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The ground-motion simulation of regional-specific earthquake scenarios is crucial for the seismic design of key facilities. Herein, we considered parameter uncertainty in ground-motion simulations and the impact of multiple faults when determining the maximum credible ground-motion parameters of large earthquakes at a near-field dam. The source models of the Daju–Lijiang, Xiaozhongdian–Daju, and Longpan–Qiaohou faults were established based on geological and geophysical data. Although the method for identifying asperity is not yet mature and still faces many difficulties, it provides an opportunity to identify the non-uniform slip distribution on the rupture plane by earthquake scenarios. A multi-scheme stochastic finite-fault simulation method was then used to estimate the minimum; mean; maximum; and 50th-, 84th-, and 95th-percentile values of the peak ground acceleration and pseudo-spectral acceleration response spectra. The results showed that the Longpan–Qiaohou fault can generate the largest ground-motion parameters compared with the other two faults. Moreover, this result was supported by the statistical analysis of the results of twelve thousand simulations of these three faults. Thus, it can be concluded that the maximum credible ground-motion parameters are represented by the 84th-percentile pseudo-spectral acceleration response spectrum of the Longpan–Qiaohou fault. This finding will benefit the seismic safety design of the target dam. More importantly, this multi-scheme method can be applied to other key facilities to obtain reasonable ground-motion parameters.

The East Kunlun Fault Zone, as a highly seismically active fault, has witnessed five earthquakes with magnitudes exceeding M7.0 to the west of Animaqing Mountain since 1900. Conversely, the historical records for the Maqin–Maqu segment in the east of Animaqing Mountain show no M7.0 or above earthquakes, designating it as a distinctive seismic gap within this fault zone. We analyzed the tectonic background and structural features of the Maqin–Maqu segment within the East Kunlun Fault Zone to evaluate its potential seismic capacity. Utilizing a new established probability recurrence model, we calculated the seismic hazard for both segments over the next 100 years. The results indicate that the probability of M7.0 or above earthquake occurring in the Maqu segment in the next 100 years is 11.47%, classified as a moderate probability event. The joint probability of at least one M7.0 or above strong earthquake occurring in the entire Maqin–Maqu segment in the next 100 years is 16.14%, also classified as a moderate probability event, while the probability for the Maqin segment alone is 5.36%, classified as a low probability event. Considering the uncertainty of the probability model, a qualitative hazard classification for each segment was further conducted. The comprehensive evaluation suggests a low risk of a major earthquake occurring in the Maqin segment in the next 100 years, while the Maqu segment is assessed to have a higher risk.

Core-shell (C/S) structured upconversion coated Fe3O4 nanoparticles (NPs) are of great interest due to their potential as magnetic resonance imaging (MRI) and upconversion luminescent (UCL) imaging agents, as well as near-infrared activated photodynamic therapy (PDT) platforms. When C/S structured Fe3O4@Mn2+-doped NaYF4:Yb/Er NPs were prepared previously, well-defined C/S-NPs could not be formed without the doping of Mn2+ during synthesis. Here, the role of Mn2+ doping on the synthesis of core-shell structured magnetic-upconversion nanoparticles (MUCNPs) is investigated in detail. Core-shell-shell nanoparticles (C/S/S-MUCNPs) with Fe3O4 as the core, an inert layer of Mn2+-doped NaYF4 and an outer shell consisting of Mn2+-doped NaYF4:Yb/Er were prepared. To further develop C/S/S-MUCNPs applications in the biological field, amphiphilic poly(maleic anhydride-alt-1-octadecene) (C18PMH) modified with amine functionalized methoxy poly(ethylene glycol) (C18PMH-mPEG) was used as a capping ligand to modify the surface of C/S/S-MUCNPs to improve biocompatibility. UCL imaging, T1-weighted MRI ascribed to the Mn2+ ions and T2-weighted MRI ascribed to the Fe3O4 core of C/S/S-MUCNPs were then evaluated. Finally, chlorine e6 (Ce6) was loaded on the C/S/S-MUCNPs and the PDT performance of these NPs was explored. Mn2+ doping is an effective method to control the formation of core-shell structured MUCNPs, which would be potential candidate as multifunctional nanoprobes for future T1/T2-weighted MR/UCL imaging and PDT platforms.