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Your search keyword '"Anne Frei"' showing total 9 results
Start Over Author "Anne Frei" Topic radiology, nuclear medicine and imaging
9 results on '"Anne Frei"'

3. Optimized cardiac functional MRI of small-animal models of cancer radiation therapy

Author

Elizabeth Gore, Carmen Bergom, Anne Frei, Rachel A. Schlaak, Jason Rubenstein, Matthew D. Budde, El-Sayed H. Ibrahim, and Dhiraj Baruah

Subjects
Cardiac function curve, Cancer radiation therapy, medicine.medical_treatment, Biomedical Engineering, Biophysics, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Ventricular hypertrophy, Neoplasms, Small animal, Animals, Medicine, Radiology, Nuclear Medicine and imaging, Adult female, business.industry, Cancer, Heart, medicine.disease, Magnetic Resonance Imaging, Rats, Functional imaging, Radiation therapy, Disease Models, Animal, Female, business, Nuclear medicine, 030217 neurology & neurosurgery, Radiotherapy, Image-Guided
Abstract

Cardiac MRI of small animal models of cancer radiation therapy (RT) is a valuable tool for studying the effect of RT on the heart. However, standard cardiac MRI exams require long scanning times, which is challenging for sick animals that may not survive extended periods of imaging under anesthesia. The purpose of this study is to develop an optimized, fast MRI exam for comprehensive cardiac functional imaging of small-animal models of cancer RT. Ten adult female rats (2 non-irradiated and 8 irradiated) were scanned using the developed exam. Optimal imaging parameters were determined, which minimized scanning time while ensuring measurement accuracy and avoiding imaging artifacts. This optimized, fast MRI exam lasted for 30 min, which was tolerated by all animals. EF was normal in all imaged rats, although it was significantly increased in the irradiated rats, which also showed ventricular hypertrophy. However, myocardial strain was significantly reduced in the irradiated rats. In conclusion, a fast MRI exam has been developed for comprehensive cardiac functional imaging of rats in 30 min, with optimized imaging parameters to ensure accurate measurements and tolerance by irradiated rats. The generated strain measurements provide an early marker of regional cardiac dysfunction before global function is affected.

Published
2020
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4. Differences in Radiation-Induced Cardiotoxicity Between Age-Matched Male and Female Rats Largely Due to Differences in Lung Doses

Author

Meetha Medhora, Leanne Harmann, Carmen Bergom, Rachel A. Schlaak, Anne Frei, A.M. Schottstaedt, T. Gasparetti, and Brian L. Fish

Subjects
Cancer Research, Cardiotoxicity, Radiation, Lung, medicine.anatomical_structure, Oncology, business.industry, Medicine, Physiology, Radiology, Nuclear Medicine and imaging, Radiation induced, business
Published
2020
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5. Assessment of Functional Enrichment of Genes Associated with Radiation Cardiosensitivity in Rat Pre-Clinical Models in Human Genome-wide Association Study (GWAS) of Heart Failure

Author

Rachel A. Schlaak, S.L. Kerns, Carmen Bergom, O. El Charif, Anne Frei, and Shirng-Wern Tsaih

Subjects
Cancer Research, Radiation, business.industry, Association (object-oriented programming), Genome-wide association study, Computational biology, medicine.disease, Oncology, Heart failure, medicine, Radiology, Nuclear Medicine and imaging, Human genome, business, Gene
Published
2020
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6. Consomic Rat Models Identify Genetic Factors that Modulate Radiation-Induced Cardiac Toxicity and Inflammation

Author

A.M. Schottstaedt, C.A. Mascari, Michael J. Flister, Meetha Medhora, Tracy Gasperetti, Carmen Bergom, Jennifer L. Strande, Rachel A. Schlaak, Anne Frei, Leanne Harmann, and Brian L. Fish

Subjects
Cancer Research, Radiation, Oncology, business.industry, Cardiac toxicity, Rat model, Medicine, Radiology, Nuclear Medicine and imaging, Inflammation, Radiation induced, medicine.symptom, Pharmacology, business
Published
2018
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7. Identification of Pathways and Genetic Variants Important for Radiation-Induced Cardiotoxicity Using Genetic Mapping

Author

Q. Liu, Leanne Harmann, Meetha Medhora, Michael J. Flister, Brian L. Fish, A.M. Schottstaedt, Rachel A. Schlaak, Yunguang Sun, Carmen Bergom, Anne Frei, Hallgeir Rui, T. Gasparetti, and Jennifer L. Strande

Subjects
Cancer Research, Cardiotoxicity, Radiation, Oncology, Gene mapping, business.industry, Genetic variants, Medicine, Radiology, Nuclear Medicine and imaging, Identification (biology), Radiation induced, Computational biology, business
Published
2019
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8. (P06) Identifying Genetic Factors Influencing Radiation-Induced Cardiac Toxicity Using Novel Genetic Rat Models

Author

Brian L. Fish, Meetha Medhora, Rachel A. Schlaak, Leanne Harmann, A.M. Schottstaedt, Carmen Bergom, Anne Frei, Michael J. Flister, Jennifer L. Strande, and Tracy Gasperetti

Subjects
Cancer Research, Radiation, Oncology, business.industry, Cardiac toxicity, Rat model, Medicine, Radiology, Nuclear Medicine and imaging, Radiation induced, Pharmacology, business
Published
2018
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9. A Novel Breast Cancer Xenograft Model Identifies Genetic Variants in the Tumor Microenvironment that Enhance Radiation Responses

Author

Michael J. Flister, Shirng-Wern Tsaih, Amy Rymaszewski, Carmen Bergom, M.W. Straza, Angela Lemke, and Anne Frei

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Tumor microenvironment, Radiation, business.industry, Genetic variants, medicine.disease, Breast cancer, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, business
Published
2016
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