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The most common worm infections are those caused by soil-transmitted helminths (STH) infection. Soil contamination is one of the causes of helminth transmission to humans. Poor environmental sanitation and personal hygiene facilitate the spread and transmission of STH. Jember is a district where the majority of the population lives in rural areas with poor sanitation access. This study aims to determine the correlation between soil contamination and incident of STH infection in Sukokerto Village, Sukowono District, Jember Regency. This cross-sectional analytic observational study was conducted from August 2022 to February 2023. The total of samples in this study was 44 fecal and soil around the house. The data obtained from the laboratory examination showed that the total fecal positive of STH was 11 or 25%, and soil was 13 or 29.5%. The results of the Chi-Square test analysis obtained Ï

Abstract Phacoemulsification is cataract therapy’s gold standard with lowest complication rate and best visual outcome. However, phacoemulsification is expensive and difficult to use widely. Pathogenesis of cataract related to Crystalline P23T γD protein in congenital cataracts and β-amyloid protein in senile cataract. Papain enzymes and zingibain enzymes are cataract’s alternatives therapy with proteolytic effects that potentially lyse these proteins. Proteolytic injection with 30-gauge needle results in small, safe incision. Papain enzyme from Carica Papaya plant and zingibain enzyme from Zingiber Officinale plant which grows plentifully in Indonesia that becomes cheap source of proteolytic. This study’s purpose is to compare probability of binding energy based on Binding Interaction Model (BIM) between papain and zingibain enzymes against Crystalline P23T γD protein and β-amyloid protein with molecular docking. This research uses https://cluspro.bu.edu./login.php. BIM with lowest binding energy has most stable bond. Docking results show interaction probability between papain enzyme and Crystalline P23T γD protein has lowest binding energy of -730.4 kJ/mol at BIM 1. Probability of interaction between papain enzyme and β-amyloid protein has lowest binding energy of -697.2 kJ/mol at BIM 1. Probability of interaction between the enzyme zingibain and the crystalline P23T protein γD has lowest binding energy of -890.5 kJ/mol at BIM 2. Probability of interaction between the enzyme zingibain and the β-amyloid protein has lowest binding energy of -873.5 kJ/mol at BIM 0. It was concluded that the zingibain enzyme has the most stable probability of forming a stable bond to Crystalline P23T γD protein and β-amyloid protein. Keyword:In silico, papain, zingibain, cataract

Kualitas tidur yang baik harus dicapai seseorang untuk mendapatkan manfaat dari tidur. Selama periode tidur, tubuh menyekresikan GH dalam darah. Sekresi GH mencapai puncaknya saat tidur nyenyak terutama tengah malam. Kadar GH yang disekresikan saat tidur dapat berpengaruh terhadap pertumbuhan fisik terutama tinggi badan pada masa pertumbuhan. Penelitian ini merupakan observasional analitik, menggunakan pendekatan cross sectional. Bertujuan untuk mengetahui hubungan kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Teknik pengambilan sampel menggunakan teknik proportional stratified random sampling dengan menggunakan kriteria inklusi dan eksklusi. Teknik pengambilan data dilakukan dengan cara wawancara, pemeriksaan tinggi badan berat badan. Analisis data dilakukan menggunakan uji Chi Square. Penelitian menunjukkan sampel yang mempunyai kualitas tidur baik yakni 26 sampel (86,7%), kualitas tidur buruk sebanyak 4 sampel (13,3%). Sebanyak 16 sampel (53,3%) mempunyai tinggi badan sesuai nilai normal menurut usia dalam pedoman WHO, Kemenkes RI, dan CDC pada tahun 2001, 14 sampel (46,7%) lainnya tidak sesuai pedoman tersebut. Hasil uji Chi Square menunjukkan hubungan yang signifikan antara kualitas tidur dengan tinggi badan (p=0,022). Hal ini menunjukkan bahwa terdapat hubungan antara kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Semakin baik kualitas tidur, maka tinggi badan anak akan semakin sesuai dengan nilai normal menurut usia.

Aluminum is known has neurotoxin effect that can lead to alzheimer's disease, dementia, and parkinson's. Metal ions such as aluminum can distract homeostasis and increase oxidative stress level, formation of reactive oxygen species (ROS) that can overwhelm antioxidant defenses and cause DNA damage, lipid peroxidase, leading to the destruction of testicular cells. Tamarindus indica’s seeds are one of the traditional plant and useful as antioxidants. Tamarindus indica’s seeds are able to protect testicular cells from damage caused by ROS. The purpose of this study to determine the effect of methanol extract from Tamarindus indica’s seeds to prevent aluminum chloride induced testicular damage to be measured from the histopathological features. This study is a quasi experimental design with a posttest design only with non-equivalent groups using thirty male Wistar rats divided into five groups, one control group and four treatment groups. The control group was given 1 mL of aquabides solution orally. Group P1 was given a dose of aluminum solution 300 mg/kgBW orally. Groups P2, P3, and P4 were each given an aluminum solution at dose of 300 mg/kgBW orally and an extract solution at a dose of 25, 50, 100 mg/kgBW orally for 10 weeks. The results of the observations showed that the scores varied between groups. Data analysis using Kruskal-Wallis test obtained p value = 0.006 (p