention & control, Radius Fractures complications, Radius Fractures diagnostic imaging, Radius Fractures drug therapy, Wrist Fractures complications, Wrist Fractures diagnostic imaging, Wrist Fractures drug therapy
- Abstract
Purpose: The aim of this prospective, randomized, controlled, double-blinded pilot study was to determine the rates of post-traumatic osteoarthritis and assess joint space width in the presence or absence of a single intra-articular injection of corticosteroid after an acute, intra-articular distal radius fracture (DRF)., Methods: Forty patients received a single, intra-articular, radiocarpal joint injection of 4 mg of dexamethasone (DEX) (n = 19) or normal saline placebo (n = 21) within 2 weeks of a surgically or nonsurgically treated intra-articular DRF. The primary outcome measure was minimum radiocarpal joint space width (mJSW) on noncontrast computed tomography scans at 2 years postinjection. Secondary outcomes were obtained at 3 months, 6 months, 1 year, and 2 years postinjection and included Disabilities of the Arm, Shoulder, and Hand; Michigan Hand Questionnaire; Patient-Rated Wrist Evaluation; wrist range of motion; and grip strength., Results: At 2-year follow-up, there was no difference in mean mJSW between the DEX group (2.2 mm; standard deviation, 0.6; range, 1.4-3.2) and the placebo group (2.3 mm; standard deviation, 0.7; range, 0.9-3.9). Further, there were no differences in any secondary outcome measures at any postinjection follow-up interval., Conclusions: Radiocarpal joint injection of corticosteroid within 2 weeks of an intra-articular DRF does not appear to affect the development of post-traumatic osteoarthritis within 2 years follow-up in a small pilot cohort., Type of Study/level of Evidence: Therapeutic II., (Copyright © 2024 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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