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Purpose: Due to the electron return effect (ERE) during magnetic resonance imaging guided radiotherapy (MRIgRT), rectal gas during pelvic treatments can result in hot spots of over‐dosage in the rectal wall. Determining the clinical impact of this effect on rectal toxicity requires estimation of the amount and mobility (and stability) of rectal gas during treatment. We therefore investigated the amount of rectal gas and local inter‐ and intra‐fractional changes of rectal gas in pelvic cancer patients. Methods: To estimate the volume of gas present at treatment planning, the rectal gas contents in the planning computed tomography (CT) scans of 124 bladder, 70 cervical and 2180 prostate cancer patients were calculated. To estimate inter‐ and intra‐fractional variations in rectal gas, 174 and 131 T2‐w MRIs for six cervical and eleven bladder cancer patients were used. These scans were acquired during four scan‐sessions (~20–25 min each) at various time‐points. Additionally, 258 T2‐w MRIs of the first five prostate cancer patients treated using MRIgRT at our center, acquired during each fraction, were analyzed. Rectums were delineated on all scans. The area of gas within the rectum delineations was identified on each MRI slice using thresholding techniques. The area of gas on each slice of the rectum was used to calculate the inter‐ and intra‐fractional group mean, systematic and random variations along the length of the rectum. The cumulative dose perturbation as a result of the gas was estimated. Two approaches were explored: accounting or not accounting for the gas at the start of the scan‐session. Results: Intra‐fractional variations in rectal gas are small compared to the absolute volume of rectal gas detected for all patient groups. That is, rectal gas is likely to remain stable for periods of 20–25 min. Larger volumes of gas and larger variations in gas volume were observed in bladder cancer patients compared with cervical and prostate cancer patients. For all patients, local cumulative dose perturbations per beam over an entire treatment in the order of 60 % were estimated when gas had not been accounted for in the daily adaption. The calculated dose perturbation over the whole treatment was dramatically reduced in all patients when accounting for the gas in the daily set‐up image. Conclusion: Rectal gas in pelvic cancer patients is likely to remain stable over the course of an MRIgRT fraction, and also likely to reappear in the same location in multiple fractions, and can therefore result in clinically relevant over‐dosage in the rectal wall. The over‐dosage is reduced when accounting for gas in the daily adaption. [ABSTRACT FROM AUTHOR]

Purpose: Dose deposition around unplanned air cavities during magnetic resonance‐guided radiotherapy (MRgRT) is influenced by the electron return effect (ERE). This is clinically relevant for gas forming close to or inside organs at risk (OARs) that lie in the path of a single beam, for example, intestinal track during pelvic treatment. This work aims to verify Monte Carlo calculations that predict the dosimetric effects of ERE around air cavities. For this, we use GafChromic EBT3 film inside poly‐methyl methacrylate (PMMA) –air phantoms. Method: Four PMMA phantoms were produced. Three of the phantoms contained centrally located spherical air cavities (0.5, 3.5, 7.5 cm diameter), and one phantom contained no air. The phantoms were split to sandwich GafChromic EBT3 film in the center. The phantoms were irradiated on an Elekta Unity system using a single 10 × 10 cm2 7‐MV photon beam under the influence of a 1.5‐T transverse magnetic field. The measurements were replicated using the Elekta Monaco treatment planning system (TPS). Gamma analysis with pass criteria 3%/3 mm was used to compare the measured and calculated dose distributions. We also consider 3%/2 mm, 2%/3 mm, and 2%/2 mm pass criteria for interest. Results: The gamma analysis showed that >95% of the points agreed between the TPS‐calculated and measured dose distributions, using 3%/3 mm criteria. The phantom containing the largest air cavity had the lowest agreement, with most of the disagreeing points lying inside the air cavity (dose to air region). Conclusions: The dose effects due to ERE around spherical air cavities are being calculated in the TPS with sufficient accuracy for clinical use. [ABSTRACT FROM AUTHOR]

Poster: Physics track: Radiobiological and predictive modelling, and radiomics PO-1569: Early prediction of tumour-response to radiotherapy in NSCLC patients. L.M. Amugongo, E. Vasquez Osorio, A. Green, D. Cobben, M. Van Herk, A. McWilliam. [Extracted from the article]