1. ANGIOGENESIS AND COX2 IN PYOGENIC GRANULOMAS: AN IMMUNOHISTOCHEMICAL STUDY
- Author
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Ondina Karla Mousinho Rocha Torres, Dennys Ramon de Melo Fernandes Almeida, Márcia Cristina da Costa Miguel, Lucas Melo da Costa, Igor Lucena, Éricka Janine Dantas da Silveira, and Luiz Arthur Barbosa Da Silva
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Angiogenesis ,Capillary hemangioma ,CD34 ,Inflammation ,medicine.disease ,Pathology and Forensic Medicine ,Lesion ,Oral pyogenic granuloma ,Medicine ,Immunohistochemistry ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,medicine.symptom ,business - Abstract
Oral pyogenic granuloma (PG) is a frequent reactive lesion. Angiogenesis and inflammation are involved in its development, however, its etiopathogenesis is still not fully understood. Objective: The immunoexpression of CD34 and COX2, markers used in the study of angiogenesis and inflammation, respectively, was evaluated. Study Design: Forty-nine PG cases were selected and divided into 25 cases of lobular capillary hemangioma (LCH) and 24 cases of non-LCH. For the analysis of CD34, 5 hot spot areas were chosen, from which 2 fields were selected, in which the positive cells were counted and a mean was taken from these values. The evaluation of COX immunoexpression was by means of a semi-quantitative analysis in 5 selected fields. For all evaluations, significant values were considered with P
- Published
- 2020
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