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Purpose -- This paper aims to present an optimal prototyping technology for the manufacture of occlusal splints. Design/methodology/approach -- To carry out this study, a comparative technique was used to analyze models obtained by different prototyping techniques. Subsequently, further tests were carried out with respect to the manufacturing of splints by means of thermoforming in a vacuum. This involved an analysis of the most important variables such as prototype material, geometric accuracy, surface finish and costs. Findings -- It was found that there is a group of prototyping technologies that are suitable for the manufacture of the models used in the thermoforming of correction splints, the most appropriate technologies being based on ink jet printing (IJP-Objet), ultraviolet photo polymerization and fused deposition modelling due to the fact that they offer an optimal relationship between the cost and the quality of the model required for thermoforming. Practical implications -- The application of rapid prototyping techniques in medicine makes the production of physical models from three-dimensional medical image processing and their subsequent use in different specialties possible. It also makes preoperative planning processes, the production of prostheses and the preparation of surgical templates possible, thereby offering a higher quality of diagnosis, safer surgery and cost and time savings compared to conventional manufacturing technologies. Originality/value -- This paper suggests that there exists a group of prototyping technologies for the manufacture of splints that offer advantages over existing technologies. The results also suggest that, in many cases, the most expensive technology is not the most appropriate: there are other options that provide an optimal model in terms of the cost and the quality needed for thermoforming. [ABSTRACT FROM AUTHOR]