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Your search keyword '"Yun Young Byon"' showing total 4 results
Start Over Author "Yun Young Byon" Topic radiation-protective agents
4 results on '"Yun Young Byon"'

1. Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells

Author

Jae Woo Park, Youngheun Jee, Yun Young Byon, Hyun Ji Kim, Hong Gu Joo, and Mi Hyoung Kim

Subjects
CD4-Positive T-Lymphocytes, Cell Survival, medicine.medical_treatment, education, ginsan, Panax, Bone Marrow Cells, Radiation-Protective Agents, Pharmacology, Biology, Nitric Oxide, Ginseng, Mice, Immune system, In vivo, Polysaccharides, medicine, Animals, Viability assay, radioprotection, Mice, Inbred BALB C, General Veterinary, digestive, oral, and skin physiology, gamma radiation, Panax ginseng, Flow Cytometry, Interleukin-12, In vitro, Mice, Inbred C57BL, stomatognathic diseases, Cytokine, medicine.anatomical_structure, Gamma Rays, Immunology, Interleukin 12, Original Article, Bone marrow
Abstract

An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the detailed mechanism was not fully elucidated. This study examined the effects of APG on bone marrow cells (BMs). The phenotypical and functional changes in APG-treated BMs after gamma radiation were studied. The benefit of APG on BMs damaged by gamma radiation was determined by measuring the cell viability. Using 2 different assays, a pretreatment with APG significantly increased the viability of BMs against gamma radiation. APG-treated BMs had a significantly higher amount of IL-12, which is a major cytokine for immune responses, compared with the medium-treated BMs. The expression of MHC class II molecules of APG-treated BMs was also increased, and APG-treated BMs showed significantly higher levels of allogeneic CD4(+) T lymphocyte proliferation. Furthermore, APG-treated mice had a larger number of BMs after gamma radiation than the control mice, and the BMs of APG-treated mice were successfully cultured into dendritic cells, which are the representative antigenpresenting cells. Overall, this study shows that APG alters the phenotype of BMs, increases the viability and alloreactivity of BMs after gamma radiation both in vitro and in vivo. Therefore, APG may be a good candidate radioprotective agent for BMs.

Published
2007

2. Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity

Author

Hong Gu Joo, Taekyun Shin, Kyu Kye Hwang, Yun Young Byon, Eun Sook Yoo, Youngheun Jee, and Mi Hyoung Kim

Subjects
Programmed cell death, Cell Survival, Bone Marrow Cells, Radiation-Protective Agents, Biology, chemistry.chemical_compound, Mice, Immune system, fucoidan, Polysaccharides, medicine, Animals, Viability assay, radioprotection, Cells, Cultured, Cell Proliferation, Mice, Inbred BALB C, General Veterinary, Cell Death, Fucoidan, Cell growth, Mice, Inbred C57BL, Haematopoiesis, medicine.anatomical_structure, chemistry, Apoptosis, Gamma Rays, Immunology, Cancer research, Female, Original Article, Bone marrow, immunoreactivity, Spleen
Abstract

Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan stimulates the antigen-presenting functions of dendritic cells. In this study, we investigated the radioprotective effects of fucoidan on bone marrow cells (BMCs), which are the main cellular reservoir for the hematopoietic and immune system. To evaluate the effects of fucoidan, we assayed cell viability and immune responses. In a viability assay, fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis, the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore, fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together, our study demonstrated that fucoidan has radioprotective effects on BMCs with respect to cell viability and immunoreactivity. These results may provide valuable information, useful in the field of radiotherapy.

Published
2008

3. Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells.

Author

Hyun-Ji Kim, Mi-Hyoung Kim, Yun-Young Byon, Jae Woo Park, Youngheun Jee, and Hong-Gu Joo

Subjects
GINSENG, BONE marrow cells, CYTOKINES, LYMPHOCYTES, GAMMA rays, RADIATION-protective agents
Abstract

An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the detailed mechanism was not fully elucidated. This study examined the effects of APG on bone marrow cells (BMs). The phenotypical and functional changes in APG-treated BMs after gamma radiation were studied. The benefit of APG on BMs damaged by gamma radiation was determined by measuring the cell viability. Using 2 different assays, a pretreatment with APG significantly increased the viability of BMs against gamma radiation. APG-treated BMs had a significantly higher amount of IL-12, which is a major cytokine for immune responses, compared with the medium-treated BMs. The expression of MHC class II molecules of APG-treated BMs was also increased, and APG-treated BMs showed significantly higher levels of allogeneic CD4+ T lymphocyte proliferation. Furthermore, APG-treated mice had a larger number of BMs after gamma radiation than the control mice, and the BMs of APG-treated mice were successfully cultured into dendritic cells, which are the representative antigenpresenting cells. Overall, this study shows that APG alters the phenotype of BMs, increases the viability and alloreactivity of BMs after gamma radiation both in vitro and in vivo. Therefore, APG may be a good candidate radioprotective agent for BMs. [ABSTRACT FROM AUTHOR]

Published
2008

4. Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells.

Author

Hyun-Ji Kim, Mi-Hyoung Kim, Yun-Young Byon, Jae Woo Park, Youngheun Jee, and Hong-Gu Joo

Subjects
GAMMA rays, RADIATION-protective agents, BONE marrow cells, IMMUNE response, CYTOKINES
Abstract

An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the detailed mechanism was not fully elucidated. This study examined the effects of APG on bone marrow cells (BMs). The phenotypical and functional changes in APG-treated BMs after gamma radiation were studied. The benefit of APG on BMs damaged by gamma radiation was determined by measuring the cell viability. Using 2 different assays, a pretreatment with APG significantly increased the viability of BMs against gamma radiation. APG-treated BMs had a significantly higher amount of IL-12, which is a major cytokine for immune responses, compared with the medium-treated BMs. The expression of MHC class II molecules of APG-treated BMs was also increased, and APG-treated BMs showed significantly higher levels of allogeneic CD4+ T lymphocyte proliferation. Furthermore, APG-treated mice had a larger number of BMs after gamma radiation than the control mice, and the BMs of APG-treated mice were successfully cultured into dendritic cells, which are the representative antigenpresenting cells. Overall, this study shows that APG alters the phenotype of BMs, increases the viability and alloreactivity of BMs after gamma radiation both in vitro and in vivo. Therefore, APG may be a good candidate radioprotective agent for BMs. [ABSTRACT FROM AUTHOR]

Published
2007
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