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Your search keyword '"Deretz-Picoulet S"' showing total 2 results
Start Over Author "Deretz-Picoulet S" Topic rabbit
2 results on '"Deretz-Picoulet S"'

1. A first-generation microsatellite-based integrated genetic and cytogenetic map for the European rabbit ( Oryctolagus cuniculus) and localization of angora and albino.

Author

Chantry-Darmon, C., Urien, C., de Rochambeau, H., Allain, D., Pena, B., Hayes, H., Grohs, C., Cribiu, E. P., Deretz-Picoulet, S., Larzul, C., Save, J. C., Neau, A., Chardon, P., and Rogel-Gaillard, C.

Subjects
RABBITS, MICROSATELLITE repeats, RABBIT breeds, GENE mapping, LINKAGE (Genetics), CHROMOSOMES
Abstract

Although the European rabbit ( Oryctolagus cuniculus) is used both in agronomics and in research, genomic resources for this species are still limited and no microsatellite-based genetic map has been reported. Our aim was to construct a rabbit genetic map with cytogenetically mapped microsatellites so as to build an integrated genetic and cytogenetic map. A reference population of 187 rabbits comprising eight three-generation families with 10–25 offspring per family was produced. One hundred and ninety-four of 305 previously identified microsatellites were included in this study. Of these, 158 were polymorphic with two to seven alleles. The map reported here comprises 111 markers, including 104 INRA microsatellites, five microsatellites from another source and two phenotypic markers ( angora and albino). Ninety markers were integrated into 20 linkage groups. The remaining 21 microsatellites mapped to separate linkage groups, 19 with a precise cytogenetic position and two with only a chromosomal assignment. The genetic map spans 2766.6 cM and covers 20 rabbit chromosomes, excluding chromosomes 20, 21 and X. The density of this map is limited, but we used it to verify the location of angora and albino on chromosomes 15q and 1q, respectively, in agreement with previously published data. This first generation genetic/cytogenetic map will help gene identification and quantitative trait loci mapping projects in rabbit. [ABSTRACT FROM AUTHOR]

Published
2006
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2. Characterization of the rabbit agouti signaling protein (ASIP) gene: Transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour

Author

Lionel Forestier, Vincenzo Russo, Ahmad Oulmouden, Séverine Deretz-Picoulet, Daniel Allain, Terence J. Robinson, Luca Fontanesi, Elena Pecchioli, Cristiano Vernesi, Francesca Beretti, Emilio Scotti, Jason L. Malaney, Sezione di Allevamenti Zootecnici, Alma Mater Studiorum University of Bologna (UNIBO), Unité de Génétique Moléculaire Animale (UGMA), Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA), Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Génétique Expérimentale en Productions Animales (GEPA), Research and Innovation Centre, Edmund Mach Foundation (FEM), Department of Botany and Zoology, Evolutionary Genomics Group, Stellenbosch University, Museum of Southwestern Biology and Department of Biology, The University of New Mexico [Albuquerque], Unité de Génétique Moléculaire Animale (UMR GMA), Institut National de la Recherche Agronomique (INRA)-Université de Limoges (UNILIM), Fontanesi L., Forestier L., Allain D., Scotti E., Beretti F., Deretz-Picoulet S., Pecchioli E., Vernesi C., Robinson T.J., Malaney J.L., Russo V., and Oulmouden A.

Subjects
Coat, GENE EXPRESSION, Genotype, [SDV]Life Sciences [q-bio], DNA Mutational Analysis, Molecular Sequence Data, rabbit, Locus (genetics), transcription analysis, Biology, oryctolagus cuniculus, 03 medical and health sciences, Exon, Signaling proteins, Genetics, Animals, Allele, lagomorpha, Gene, Alleles, Phylogeny, 030304 developmental biology, Melanins, 0303 health sciences, Phylogenetic tree, integumentary system, Pigmentation, 0402 animal and dairy science, Wild type, 04 agricultural and veterinary sciences, Sequence Analysis, DNA, 040201 dairy & animal science, Molecular biology, Mutation, agouti, Agouti Signaling Protein, Rabbits, Hair, coat colour
Abstract

The agouti locus encodes the agouti signalling protein (ASIP) which is involved in determining the switch from eumelanin to pheomelanin synthesis in melanocytes. In the domestic rabbit (Oryctolagus cuniculus) early studies indicated three alleles at this locus: A, light-bellied agouti (wild type); at, black and tan; a, black nonagouti. We characterized the rabbit ASIP gene and identified the causative mutation (an insertion in exon 2) of the black nonagouti allele whose frequency was evaluated in 31 breeds. Phylogenetic analysis of ASIP sequences from Oryctolagus and 9 other species of the family Leporidae placed Oryctolagus as sister species to Pentalagus and Bunolagus. Transcription analysis in wild type agouti rabbits revealed the presence of two major transcripts with different 5′-untranslated regions having ventral or dorsal skin specific expression. ASIP gene transcripts were also detected in all examined rabbit tissues distinguishing the rabbit expression pattern from what was observed in wild type mice.

Published
2010
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