23 results on '"Johansson, Peter A."'
Search Results
2. Early osteoarthritis after slipped capital femoral epiphysis
- Author
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Helgesson, Lukas, Johansson, Peter Kälebo, Aurell, Ylva, Tiderius, Carl-Johan, Kärrholm, Johan, and Riad, Jacques
- Subjects
Adult ,Male ,Slipped Capital Femoral Epiphysis ,Bone Screws ,Slipped Capital Femoral Epiphyses ,Bone Nails ,Middle Aged ,Magnetic Resonance Imaging ,Osteoarthritis, Hip ,Young Adult ,Quality of Life ,Humans ,Female ,Self Report - Abstract
Background and purpose - Slipped capital femoral epiphysis (SCFE) results in a more or less pronounced deformity of the proximal femur, sometimes causing impingement and early osteoarthritis. We studied early osteoarthritis after SCFE and the association with deformity and self-reported hip function, pain, and quality of life. Patients and methods - 9 women and 16 men, mean age 32 (21-50) years, 19 with unilateral and 6 with bilateral SCFE, participated. All patients had primarily been operated by pin or screw with no attempt at reposition of the slip. Hips were examined by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), which quantifies and locates cartilage degeneration. Plain radiographs were used to measure deformity as determined by the alpha angle. Outcome was assessed by Oxford hip score, Hip Groin Outcome score and EQ-5D-Visual scale. Results - In the 19 unilateral SCFE, on the slip side dGEMRIC mean value was 533 ms (SD 112, range 357-649) versus mean 589 ms (SD 125, range 320-788) on the non-slip side, (p = 0.01). The dGEMRIC correlated negatively to the alpha angle, correlation coefficient (CC) = -0.60, (p = 0.002). Oxford hip score, pain, and EQ-5D-Visual scale correlated to dGEMRIC CC =0.43 (p = 0.03), CC =0.40 (p = 0.05), and CC =0.49 (p = 0.01) respectively. Interpretation - After SCFE, even relatively mild residual hip deformity can be associated with cartilage degeneration. A high alpha angle was associated with worse cartilage status. The Oxford hip score identified symptoms even though our patients had not previously sought medical care after the index operation. Quality of life showed strong inverse correlation with cartilage degeneration. Objective assessment of early cartilage degeneration may be useful for treatment decisions and follow-up.
- Published
- 2017
3. The effect of nurse‐led Internet‐based cognitive behavioural therapy for insomnia on patients with cardiovascular disease: A randomized controlled trial with 6‐month follow‐up.
- Author
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Siebmanns, Sandra, Johansson, Peter, Ulander, Martin, Johansson, Linda, Andersson, Gerhard, and Broström, Anders
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INSOMNIA treatment ,OCCUPATIONAL roles ,SLEEP quality ,INTERNET ,MEDICAL care ,CARDIOVASCULAR diseases ,TREATMENT effectiveness ,RANDOMIZED controlled trials ,NURSES ,QUALITY of life ,QUALITY assurance ,QUESTIONNAIRES ,RESEARCH funding ,STATISTICAL sampling ,INSOMNIA ,PATIENT compliance ,BODY mass index ,COGNITIVE therapy ,LONGITUDINAL method ,COMORBIDITY ,SYMPTOMS - Abstract
Aim: To test the effect of nurse‐led Internet‐based cognitive behavioural therapy for insomnia (I‐CBTI), tailored for patients with cardiovascular disease (CVD), with a 6‐month follow‐up. Design: A two‐arm parallel‐group randomized controlled trial (RCT) registered at clinicaltrials.gov (NTC03938805) and reported according to the CONSORT checklist. Methods: Forty‐eight patients (mean age 72 years, 65% men) diagnosed with CVD and insomnia were randomized to either 9‐week nurse‐led I‐CBTI with support, or an Internet‐based self‐study programme without support (control group). Insomnia Severity Index (ISI) and Short Form Health Survey (SF‐12) were used as primary and secondary outcomes. Results: ISI showed a significant treatment effect of I‐CBTI compared to the control group at 9‐week follow‐up. The mean ISI score in the I‐CBTI group at 9 weeks post‐treatment was maintained at the 6‐month follow‐up. Patients' adherence to I‐CBTI was associated with a better effect on both the ISI and SF‐12. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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4. The associations between psychological distress and health-related quality of life in patients with non-cardiac chest pain.
- Author
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Mourad, Ghassan, Alwin, Jenny, Jaarsma, Tiny, Strömberg, Anna, and Johansson, Peter
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PSYCHOLOGICAL distress ,QUALITY of life ,CHEST pain ,SOMATIZATION disorder ,HEART diseases - Abstract
Background: Recurrent chest pain episodes with no clear explanation may affect patients' psychological wellbeing and health-related quality of life (HRQoL) negatively. Despite the fact that a significant amount of patients with non-cardiac chest pain (NCCP) might have a history of Cardiac Disease (CD), there is today a lack of knowledge on how CD influences the association between psychological wellbeing and HRQoL in patients with NCCP. Therefore, the aim of this study is to describe HRQoL in patients with NCCP, with or without history of CD, and to explore the association between HRQoL and cardiac anxiety, depressive symptoms, fear of body sensations and somatization.Methods: Five hundred fifty-two patients discharged with NCCP from four hospitals in Southeast Sweden completed the EQ-5D, Cardiac Anxiety Questionnaire, Patient Health Questionnaire-9, Body Sensations Questionnaire, and Patient Health Questionnaire-15.Results: Fifty precent reported at least moderate problems regarding pain/discomfort and 25% reported at least moderate problems in the HRQoL dimensions mobility, usual activities, and anxiety/depression. Patients with NCCP and history of CD reported significantly lower HRQoL (p ≤ 0.05) compared to patients with NCCP without CD. In the total study population, cardiac anxiety, depressive symptoms, and somatization had weak significant negative associations (beta = 0.187-0.284, p < 0.001) with HRQoL. In patients with history of CD, the association between depressive symptoms and HRQoL was moderate (beta = - 0.339, p < 0.001), compared to weak association in patients without CD (beta = - 0.193, p < 0.001). On the other hand, the association between cardiac anxiety and HRQoL was weak in both patients with history of CD (beta = - 0.156, p = 0.05), and in those without (beta = - 0.229, p < 0.001).Conclusions: Patients with NCCP, in particular those with history of CD, reported low levels of HRQoL, which was associated with psychological distress. This should be considered when developing psychological interventions aiming to improve HRQoL in patients with NCCP. [ABSTRACT FROM AUTHOR]- Published
- 2020
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5. Myeloproliferative Neoplasm (MPN) Symptom Assessment Form Total Symptom Score: Prospective International Assessment of an Abbreviated Symptom Burden Scoring System Among Patients With MPNs
- Author
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Emanuel, Robyn M, Dueck, Amylou C, Geyer, Holly L, Kiladjian, Jean-Jacques, Slot, Stefanie, Zweegman, Sonja, Te Boekhorst, Peter A W, Commandeur, Suzan, Schouten, Harry C, Sackmann, Federico, Kerguelen Fuentes, Ana, Hernández-Maraver, Dolores, Pahl, Heike L, Griesshammer, Martin, Stegelmann, Frank, Doehner, Konstanze, Lehmann, Thomas, Bonatz, Karin, Reiter, Andreas, Boyer, Francoise, Etienne, Gabriel, Ianotto, Jean-Christophe, Ranta, Dana, Roy, Lydia, Cahn, Jean-Yves, Harrison, Claire N, Radia, Deepti, Muxi, Pablo, Maldonado, Norman, Besses, Carlos, Cervantes, Francisco, Johansson, Peter L, Barbui, Tiziano, Barosi, Giovanni, Vannucchi, Alessandro M, Passamonti, Francesco, Andreasson, Bjorn, Ferrari, Maria L, Ferarri, Maria L, Rambaldi, Alessandro, Samuelsson, Jan, Birgegard, Gunnar, Tefferi, Ayalew, Mesa, Ruben A, Interne Geneeskunde, RS: GROW - School for Oncology and Reproduction, Service d'hématologie clinique [Avicenne], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Paleontology section, Transvaal Museum, Département d'Hématologie, Institut de Cancéro-hématologie, Hôpital Morvan [Brest], Service d'Hematologie et Médecine Interne, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), TheREx, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Hematology, Ospedali Riuniti, Department of Oncology and Hematology, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Department of Haematology, Division of Medicine, Institution for Medical Sciences, University Hospital, and CCA - Innovative therapy
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Male ,Cancer Research ,Disease ,Severity of Illness Index ,0302 clinical medicine ,fluids and secretions ,MESH: Aged, 80 and over ,Quality of life ,Weight loss ,Sickness Impact Profile ,Surveys and Questionnaires ,Prospective Studies ,Young adult ,Prospective cohort study ,Aged, 80 and over ,MESH: Aged ,MESH: Middle Aged ,food and beverages ,ORIGINAL REPORTS ,Middle Aged ,3. Good health ,MESH: Sickness Impact Profile ,Oncology ,MESH: Young Adult ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,MESH: Myeloproliferative Disorders ,Adult ,medicine.medical_specialty ,myelofibrosis ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,03 medical and health sciences ,Young Adult ,Internal medicine ,MESH: Severity of Illness Index ,Severity of illness ,medicine ,otorhinolaryngologic diseases ,Humans ,Bone pain ,Myeloproliferative neoplasm ,Aged ,Myeloproliferative Disorders ,MESH: Humans ,business.industry ,MESH: Questionnaires ,MESH: Quality of Life ,MESH: Adult ,medicine.disease ,equipment and supplies ,bacterial infections and mycoses ,MESH: Male ,MESH: Prospective Studies ,Surgery ,carbohydrates (lipids) ,Quality of Life ,business ,MESH: Female ,030215 immunology - Abstract
Purpose Myeloproliferative neoplasm (MPN) symptoms are troublesome to patients, and alleviation of this burden represents a paramount treatment objective in the development of MPN-directed therapies. We aimed to assess the utility of an abbreviated symptom score for the most pertinent and representative MPN symptoms for subsequent serial use in assessing response to therapy. Patients and Methods The Myeloproliferative Neoplasm Symptom Assessment Form total symptom score (MPN-SAF TSS) was calculated as the mean score for 10 items from two previously validated scoring systems. Questions focus on fatigue, concentration, early satiety, inactivity, night sweats, itching, bone pain, abdominal discomfort, weight loss, and fevers. Results MPN-SAF TSS was calculable for 1,408 of 1,433 patients with MPNs who had a mean score of 21.2 (standard deviation [SD], 16.3). MPN-SAF TSS results significantly differed among MPN disease subtypes (P < .001), with a mean of 18.7 (SD, 15.3), 21.8 (SD, 16.3), and 25.3 (SD, 17.2) for patients with essential thrombocythemia, polycythemia vera, and myelofibrosis, respectively. The MPN-SAF TSS strongly correlated with overall quality of life (QOL; r = 0.59; P < .001) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) functional scales (all P < .001 and absolute r ≥ 0.50 except social functioning r = 0.48). No significant trends were present when comparing therapy subgroups. The MPN-SAF TSS had excellent internal consistency (Cronbach's α = .83). Factor analysis identified a single underlying construct, indicating that the MPN-SAF TSS is an appropriate, unified scoring method. Conclusion The MPN-SAF TSS is a concise, valid, and accurate assessment of MPN symptom burden with demonstrated clinical utility in the largest prospective MPN symptom study to date. This new prospective scoring method may be used to assess MPN symptom burden in both clinical practice and trial settings.
- Published
- 2012
6. Early osteoarthritis after slipped capital femoral epiphysis.
- Author
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Helgesson, Lukas, Johansson, Peter Kälebo, Aurell, Ylva, Tiderius, Carl-Johan, Kärrholm, Johan, and Riad, Jacques
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HIP joint radiography , *HIP joint physiology , *ARTICULAR cartilage , *BONE screws , *STATISTICAL correlation , *HIP joint , *HIP joint diseases , *MAGNETIC resonance imaging , *OSTEOARTHRITIS , *HEALTH outcome assessment , *PAIN , *QUALITY of life , *SELF-evaluation , *DESCRIPTIVE statistics , *EPIPHYSIOLYSIS - Abstract
Background and purpose — Slipped capital femoral epiphysis (SCFE) results in a more or less pronounced deformity of the proximal femur, sometimes causing impingement and early osteoarthritis. We studied early osteoarthritis after SCFE and the association with deformity and self-reported hip function, pain, and quality of life. Patients and methods — 9 women and 16 men, mean age 32 (21-50) years, 19 with unilateral and 6 with bilateral SCFE, participated. All patients had primarily been operated by pin or screw with no attempt at reposition of the slip. Hips were examined by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), which quantifies and locates cartilage degeneration. Plain radiographs were used to measure deformity as determined by the alpha angle. Outcome was assessed by Oxford hip score, Hip Groin Outcome score and EQ-5D-Visual scale. Results — In the 19 unilateral SCFE, on the slip side dGEMRIC mean value was 533 ms (SD 112, range 357-649) versus mean 589 ms (SD 125, range 320-788) on the non-slip side, (p = 0.01). The dGEMRIC correlated negatively to the alpha angle, correlation coefficient (CC) = -0.60, (p = 0.002). Oxford hip score, pain, and EQ-5D-Visual scale correlated to dGEMRIC CC =0.43 (p = 0.03), CC =0.40 (p = 0.05), and CC =0.49 (p = 0.01) respectively. Interpretation — After SCFE, even relatively mild residual hip deformity can be associated with cartilage degeneration. A high alpha angle was associated with worse cartilage status. The Oxford hip score identified symptoms even though our patients had not previously sought medical care after the index operation. Quality of life showed strong inverse correlation with cartilage degeneration. Objective assessment of early cartilage degeneration may be useful for treatment decisions and follow-up. [ABSTRACT FROM AUTHOR]- Published
- 2018
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7. 1323: Depressive symptoms in men and women with chronic heart failure—effects on sleep, daytime sleepiness and health-related quality of life.
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Broström, Anders, Johansson, Peter, Kihl, John, Forslund, Per, Dahlström, Ulf, Svanborg, Eva, and Fridlund, Bengt
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SLEEP quality , *PSYCHOLOGY of men , *CONFERENCES & conventions , *MENTAL depression , *QUALITY of life , *PSYCHOLOGY of women , *HEART failure , *DROWSINESS - Abstract
The article discusses the relationship between depressive symptoms, sleep disturbances, daytime sleepiness, and health-related quality of life (HRQOL) in patients with chronic heart failure (CHF).
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- 2022
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8. The Effect of Guided Web-Based Cognitive Behavioral Therapy on Patients With Depressive Symptoms and Heart Failure: A Pilot Randomized Controlled Trial.
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Lundgren, Johan Gustav, Dahlström, Örjan, Andersson, Gerhard, Jaarsma, Tiny, Köhler, Anita Kärner, Johansson, Peter, and Kärner Köhler, Anita
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COGNITIVE therapy ,INTERNET in psychotherapy ,MENTAL depression ,THERAPEUTICS ,HEART failure patients ,SYMPTOMS ,QUALITY of life ,HEART failure treatment ,COMPARATIVE studies ,HEALTH behavior ,INTERNET ,RESEARCH methodology ,MEDICAL cooperation ,COMPUTERS in medicine ,QUESTIONNAIRES ,RESEARCH ,TELEMEDICINE ,PILOT projects ,EVALUATION research ,RANDOMIZED controlled trials - Abstract
Background: Depressive symptoms, and the associated coexistence of symptoms of anxiety and decreased quality of life (QoL), are common in patients with heart failure (HF). However, treatment strategies for depressive symptoms in patients with HF still remain to be established. Internet-based cognitive behavioral therapy (ICBT), as guided self-help CBT programs, has shown good effects in the treatment of depression. Until now, ICBT has not been evaluated in patients with HF with depressive symptoms.Objective: The aims of this study were to (1) evaluate the effect of a 9-week guided ICBT program on depressive symptoms in patients with HF; (2) investigate the effect of the ICBT program on cardiac anxiety and QoL; and (3) assess factors associated with the change in depressive symptoms.Methods: Fifty participants were randomized into 2 treatment arms: ICBT or a Web-based moderated discussion forum (DF). The Patient Health Questionnaire-9 was used to measure depressive symptoms, the Cardiac Anxiety Questionnaire (CAQ) was used to measure cardiac-related anxiety, and the Minnesota Living with Heart Failure questionnaire was used to measure QoL. Data were collected at baseline and at follow-up at the end of the 9-week intervention. Intention-to-treat analysis was used, and missing data were imputed by the Expectation-Maximization method. Between-group differences were determined by analysis of covariance with control for baseline score and regression to the mean.Results: No significant difference in depressive symptoms between the ICBT and the DF group at the follow-up was found, [F(1,47)=1.63, P=.21] and Cohen´s d=0.26. Secondary within-group analysis of depressive symptoms showed that such symptoms decreased significantly in the ICBT group from baseline to the follow-up (baseline M=10.8, standard deviation [SD]=5.7 vs follow-up M=8.6, SD=4.6, t(24)=2.6, P=.02, Cohen´s d=0.43), whereas in the DF group, there was no significant change (baseline M=10.6, SD=5.0, vs follow-up M=9.8, SD=4.3, t(24)=0.93, P=.36. Cohen´s d=0.18). With regard to CAQ and QoL no significant differences were found between the groups (CAQ [d(1,47)=0.5, P=.48] and QoL [F(1,47)=2.87, P=.09]). In the ICBT group in the CAQ subscale of fear, a significant within-group decrease was shown (baseline M=1.55 vs follow-up M=1.35, P=.04). In the ICBT group, the number of logins to the Web portal correlated significantly with improvement in depressive symptoms (P=.02), whereas higher age (P=.01) and male sex (P=.048) were associated with less change in depressive symptoms. This study is underpowered because of difficulties in the recruitment of patients.Conclusions: Guided ICBT adapted for persons with HF and depressive symptoms was not statistically superior to participation in a Web-based DF. However, within the ICBT group, a statically significant improvement of depressive symptoms was detected.Clinicaltrial: Clinicaltrials.gov NCT01681771; https://clinicaltrials.gov/ct2/show/NCT01681771 (Archived by WebCite at http://www.webcitation.org/6ikzbcuLN). [ABSTRACT FROM AUTHOR]- Published
- 2016
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9. Can BNP-guided therapy improve health-related quality of life, and do responders to BNP-guided heart failure treatment have improved health-related quality of life? Results from the UPSTEP study.
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Karlström, Patric, Johansson, Peter, Dahlström, Ulf, Boman, Kurt, and Alehagen, Urban
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NATRIURETIC peptides ,HEART failure treatment ,HEART failure patients ,QUALITY of life ,RANDOMIZED controlled trials - Abstract
Background: To investigate whether B-type natriuretic peptide (NP)-guided treatment of heart failure (HF) patients improved their health related quality of life (Hr-QoL) compared to routine HF treatment, and whether changes in Hr-QoL differed depending on whether the patient was a responder to NP-guided therapy or not. Methods: A secondary analysis of the UPSTEP-study, a Scandinavian multicentre study using a prospective, randomized, open, blinded evaluation design on patients with HF with New York Heart Association (NYHA) class II-IV. NP-guiding was aimed to reduce BNP <150 ng/L if < 75 years or BNP < 300 ng/L if > 75 years. A responder was defined as a patient with a BNP < 300 ng/L and/or a decrease in BNP of at least 40 % in week 16 compared to study start. Short form-36 (SF-36) was used to measure Hr-QoL. At the study start, 258 patients presented evaluable SF-36 questionnaires, 131 in the BNP group and 127 in the control group. At the study end 100 patients in the NP-guided group and 98 in the control group, presenting data from both the study start and the study end. Results: There were no significant differences in Hr-QoL between NP-guided HF treatment and control group; however significant improvements could be seen in four of the eight domains in the NP-guided group, whereas in the control group improvements could be seen in six of the domains. Among the responders improvements could be noted in four domains whereas in the non-responders improvements could be seen in only one domain evaluating within group changes. Conclusions: Improved Hr-QoL could be demonstrated in several of the domains in both the NP-guided and the control group. In the responder group within group analyses showed more increased Hr-QoL compared to the non-responder group. However, all groups demonstrated increase in Hr-QoL. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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10. Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. Results from a double blind, placebo-controlled prospective study.
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Johansson, Peter, Dahlström, Ö., Dahlström, U., and Alehagen, U.
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DIETARY supplements ,HEALTH surveys ,HEART ,HOSPITAL care ,LONGITUDINAL method ,PHYSICAL fitness ,QUALITY of life ,QUESTIONNAIRES ,SELENIUM ,UBIQUINONES ,RANDOMIZED controlled trials ,BLIND experiment - Abstract
Background: The impact of supplementation with selenium and coenzyme Q10 (CoQ10) on health-care usage and health-related quality of life (Hr-QoL) in community-dwelling elderly people has, to our knowledge, not previously been investigated. Aim: To investigate the effect of 48 months supplementation with CoQ10 and selenium on community-dwelling elderly as regards: (I) the number of days out of hospital, and (II) the effect on Hr-QoL. Methods: A 48-month double-blind randomized placebo-controlled trial was carried out. A total of 443 participants were given CoQ10 and organic selenium yeast combined, or a placebo. All admissions to the Department of Internal Medicine or Cardiology were evaluated. Hr-QoL were measured with the Short Form-36 (SF-36), the Cardiac Health Profile (CHP) and one item overall-quality of life (overall-QoL). Results: A total of 206 participants were evaluated after 48 months. No changes were found in the number of days out of hospital or Hr-QoL. A sub-analysis of participants matched for age, gender and baseline cardiac wall tension as measured by NT-proBNP was performed. The mean number of days out of hospital was 1779 for those taking the active substance compared to 1533 for those taking the placebo (p=0.03). Those with active substance declined significantly less in the HR-QoL domains of physical role performance (p=0.001), vitality (p=0.001), physical component score (p=0.001), overall QoL (p=0.001), somatic dimension (p=0.001), conative dimension (p=0.001) and global function (p=0.001). Conclusion: In a match-group analysis selenium and CoQ10 increased the number of days out of hospital and slowed the deterioration in Hr-QoL. [ABSTRACT FROM AUTHOR]
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- 2015
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11. Depression and cardiovascular disease: a clinical review.
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Hare, David L., Toukhsati, Samia R., Johansson, Peter, and Jaarsma, Tiny
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Cardiovascular disease (CVD) and depression are common. Patients with CVD have more depression than the general population. Persons with depression are more likely to eventually develop CVD and also have a higher mortality rate than the general population. Patients with CVD, who are also depressed, have a worse outcome than those patients who are not depressed. There is a graded relationship: the more severe the depression, the higher the subsequent risk of mortality and other cardiovascular events.It is possible that depression is only a marker for more severe CVD which so far cannot be detected using our currently available investigations. However, given the increased prevalence of depression in patients with CVD, a causal relationship with either CVD causing more depression or depression causing more CVD and a worse prognosis for CVD is probable. There are many possible pathogenetic mechanisms that have been described, which are plausible and that might well be important.However, whether or not there is a causal relationship, depression is the main driver of quality of life and requires prevention, detection, and management in its own right. Depression after an acute cardiac event is commonly an adjustment disorder than can improve spontaneously with comprehensive cardiac management. Additional management strategies for depressed cardiac patients include cardiac rehabilitation and exercise programmes, general support, cognitive behavioural therapy, antidepressant medication, combined approaches, and probably disease management programmes. [ABSTRACT FROM PUBLISHER]
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- 2014
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12. Psychological distress in patients with cardiovascular disease: time to do something about it?
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Johansson, Peter, Andersson, Gerhard, Jaarsma, Tiny, Lundgren, Johan, Westas, Mats, and Mourad, Ghassan
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OCCUPATIONAL roles , *SOCIAL support , *PATIENT selection , *CARDIOVASCULAR diseases , *MEDICAL care , *QUALITY of life , *MIND & body therapies , *PSYCHOLOGICAL distress , *HEALTH self-care , *HEALTH promotion - Abstract
An editorial is presented on the psychological distress such as depression and anxiety have been recognized as risk factors for poorer quality of life and a worse prognosis in patients with cardiovascular disease (CVD) and European Society of Cardiology guidelines on CVD prevention state.
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- 2021
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13. Patients with polycythemia vera have worst impairment of quality of life among patients with newly diagnosed myeloproliferative neoplasms.
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Abelsson, Johanna, Andréasson, Björn, Samuelsson, Jan, Hultcrantz, Malin, Ejerblad, Elisabeth, Johansson, Berit, Emanuel, Robyn, Mesa, Ruben, and Johansson, Peter
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HEALTH outcome assessment ,QUALITY of life ,POLYCYTHEMIA vera ,POLYCYTHEMIA ,BLOOD hyperviscosity syndrome ,MYELOPROLIFERATIVE neoplasms ,TUMORS ,PATIENTS - Abstract
The quality of life (QoL) at the time of diagnosis of myeloproliferative neoplasm (MPN) has, to date, not been studied. One hundred and seventy-nine patients with MPN: 80 with essential thrombocythemia (ET), 73 with polycythemia vera (PV), 22 with primary myelofibrosis (PMF) and four with MPN undifferentiated, were included in this study. European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQC30) and the MPN-Symptom Assessment Form (MPN-SAF) were used to evaluate QoL. Fatigue was the most reported symptom in these patients. Patients with PV reported significantly higher mean scores for inactivity, dizziness, cough, itching, depression and lower total QoL compared to patients with ET. Patients with PV had significantly more headache and itching compared to patients with PMF. When the newly diagnosed patients with MPN were compared with a cohort of patients with MPN with mean disease duration of 7.8 years, the differences were most striking for patients with PMF, with significantly more fatigue, abdominal discomfort, concentration problems, insomnia, fever, weight loss and lower overall QoL developed over time. [ABSTRACT FROM AUTHOR]
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- 2013
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14. Social support and its association with health-related quality of life among older patients with chronic heart failure.
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Årestedt, Kristofer, Saveman, Britt-Inger, Johansson, Peter, and Blomqvist, Kerstin
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HEART failure ,ANALYSIS of variance ,RESEARCH methodology ,QUALITY of life ,QUESTIONNAIRES ,SEX distribution ,SURVEYS ,MULTIPLE regression analysis ,SOCIAL support ,SOCIOECONOMIC factors ,REPEATED measures design ,SEVERITY of illness index ,DESCRIPTIVE statistics ,OLD age ,PSYCHOLOGY - Published
- 2013
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15. Association between quality of life and clinical parameters in patients with myeloproliferative neoplasms.
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Johansson, Peter, Mesa, Ruben, Scherber, Robyn, Abelsson, Johanna, Samuelsson, Jan, Birgegård, Gunnar, and Andréasson, Björn
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QUALITY of life , *MYELOPROLIFERATIVE neoplasms , *FATIGUE (Physiology) , *THROMBOCYTOSIS , *MYELOFIBROSIS , *DISEASE duration , *HEMOGLOBINS , *WEIGHT loss , *PATIENTS - Abstract
The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) is a validated quality of life (QoL) instrument. In our Swedish cohort of 114 patients the symptomatic burden was found to be severe, with fatigue reported in 88% of the patients and reduced QoL in the majority of patients. Patients with primary myelofibrosis had the highest scores, low QoL, for most MPN-SAF items, compared to patients with polycythemia vera and essential thrombocythemia. Higher age showed significant associations with the BFI (Brief Fatigue Inventory) score, early satiety, concentration problems, dizziness, insomnia, cough and weight loss. Blood values, disease duration and myelosuppressive treatment did not significantly associate with any of the MPN-SAF items, with the exception of higher hemoglobin, which correlated with sad mood. Male patients with MPN scored significantly higher as regards sexual problems and weight loss compared to female patients. Overall, the MPN-SAF was found to be a valid instrument for assessing symptomatic burden among this population. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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16. Quality of life and symptoms of depression in advanced heart failure patients and their partners.
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Jaarsma, Tiny, Johansson, Peter, Ågren, Susanna, and Strömberg, Anna
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QUALITY of life ,MENTAL depression ,HEART failure ,DISEASE management ,HEALTH self-care - Abstract
The article looks at demographic, psychosocial and clinical factors associated with the quality of life and symptoms of depression in patients with heart failure and their partners. An overview of interventions used to enhance the quality of life and reduce mental depression in heart failure patients is provided. The authors claims that education on self-care management and exercise are vital elements of disease management schemes. They emphasize the need for treatment and care to not focus on heart failure.
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- 2010
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17. Sleep disordered breathing, insomnia, and health related quality of life — A comparison between age and gender matched elderly with heart failure or without cardiovascular disease
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Johansson, Peter, Årestedt, Kristoffer, Alehagen, Urban, Svanborg, Eva, Dahlström, Ulf, and Broström, Anders
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SLEEP apnea syndromes in old age , *INSOMNIA , *PATIENTS , *CARDIOVASCULAR diseases , *HEART failure , *AGE factors in disease , *SEX factors in disease , *QUALITY of life , *COMPARATIVE studies - Abstract
Abstract: Aims: The aims of this study are (I) to compare the prevalence of sleep disordered breathing (SDB) and insomnia between elderly with heart failure (HF) and age and gender matched elderly without cardiovascular disease (CVD), and (II) to examine the association between HF, SDB and insomnia, as well as their impact on health related quality of life (Hr-QoL). Methods: Three hundred and thirty-one elderly (71–87years) community-living individuals underwent sleep recordings and echocardiography. Questionnaires assessed insomnia and Hr-QoL. Comparisons were made between age and gender matched individuals with HF (n =36) and without CVD (n =36). Results: The HF group had higher mean apnoea–hypopnoea index (17.6 vs. 6.3, p <0.001). Moderate/severe SDB was found in 42% of those with HF vs. 8% in those without CVD (p =0.001). Those with HF had more difficulties maintaining sleep (DMS) (72% vs. 50%, p =0.05) and excessive daytime sleepiness (EDS) (25% vs. 8%, p =0.05) and scored worse Hr-QoL in five of eight SF-36 domains. In regression analysis SDB had no association to Hr-QoL. DMS associated to the physical-, and non restorative sleep to the mental domain of Hr-QoL. SDB had no correlations to insomnia or EDS. Conclusions: SDB, DMS and EDS are more common in elderly with HF. SDB is not an obvious cause for sleep complaints or poor Hr-QoL in elderly. [Copyright &y& Elsevier]
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- 2010
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18. Global perceived health and ten-year cardiovascular mortality in elderly primary care patients with possible heart failure
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Johansson, Peter, Broström, Anders, Dahlström, Ulf, and Alehagen, Urban
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HEART failure patients , *HEART disease related mortality , *PRIMARY care , *HEALTH status indicators , *QUALITY of life , *HEART disease prognosis - Abstract
Abstract: Introduction: Although multi-item health-related quality of life (HRQoL) instruments provide prognostic information, they are rarely used in routine clinical practice. Aim: To examine whether a single question about global perceived health (GPH) was a prognostic indicator of cardiovascular (CV) mortality over 10 years of follow-up in elderly patients with possible heart failure (HF) in primary care. Method: GPH was measured using the first question on the Short-Form-36 concerning current health status. Of the 510 patients who underwent baseline evaluation, 448 patients were included. Results: Cox proportional regression hazard analysis controlled for age, sex, NYHA class, diabetes, ischaemic heart disease, left ventricular ejection fraction and B-type natriuretic peptide plasma concentrations, showed that patients with GPH rated as “poor” or “good” were at four (HR 4.1 CI 95% 1.8–9.4) and three times (HR 3.4 CI 95% 1.4–7.8) the risk of CV mortality, respectively. Conclusion: GPH is an independent predictor of CV mortality in elderly patients with possible HF. As a complement to clinical factors when evaluating severity of HF, GPH could be an important tool for identifying patients at risk of adverse CV events and in need of improved treatment. [Copyright &y& Elsevier]
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- 2008
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19. Consequences and Predictors of Depression in Patients With Chronic Heart Failure: Implications for Nursing Care and Future Research.
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Johansson, Peter, Dahlström, Ulf, and Brostrom, Anders
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MENTAL depression ,HEART failure patients ,QUALITY of life ,MEDICAL care ,THERAPEUTICS ,EXERCISE therapy ,STRESS management - Abstract
Depression is common among patients with chronic heart failure (HF) and leads to more symptoms of HF, decreased quality of life, and an increased risk for premature death. Depressed HF patients also use more health care resources, which increases the economic burden on the health care system. The assessment of risk factors of depression such as age younger than 60-65 years, poor physical functioning, previous depression, poor self-efficacy, living alone, and distressful relationships, in combination with the use of depression instruments, can be helpful in detecting depression in HF patients. Unfortunately, interventions on how to relieve depression in patients with HF have not been investigated thoroughly; however, depression agents as well as HF education, social support, exercise therapy, stress management, and relaxation have been shown to be useful interventions. Because of poor outcomes, studies that examine the effectiveness and/or side effects of pharmacologic as well as nonpharmacologic interventions on depressed patients with HF are needed. [ABSTRACT FROM AUTHOR]
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- 2006
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20. Factors and interventions influencing health-related quality of life in patients with heart failure: A review of the literature
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Johansson, Peter, Dahlström, Ulf, and Broström, Anders
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CARDIAC patients , *QUALITY of life , *MORTALITY , *PERSONALITY , *NURSING - Abstract
Abstract: Introduction: Because of the lack of a cure for patients with chronic heart failure (HF), there has been a progressive interest in the use of health-related quality of life (Hr-QoL) as complementary end-point to mortality and morbidity. Aim: The aim of this review was from a nursing perspective to describe Hr-QoL and the influencing factors of Hr-QoL, as well as to identify interventions aimed at influencing Hr-QoL in HF patients. Method: Medline, Cinahl and PsycInfo databases were searched from 1995 to 2004. A total of 58 papers were included. Results: HF symptoms and activity status influence Hr-QoL negatively. However, several individual characteristics such as personality, gender and age must also be taken into consideration because different values might exist regarding what constitutes a good Hr-QoL. Nurse led interventions based on education, support and exercise can influence Hr-QoL positively. There is also a need of more studies about the effects of depression, sleep disturbances, support as well as education on Hr-QoL. There is also a need of exercise studies with larger sample sizes and older patients in higher NYHA classes. Conclusion: Several individual factors impact Hr-QoL, therefore, must nursing interventions are individually adapted to the patient''s resources. [Copyright &y& Elsevier]
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- 2006
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21. The Measurement and Prevalence of Depression in Patients With Chronic Heart Failure.
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Johansson, Peter, Dahlström, Ulf, and Broström, Anders
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HEART failure ,MENTAL health ,MENTAL depression ,SYMPTOMS ,MORTALITY ,HOSPITAL care ,QUALITY of life - Abstract
Chronic heart failure is a common disease accompanied by poor mental health and depression. The diagnosis of depression is based on the presence of affective, cognitive, and somatic symptoms assessed by categoric or dimensional instruments. Depression is prominent and high rates are found with dimensional instruments in hospitalized heart failure patients. Categoric instruments seem to be more reliable but are more complex to use. Because of poor outcomes, attention should also be paid to subthreshold depression. In screening for such cases, dimensional instruments might be preferable because of the risk for underestimation by categoric instruments. Dimensional instruments might also be easier to implement in daily practice but, to reduce bias, cutoff scores might need refinement according to the clinical setting. Therefore, studies that evaluate different cutoff values are needed to find a critical level of burden from a depressive symptomatology on outcomes such as mortality, hospitalizations, and quality of life. [ABSTRACT FROM AUTHOR]
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- 2006
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22. Sleep disturbances in patients with chronic heart failure and their holistic consequences—what different care actions can be implemented?
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Broström, Anders and Johansson, Peter
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HEART failure , *HEART diseases , *QUALITY of life , *CARDIAC arrest , *SLEEP deprivation - Abstract
Abstract: Background: Sleep disturbances are prevalent among elderly, especially among those with chronic heart failure (CHF) and can affect all dimensions of quality of life (QOL) negatively. Aim: To describe the most common causes leading to sleep disturbances in patients with CHF, their consequences from a holistic perspective and different care actions that can be implemented. Methods: MEDLINE and CINAHL databases were searched from 1989 to July 2004. Findings: Sleep disordered breathing (SDB), and insomnia were the most common causes for sleep disturbances and occurs in 45–82% (SDB) and one-third (insomnia) of all patients with CHF. SDB cause a disturbed sleep structure with frequent awakenings, as well as several adverse effects on the cardiovascular system causing increased morbidity and mortality. Insomnia, caused by anxiety, an unknown life situation in relation to the debut of CHF, or symptoms/deteriorations of CHF can lead to negative effects on all aspects of QOL, as well as daytime sleepiness. Conclusion: The high prevalence of sleep disturbances and their holistic consequences should be taken into account when nurses asses and plan the care for patients with CHF. Randomized studies with large sample sizes evaluating non-pharmacological nursing interventions that improve sleep are needed. [Copyright &y& Elsevier]
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- 2005
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23. The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 patients.
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Scherber, Robyn, Dueck, Amylou C., Johansson, Peter, Barbui, Tiziano, Barosi, Giovanni, Vannucchi, Alessandro M., Passamonti, Francesco, Andreasson, Bjorn, Ferarri, Maria L., Rambaldi, Alessandro, Samuelsson, Jan, Birgegard, Gunnar, Tefferi, Ayalew, Harrison, Claire N., Radia, Deepti, and Mesa, Ruben A.
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MYELOPROLIFERATIVE neoplasms , *TUMORS , *QUALITY of life , *THROMBOCYTOSIS , *POLYCYTHEMIA vera , *CLINICAL trials , *STATISTICAL correlation - Abstract
Symptomatic burden in myeloproliferative neoplasms is present in most patients and compromises quality of life. We sought to validate a broadly applicable 18-item instrument (Myeloproliferative Neoplasm Symptom Assessment Form [MPN-SAF], coadministered with the Brief Fatigue Inventory) to assess symptoms of myelofibrosis, essential thrombocythemia, and polycythemia vera among prospective cohorts in the United States, Sweden, and Italy. A total of 402 MPN-SAF surveys were administered (English [25%], Italian [46%], and Swedish [28%]) in 161 patients with essential thrombocythemia, 145 patients with polycythemia vera, and 96 patients with myelofibrosis. Responses among the 3 administered languages showed great consistency after controlling for MPN subtype. Strong correlations existed between individual items and key symptomatic elements represented on both the MPN-SAF and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30. Enrolling physicians' blinded opinion of patient symptoms (6 symptoms assessed) were highly correlated with corresponding patients' responses. Serial administration of the English MPN-SAF among 53 patients showed that most MPN-SAF items are well correlated (r > 0.5, P < .001) and highly reproducible (intraclass correlation coefficient > 0.7). The MPN-SAF is a comprehensive and reliable instrument that is available in multiple languages to evaluate symptoms associated with all types of MPNs in clinical trials globally. [ABSTRACT FROM AUTHOR]
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- 2011
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