1. Magnetic Resonance Prediction of Lung Maturity in Fetuses With Congenital Diaphragmatic Hernia
- Author
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Mariam Moshiri, Theodore J. Dubinsky, Mladen Zecevic, Eve Wiggins, Daniel S. Hippe, and Thomas C. Winter
- Subjects
medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Gestational Age ,Lower risk ,Ultrasonography, Prenatal ,Fetus ,Pregnancy ,medicine ,Humans ,Lung ,medicine.diagnostic_test ,business.industry ,Hazard ratio ,Infant, Newborn ,Gestational age ,Congenital diaphragmatic hernia ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Confidence interval ,medicine.anatomical_structure ,Female ,Apgar score ,Radiology ,Hernias, Diaphragmatic, Congenital ,business - Abstract
To determine if lung to liver MR T2 signal ratio is predictive of neonatal outcome in fetuses with congenital diaphragmatic hernia (CDH).After Interal Review Board approval, the PACS systems at the University of Washington and University of Utah were searched for cases having an in utero fetal MR examination diagnostic of CDH. Inclusion criteria were at least 1 prior ultrasound demonstrating a CDH and an MR obtained within 1 week of that prior ultrasound.A total of 69 patients from the University of Utah and 13 from the University of Washington satisfied the inclusion criteria for a total of 82. After adjusting for gestational age and contralateral lung volume, there was little apparent association between contralateral lung to liver MR T2 signal and 5-minute Apgar score and neonatal mortality When considering neonatal Apgar and mortality, increasing contralateral lung volume was significantly associated with lower risk (hazard ratio, 0.40 per doubling; 95% confidence interval, 0.24-0.69; P = 0.001) as expected.Our data demonstrate that the lung to liver MR signal ratio was not predictive of outcome. The measurement of contralateral lung area, and gestational age at the time of the examination (time of diagnosis) are still the best predictors of poor neonatal outcome.
- Published
- 2021
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