169 results on '"Linda Moy"'
Search Results
2. Top Covers of the Centennial
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Peter Li, Simon Lennartz, Nikita Consul, Linda Moy, and Susanna I. Lee
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Radiology, Nuclear Medicine and imaging - Published
- 2023
3. ACR Appropriateness Criteria® Imaging After Breast Surgery
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Tejas S. Mehta, Ana P. Lourenco, Bethany L. Niell, Debbie L. Bennett, Ann Brown, Alison Chetlen, Phoebe Freer, Lillian K. Ivansco, Maxine S. Jochelson, Katherine A. Klein, Sharp F. Malak, Marion McCrary, David Mullins, Colleen H. Neal, Mary S. Newell, Gary A. Ulaner, and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2022
4. ACR Appropriateness Criteria® Evaluation of Nipple Discharge: 2022 Update
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Matthew F. Sanford, Priscilla J. Slanetz, Alana A. Lewin, Arnold M. Baskies, Laura Bozzuto, Susan A. Branton, Jessica H. Hayward, Huong T. Le-Petross, Mary S. Newell, John R. Scheel, Richard E. Sharpe, Gary A. Ulaner, Susan P. Weinstein, and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2022
5. Women 75 Years Old or Older: To Screen or Not to Screen?
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Cindy S. Lee, Alana Lewin, Beatriu Reig, Laura Heacock, Yiming Gao, Samantha Heller, and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
6. Climate Change and Sustainability
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Kate Hanneman, Jose Arimateia Batista Araujo-Filho, Cesar Higa Nomura, Jenna Jakubisin, and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
7. New Screening Performance Metrics for Digital Breast Tomosynthesis in U.S. Community Practice from the Breast Cancer Surveillance Consortium
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Cindy S. Lee and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
8. Breast Cancer Screening for Women at Higher-Than-Average Risk: Updated Recommendations From the ACR
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Debra L. Monticciolo, Mary S. Newell, Linda Moy, Cindy S. Lee, and Stamatia V. Destounis
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Radiology, Nuclear Medicine and imaging - Published
- 2023
9. Preoperative Breast MRI Is Not a Significant Prognostic Factor of Recurrence-Free Survival and Overall Survival in Young Women
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Eric Kim and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
10. Detecting Common Sources of AI Bias: Questions to Ask When Procuring an AI Solution
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Ali S. Tejani, Tara A. Retson, Linda Moy, and Tessa S. Cook
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Radiology, Nuclear Medicine and imaging - Published
- 2023
11. ChatGPT and Other Large Language Models Are Double-edged Swords
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Yiqiu Shen, Laura Heacock, Jonathan Elias, Keith D. Hentel, Beatriu Reig, George Shih, and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
12. Editor’s Recognition Awards
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Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
13. Ultrafast Breast MRI to Predict Pathologic Response after Neoadjuvant Therapy
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Cindy Lee and Linda Moy
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Humans ,Radiology, Nuclear Medicine and imaging ,Breast ,Magnetic Resonance Imaging ,Neoadjuvant Therapy - Published
- 2022
14. ACR Appropriateness Criteria® Imaging of the Axilla
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Huong T, Le-Petross, Priscilla J, Slanetz, Alana A, Lewin, Jean, Bao, Elizabeth H, Dibble, Mehra, Golshan, Jessica H, Hayward, Charlotte D, Kubicky, A Marilyn, Leitch, Mary S, Newell, Christine, Prifti, Matthew F, Sanford, John R, Scheel, Richard E, Sharpe, Susan P, Weinstein, and Linda, Moy
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Diagnosis, Differential ,Evidence-Based Medicine ,Axilla ,Humans ,Radiology, Nuclear Medicine and imaging ,Societies, Medical ,United States ,Mammography - Abstract
This publication reviews the current evidence supporting the imaging approach of the axilla in various scenarios with broad differential diagnosis ranging from inflammatory to malignant etiologies. Controversies on the management of axillary adenopathy results in disagreement on the appropriate axillary imaging tests. Ultrasound is often the appropriate initial imaging test in several clinical scenarios. Clinical information (such as age, physical examinations, risk factors) and concurrent complete breast evaluation with mammogram, tomosynthesis, or MRI impact the type of initial imaging test for the axilla. Several impactful clinical trials demonstrated that selected patient's population can received sentinel lymph node biopsy instead of axillary lymph node dissection with similar overall survival, and axillary lymph node dissection is a safe alternative as the nodal staging procedure for clinically node negative patients or even for some node positive patients with limited nodal tumor burden. This approach is not universally accepted, which adversely affect the type of imaging tests considered appropriate for axilla. This document is focused on the initial imaging of the axilla in various scenarios, with the understanding that concurrent or subsequent additional tests may also be performed for the breast. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
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- 2022
15. Change Is Good: The Evolution and Future of Breast Imaging
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Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
16. Beyond Breast Density: Risk Measures for Breast Cancer in Multiple Imaging Modalities
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Raymond J. Acciavatti, Su Hyun Lee, Beatriu Reig, Linda Moy, Emily F. Conant, Despina Kontos, and Woo Kyung Moon
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Radiology, Nuclear Medicine and imaging - Published
- 2023
17. Radiology Editorial Board 2023
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Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
18. Phase-Sensitive Breast Tomosynthesis May Address Shortcomings of Digital Breast Tomosynthesis
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Given Names Deactivated Family Name Deactivated and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
19. Top Publications in Radiology, 2022
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Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2023
20. Standalone AI for Breast Cancer Detection at Screening Digital Mammography and Digital Breast Tomosynthesis: A Systematic Review and Meta-Analysis
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Jung Hyun Yoon, Fredrik Strand, Pascal A. T. Baltzer, Emily F. Conant, Fiona J. Gilbert, Constance D. Lehman, Elizabeth A. Morris, Lisa A. Mullen, Robert M. Nishikawa, Nisha Sharma, Ilse Vejborg, Linda Moy, and Ritse M. Mann
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All institutes and research themes of the Radboud University Medical Center ,Radiology, Nuclear Medicine and imaging ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] - Abstract
Item does not contain fulltext
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- 2023
21. Artificial Intelligence and Radiology Education
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Ali S. Tejani, Hesham Elhalawani, Linda Moy, Marc Kohli, and Charles E. Kahn
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Quality Education ,Good Health and Well Being ,Radiological and Ultrasound Technology ,Medical Education ,Artificial Intelligence ,Imaging Informatics ,Impact of AI on Education ,Use of AI in Education ,Biomedical Imaging ,Radiology, Nuclear Medicine and imaging ,Precision Education ,Special Report ,Natural Language Processing - Abstract
Implementation of artificial intelligence (AI) applications into clinical practice requires AI-savvy radiologists to ensure the safe, ethical, and effective use of these systems for patient care. Increasing demand for AI education reflects recognition of the translation of AI applications from research to clinical practice, with positive trainee attitudes regarding the influence of AI on radiology. However, barriers to AI education, such as limited access to resources, predispose to insufficient preparation for the effective use of AI in practice. In response, national organizations have sponsored formal and self-directed learning courses to provide introductory content on imaging informatics and AI. Foundational courses, such as the National Imaging Informatics Course - Radiology and the Radiological Society of North America Imaging AI Certificate, lay a framework for trainees to explore the creation, deployment, and critical evaluation of AI applications. This report includes additional resources for formal programming courses, video series from leading organizations, and blogs from AI and informatics communities. Furthermore, the scope of "AI and radiology education" includes AI-augmented radiology education, with emphasis on the potential for "precision education" that creates personalized experiences for trainees by accounting for varying learning styles and inconsistent, possibly deficient, clinical case volume. © RSNA, 2022 Keywords: Use of AI in Education, Impact of AI on Education, Artificial Intelligence, Medical Education, Imaging Informatics, Natural Language Processing, Precision Education.
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- 2023
22. The Economic Impact of AI on Breast Imaging
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Dana Smetherman, Lauren Golding, Linda Moy, and Eric Rubin
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
This article explores the development of computer-aided detection (CAD) and artificial or augmented intelligence (AI) for breast radiology examinations and describes the current applications of AI in breast imaging. Although radiologists in other subspecialties may be less familiar with the use of these technologies in their practices, CAD has been used in breast imaging for more than two decades, as mammography CAD programs have been commercially available in the United States since the late 1990s. Likewise, breast radiologists have seen payment for CAD in mammography and breast MRI evolve over time. With the rapid expansion of AI products in radiology in recent years, many new applications for these technologies in breast imaging have emerged. This article outlines the current state of reimbursement for breast radiology AI algorithms within the traditional fee-for-service model used by Medicare and commercial insurers as well as potential future payment pathways. In addition, the inherent challenges of employing the existing payment framework in the United States to AI programs in radiology are detailed for the reader. This article aims to give breast radiologists a better understanding of how AI will be reimbursed as they seek to further incorporate these emerging technologies into their practices to advance patient care and improve workflow efficiency.
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- 2022
23. Estimation of the capillary level input function for dynamic contrast‐enhanced MRI of the breast using a deep learning approach
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Jonghyun Bae, Zhengnan Huang, Florian Knoll, Krzysztof Geras, Terlika Pandit Sood, Li Feng, Laura Heacock, Linda Moy, and Sungheon Gene Kim
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Deep Learning ,Contrast Media ,Humans ,Reproducibility of Results ,Breast Neoplasms ,Female ,Radiology, Nuclear Medicine and imaging ,Magnetic Resonance Imaging ,Article ,Algorithms - Abstract
PURPOSE: To develop a deep learning approach to estimate the local capillary-level input function (CIF) for pharmacokinetic model analysis of dynamic contrast enhanced (DCE)-MRI. METHODS: A deep convolutional network was trained with numerically simulated data to estimate the CIF. The trained network was tested using simulated lesion data and used to estimate voxel-wise CIF for pharmacokinetic model analysis of breast DCE-MRI data using an abbreviated protocol from women with malignant (n=25) and benign (n=28) lesions. The estimated parameters were used to build a logistic regression model to detect the malignancy. RESULT: The pharmacokinetic parameters estimated using the network-predicted CIF from our breast DCE data showed significant differences between the malignant and benign groups for all parameters. Testing the diagnostic performance with the estimated parameters, the conventional approach with AIF showed an AUC between 0.76 and 0.87, and the proposed approach with CIF demonstrated similar performance with an AUC between 0.79 and 0.81. CONCLUSION: This study shows the feasibility of estimating voxel-wise CIF using a deep neural network. The proposed approach could eliminate the need to measure AIF manually without compromising the diagnostic performance to detect the malignancy in the clinical setting.
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- 2022
24. Diffusion weighted imaging for evaluation of breast lesions: Comparison between high b-value single-shot and routine readout-segmented sequences at 3 T
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Jonas Teuwen, Ritse M. Mann, Linda Moy, Wendelien B.G. Sanderink, Elisabeth Weiland, Linda Appelman, Ioannis Sechopoulos, and Laura Heacock
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Image quality ,Biomedical Engineering ,Biophysics ,Breast Neoplasms ,Malignancy ,Lesion ,All institutes and research themes of the Radboud University Medical Center ,Breast cancer ,McNemar's test ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Breast ,Echo-Planar Imaging ,business.industry ,Area under the curve ,High B-Value ,medicine.disease ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Diffusion Magnetic Resonance Imaging ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Female ,medicine.symptom ,business ,Nuclear medicine ,Diffusion MRI - Abstract
Purpose In this study, we compare readout-segmented echo-planar imaging (rs-EPI) Diffusion Weighted Imaging (DWI) to a work-in-progress single-shot EPI with modified Inversion Recovery Background Suppression (ss-EPI-mIRBS) sequence at 3 T using a b-value of 2000 s/mm2 on image quality, lesion visibility and evaluation time. Method From September 2017 to December 2018, 23 women (one case used for training) with known breast cancer were included in this study, after providing signed informed consent. Women were scanned with the conventional rs-EPI sequence and the work-in-progress ss-EPI-mIRBS during the same examination. Four breast radiologists (4–13 years of experience) independently scored both series for overall image quality (1: extremely poor to 9: excellent). All lesions (47 in total, 36 malignant, and 11 benign and high-risk) were evaluated for visibility (1: not visible, 2: visible if location is given, 3: visible) and probability of malignancy (BI-RADS 1 to 5). ADC values were determined by measuring signal intensity in the lesions using dynamic contrast-enhanced (DCE) images for reference. Evaluation times for all assessments were automatically recorded. Results were analyzed using the visual grading characteristics (VGC) and the resulting area under the curve (AUCVGC) method. Statistical analysis was performed in SPSS, with McNemar tests, and paired t-tests used for comparison. Results No significant differences were detected between the two sequences in image quality (AUCVGC: 0.398, p = 0.087) and lesion visibility (AUCVGC: 0.534, p = 0.336) scores. Lesion characteristics (e.g benign and high-risk, versus malignant; small (≤10 mm) vs. larger (>10 mm)) did not result in different image quality or lesion visibility between sequences. Sensitivity (rs-EPI: 72.2% vs. ss-EPImIRBS: 78.5%, p = 0.108) and specificity (70.5% vs. 56.8%, p = 0.210, respectively) were comparable. In both sequences the mean ADC value was higher for benign and high-risk lesions than for malignant lesions (ss-EPI-mIRBS: p = 0.022 and rs-EPI: p = 0.055). On average, ss-EPI-mIRBS resulted in decreased overall reading time by 7.7 s/case (p = 0.067); a reduction of 17%. For malignant lesions, average reading time was significantly shorter using ss-EPI-mIRBS compared to rs-EPI (64.0 s/lesion vs. 75.9 s/lesion, respectively, p = 0.039). Conclusion Based on this study, the ss-EPI sequence using a b-value of 2000 s/mm2 enables for a mIRBS acquisition with quality and lesion conspicuity that is comparable to conventional rs-EPI, but with a decreased reading time.
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- 2021
25. ACR Appropriateness Criteria® Transgender Breast Cancer Screening
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Ana Lourenço, Samantha L. Heller, Maxine S. Jochelson, Daymen S Tuscano, Jennifer F. Tseng, Tejas S. Mehta, Ashley R Stuckey, Juliana E. Hansen, Katherine A. Klein, Baer Karrington, Bethany L. Niell, Mary S. Newell, Maggie L DiNome, Linda Moy, Mary E Swain, Mita Sanghavi Goel, Beth Cronin, Elizabeth H. Dibble, Ann L. Brown, and Loren S. Schechter
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education.field_of_study ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Population ,medicine.disease ,Appropriate Use Criteria ,Breast cancer screening ,Breast cancer ,Family medicine ,Transgender ,Medicine ,Radiology, Nuclear Medicine and imaging ,Hormone therapy ,business ,education ,Medical literature ,Cohort study - Abstract
Breast cancer screening recommendations for transgender and gender nonconforming individuals are based on the sex assigned at birth, risk factors, and use of exogenous hormones. Insufficient evidence exists to determine whether transgender people undergoing hormone therapy have an overall lower, average, or higher risk of developing breast cancer compared to birth-sex controls. Furthermore, there are no longitudinal studies evaluating the efficacy of breast cancer screening in the transgender population. In the absence of definitive data, current evidence is based on data extrapolated from cisgender studies and a limited number of cohort studies and case reports published on the transgender community. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
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- 2021
26. ACR Appropriateness Criteria® Supplemental Breast Cancer Screening Based on Breast Density
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Priscilla J. Slanetz, Susan P. Weinstein, Jessica H. Hayward, Elizabeth H. Dibble, Alana A. Lewin, Charlotte Dai Kubicky, Mary S. Newell, Nina S. Vincoff, Mita Sanghavi Goel, Tracy A. Battaglia, John R. Scheel, Linda Moy, Katherine Yao, Anees B. Chagpar, Huong T. Le-Petross, Sandra Dayaratna, and Matthew F. Sanford
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education.field_of_study ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Population ,medicine.disease ,Appropriate Use Criteria ,Breast cancer screening ,Breast cancer ,medicine ,Breast MRI ,Mammography ,Radiology, Nuclear Medicine and imaging ,Medical physics ,skin and connective tissue diseases ,business ,education ,Grading (tumors) ,Breast ultrasound - Abstract
Mammography remains the only validated screening tool for breast cancer, however, there are limitations to mammography. One of the limitations of mammography is the variable sensitivity based on breast density. Supplemental screening may be considered based on the patient’s risk level and breast density. For average-risk women with nondense breasts, the sensitivity of digital breast tomosynthesis (DBT) screening is high; additional supplemental screening is not warranted in this population. For average-risk women with dense breasts, given the decreased sensitivity of mammography/DBT, this population may benefit from additional supplemental screening with contrast-enhanced mammography, screening ultrasound (US), breast MRI, or abbreviated breast MRI. In intermediate-risk women, there is emerging evidence suggesting that women in this population may benefit from breast MRI or abbreviated breast MRI. In intermediate-risk women with dense breasts, given the decreased sensitivity of mammography/DBT, this population may benefit from additional supplemental screening with contrast-enhancedmammography or screening US. There is strong evidence supporting screening high-risk women with breast MRI regardless of breast density. Contrast-enhanced mammography, whole breast screening US, or abbreviated breast MRI may be also considered. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
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- 2021
27. Lessons Learned from the Randomized Controlled TOmosynthesis plus SYnthesized MAmmography (TOSYMA) Trial
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Cindy Lee and Linda Moy
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Radiology, Nuclear Medicine and imaging - Published
- 2022
28. Point-of-Care Low-Field-Strength MRI Is Moving Beyond the Hype
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Yoshimi Anzai and Linda Moy
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Point-of-Care Systems ,Humans ,Brain ,Radiology, Nuclear Medicine and imaging ,Neuroimaging ,Magnetic Resonance Imaging ,Retrospective Studies - Published
- 2022
29. Breast MRI for Evaluation of Response to Neoadjuvant Therapy
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Laura Heacock, Samantha L. Heller, Linda Du, Linda Moy, Alana A Lewin, Yiming Gao, Beatriu Reig, and Hildegard K. Toth
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medicine.medical_specialty ,medicine.medical_treatment ,Breast Neoplasms ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Fibrosis ,medicine ,Humans ,Breast MRI ,Radiology, Nuclear Medicine and imaging ,Breast ,Neoadjuvant therapy ,medicine.diagnostic_test ,business.industry ,Axillary Lymph Node Dissection ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Neoadjuvant Therapy ,Axilla ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Invasive lobular carcinoma ,Female ,Radiology ,medicine.symptom ,business - Abstract
Neoadjuvant therapy is increasingly being used to treat early-stage triple-negative and human epidermal growth factor 2-overexpressing breast cancers, as well as locally advanced and inflammatory breast cancers. The rationales for neoadjuvant therapy are to shrink tumor size and potentially decrease the extent of surgery, to serve as an in vivo test of response to therapy, and to reveal prognostic information for the patient. MRI is the most accurate modality to demonstrate response to therapy and to help ensure accurate presurgical planning. Changes in lesion diameter, volume, and enhancement are used to predict complete response, partial response, or nonresponse to therapy. However, residual disease may be overestimated or underestimated at MRI. Fibrosis, necrotic tumors, and residual benign masses may be causes of overestimation of residual disease. Nonmass lesions, invasive lobular carcinoma, hormone receptor-positive tumors, nonconcentric shrinkage patterns, the use of antiangiogenic therapy, and late-enhancing foci may be causes of underestimation of residual disease. In patients with known axillary lymph node metastasis, neoadjuvant therapy may be followed by targeted axillary dissection to avoid the potential morbidity associated with an axillary lymph node dissection. Diffusion-weighted imaging, radiomics, machine learning, and deep learning methods are under investigation to improve MRI accuracy in predicting treatment response.©RSNA, 2021.
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- 2021
30. Follow-up of COVID-19 Vaccine–related Axillary Lymphadenopathy before 12 Weeks Is Unnecessary
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Eric Kim and Linda Moy
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COVID-19 Vaccines ,Vaccination ,COVID-19 ,Humans ,Lymphadenopathy ,Radiology, Nuclear Medicine and imaging ,Longitudinal Studies ,Prospective Studies ,Follow-Up Studies - Published
- 2022
31. Magnetic Resonance Imaging in Screening of Breast Cancer
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Samantha L. Heller, Beatriu Reig, Yiming Gao, Laura Heacock, Debbie L Bennett, and Linda Moy
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Breast Neoplasms ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Mr imaging ,Article ,Functional imaging ,Breast cancer screening ,Survival benefit ,Breast cancer ,medicine ,Humans ,Female ,Radiology, Nuclear Medicine and imaging ,Breast ,Radiology ,business ,Early Detection of Cancer ,Primary screening - Abstract
Magnetic Resonance (MR) imaging is the most sensitive modality for breast cancer detection but is currently limited to screening women at high risk due to limited specificity and test accessibility. However, specificity of MR imaging improves with successive rounds of screening, and abbreviated approaches have the potential to increase access and decrease cost. There is growing evidence to support supplemental MR imaging in moderate-risk women, and current guidelines continue to evolve. Functional imaging has the potential to maximize survival benefit of screening. Leveraging MR imaging as a possible primary screening tool is therefore also being investigated in average-risk women.
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- 2021
32. Abbreviated MR Imaging for Breast Cancer
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Linda Moy, Alana A. Lewin, Hildegard K. Toth, Laura Heacock, and Beatriu Reig
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medicine.medical_specialty ,Breast imaging ,Breast Neoplasms ,Cancer detection ,Sensitivity and Specificity ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Breast cancer screening ,0302 clinical medicine ,Breast cancer ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Mammography ,Radiology, Nuclear Medicine and imaging ,Breast ,skin and connective tissue diseases ,Early Detection of Cancer ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Reproducibility of Results ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Mr imaging ,Clinical trial ,030220 oncology & carcinogenesis ,Female ,Radiology ,business - Abstract
Breast MR imaging is the most sensitive imaging method for the detection of breast cancer and detects more aggressive malignancies than mammography and ultrasound examination. Despite these advantages, breast MR imaging has low use rates for breast cancer screening. Abbreviated breast MR imaging, in which a limited number of breast imaging sequences are obtained, has been proposed as a way to solve cost and patient tolerance issues while preserving the high cancer detection rate of breast MR imaging. This review discusses abbreviated breast MR imaging, including protocols, multicenter clinical trial results, clinical workflow implementation challenges, and future directions.
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- 2021
33. Factors Affecting Image Quality and Lesion Evaluability in Breast Diffusion-weighted MRI: Observations from the ECOG-ACRIN Cancer Research Group Multisite Trial (A6702)
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Basak E. Dogan, Linda Moy, Thomas L. Chenevert, Bonnie N. Joe, Wei T. Yang, Habib Rahbar, Nola M. Hylton, Christopher Comstock, Karen Y. Oh, Jennifer G. Whisenant, Lilian C. Wang, Sara M. Harvey, Luminita A. Tudorica, Savannah C. Partridge, Elizabeth S. McDonald, Dariya I. Malyarenko, Justin Romanoff, Thomas E. Yankeelov, Wendy B. DeMartini, Lisa J. Wilmes, Colleen H. Neal, and Averi E. Kitsch
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medicine.medical_specialty ,Image quality ,Low Confidence ,Clinical Trials and Supportive Activities ,artifacts ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,multicenter trial ,0302 clinical medicine ,diagnostic performance ,Clinical Research ,Multicenter trial ,Breast Cancer ,medicine ,Effective diffusion coefficient ,Breast MRI ,Radiology, Nuclear Medicine and imaging ,breast magnetic resonance imaging ,Cancer ,Original Research ,screening and diagnosis ,Radiological and Ultrasound Technology ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,Detection ,030220 oncology & carcinogenesis ,apparent diffusion coefficient ,Biomedical Imaging ,Radiology ,medicine.symptom ,business ,4.2 Evaluation of markers and technologies ,Diffusion MRI - Abstract
Objective The A6702 multisite trial confirmed that apparent diffusion coefficient (ADC) measures can improve breast MRI accuracy and reduce unnecessary biopsies, but also found that technical issues rendered many lesions non-evaluable on diffusion-weighted imaging (DWI). This secondary analysis investigated factors affecting lesion evaluability and impact on diagnostic performance. Methods The A6702 protocol was IRB-approved at 10 institutions; participants provided informed consent. In total, 103 women with 142 MRI-detected breast lesions (BI-RADS assessment category 3, 4, or 5) completed the study. DWI was acquired at 1.5T and 3T using a four b-value, echo-planar imaging sequence. Scans were reviewed for multiple quality factors (artifacts, signal-to-noise, misregistration, and fat suppression); lesions were considered non-evaluable if there was low confidence in ADC measurement. Associations of lesion evaluability with imaging and lesion characteristics were determined. Areas under the receiver operating characteristic curves (AUCs) were compared using bootstrapping. Results Thirty percent (42/142) of lesions were non-evaluable on DWI; 23% (32/142) with image quality issues, 7% (10/142) with conspicuity and/or localization issues. Misregistration was the only factor associated with non-evaluability (P = 0.001). Smaller (≤10 mm) lesions were more commonly non-evaluable than larger lesions (p Conclusion Image quality remains a technical challenge in breast DWI, particularly for smaller lesions. Protocol optimization and advanced acquisition and post-processing techniques would help to improve clinical utility.
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- 2020
34. Impact of the COVID-19 Pandemic on Breast Imaging: An Analysis of the National Mammography Database
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Lars J. Grimm, Cindy Lee, Robert D. Rosenberg, Judy Burleson, Michael Simanowith, Tom Fruscello, Casey E. Pelzl, Sarah M. Friedewald, Linda Moy, and Margarita L. Zuley
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COVID-19 ,Humans ,Mass Screening ,Radiology, Nuclear Medicine and imaging ,Breast Neoplasms ,Female ,Pandemics ,Early Detection of Cancer ,Aged ,Mammography - Abstract
The aim of this study was to quantify the initial decline and subsequent rebound in breast cancer screening metrics throughout the coronavirus disease 2019 (COVID-19) pandemic.Screening and diagnostic mammographic examinations, biopsies performed, and cancer diagnoses were extracted from the ACR National Mammography Database from March 1, 2019, through May 31, 2021. Patient (race and age) and facility (regional location, community type, and facility type) demographics were collected. Three time periods were used for analysis: pre-COVID-19 (March 1, 2019, to May 31, 2019), peak COVID-19 (March 1, 2020, to May 31, 2020), and COVID-19 recovery (March 1, 2021, to May 31, 2021). Analysis was performed at the facility level and overall between time periods.In total, 5,633,783 screening mammographic studies, 1,282,374 diagnostic mammographic studies, 231,390 biopsies, and 69,657 cancer diagnoses were analyzed. All peak COVID-19 metrics were less than pre-COVID-19 volumes: 36.3% of pre-COVID-19 for screening mammography, 57.9% for diagnostic mammography, 47.3% for biopsies, and 48.7% for cancer diagnoses. There was some rebound during COVID-19 recovery as a percentage of pre-COVID-19 volumes: 85.3% of pre-COVID-19 for screening mammography, 97.8% for diagnostic mammography, 91.5% for biopsies, and 92.0% for cancer diagnoses. Across various metrics, there was a disproportionate negative impact on older women, Asian women, facilities in the Northeast, and facilities affiliated with academic medical centers.COVID-19 had the greatest impact on screening mammography volumes, which have not returned to pre-COVID-19 levels. Cancer diagnoses declined significantly in the acute phase and have not fully rebounded, emphasizing the need to increase outreach efforts directed at specific patient population and facility types.
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- 2022
35. Axillary Adenopathy after COVID-19 Vaccine: No Reason to Delay Screening Mammogram
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Stacey Wolfson, Eric Kim, Anastasia Plaunova, Rita Bukhman, Ruth D. Sarmiento, Naziya Samreen, Divya Awal, Monica M. Sheth, Hildegard B. Toth, Linda Moy, and Beatriu Reig
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COVID-19 Vaccines ,COVID-19 ,Humans ,Lymphadenopathy ,Radiology, Nuclear Medicine and imaging ,Early Detection of Cancer ,Mammography - Published
- 2022
36. Supplemental MRI in Extremely Dense Breasts: Sharp Reduction in False-Positive Rate in the Second Screening Round of the DENSE Trial
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Linda Moy and Yiming Gao
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medicine.medical_specialty ,business.industry ,Breast Neoplasms ,Magnetic Resonance Imaging ,Reduction (complexity) ,Humans ,Mass Screening ,Medicine ,Female ,Radiology, Nuclear Medicine and imaging ,Radiology ,False positive rate ,business ,Breast Density ,Mammography - Published
- 2021
37. Architectural Distortion on Digital Breast Tomosynthesis: Management Algorithm and Pathological Outcome
- Author
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Naziya Samreen, Cindy Lee, and Linda Moy
- Subjects
medicine.medical_specialty ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Digital Breast Tomosynthesis ,Outcome (game theory) ,030218 nuclear medicine & medical imaging ,Management algorithm ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Architectural Distortion ,Medical imaging ,medicine ,Mammography ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Pathological - Abstract
Architectural distortion on digital breast tomosynthesis (DBT) can occur due to benign and malignant causes. With DBT, there is an increase in the detection of architectural distortion compared with 2D digital mammography, and the positive predictive value is high enough to justify tissue sampling when imaging findings are confirmed. Workup involves supplemental DBT views and ultrasound, with subsequent image-guided percutaneous biopsy using the modality on which it is best visualized. If architectural distortion is subtle and/or questionable on diagnostic imaging, MRI may be performed for problem solving, with subsequent biopsy of suspicious findings using MRI or DBT guidance, respectively. If no suspicious findings are noted on MRI, a six-month follow-up DBT may be performed. On pathology, malignant cases are noted in 6.8%–50.7% of the cases, most commonly due to invasive ductal carcinoma, followed by invasive lobular carcinoma. Radial scars are the most common benign cause, with stromal fibrosis and sclerosing adenosis being much less common. As there is an increase in the number of benign pathological outcomes for architectural distortion on DBT compared with 2D digital mammography, concordance should be based on the level of suspicion of imaging findings. As discordant cases have upgrade rates of up to 25%, surgical consultation is recommended for discordant radiologic-pathologic findings.
- Published
- 2020
38. Axillary Nodal Evaluation in Breast Cancer: State of the Art
- Author
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Woo Kyung Moon, Linda Moy, Jessica W.T. Leung, Jung Min Chang, and Su Min Ha
- Subjects
Image-Guided Biopsy ,medicine.medical_specialty ,Sentinel lymph node ,Breast Neoplasms ,030218 nuclear medicine & medical imaging ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Intersectoral Collaboration ,Lymph node ,business.industry ,Cancer ,Prognosis ,medicine.disease ,Axilla ,Dissection ,medicine.anatomical_structure ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Female ,Interdisciplinary Communication ,Lymph Nodes ,Radiology ,Neoplasm Recurrence, Local ,Sentinel Lymph Node ,business - Abstract
Axillary lymph node (LN) metastasis is the most important predictor of overall recurrence and survival in patients with breast cancer, and accurate assessment of axillary LN involvement is an essential component in staging breast cancer. Axillary management in patients with breast cancer has become much less invasive and individualized with the introduction of sentinel LN biopsy (SLNB). Emerging evidence indicates that axillary LN dissection may be avoided in selected patients with node-positive as well as node-negative cancer. Thus, assessment of nodal disease burden to guide multidisciplinary treatment decision making is now considered to be a critical role of axillary imaging and can be achieved with axillary US, MRI, and US-guided biopsy. For the node-positive patients treated with neoadjuvant chemotherapy, restaging of the axilla with US and MRI and targeted axillary dissection in addition to SLNB is highly recommended to minimize the false-negative rate of SLNB. Efforts continue to develop prediction models that incorporate imaging features to predict nodal disease burden and to select proper candidates for SLNB. As methods of axillary nodal evaluation evolve, breast radiologists and surgeons must work closely to maximize the potential role of imaging and to provide the most optimized treatment for patients.
- Published
- 2020
39. Dynamic Contrast-Enhanced MRI Evaluation of Pathologic Complete Response in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer After HER2-Targeted Therapy
- Author
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Laura Heacock, James S. Babb, Linda Moy, Alana A. Lewin, Sungheon Kim, Abimbola Ayoola, and Melanie Moccaldi
- Subjects
Oncology ,medicine.medical_specialty ,Receptor, ErbB-2 ,Intraclass correlation ,medicine.medical_treatment ,Breast Neoplasms ,Article ,030218 nuclear medicine & medical imaging ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Breast MRI ,Radiology, Nuclear Medicine and imaging ,Mastectomy ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Area under the curve ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Neoadjuvant Therapy ,Treatment Outcome ,030220 oncology & carcinogenesis ,Dynamic contrast-enhanced MRI ,business - Abstract
Rationale and Objectives Pathologic complete response (pCR) in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer after HER2-targeted therapy correlates increased disease-free survival and decreased mastectomy rates. The aim of this study was to explore tumor shrinkage patterns and initial tumor enhancement with pCR in HER2-positive breast cancer. Materials and Methods This was an institutional review board-approved retrospective analysis of 51 HER2 positive breast cancer patients with breast MRI both pre- and post-HER2-targeted therapy. Initial enhancement ratio (IER, initial enhancement percentage over baseline at first postcontrast imaging), pattern of tumor shrinkage, and Dynamic contrast enhanced (DCE)-MRI imaging features were assessed. Wilcoxon rank, Spearman correlation, Fisher's exact, and Mann-Whitney tests were used to correlate MRI imaging features with pCR. IER reader agreement was evaluated by intraclass correlation. Binary logistic regression was used to evaluate multivariate associations with pCR. Results 56.9% (29/51) of patients had pCR at surgery. Concentric tumor shrinkage pattern was associated with pCR (p = 0.001, Area under the curve (AUC) 0.778): accuracy 80.4%, specificity 96.6%, and sensitivity of 59.1%. There was no association with pCR and imaging response as defined by RECIST criteria (p = 0.169), pretreatment IER (Reader 1 (R1) p = 0.665, Reader 2 (R2) p = 0.766), or lesion size (p = 0.69). IER was associated with axillary metastases (R1 p = 0.016, R2 Conclusion The shrinkage pattern of HER2-positive tumors after targeted therapy may be associated with pCR. There was no association between IER and pCR. Future studies evaluating the correlation of shrinkage patterns to texture radiomics are of interest.
- Published
- 2020
40. Abbreviated Breast MRI: Road to Clinical Implementation
- Author
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Linda Moy, Laura Heacock, Beatriu Reig, Alana A. Lewin, Cindy Lee, and Hildegard K. Toth
- Subjects
medicine.medical_specialty ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,030220 oncology & carcinogenesis ,Medical imaging ,medicine ,Breast MRI ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Abstract
Breast MRI offers high sensitivity for breast cancer detection, with preferential detection of high-grade invasive cancers when compared to mammography and ultrasound. Despite the clear benefits of breast MRI in cancer screening, its cost, patient tolerance, and low utilization remain key issues. Abbreviated breast MRI, in which only a select number of sequences and postcontrast imaging are acquired, exploits the high sensitivity of breast MRI while reducing table time and reading time to maximize availability, patient tolerance, and accessibility. Worldwide studies of varying patient populations have demonstrated that the comparable diagnostic accuracy of abbreviated breast MRI is comparable to a full diagnostic protocol, highlighting the emerging role of abbreviated MRI screening in patients with an intermediate and high lifetime risk of breast cancer. The purpose of this review is to summarize the background and current literature relating to abbreviated MRI, highlight various protocols utilized in current multicenter clinical trials, describe workflow and clinical implementation issues, and discuss the future of abbreviated protocols, including advanced MRI techniques.
- Published
- 2020
41. Response to COVID-19 in Breast Imaging
- Author
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Linda Moy, Jennifer A Harvey, Jessica W.T. Leung, Hildegard K. Toth, Mary S. Newell, and Donna Plecha
- Subjects
2019-20 coronavirus outbreak ,Radiological and Ultrasound Technology ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Breast imaging ,breast imaging ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,COVID-19 ,infection prevention ,Virology ,Editorial Commentary ,coronavirus disease 2019 ,Radiology Nuclear Medicine and imaging ,Medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2020
42. ACR Appropriateness Criteria® Stage I Breast Cancer: Initial Workup and Surveillance for Local Recurrence and Distant Metastases in Asymptomatic Women
- Author
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Alana A. Lewin, Linda Moy, Paul Baron, Aarati D. Didwania, Roberta M. diFlorio-Alexander, Jessica H. Hayward, Huong T. Le-Petross, Mary S. Newell, Amar Rewari, John R. Scheel, Ashley R. Stuckey, W. Warren Suh, Gary A. Ulaner, Nina S. Vincoff, Susan P. Weinstein, and Priscilla J. Slanetz
- Subjects
Quality Control ,Evidence-Based Medicine ,Breast Neoplasms ,Prognosis ,Asymptomatic Diseases ,Practice Guidelines as Topic ,Humans ,Female ,Neoplasm Invasiveness ,Radiology, Nuclear Medicine and imaging ,Neoplasm Recurrence, Local ,Radiology ,Early Detection of Cancer ,Mastectomy ,Societies, Medical ,Mammography ,Monitoring, Physiologic ,Neoplasm Staging - Abstract
As the proportion of women diagnosed with early stage breast cancer increases, the role of imaging for staging and surveillance purposes is considered. National and international guidelines discourage the use of staging imaging for asymptomatic patients newly diagnosed with stage 0 to II breast cancer, even if there is nodal involvement, as unnecessary imaging can delay care and affect outcomes. In asymptomatic patients with a history of stage I breast cancer that received treatment for curative intent, there is no role for imaging to screen for distant recurrences. However, routine surveillance with an annual mammogram is the only imaging test that should be performed to detect an in-breast recurrence or a new primary breast cancer in women with a history of stage I breast cancer. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
- Published
- 2019
43. Advances in Abbreviated Breast MRI and Ultrafast Imaging
- Author
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Shalin Patel, Laura Heacock, Yiming Gao, Kristin Elias, Linda Moy, and Samantha Heller
- Subjects
Contrast Media ,Humans ,Mass Screening ,Radiology, Nuclear Medicine and imaging ,Breast Neoplasms ,Female ,Breast ,Magnetic Resonance Imaging ,Sensitivity and Specificity - Abstract
Abbreviated breast MRI is an emerging technique that is being incorporated into clinical practice for breast cancer imaging and screening. Conventional breast MRI includes barriers such as high examination cost and lengthy examination times which make its use in the screening setting challenging. Abbreviated MRI aims to address these pitfalls by reducing overall examination time and increasing accessibility to MRI while preserving diagnostic accuracy. Sequences selected for abbreviated MRI protocols allow for preserved accuracy in breast cancer detection and characterization. Novel techniques such as ultrafast imaging are being used to provide kinetic information from early post-contrast imaging.
- Published
- 2021
44. Reducing False-Positive Biopsies using Deep Neural Networks that Utilize both Local and Global Image Context of Screening Mammograms
- Author
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Linda Moy, Taro Makino, Kyunghyun Cho, Yiqiu Shen, Laura Heacock, Zhe Huang, Nan Wu, Jason Phang, Jungkyu Park, S. Gene Kim, and Krzysztof J. Geras
- Subjects
Computer science ,Biopsy ,Context (language use) ,Breast Neoplasms ,Machine learning ,computer.software_genre ,Article ,Image (mathematics) ,Breast cancer ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Early Detection of Cancer ,Radiological and Ultrasound Technology ,Screening mammography ,business.industry ,Cancer ,medicine.disease ,Computer Science Applications ,Test set ,Deep neural networks ,Female ,Artificial intelligence ,Neural Networks, Computer ,business ,computer ,Mammography - Abstract
Breast cancer is the most common cancer in women, and hundreds of thousands of unnecessary biopsies are done around the world at a tremendous cost. It is crucial to reduce the rate of biopsies that turn out to be benign tissue. In this study, we build deep neural networks (DNNs) to classify biopsied lesions as being either malignant or benign, with the goal of using these networks as second readers serving radiologists to further reduce the number of false-positive findings. We enhance the performance of DNNs that are trained to learn from small image patches by integrating global context provided in the form of saliency maps learned from the entire image into their reasoning, similar to how radiologists consider global context when evaluating areas of interest. Our experiments are conducted on a dataset of 229,426 screening mammography examinations from 141,473 patients. We achieve an AUC of 0.8 on a test set consisting of 464 benign and 136 malignant lesions.
- Published
- 2021
45. Radiologist Characteristics Associated with Interpretive Performance of Screening Mammography: A National Mammography Database (NMD) Study
- Author
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Jennifer Hemingway, Linda Moy, Mythreyi Bhargavan-Chatfield, Dan Golden, Danny R. Hughes, Cindy Lee, Richard Duszak, Agnieszka Geras, and Andrew B. Rosenkrantz
- Subjects
Percentile ,medicine.medical_specialty ,Databases, Factual ,Breast imaging ,MEDLINE ,Breast Neoplasms ,computer.software_genre ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,Radiologists ,medicine ,Mammography ,Humans ,Mass Screening ,Radiology, Nuclear Medicine and imaging ,Early Detection of Cancer ,Database ,medicine.diagnostic_test ,business.industry ,Professional Practice Location ,Retrospective cohort study ,Odds ratio ,Stepwise regression ,United States ,030220 oncology & carcinogenesis ,Female ,Radiology ,Clinical Competence ,business ,Diagnostic Mammography ,computer ,Specialization - Abstract
Background Factors affecting radiologists' performance in screening mammography interpretation remain poorly understood. Purpose To identify radiologists characteristics that affect screening mammography interpretation performance. Materials and Methods This retrospective study included 1223 radiologists in the National Mammography Database (NMD) from 2008 to 2019 who could be linked to Centers for Medicare & Medicaid Services (CMS) datasets. NMD screening performance metrics were extracted. Acceptable ranges were defined as follows: recall rate (RR) between 5% and 12%; cancer detection rate (CDR) of at least 2.5 per 1000 screening examinations; positive predictive value of recall (PPV1) between 3% and 8%; positive predictive value of biopsies recommended (PPV2) between 20% and 40%; positive predictive value of biopsies performed (PPV3) between the 25th and 75th percentile of study sample; invasive CDR of at least the 25th percentile of the study sample; and percentage of ductal carcinoma in situ (DCIS) of at least the 25th percentile of the study sample. Radiologist characteristics extracted from CMS datasets included demographics, subspecialization, and clinical practice patterns. Multivariable stepwise logistic regression models were performed to identify characteristics independently associated with acceptable performance for the seven metrics. The most influential characteristics were defined as those independently associated with the majority of the metrics (at least four). Results Relative to radiologists practicing in the Northeast, those in the Midwest were more likely to achieve acceptable RR, PPV1, PPV2, and CDR (odds ratio [OR], 1.4-2.5); those practicing in the West were more likely to achieve acceptable RR, PPV2, and PPV3 (OR, 1.7-2.1) but less likely to achieve acceptable invasive CDR (OR, 0.6). Relative to general radiologists, breast imagers were more likely to achieve acceptable PPV1, invasive CDR, percentage DCIS, and CDR (OR, 1.4-4.4). Those performing diagnostic mammography were more likely to achieve acceptable PPV1, PPV2, PPV3, invasive CDR, and CDR (OR, 1.9-2.9). Those performing breast US were less likely to achieve acceptable PPV1, PPV2, percentage DCIS, and CDR (OR, 0.5-0.7). Conclusion The geographic location of the radiology practice, subspecialization in breast imaging, and performance of diagnostic mammography are associated with better screening mammography performance; performance of breast US is associated with lower performance. ©RSNA, 2021 Online supplemental material is available for this article.
- Published
- 2021
46. Digital Mammography Is Similar to Screen-Film Mammography for Women with Personal History of Breast Cancer
- Author
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Yiming Gao and Linda Moy
- Subjects
medicine.medical_specialty ,Digital mammography ,business.industry ,MEDLINE ,Breast Neoplasms ,medicine.disease ,Screen film mammography ,Radiographic Image Enhancement ,Breast cancer ,Personal history ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Female ,business ,Mammography ,Original Research - Abstract
BACKGROUND: Since 2007, digital mammography and digital breast tomosynthesis (DBT) replaced screen-film mammography. Whether these technologic advances have improved diagnostic performance has, to the knowledge of the authors, not yet been established. PURPOSE: To evaluate the performance and outcomes of surveillance mammography (digital mammography and DBT) performed from 2007 to 2016 in women with a personal history of breast cancer and compare with data from 1996 to 2007 and the performance of digital mammography screening benchmarks. MATERIALS AND METHODS: In this observational cohort study, five Breast Cancer Surveillance Consortium registries provided prospectively collected mammography data linked with tumor registry and pathologic outcomes. This study identified asymptomatic women with American Joint Committee on Cancer anatomic stages 0–III primary breast cancer who underwent surveillance mammography from 2007 to 2016. The primary outcome was a second breast cancer diagnosis within 1 year of mammography. Performance measures included the recall rate, cancer detection rate, interval cancer rate, positive predictive value of biopsy recommendation, sensitivity, and specificity. RESULTS: Among 32 331 women who underwent 117 971 surveillance mammographic examinations (112 269 digital mammographic examinations and 5702 DBT examinations), the mean age at initial diagnosis was 59 years ± 12 (standard deviation). Of 1418 second breast cancers diagnosed, 998 were surveillance-detected cancers and 420 were interval cancers. The recall rate was 8.8% (10 365 of 117 971; 95% CI: 8.6%, 9.0%), the cancer detection rate was 8.5 per 1000 examinations (998 of 117 971; 95% CI: 8.0, 9.0), the interval cancer rate was 3.6 per 1000 examinations (420 of 117 971; 95% CI: 3.2, 3.9), the positive predictive value of biopsy recommendation was 31.0% (998 of 3220; 95% CI: 29.4%, 32.7%), the sensitivity was 70.4% (998 of 1418; 95% CI: 67.9%, 72.7%), and the specificity was 98.1% (114 331 of 116 553; 95% CI: 98.0%, 98.2%). Compared with previously published studies, interval cancer rate was comparable with rates from 1996 to 2007 in women with a personal history of breast cancer and was higher than the published digital mammography screening benchmarks. CONCLUSION: In transitioning from screen-film to digital mammography and digital breast tomosynthesis, surveillance mammography performance demonstrated minimal improvement over time and remained inferior to the performance of screening mammography benchmarks. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Moy and Gao in this issue
- Published
- 2021
47. Breast Cancer Screening Recommendations Inclusive of All Women at Average Risk: Update from the ACR and Society of Breast Imaging
- Author
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Mary S. Newell, R. Edward Hendrick, Debra L. Monticciolo, Peter R. Eby, Stamatia Destounis, Sharp F. Malak, Dana Smetherman, Linda Moy, Jessica W.T. Leung, and Sarah M. Friedewald
- Subjects
Adult ,Pediatrics ,medicine.medical_specialty ,Breast imaging ,Breast Neoplasms ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Breast cancer screening ,0302 clinical medicine ,Breast cancer ,medicine ,Mammography ,Humans ,Mass Screening ,Radiology, Nuclear Medicine and imaging ,Breast ,Overdiagnosis ,Early Detection of Cancer ,Aged ,medicine.diagnostic_test ,business.industry ,Cancer ,Middle Aged ,medicine.disease ,Annual Screening ,030220 oncology & carcinogenesis ,Research Highlights ,Life expectancy ,Female ,business - Abstract
Breast cancer remains the most common nonskin cancer, the second leading cause of cancer deaths, and the leading cause of premature death in US women. Mammography screening has been proven effective in reducing breast cancer deaths in women age 40 years and older. A mortality reduction of 40% is possible with regular screening. Treatment advances cannot overcome the disadvantage of being diagnosed with an advanced-stage tumor. The ACR and Society of Breast Imaging recommend annual mammography screening beginning at age 40, which provides the greatest mortality reduction, diagnosis at earlier stage, better surgical options, and more effective chemotherapy. Annual screening results in more screening-detected tumors, tumors of smaller sizes, and fewer interval cancers than longer screening intervals. Screened women in their 40s are more likely to have early-stage disease, negative lymph nodes, and smaller tumors than unscreened women. Delaying screening until age 45 or 50 will result in an unnecessary loss of life to breast cancer and adversely affects minority women in particular. Screening should continue past age 74 years, without an upper age limit unless severe comorbidities limit life expectancy. Benefits of screening should be considered along with the possibilities of recall for additional imaging and benign biopsy and the less tangible risks of anxiety and overdiagnosis. Although recall and biopsy recommendations are higher with more frequent screening, so are life-years gained and breast cancer deaths averted. Women who wish to maximize benefit will choose annual screening starting at age 40 years and will not stop screening prematurely.
- Published
- 2021
48. Assessing Radiology Research on Artificial Intelligence: A Brief Guide for Authors, Reviewers, and Readers—From the Radiology Editorial Board
- Author
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Linda Moy, Mark L. Schiebler, Miriam A. Bredella, Elkan F. Halpern, David A. Bluemke, Birgit Ertl-Wagner, Clifford R. Weiss, Kathryn J. Fowler, Christopher P. Hess, and Vicky Goh
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Editorial board ,business - Published
- 2020
49. Unknown Case #4: Part 2
- Author
-
Stephanie H Chung, Linda Moy, and Yiming Gao
- Subjects
medicine.medical_specialty ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Augmentation Mammoplasty ,business.industry ,medicine ,Medical imaging ,Mammography ,Radiology, Nuclear Medicine and imaging ,Radiology ,Differential diagnosis ,business - Published
- 2020
50. A dual‐tuned multichannel bilateral RF coil for 1 H/ 23 Na breast MRI at 7 T
- Author
-
Guillaume Madelin, Ryan Brown, Linda Moy, and Carlotta Ianniello
- Subjects
Materials science ,medicine.diagnostic_test ,Breast imaging ,Sodium ,chemistry.chemical_element ,Solenoid ,Signal ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,chemistry ,Electromagnetic coil ,Sodium MRI ,medicine ,Breast MRI ,Radiology, Nuclear Medicine and imaging ,030217 neurology & neurosurgery ,Biomedical engineering ,Radiofrequency coil - Abstract
Purpose Sodium MRI has shown promise for monitoring neoadjuvant chemotherapy response in breast cancer. The purpose of this work was to build a dual-tuned bilateral proton/sodium breast coil for 7T MRI that provides sufficient SNR to enable sodium breast imaging in less than 10 minutes. Methods The proton/sodium coil consists of 2 shielded unilateral units: 1 for each breast. Each unit consists of 3 nested layers: (1) a 3-loop solenoid for sodium excitation, (2) a 3-loop solenoid for proton excitation and signal reception, and (3) a 4-channel receive array for sodium signal reception. Benchmark measurements were performed in phantoms with and without the sodium receive array insert. In vivo images were acquired on a healthy volunteer. Results The sodium receive array boosted 1.5 to 3 times the SNR compared with the solenoid. Proton SNR loss due to residual interaction with the sodium array was less than 10%. The coil enabled sodium imaging in vivo with 2.8-mm isotropic nominal resolution (~5-mm real resolution) in 9:36 minutes. Conclusion The coil design that we propose addresses challenges associated with sodium's low SNR from a hardware perspective and offers the opportunity to investigate noninvasively breast tumor metabolism as a function of sodium concentration in patients undergoing neoadjuvant chemotherapy.
- Published
- 2019
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