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Bipolar disorder is a chronic, episodic disease characterized by intermittent episodes of depressive and manic symptoms. It causes significant and long-lasting distress, functional impairment and morbidity, and is associated with a high risk of mortality. Quality of life and disease burden, particularly in terms of lifestyle and general functioning, are gaining increasing recognition as valid therapeutic targets for intervention. Quality of life among patients with bipolar disorders is significantly impaired both during and between acute episodes. Somatic and mood symptoms, stigmatization, comorbid conditions, associated cognitive deficits and the burden of treatment all can combine to severely undermine patient quality of life and functioning at all levels. The tolerability of treatment is an important consideration when choosing a therapeutic option as patient satisfaction with, and adherence to, treatment can influence health outcomes and quality of life. Early intervention with the appropriate treatment can alter the course of bipolar disorder and improve the long-term experience of patients in their management of the disease.