28 results on '"Spire, B"'
Search Results
2. Developing a patient-reported outcome measure for HIV care on perceived barriers to antiretroviral adherence: assessing the needs of HIV clinicians through qualitative analysis.
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Toupin I, Engler K, Lessard D, Wong L, Lènàrt A, Spire B, Raffi F, and Lebouché B
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- Cross-Sectional Studies, Female, Humans, Male, Anti-HIV Agents therapeutic use, Focus Groups standards, HIV Infections diagnosis, Medication Adherence psychology, Patient Reported Outcome Measures, Physicians standards, Quality of Life psychology
- Abstract
Purpose: To identify HIV clinicians' needs for the clinical use of a new patient-reported outcome measure (PRO) on barriers to antiretroviral therapy (ART) adherence., Methods: In 2015, five focus groups with 31 clinicians from France were transcribed, coded with Atlas.ti, and submitted to a typological analysis., Results: The analysis identified seven patient profiles, each tied to distinct barriers to adherence and to specific needs for the PRO's content, data collection and transmission. Clinicians preferred, for the patient who is: (1) 'passive,' that the PRO collect information on ART knowledge, to ensure that the prescription's instructions are being respected; (2) 'misleading,' that it be able to detect adherence to ART and socially desirable responses; (3) 'stoic,' that questions challenge the patient to recognize treatment-specific side effects; (4) 'hedonistic,' that the PRO contains content on lifestyle and risk-taking; (5) 'obsessive,' that the PRO captures quality of life and stressful life events; (6) 'overburdened,' that the PRO provides information on the person's home environment, socioeconomic status and cultural constraints. For all or most patient profiles, the clinicians wished that the PRO be completed, minimally, prior to the medical consultation and to receive alerts, under varying conditions, when problematic scores were detected. Depending on the profile, there was preference for the inclusion of open-ended questions and transmission of cross-sectional, periodic or longitudinal PRO data., Conclusion: Overall, this study's findings suggest that to support the clinical management of ART adherence, our PRO must meet the needs of a wide variety of patients and must perform multiple functions.
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- 2018
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3. Short article: Anger and quality of life in patients co-infected with HIV and hepatitis C virus: a cross-sectional study (ANRS CO13-HEPAVIH).
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Marcellin F, Protopopescu C, Esterle L, Wittkop L, Piroth L, Aumaitre H, Bouchaud O, Goujard C, Vittecoq D, Dabis F, Salmon-Ceron D, Spire B, Roux P, and Carrieri MP
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- Adult, Alcoholism epidemiology, Alcoholism psychology, Chi-Square Distribution, Cross-Sectional Studies, Female, France epidemiology, HIV Infections diagnosis, HIV Infections epidemiology, Hepatitis C diagnosis, Hepatitis C epidemiology, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Prospective Studies, Risk Factors, Substance Abuse, Intravenous epidemiology, Substance Abuse, Intravenous psychology, Surveys and Questionnaires, Anger, Coinfection, HIV Infections psychology, Hepatitis C psychology, Quality of Life
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Objective: The aim of this study is to document the relationship between anger dimensions (state, trait, expression, and control) and quality of life (QoL) in patients co-infected with HIV and hepatitis C virus (HCV)., Patients and Methods: This is a cross-sectional study nested in the ANRS CO13-HEPAVIH French national cohort. Anger and QoL were assessed using self-administered questionnaires in 536 HIV-HCV-co-infected patients. Correlations between anger scores (STAXI-2 scale) and QoL scores (WHOQOL-HIV BREF scale) were assessed using Spearman's coefficients. Multiple linear regression models were then used to test the relationship between the different dimensions of anger and QoL after adjustment for statistically significant psychosocial, sociobehavioral, and clinical characteristics., Results: Patients with excessive alcohol use or history of injecting drug use had higher levels of anger. All dimensions of anger were significantly correlated with impaired QoL for all six dimensions of the WHOQOL-HIV BREF scale. Greater internal experience of anger and impaired anger control were confirmed as independent correlates of impaired QoL related to psychological health, social relationships, and patients' beliefs after adjustment for depressive symptoms, functional impact of fatigue, socioeconomic status, and HIV-related characteristics., Conclusion: Anger issues need close monitoring in HIV-HCV-co-infected patients, especially in patients with addictive behaviors. Screening for problems in anger management and implementing individualized psychotherapeutic strategies may help improve QoL in this population.
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- 2017
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4. Quality of life improvement in HIV-1 patients treated with raltegravir in a real-life observational study: RACING.
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Spire B, Nait-Ighil L, Pugliese P, Poizot-Martin I, Jullien V, Marcelin AG, and Billaud E
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- Adolescent, Adult, Anti-HIV Agents adverse effects, Fatigue diagnosis, Female, HIV Infections transmission, Humans, Male, Middle Aged, Raltegravir Potassium adverse effects, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Time Factors, Treatment Outcome, Young Adult, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, HIV Infections epidemiology, HIV-1 genetics, Quality of Life, Raltegravir Potassium therapeutic use
- Abstract
Background: Good efficacy and safety of raltegravir in person living with HIV was demonstrated in clinical trials over five years, but real-life data, particularly about quality of life (QoL), are lacking. QoL was evaluated over time in adult patients first treated or switched to regimens containing raltegravir in an observational cohort study., Methods: Patient QoL was evaluated using the Fatigue Impact Scale (FIS) and the HIV Symptom Index (HSI). Data were collected at baseline and at 1, 3, 6, 12, 18, and 24 months. Baseline FIS and HSI subscores were compared with the scores at each visit using the paired Wilcoxon test. The impact of time, sociodemographic and medical variables upon patient-perceived fatigue and symptoms was also assessed using mixed multivariate models., Results: From baseline, all FIS and HSI subscores improved significantly after one month of treatment. In addition, psychosocial FIS subscores and both the frequency of bothersome symptoms and HSI subscores improved significantly at each visit. Physical FIS subscores also improved significantly, except at month 18, whereas both cognitive and total FIS subscores improved only after 6 months and 24 months, respectively. In multivariate analysis, employment was independently associated over time with improved improvement in both FIS and HSI subscores., Conclusion: Patient QoL improved significantly over a 24-month period of treatment with a raltegravir-containing regimen. FIS and HSI are sensitive tools to measure the impact of new antiretroviral combinations on a patient's perception of QoL.
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- 2017
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5. A reduced factor structure for the PROQOL-HIV questionnaire provided reliable indicators of health-related quality of life.
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Lalanne C, Chassany O, Carrieri P, Marcellin F, Armstrong AR, Lert F, Spire B, Dray-Spira R, and Duracinsky M
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- Adult, Age Factors, Anti-HIV Agents therapeutic use, Cross-Sectional Studies, Factor Analysis, Statistical, Female, HIV Infections drug therapy, Humans, Male, Middle Aged, Psychometrics, Reproducibility of Results, Severity of Illness Index, Sex Factors, Socioeconomic Factors, Young Adult, HIV Infections physiopathology, HIV Infections psychology, Quality of Life, Surveys and Questionnaires
- Abstract
Objectives: To identify a simplified factor structure for the PROQOL-human immunodeficiency virus (HIV) questionnaire to improve the measurement of the health-related quality of life (HRQL) of HIV-positive patients in clinical care and research settings., Study Design and Setting: HRQL data were collected using the eight-dimension PROQOL-HIV questionnaire from 2,537 patients (VESPA2 study). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) validated a simpler four-factor structure and assessed measurement invariance (MI). Multigroup analysis assessed the effect of sex, age, and antiretroviral therapy (ART) on the resulting factor scores. Correlations with symptom and Short Form (SF)-12 self-reports assessed convergent validity., Results: Item analysis, EFA, and CFAs confirmed the validity [comparative fit index (CFI), 0.948; root mean square error of approximation, 0.064] and reliability (α's ≥ 0.8) of four dimensions: physical health and symptoms, health concerns and mental distress, social and intimate relationships, and treatment-related impact. Strong MI was demonstrated across sex and age (decrease in CFI <0.01). A multiple-cause multiple-indicator model indicated that HRQL correlated as expected with sex, age, and the ART status. Correlations of HRQL, symptom reports, and SF-12 scores evidenced convergent validity criterion., Conclusion: The simplified factor structure and scoring scheme for PROQOL-HIV will allow clinicians to monitor with greater reliability the HRQL of patients in clinical care and research settings., (Copyright © 2016 Elsevier Inc. All rights reserved.)
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- 2016
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6. Spontaneous and post-treatment HCV clearance: relationships with health-related quality of life in HIV infection (ANRS-VESPA2 study).
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Marcellin F, Demoulin B, Spire B, Suzan-Monti M, Roux P, Protopopescu C, Sagaon-Teyssier L, Duracinsky M, Dray-Spira R, and Carrieri MP
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- Adult, Aged, Coinfection psychology, Cross-Sectional Studies, Female, HIV Infections drug therapy, HIV Infections psychology, Health Surveys, Hepatitis C, Chronic complications, Hepatitis C, Chronic psychology, Humans, Linear Models, Male, Middle Aged, Remission, Spontaneous, Treatment Outcome, Antiviral Agents therapeutic use, Coinfection drug therapy, HIV Infections complications, Hepatitis C, Chronic drug therapy, Quality of Life psychology
- Abstract
Background: Post-treatment clearance of HCV is associated with improved health-related quality of life (HRQL) in HIV-HCV co-infection. However, the potential differences in HRQL between post-treatment and spontaneous clearers remain poorly documented., Methods: Linear regression models were used to assess the relationships between HCV status and HRQL (PROQOL-HIV scale) in 411 co-infected adults followed-up in French hospitals in 2011 (ANRS-VESPA2 survey)., Results: After adjustment for socio-economic and clinical factors, patients previously exposed to HCV treatment showed better physical HRQL and better experience of HIV treatment than treatment-naive HCV-chronic patients. Post-treatment clearers showed better mental HRQL. Spontaneous clearers showed better experience of HIV treatment., Conclusion: Spontaneous and post-treatment HCV clearance may influence different dimensions of HRQL of HIV-HCV co-infected patients. Further studies in real-life settings are needed to document patient-reported outcomes in the era of direct-acting antiviral agents for HCV treatment.
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- 2015
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7. Benefits of task-shifting HIV care to nurses in terms of health-related quality of life in patients initiating antiretroviral therapy in rural district hospitals in Cameroon [Stratall Agence Nationale de Recherche sur le SIDA (ANRS) 12110/Ensemble pour une Solidarité Thérapeutique Hospitalière en Réseau (ESTHER) substudy].
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Suzan-Monti M, Blanche J, Boyer S, Kouanfack C, Delaporte E, Bonono RC, Carrieri PM, Protopopescu C, Laurent C, and Spire B
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- Adult, CD4 Lymphocyte Count economics, Cameroon epidemiology, Cost-Benefit Analysis, Disease Progression, Female, Follow-Up Studies, HIV Infections economics, HIV Infections epidemiology, Health Status, Hospitals, District economics, Humans, Longitudinal Studies, Male, Monitoring, Physiologic economics, Nurses, Patient Satisfaction, Physicians, Practice Guidelines as Topic, Rural Population statistics & numerical data, Viral Load, World Health Organization, Anti-HIV Agents administration & dosage, HIV Infections drug therapy, HIV Infections nursing, Hospitals, District organization & administration, Monitoring, Physiologic nursing, Quality of Life
- Abstract
Objectives: The World Health Organization (WHO) recommends task-shifting HIV care to nurses in low-resource settings with limited numbers of physicians. However, the effect of such task-shifting on the health-related quality of life (HRQL) of people living with HIV (PLHIV) has seldom been evaluated. We aimed to investigate the effect of task-shifting HIV care to nurses on HRQL outcomes in PLHIV initiating antiretroviral therapy (ART) in rural district hospitals in Cameroon., Methods: Outcomes in PLHIV were longitudinally collected in the 2006-2010 Stratall trial. PLHIV were followed up for 24 months by nurses and/or physicians. Six HRQL dimensions were assessed during face-to-face interviews using the WHO Quality of Life (WHOQOL)-HIV BREF scale: physical health; psychological health; independence level; social relationships; environment; and spirituality/religion/personal beliefs. The degree of task-shifting was estimated using a consultant ratio (i.e. the ratio of nurse-led to physician-led visits). The effect of task-shifting and other potential correlates on HRQL dimensions was explored using a Heckman two-stage approach based on linear mixed models to adjust for the potential bias caused by missing data in the outcomes., Results: Of 1424 visits in 440 PLHIV (70.5% female; median age 36 years; median CD4 count 188 cells/μL at enrolment), 423 (29.7%) were task-shifted to nurses. After multiple adjustment, task-shifting was associated with higher HRQL level for four dimensions: physical health [coefficient 0.7; 95% confidence interval (CI) 0.1-1.2; P = 0.01], psychological health (coefficient 0.5; 95% CI 0.0-1.0; P = 0.05), independence level (coefficient 0.6; 95% CI 0.1-1.1; P = 0.01) and environment (coefficient 0.6; 95% CI 0.1-1.0; P = 0.02)., Conclusions: Task-shifting HIV care to nurses benefits the HRQL of PLHIV. Together with the previously demonstrated comparable clinical effectiveness of physician-based and nurse-based models of HIV care, our results support the WHO recommendation for task-shifting., (© 2015 British HIV Association.)
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- 2015
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8. Health-related quality of life of people living with HIV followed up in hospitals in France: comparing trends and correlates between 2003 and 2011 (ANRS-VESPA and VESPA2 national surveys).
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Douab T, Marcellin F, Vilotitch A, Protopopescu C, Préau M, Suzan-Monti M, Sagaon-Teyssier L, Lert F, Carrieri MP, Dray-Spira R, and Spire B
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- Adolescent, Adult, Anti-HIV Agents therapeutic use, Antiretroviral Therapy, Highly Active, Cross-Sectional Studies, Female, Follow-Up Studies, France, HIV Infections drug therapy, Humans, Interviews as Topic, Male, Middle Aged, Surveys and Questionnaires, Young Adult, HIV Infections psychology, Health Status Indicators, Quality of Life
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In recent years, France has witnessed both structural changes in the population of people living with HIV and a relative improvement in the social representation of HIV infection. However, potential changes in people's day-to-day experience with HIV have not been documented. We used data from the national surveys ANRS-VESPA (2003) and VESPA2 (2011) to compare the levels and patterns of correlates of health-related quality of life (HRQL) in adult HIV-infected patients followed up in French hospitals over a period of eight years. Mean physical and mental SF-12 scores were compared (VESPA, n = 2072; and VESPA2, n = 2267) using analysis of variance (ANOVA) F tests. Heckman regression models were then used to identify independent correlates of physical and mental quality of life in the two surveys, while accounting for possible bias due to missing score values. A common set of potential socio-demographic, clinical, behavioral, and psychosocial correlates was tested. Individuals reported a decrease in physical quality of life in VESPA2 compared with VESPA (mean score (standard error): 47.5 (0.2) versus 49.6 (0.2), p < .0001), and better mental HRQL (44.3 (0.3) versus 42.3 (0.3), p < 0.0001). In both surveys, financial difficulties and patient-perceived experience of rejection behaviors by medical staff were independently associated with impaired physical and mental quality of life. Older age and unemployment were independently associated with impaired physical quality of life. Immigrants from Sub-Saharan Africa reported better mental quality of life. Findings show that quality of life levels in adult HIV-infected patients followed up at hospital in France has significantly, yet modestly, changed in recent years. However, the pattern of quality of life correlates has remained relatively stable. The impact of patient-provider relationships on self-reported outcomes is confirmed. Further research is needed to identify potential differences in quality of life correlates in specific subgroups of patients, such as men who have sex with men, women, immigrants, and injecting drug users.
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- 2014
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9. Performance of HIV care decentralization from the patient's perspective: health-related quality of life and perceived quality of services in Cameroon.
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Boyer S, Protopopescu C, Marcellin F, Carrieri MP, Koulla-Shiro S, Moatti JP, and Spire B
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- Adult, Cameroon, Female, Humans, Male, Middle Aged, HIV Infections drug therapy, Health Status, Patient Satisfaction, Politics, Quality of Health Care, Quality of Life
- Abstract
Objective: (i) To assess HIV care decentralization in Cameroon from the patients' point of view, in terms of health-related quality of life (HRQL) and perceived quality of services; (ii) to identify patient- and hospital-related factors undermining HRQL., Methods: Perceived quality of services was compared among 1985 HIV-infected patients treated with antiretroviral therapy (ART) for at least 6 months in 27 treatment centres at different levels of health care delivery (central, provincial and district) (EVAL-ANRS 12-116 survey, 2007) using chi-square and non-parametric tests. Correlates of the SF-12 physical (PCS) and mental (MCS) HRQL scores were identified using two-level linear models., Results: Patients followed-up at central and district levels had similar physical HRQL, while those followed-up at the more decentralized district level reported significantly better mental HRQL. Patients at district level also expressed better relationships with caregivers, easier access to consultations and more reliable drug supply. Financial barriers to access to HIV care and self-reported side-effects were independently associated with both lower PCS and lower MCS. Caregivers' heavy workload tended to impair both PCS and MCS, while availability of counselling by social workers in the hospital was independently associated with higher MCS., Conclusions: Despite limited resources, the decentralization of ART delivery can improve quality of care, providing a positive impact on HIV-infected patients' well-being. The development of psychosocial support interventions is necessary but not sufficient for improving quality of care in ART scaling-up programmes, and should be related to global strengthening of health human resources.
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- 2012
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10. Quality of life assessment in HIV clinical research in resource-limited settings: better late than never.
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Becquet R, Burgos-Soto J, Carrieri MP, and Spire B
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- Africa, Clinical Trials as Topic, HIV Infections drug therapy, Humans, Time Factors, Anti-HIV Agents therapeutic use, HIV Infections psychology, Quality of Life psychology
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Comprehensive and sustained optimal care for patients infected with HIV can now be achieved in resource-constrained settings, thanks to the sustainability of programs providing antiretroviral therapy (ART). But the primary goals of HIV virological suppression and improved survival need to be accompanied by a substantial improvement in patient's experience with HIV care and treatment. An assessment of both patients' quality of life and perceived toxicity and symptoms should now be systematically integrated into HIV clinical research in resource-constrained countries. This will allow treatment strategies aimed at optimizing the durability of response to ART in these settings to be properly evaluated and compared., (© 2010 Blackwell Publishing Ltd.)
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- 2010
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11. Higher risk of unsafe sex and impaired quality of life among patients not receiving antiretroviral therapy in Cameroon: results from the EVAL survey (ANRS 12-116).
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Marcellin F, Bonono CR, Blanche J, Carrieri MP, Spire B, and Koulla-Shiro S
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- Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Cameroon epidemiology, Cross-Sectional Studies, Depressive Disorder epidemiology, Female, HIV Infections epidemiology, HIV Infections immunology, Humans, Male, Politics, Practice Guidelines as Topic, Risk Factors, Unsafe Sex statistics & numerical data, Anti-HIV Agents administration & dosage, Depressive Disorder psychology, HIV Infections psychology, Quality of Life psychology, Unsafe Sex psychology
- Abstract
Objective: Cameroon has initiated a national programme of HIV care decentralization providing access to antiretroviral therapy (ART) for patients with CD4 cell counts less than 200 cells/microl or AIDS stage. Current clinical research suggests these criteria may be too stringent. This study aimed at evaluating the effect of not receiving ART on patients' psychosocial outcomes., Design: The national cross-sectional survey EVAL (ANRS 12-116) collected psychosocial and clinical data for 3151 patients attending HIV services (September 2006 to March 2007)., Methods: Propensity score matching was used to control for demographic/clinical-immunological differences between patients receiving ART and those who did not. Generalized linear models were used to assess the impact, for different CD4 cell levels, of "not receiving" ART on health-related quality of life (HRQoL) inconsistent condom use with a sexual partner either serodiscordant or of unknown HIV status, self-reported symptoms and disclosure of HIV status to relatives or friends., Results: Seventy-eight per cent of patients included in the survey were receiving ART. Non-treated patient breakdown was as follows: 8% (CD4<200 or AIDS stage), 5% (200
350). In the multivariate matched-pairs analysis, impaired physical HRQoL, more frequent inconsistent condom use, more self-reported symptoms and less frequent disclosure of HIV status were all significantly associated (P < 0.0001) with not receiving ART, irrespective of the CD4 cell level., Conclusion: In addition to increasing clinical effectiveness, earlier initiation of ART at less severe immune-depression levels than previously recommended by World Health Organization guidelines for low-resource settings may be justified for improving subjective health and positive prevention among people living with HIV. - Published
- 2010
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12. Better health-related quality of life after switching from a virologically effective regimen to a regimen containing efavirenz or nevirapine.
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Potard V, Chassany O, Lavignon M, Costagliola D, and Spire B
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- Adult, Aged, Alkynes, Anxiety diagnosis, Cyclopropanes, Depression diagnosis, Female, France, HIV Infections psychology, Health Status, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Treatment Outcome, Viral Load, Young Adult, Benzoxazines therapeutic use, HIV Infections drug therapy, Nevirapine therapeutic use, Quality of Life psychology, Reverse Transcriptase Inhibitors therapeutic use
- Abstract
Switching antiretroviral therapy has been shown as safe and effective, but its impact on health-related quality of life (HRQL) was rarely measured. Our objective was to assess changes in HRQL after switching to an non-nucleoside reverse transcriptase inhibitors (NNRTI) containing regimen among NNRTI-naive HIV-infected patients with viral load (VL) <500 copies/mL. In this prospective observational study, the Hospital Anxiety and Depression, Symptoms checklist, specific World Health Organization Quality of Life (WHOQoL) and generic SF-12v2 HRQL questionnaires were used to assess anxiety, depression, symptoms, and HRQL at baseline and months 1 (M1), 6 (M6), and 12 (M12). The statistical significance of changes in the frequency of anxiety and depression was determined with the McNemar test. Mean changes in the number of symptoms and in HRQL scores were compared using Wilcoxon's paired test. Data were available for 239 patients at baseline (162 with a switch to nevirapine) and for 164 patients at M6. The median age of the patients was 42 years and 67% of patients were male. The proportion of anxious patients diminished at M6 (11%, P=0.02) but not yet at M1. There was no change in the frequency of depression. Significant reductions (p<0.01) were observed at M6 in the mean number of all symptoms (-3.3), lipodystrophy symptoms (-0.8), other symptoms (-2.5), bothersome symptoms (-1.7), bothersome lipodystrophy symptoms (-0.4), and bothersome other symptoms (-1.3). HRQL as assessed with WHOQoL, improved in the physical, independence, and spirituality domains, with a small effect sizes at M6. Both for symptoms and HRQL, these changes were already significant at M1 and persisted at M12. This study shows that in patients with controlled VL, switching to an NNRTI regimen was associated with less anxiety, fewer perceived symptoms, and a small improvement in HRQL, while maintaining virological suppression.
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- 2010
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13. Effect of lopinavir/ritonavir monotherapy on quality of life and self-reported symptoms among antiretroviral-naive patients: results of the MONARK trial.
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Spire B, Marcellin F, Cohen-Codar I, Flandre P, Boue F, Dellamonica P, Raffi F, Norton M, Van Philippe N, and Delfraissy JF
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- Anti-HIV Agents administration & dosage, Anti-HIV Agents therapeutic use, Drug Therapy, Combination, HIV Infections virology, HIV-1 drug effects, HIV-1 physiology, Humans, Lamivudine administration & dosage, Lamivudine therapeutic use, Lopinavir, Reverse Transcriptase Inhibitors administration & dosage, Reverse Transcriptase Inhibitors therapeutic use, Treatment Outcome, Viral Load, Zidovudine administration & dosage, Zidovudine therapeutic use, HIV Infections drug therapy, HIV Protease Inhibitors administration & dosage, HIV Protease Inhibitors adverse effects, HIV Protease Inhibitors therapeutic use, Pyrimidinones administration & dosage, Pyrimidinones adverse effects, Pyrimidinones therapeutic use, Quality of Life, Ritonavir administration & dosage, Ritonavir adverse effects, Ritonavir therapeutic use
- Abstract
Background: Standard-of-care for HIV-infected patients consists of combining three antiretroviral drugs. However, other therapeutic strategies could be beneficial given long-term toxicity and quality of life (QOL) issues associated with taking multiple antiretroviral drugs for many years. In the prospective, open label, randomized, pilot monotherapy antiretroviral Kaletra (MONARK) trial among antiretroviral-naive patients, lopinavir/ritonavir (LPV/r) monotherapy was found to be less suppressive for HIV RNA than a standard triple-drug therapy of LPV/r plus zidovudine/lamivudine (on-treatment analysis after 48 weeks). We present data from the MONARK trial concerning QOL and patient-reported symptoms., Methods: Patient-reported symptoms were collected at baseline and at weeks 4, 12, 24 and 48 using a list of 22 symptoms. QOL was assessed at baseline, week 24 and week 48 using the six-domain World Health Organization QOL short form questionnaire for HIV-infected individuals including an evaluation of global health perception., Results: Patients treated with the standard triple-drug therapy reported significantly more symptoms over 48 weeks of treatment than patients treated with LPV/r monotherapy (incidence rate ratio [95% confidence interval] 1.3 [1.1, 1.6] P=0.001 and 1.4 [1.2, 1.7] P=0.0004 for the total number of symptoms and the number of symptoms causing discomfort, respectively). No baseline differences and no significant changes were observed in the six QOL scores. The percentage of patients with a positive perception of their global health status increased significantly in the monotherapy arm from 32% at baseline to 67% at week 48 (P<0.0001)., Conclusions: These results suggest that the number of self-reported symptoms could be used as a treatment-sensitive measure of patients' well-being in clinical trials.
- Published
- 2008
14. Self-reported fatigue and depressive symptoms as main indicators of the quality of life (QOL) of patients living with HIV and Hepatitis C: implications for clinical management and future research.
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Marcellin F, Préau M, Ravaux I, Dellamonica P, Spire B, and Carrieri MP
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- Adult, Female, Humans, Male, Middle Aged, Statistics as Topic, Depression etiology, Fatigue etiology, HIV Infections complications, Hepatitis C complications, Quality of Life
- Abstract
Purpose: To analyze the impact of self-reported fatigue and depressive symptoms on the quality of life (QOL) of patients co-infected with HIV and hepatitis C virus (HCV) not receiving anti-HCV therapy., Method: We used data from a cross-sectional survey conducted among 115 co-infected adults including an assessment of QOL (WHOQOL-HIV bref questionnaire), depressive symptomatology (Center for Epidemiological Studies Depression Scale [CES-D]), and fatigue (Fatigue Impact Scale [FIS])., Results: Eighty-four percent of patients had been infected through injecting drug use (IDU). Half reported a history of depression or other psychiatric co-morbidities, 57% presented depressive symptoms, and 69% reported fatigue. FIS and CES-D scores accounted for 54% and 66% of total variance in psychological QOL and level of independence-related QOL, respectively, in a multivariate analysis adjusted for sociodemographic and clinical characteristics and alcohol or drug use. High FIS scores were independently associated with impaired physical QOL and social relationships, whereas high CES-D scores were independently associated with lower environmental QOL., Conclusion: Self-reported fatigue and depressive symptoms are the best indicators of co-infected patients' QOL. These two indicators could be more easily used for a better clinical management of co-infected patients and also introduced as patient outcome measures in clinical research.
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- 2007
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15. Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8).
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Protopopescu C, Marcellin F, Spire B, Préau M, Verdon R, Peyramond D, Raffi F, Chêne G, Leport C, and Carrieri MP
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- Adult, Female, France, HIV Infections complications, HIV Infections metabolism, HIV-1 enzymology, Health Status, Hepatitis C complications, Humans, Longitudinal Studies, Male, Models, Statistical, Patient Dropouts, Prospective Studies, Protease Inhibitors pharmacology, Protease Inhibitors therapeutic use, Time Factors, Antiretroviral Therapy, Highly Active, HIV Infections drug therapy, HIV-1 drug effects, Outcome Assessment, Health Care statistics & numerical data, Quality of Life, Sickness Impact Profile, Treatment Outcome
- Abstract
Background: The long-term efficacy of Highly Active Antiretroviral Therapies (HAART) has enlightened the crucial role of health-related quality of life (HRQL) among HIV-infected patients. However, any analysis of such extensive longitudinal data necessitates a suitable handling of dropout which may correlate with patients' health status., Methods: We analysed the HRQL evolution over 5 years for 1,000 patients initiating a protease inhibitor (PI)-containing therapy, using MOS SF-36 physical (PCS) and mental (MCS) scores. In parallel with a classical separate random effects model, we used a joint parameter-dependent selection model to account for non-ignorable dropout., Results: HRQL evolved according to a two-phase pattern, characterized by an initial improvement during the year following HAART initiation and a relative stabilization thereafter. Immunodepression and self-reported side effects were found to be negative predictors of both PCS and MCS scores. Hepatitis C virus coinfection and AIDS clinical stage were found to affect physical HRQL. Results were not significantly altered when accounting for dropout., Conclusion: Such results, obtained on a large sample of HIV-infected patients with extensive follow-up, underline the need for a regular monitoring of patients' immunological status and for a better management of their experience with hepatitis C and HAART.
- Published
- 2007
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16. Time perspective and quality of life among HIV-infected patients in the context of HAART.
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Préau M, Apostolidis T, Francois C, Raffi F, and Spire B
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- Adult, Affect, Cross-Sectional Studies, Female, HIV Infections drug therapy, HIV Infections pathology, Humans, Male, Regression Analysis, Self Concept, Surveys and Questionnaires, Time Factors, Antiretroviral Therapy, Highly Active, HIV Infections psychology, Quality of Life
- Abstract
We explored associations between time perspective (TP) and quality of life (QOL) among HIV-infected patients. With the French validated version of the Zimbardo Time Perspective Inventory, we evaluated the TP of patients. A self-administered questionnaire gathered information about QOL (WHOQOL-HIV), TP, relationship with medical staff and self-reported side effects of HAART. Six scores of QOL - physical, psychological, social relationship, environment, patient independence and spirituality were used as dependent variables in the linear regressions to identify factors associated with QOL. The sample (n=72) for this study was recruited from a hospital department specialising in HIV care and consisted of 48 (67%) HIV-infected women and 24 (33%) HIV-infected men with a mean age of 42 years. Using hierarchical regression analysis adjusted on socio-demographic characteristics, clinical characteristics and co-factors, significant relationships were observed between the several TP orientations and an impaired physical, environmental QOL as well as level-of-independence QOL. Specific dimensions of QOL are influenced by specific orientations of TP, which provides information on self-perception and subjective evaluation of QOL. The TP construct provides keys to managing HIV infection in order to improve QOL.
- Published
- 2007
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17. Health related quality of life among both current and former injection drug users who are HIV-infected.
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Préau M, Protopopescu C, Spire B, Sobel A, Dellamonica P, Moatti JP, and Carrieri MP
- Subjects
- Adult, Diarrhea, Female, Humans, Male, Surveys and Questionnaires, Antiretroviral Therapy, Highly Active adverse effects, HIV Infections etiology, HIV Infections psychology, Quality of Life, Substance Abuse, Intravenous complications, Substance Abuse, Intravenous psychology
- Abstract
Background: This study aimed to determine factors associated with higher levels of health related quality of life (HRQL) among individuals HIV-infected through drug injection and to evaluate the impact of injecting drug status and opiate substitution treatment (OST) on HRQL., Methods: Two hundred and forty-three patients, enrolled in the MANIF cohort of patients HIV-infected through IDUs, participated. They completed a self-administered questionnaire, which included an HRQL evaluation (SF-12) and socio-demographic/clinical characteristics at the 42-month visit. Injecting drug status, OST and experience of negative life events (NLE) were collected at any follow-up visit in order to reconstitute individual trajectories., Results: Among the 243 patients, 35% reported a normal mental HRQL and 37% a normal physical HRQL. Independent predictors of "normal" mental HRQL were social support from partner, being a former IDU, no experience of violence-related NLE and few self-reported HAART-related side effects. "Normal" physical HRQL was predicted by younger age, stable partner, being a former IDU (> or = 6 months), CD4 cell count > 500, no experience of financial-related NLE and few HAART self-reported side effects., Conclusions: As HRQL has been found to have a prognostic value on the survival of HIV patients infected through drug injection, then providing more comprehensive care (for example by paying more attention to patients' experience of stressful events, meeting their needs in psychosocial support and better management of perceived toxicity) could globally improve treatment outcomes in this vulnerable population.
- Published
- 2007
- Full Text
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18. Health-related quality of life in French people living with HIV in 2003: results from the national ANRS-EN12-VESPA Study.
- Author
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Préau M, Marcellin F, Carrieri MP, Lert F, Obadia Y, and Spire B
- Subjects
- Adult, Anti-HIV Agents therapeutic use, Antiretroviral Therapy, Highly Active, Attitude to Health, Epidemiologic Methods, Female, HIV Infections drug therapy, HIV Infections psychology, Health Status Indicators, Humans, Male, Mental Health, Middle Aged, Psychiatric Status Rating Scales, Psychometrics, Selection Bias, HIV Infections rehabilitation, Quality of Life
- Abstract
Objective: Since the advent of HAART, the assessment of health-related quality of life (HRQL) has become a major concern in the therapeutic follow-up of people living with HIV., Design: HRQL was evaluated for 2235 participants in the ANRS-EN12-VESPA Study. These participants completed the Medical Outcome Study 36-Item Short Form Health Survey (MOS SF-36) questionnaire. Anxiety and depression were assessed using the Hospital Anxiety and Depression (HAD) scale. Individuals were considered to have an 'acceptable' physical (and mental) HRQL if their MOS SF-36 scores were greater than the 25 percentile of the corresponding age-sex-specific distribution of scores in the French general population., Methods: Logistic regression models were used to identify factors associated with an 'acceptable' physical and mental HRQL among demographic, psychosocial and clinical characteristics. Potential selection bias caused by non-random missing responses to the MOS SF-36 questionnaire was statistically tested., Results: Physical and mental HRQL were 'acceptable' in 1176 (53%) and 1152 (51%) individuals, respectively. After adjusting for sociodemographic factors, HIV clinical status and hepatitis C co-infection, high HAD scores and the consumption of anxiolytic, antidepressant and hypnotic drugs were found to be negatively associated with normal physical and mental HRQL., Conclusion: The role of disclosure and discrimination is determinant in HRQL, and the various cultural and psychological dimensions require further research. The presence of other infections or co-morbidities requires a comprehensive care system including medical staff and social worker teams. HIV should increasingly be regarded as a chronic disease characterized by different pathological conditions requiring a comprehensive and multidisciplinary approach.
- Published
- 2007
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19. [Health related quality of life and lipodystrophy syndrome among HIV-infected patients].
- Author
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Préau M, Bouhnik AD, Spire B, Leport C, Saves M, Picard O, Reynes J, Salmon D, Dellamonica P, Raffi F, Morin M, and Aproco-Copilote E
- Subjects
- Adult, Antiretroviral Therapy, Highly Active adverse effects, Body Image, Cohort Studies, Female, France, HIV Infections drug therapy, HIV-Associated Lipodystrophy Syndrome chemically induced, Health Surveys, Humans, Male, Middle Aged, Prospective Studies, Sex Factors, Social Adjustment, HIV Infections psychology, HIV-Associated Lipodystrophy Syndrome psychology, Quality of Life psychology
- Abstract
Aim of the Study: The aim of this work is to show to what extent a psychosocial evaluation can lead bring to comprehension of the subjectivity of Quality of Life (QoL) among HIV-infected patients. Evaluation of QoL makes it possible to understand the link between the therapeutic effectiveness and the subjective evaluation of the treatment, but also to estimate more precisely how people live and take their treatment in the context of HIV infection., Method: This work confronts the variation of QoL with the variation of several social and psychosocial parameters identified as of the components of the system, which is the subjective evaluation, and more precisely to a specific side effect of Highly Active AntiRetroviral Therapies (HAART): lipodystrophy syndrome that consists in body fat redistribution. This side effect could consist in an accumulation of body fat, or a loss of body fat or a combination of both symptoms. The analysis was made on the data from APROCO-COPILOTE cohort composed of HIV-infected patients initiating HAART., Results: Among a sample of 706 patients follow-up for three years and with available QoL data, we identified the variations of QoL according to the variation of this specific side effect and according to gender. Results show that lipodystrophy syndrome has a determinant impact on QoL different among male and female patients. Adjusted on clinical and socio-demographic characteristics, impaired women's QoL is associated with accumulation of body fat and impaired men's QoL is associated with loss of body fat., Conclusion: These results underline the role of body image on subjective evaluation of QoL. The analysis of empirical data made it possible to highlight the social implication of the evaluation of QoL from the role of the social support, patient-provider relationship and the social context.
- Published
- 2006
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- View/download PDF
20. Unsafe sex with casual partners and quality of life among HIV-infected gay men: evidence from a large representative sample of outpatients attending French hospitals (ANRS-EN12-VESPA).
- Author
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Bouhnik AD, Préau M, Schiltz MA, Peretti-Watel P, Obadia Y, Lert F, and Spire B
- Subjects
- Adult, Chi-Square Distribution, Data Collection, France, Humans, Interviews as Topic, Logistic Models, Male, Risk Factors, Statistics as Topic, HIV Infections psychology, Homosexuality, Male, Quality of Life, Unsafe Sex statistics & numerical data
- Abstract
Introduction: The introduction of highly active antiretroviral therapy has relaunched the debate on risky sexual behavior among HIV-infected gay men. It was proposed to study the influences of lifestyle characteristics and health-related quality of life (HRQL) on unsafe sex with casual partners in a representative sample of HIV-infected gay men., Methods: In 2003, a national survey based on face-to-face interviews was conducted among a representative sample of patients selected in a random stratified sample of 102 French hospital departments delivering HIV care. The patients selected for this analysis were gay men who reported having had sex with casual partners during the previous 12 months. Unsafe sex was defined as at least 1 episode of anal sexual intercourse without a condom with a casual partner during the previous 12 months. Health-related quality of life was assessed using the SF-36 Scale. Patients who declared that they had engaged in unsafe sex were compared with those who declared that they had not done so, using the chi test and logistic regressions., Results: Among the 1,117 gay men who participated in the study, 607 declared having had casual partners during the previous 12 months, and 140 (20%) of this latter group had engaged in unsafe sex. Poor mental HRQL was encountered in 68% of the patients and found to be independently associated with unsafe sex, even after multiple adjustment for number of partners, occurrences of binge drinking, use of anxiolytics, use of the Internet, and use of outdoor and commercial venues for sexual encounters., Conclusions: Risky sexual behavior with casual partners is frequent among HIV-infected gay men. In addition to other well-known factors, behavior of this kind was found in this study to be related to poor mental HRQL. A more comprehensive approach to care designed to improve mental quality of life might therefore make for more effective secondary prevention.
- Published
- 2006
- Full Text
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21. [Health related quality of life among HIV-HCV co-infected patients].
- Author
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Préau M, Protopopescu C, Spire B, Dellamonica P, Poizot-Martin I, Villes V, and Carrieri MP
- Subjects
- Adult, Anti-Retroviral Agents administration & dosage, Anti-Retroviral Agents therapeutic use, Buprenorphine administration & dosage, Buprenorphine therapeutic use, Cohort Studies, Counseling, Data Interpretation, Statistical, Depression diagnosis, Depression etiology, Drug Therapy, Combination, Female, Follow-Up Studies, HIV Infections drug therapy, HIV Infections psychology, HIV Seropositivity complications, HIV Seropositivity psychology, HIV-1, Hepatitis C psychology, Humans, Male, Methadone administration & dosage, Methadone therapeutic use, Narcotic Antagonists administration & dosage, Narcotic Antagonists therapeutic use, Narcotics administration & dosage, Narcotics therapeutic use, Social Support, Socioeconomic Factors, Substance Abuse, Intravenous drug therapy, Substance Abuse, Intravenous psychology, Surveys and Questionnaires, Time Factors, HIV Infections complications, Hepatitis C complications, Quality of Life psychology, Substance Abuse, Intravenous complications
- Abstract
Background: To assess factors associated with higher levels of health-related quality-of-life among HIV-HCV co-infected injecting drug users and more specifically, to explore the role of injecting drug status and drug maintenance treatment on health-related quality-of-life., Methods: The two hundred and forty participants were patients enrolled in the MANIF cohort of HIV-HCV patients infected through injecting drug use who completed a self-administered questionnaire that included a health-related quality-of-life evaluation at the 42 month follow-up. A self-administered questionnaire collected information about socio-demographic characteristics, health-related quality-of-life (as measured by SF-12), injecting drug status and drug maintenance treatment, depressive symptoms, self-reported symptoms related to HIV treatment; clinical characteristics were obtained from medical records., Results: Higher levels of both mental and physical health-related quality-of-life were found in patients with no depressive symptoms, abstinent from drugs and experiencing few drug related problems. Patients on drug maintenance treatment who stopped injecting drugs had better mental health-related quality-of-life than injectors but lower levels of mental health-related quality-of-life than abstinent patients. Mental health-related quality-of-life was also independently higher in patients receiving high social support. Physical health-related quality-of-life was independently higher for patients who stopped injection, whether on drug maintenance treatment or not, for patients on anti-retroviral treatment and for patients who remained in clinical stage A., Conclusions: Drug maintenance treatment seems to be associated with higher health-related quality-of-life among patients HIV-HCV co-infected by drug use, but it is still necessary to help patients cope with the mental impact of drug cessation. These results underline the need to provide regular psychological support and counselling for HIV-HCV co-infected injecting drug users during the medical follow-up for HIV-disease.
- Published
- 2006
22. Health-related quality of life and health locus of control beliefs among HIV-infected treated patients.
- Author
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Préau M, Vincent E, Spire B, Reliquet V, Fournier I, Michelet C, Leport C, and Morin M
- Subjects
- Adult, Antiretroviral Therapy, Highly Active methods, CD4 Antigens blood, Female, HIV Infections drug therapy, Humans, Male, Severity of Illness Index, Surveys and Questionnaires, Attitude to Health, Culture, HIV Infections blood, HIV Infections psychology, Health Status, Internal-External Control, Quality of Life psychology
- Abstract
Objective: This study examined the relations between health locus of control (HLOC) beliefs and health-related quality of life (HRQL) in 302 HIV-infected patients enrolled in a French cohort, 44 months (M44) after they began highly active antiretroviral therapy (HAART)., Methods: HLOC beliefs were measured with the Multidimensional Health Locus of Control (MHLOC) scale and HRQL, with the Medical Outcome Study Short-Form Health Survey (MOS-SF-36)., Results: Internal HLOC beliefs at the initiation of treatment were associated with both physical HRQL in multivariate analysis, while chance HLOC beliefs on beginning HAART were associated with mental HRQL at M44., Conclusion: These findings suggest the importance of considering the psychological characteristics and psychosocial beliefs of patients at the initiation of ARV treatment to optimise the long-term HRQL of HIV-infected patient and to develop adaptive intervention on coping strategies.
- Published
- 2005
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23. Health-related quality of life and patient-provider relationships in HIV-infected patients during the first three years after starting PI-containing antiretroviral treatment.
- Author
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Préau M, Leport C, Salmon-Ceron D, Carrieri P, Portier H, Chene G, Spire B, Choutet P, Raffi F, and Morin M
- Subjects
- CD4 Lymphocyte Count methods, Cohort Studies, France epidemiology, Health Status, Humans, Patient Satisfaction, Surveys and Questionnaires, Treatment Outcome, Antiretroviral Therapy, Highly Active psychology, HIV Infections drug therapy, Physician-Patient Relations, Quality of Life psychology
- Abstract
The aim of this study was to investigate factors associated with better health-related quality of life (HRQL) during the first three years after starting PI-containing antiretroviral treatment. Clinical, social and behavioural data from the APROCO cohort enabled us to analyze simultaneously the association between HRQL and patients' relationships with their health care providers. A self-administered questionnaire collected information about HRQL (MOS-SF36) and relationships with medical staff (trust and satisfaction with information). Two aggregate scores, the physical (PCS) and mental (MCS) component summaries (adjusted for baseline HRQL), were used as dependent variables in the linear regressions to identify factors associated with HRQL. We had complete longitudinal data for 360 of the 611 patients followed through M36. Factors independently associated with a high MCS were (male) gender, no more than one change in treatment, (few) self-reported symptoms and trust in the physician. Factors independently associated with high PCS levels were employment, no children, (few) self-reported symptoms and satisfaction with the information and explanations provided by the medical staff. These results underline the need to improve patient-provider relationships to optimize long-term HRQL. Socio-behavioural interventions should focus on this goal.
- Published
- 2004
- Full Text
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24. Health-related quality of life after 1 year of highly active antiretroviral therapy.
- Author
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Carrieri P, Spire B, Duran S, Katlama C, Peyramond D, François C, Chêne G, Lang JM, Moatti JP, and Leport C
- Subjects
- Adult, Anti-HIV Agents adverse effects, CD4 Lymphocyte Count, Cohort Studies, Female, France, HIV Infections immunology, HIV Infections virology, Humans, Male, Middle Aged, Time Factors, Treatment Outcome, Anti-HIV Agents therapeutic use, Antiretroviral Therapy, Highly Active adverse effects, HIV Infections drug therapy, HIV Infections physiopathology, Quality of Life, Surveys and Questionnaires
- Abstract
Objective: We investigated the impact of the first year of highly active antiretroviral therapy (HAART) on health-related quality of life (HRQL)., Methods: Medical data for patients in the French APROCO cohort were collected at enrollment (M0) and month 12 (M12). A self-administered questionnaire gathered information about HRQL (Medical Outcome Study 36-Item Short Form Health Survey) and toxicity-related symptoms. Using the twenty-fifth percentile of HRQL scales in the French population as a threshold, patients with normal values in at least three mental and three physical scales were considered to have a "normal HRQL." RESULTS. Of the 1053 patients followed through M12, HRQL data at M0 and M12 were available for 654. Among the 233 patients with a normal baseline HRQL, 63 (27.0%) experienced a deterioration of HRQL at M12. Among the 421 patients with a low baseline HRQL, 121 achieved a normal HRQL at M12. Logistic regression showed that factors independently associated with a normal HRQL at M12 were normal baseline HRQL, baseline CD4 count <500 cells/mm, time since HIV diagnosis <8 years, undetectable HIV-RNA at M12, and lower number of self-reported symptoms at M12., Conclusion: An assessment of HRQL should be integrated to efficacy outcomes to evaluate and compare long-term strategies properly and to optimize the durability of response to antiretroviral therapy.
- Published
- 2003
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25. Satisfaction with care in HIV-infected patients treated with long-term follow-up antiretroviral therapy: the role of social vulnerability.
- Author
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Préau, M., Protopopescu, C., Raffi, F., Rey, D., Chêne, G., Marcellin, F., Perronne, C., Ragnaud, J.M., Leport, C., Spire, B., and the ANRS CO8 APROCO-COPILOTE Study Group
- Subjects
ANTIVIRAL agents ,STATISTICAL correlation ,DRUGS ,HIV infections ,LONGITUDINAL method ,PATIENT compliance ,PATIENT satisfaction ,QUESTIONNAIRES ,SCALES (Weighing instruments) ,SOCIAL values ,STATISTICS ,LOGISTIC regression analysis ,SOCIAL support ,CROSS-sectional method ,PSYCHOLOGICAL vulnerability ,DESCRIPTIVE statistics - Abstract
The aim of this study was to determine factors associated with complete satisfaction with the care provided (satisfaction with physicians and satisfaction with services and organization) among HIV-infected patients followed up in the French ANRS CO8 APROCO-COPILOTE cohort. Analyses focused on cross-sectional data collected during the ninth year of cohort follow-up. Satisfaction with care, sociodemographic characteristics, and behavioral data were collected using self-administered questionnaires, while clinical data were derived from medical records. Complete satisfaction with care was defined as being 100% satisfied. Two logistic regression models were used to identify predictors of (1) complete satisfaction with physicians (n=404) and (2) complete satisfaction with services and organization (n=396). Sixteen percent of patients were completely satisfied with physicians, while 15.9% were completely satisfied with services and organization. Being older and reporting fewer discomforting antiretroviral therapy (ART) side effects were factors independently associated with complete satisfaction with both physicians and services and organization. Strong support from friends and absence of hepatitis C (HCV) co-infection were independently associated with complete satisfaction with physicians, while strong support from one's family and comfortable housing conditions were independently associated with complete satisfaction with services and organization. Even after nine years of follow-up, social vulnerabilities still strongly influence HIV-infected patients’ interactions with the health care system. Day-to-day experience with the disease, including perceived treatment side effects, appears to play a key role in the quality of these interactions. More attention should be given to patient satisfaction, especially for socially vulnerable patients, in order to avoid potentially detrimental consequences such as poor adherence to ART. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
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26. Role of treatment for depressive symptoms in relieving the impact of fatigue in HIV–HCV co-infected patients: ANRS Co13 Hepavih, France, 2006–2008.
- Author
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Michel, L., Villes, V., Dabis, F., Spire, B., Winnock, M., Loko, M.-A., Poizot-Martin, I., Valantin, M. A., Bonnard, P., Salmon-Céron, D., and Carrieri, M. P.
- Subjects
FATIGUE (Physiology) ,HIV-positive persons ,HEPATITIS C ,MENTAL depression ,SYMPTOMS ,PATIENTS - Abstract
Fatigue is a major component of quality of life (QOL) and is associated with depression in HIV–HCV co-infected individuals. We investigated whether treating depressive symptoms (DS) could mitigate the impact of fatigue on daily functioning in co-infected patients, even those at an advanced stage of disease. The analysis was conducted on enrolment data of 328 HIV–HCV co-infected patients recruited in the French nationwide ANRS CO 13 HEPAVIH cohort. Data collection was based on medical records and self-administered questionnaires which included items on socio-behavioural data, the fatigue impact scale (FIS) in three domains (cognitive, physical and social functioning), depressive symptoms (CES-D classification) and use of treatments for depressive symptoms (TDS). After multiple adjustment for gender and unemployment, CD4 cell count <200 per mm
3 was associated with a negative impact of fatigue on the physical functioning dimension ( P = 0.002). A higher number of symptoms causing discomfort significantly predicted a higher impact of fatigue on all three dimensions ( P < 0.001). This was also true for patients with DS receiving TDS when compared with those with no DS but receiving TDS. A significant decreasing linear trend ( P < 0.001) of the impact of fatigue was found across the categories ‘DS/TDS’, ‘DS/no TDS’, ‘no DS/TDS’ and ‘no DS/no TDS’. Despite limitations related to the cross-sectional nature of this study, our results suggest that routine screening and treatment for DS can reduce the impact of fatigue on the daily functioning of HIV–HCV co-infected patients and relieve the burden of their dual infection. [ABSTRACT FROM AUTHOR]- Published
- 2010
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- View/download PDF
27. La sexualité des personnes atteintes par le VIH : l'impact d'une infection sexuellement transmissible.
- Author
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Schiltz, M.-A., Bouhnik, A.-D., Préau, M., and Spire, B.
- Subjects
HEALTH surveys ,HIV-positive persons ,QUALITY of life ,SEXUAL intercourse ,PSYCHOSOCIAL factors ,DISCRIMINATION (Sociology) ,INTERPERSONAL relations ,SOCIAL status - Abstract
Copyright of Sexologies is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
- Full Text
- View/download PDF
28. Confirmation of the Factor Structure of the Proqol-HIV Questionnaire to Assess Health-Related Quality of Life in PLWHA.
- Author
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Lalanne, C., Duracinsky, M., Marcellin, F., Lert, F., Chassany, O., Carrieri, P.M., Dray-Spira, R., and Spire, B.
- Subjects
- *
HIV infections , *THERAPEUTICS , *HIV-positive persons , *QUALITY of life , *SYMPTOMS , *QUESTIONNAIRES , *PUBLIC health - Published
- 2014
- Full Text
- View/download PDF
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