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In early-stage Alzheimer's disease (AD) amyloid-β (Aβ) deposition can induce neuronal hyperactivity, thereby potentially triggering activity-dependent neuronal secretion of phosphorylated tau (p-tau), ensuing tau aggregation and spread. Therefore, cortical excitability is a candidate biomarker for early AD detection. Moreover, lowering neuronal excitability could potentially complement strategies to reduce Aβ and tau buildup. There is, however, a lack of understanding of the relationship between cortical excitability and p-tau increase in vivo. Therefore, in a sample of 658 healthy middle-aged (between the ages of 40 and 65) participants of the Barcelona Brain Health Initiative cohort study, we examined the relation of blood-based tau, phosphorylated at amino acid 181 (p-tau181), reflecting neuronal p-tau secretion; neurofilament light chain (NfL), as a passively released control for p-tau181; and electroencephalography (EEG) markers of cortical excitability. A subsample of 47 participants also completed a controlled brain perturbation approach via transcranial magnetic stimulation (TMS) with concurrent EEG. Results show that both spontaneous (i.e., resting-state) and perturbation-based TMS-EEG markers, are associated with blood p-tau181, particularly in older individuals. The perturbation-based marker was a significantly more sensitive predictor of p-tau181 concentration than the spontaneous resting state EEG-based marker. The relationships observed are not present for the NfL control. These results show that relationships between p-tau181 and cortical excitability are present in healthy middle-aged subjects and that p-tau181 increases may reflect activity-dependent secretion.

Ion mobility spectrometry is an emerging technology in trace gas analysis that has moved from typical safety and security applications to many other fields ranging from environmental and food quality monitoring to medicine and life sciences. Nevertheless, further dissemination, including the development of new instruments and the expansion into new fields of application requires the availability of the fundamental components of ion mobility spectrometers. For example, the electronics is essential for the analytical performance, but is only provided by specialized manufacturers due to specific requirements. In this paper, we present a modular, isolated high-voltage switch that can be operated at an isolated potential. The modular design enables tailoring its configuration to the required application. Each module can switch a voltage of up to 3 kV, and can be operated with an offset voltage of up to 7 kV. The switch has rise and fall times of less than 25 ns, making it suitable for a wide range of applications, e.g., in ion mobility spectrometry. Finally, the presented modular, isolated high-voltage switch was used in a push–pull configuration to generate the injection pulse of the ion gate. The new modular, isolated high-voltage switch shows similar performance compared to a commercially available high-voltage switch.

Introduction: Endoscopic ultrasound (EUS)-guided lumen-apposing metal stents (LAMS) represent a novel tool in therapeutic endoscopy. However, the presence of LAMS may dissuade surgeons from operations with curative-intent. We report three clinical scenarios with deployment of LAMS in patients that subsequently underwent pancreaticoduodenectomy (PD). Methods: Six patients identified from our IRB-approved pancreas cancer database had EUS-LAMS placement prior to PD. Patient, tumor, treatment-related variables, and outcomes are herein reported. Results: Two patients underwent a LAMS gastrojejunostomy (GJ) for duodenal obstruction. Another patient underwent LAMS choledochoduodenostomy (CDS) for malignant biliary obstruction. In three patients, a LAMS gastrogastrostomy or jejunogastrostomy was deployed post Roux-en-Y gastric bypass (RYGB) for a EUS-directed transgastric ERCP (EDGE) procedure. The hospital length of stay after LAMS placement was 0–3 days without morbidity. Patients subsequently proceeded to either classic PD (n = 5) or PPPD (n = 1). Interval from LAMS insertion to surgery ranged from 28 to 194 days. Mean PD operative time and EBL were 513 minutes and 560 mL, respectively. Post-PD hospital length of stay was 4–17 days. Clavien-Dindo IIIb morbidity required percutaneous drainage of intra-abdominal collections in two patients. In cases involving LAMS-GJ and CDS, the LAMS directly impacted the surgeon's preference not to perform pylorus preservation. Conclusions: In this case series, PD following EUS-LAMS was feasible with acceptable morbidity. Additional studies with larger patient populations are needed to evaluate LAMS as a bridge to PD with curative-intent.

Air pollution is a global environmental and public health challenge. There is limited evidence about the air quality in Rwanda, and the concentrations of particulate matter (PM), namely PM2.5 and PM10 in schools have not been well documented. This study evaluated patterns and disparities in indoor PM levels in selected primary schools in Kigali, Rwanda.The study collected PM2.5 and PM10 concentrations from six classrooms in six selected primary schools during the regular school study period in the dry season. Data were collected using mobile air sensors (purple air/PA–II–SD air quality) and an observation checklist. A Kruskal-Wallis test was performed to assess the difference in PM2.5 and PM10 concentrations between the six schools. The post-hoc Mann-Whitney test was used to compare all group pairs.The results indicated a significant difference in both the indoor PM2.5 concentration (H (5) = 41.01, p

Introduction: Sexual violence (SV) is frequent in universities, and a link has been demonstrated between SV and toxic substance use by university students in leisure settings. In Spain there is little scientific evidence in this regard, and SV prevention programmes are practically non-existent in Spanish universities. Objectives: To develop, implement, and evaluate an educational awareness-raising intervention regarding SV aimed at empowering university students to develop healthy affective-sexual relationships. Methods: Participatory action research intervention, implemented with a convenience sample of students recruited in a public university and qualitatively evaluated using a phenomenological approach. Results: The sample was composed of 22 women students, whose discourse revealed that SV acts are normalized in university leisure settings featured by the consumption of alcohol and other drugs. Post-intervention, the participants showed an increased understanding of SV, a heightened awareness of SV, and a greater capacity to identify SV acts. The intervention empowered the participants in terms of coping with SV situations and in raising awareness in their own social circles. Conclusions: The intervention changed the participants' attitudes and behaviours regarding SV, empowering them not only regarding their own affective-sexual relationships, but also in censoring attitudes and behaviours that foster SV, and in transmitting their acquired knowledge of SV in their social circles. Post-intervention, the participants considered themselves to be agents of social change in their environment and in terms of healthy affective-sexual relationships. Public contribution: University students participated in and evaluated an intervention that trained them to identify and to censor attitudes and behaviours that promote SV, empowered them as engines of social change, and showed them how to foster healthy affective-sexual relationships.

Los coeficientes intrínsecos y extrínsecos de dispersión y absorción de ocho muestras de cristales líquidos dispersos en polímero no absorbedoras de luz, con dos diferentes tamaños del área activa y con cuatro diferentes espesores de la capa interna active, en sus estados de apariencia óptica translucidos apagados y transparentes encendidos –sin y con voltaje eléctrico aplicado respectivamente– fueron satisfactoriamente determinados siguiendo el mismo procedimiento descrito en trabajos anteriores con un dispositivo de partículas suspendidas –una muestra de ventana inteligente absorbedora de luz– y con otra muestra de ventana inteligente de cristales líquidos dispersos en polímero. Este procedimiento, basado en los modelos de transferencia radiativa de dos flujos y de cuatro flujos, considera el ángulo crítico de reflectancia interna total para determinar la reflectancia difusa interna de interface, y utiliza la misma ecuación propuesta previamente para el parámetro de camino promedio, basada en las intensidades difusas y totales de los haces de luz hacia adelante y hacia atrás, para resolver el modelo de cuatro flujos a fin de determinar los coeficientes intrínsecos. La apariencia óptica simulada resultó ser un estado apagado translucido blanco lechoso y un estado encendido transparente incoloro que llega a ser más transparente para las muestras de cristales líquidos dispersos en polímero con espesores más finos, requiriendo mayor voltaje aplicado para los estados ópticos encendidos transparente de las muestras caracterizadas de cristales líquidos dispersos en polímero.

Abstract Background Peppers, bell and chile, are a culturally and economically important worldwide. Domesticated Capsicum spp. are distributed globally and represent a complex of valuable genetic resources. Objectives Explore population structure and diversity in a collection of 467 peppers representing eight species, spanning the spectrum from highly domesticated to wild using 22,916 SNP markers distributed across the twelve chromosomes of pepper. Results These species contained varied levels of genetic diversity, which also varied across chromosomes; the species also differ in the size of genetic bottlenecks they have experienced. We found that levels of diversity negatively correlate to levels of domestication, with the more diverse being the least domesticated.

Background: Remote teaching of procedural skills has demonstrated equivalence in knowledge acquisition compared to in-person teaching. Variations in terminology for probe and needle movements may serve as a barrier in remote training of ultrasound (US)-guided renal access for percutaneous nephrolithotomy (PCNL). This pilot study investigated the utility of standardized terminology in remote training of US-guided renal access for PCNL. Hypothesis: Standardization of verbal terminology to describe US probe and needle movement instruction improves remote teaching of US-guided renal access. Methods: Fifteen urology residents (PGY1-6) were stratified by year and randomized into two groups. We provided participants with images illustrating US probe and needle movements labeled with predetermined standardized terminology for the intervention group and images without labels for the control group. Both groups were asked to perform US-guided renal access on a training mannequin with a remote faculty educator with (intervention) or without (control) use of standardized movement instructions. Quantitative outcomes included number of attempts and time to achieve access. All trainees completed pre- and post-session surveys and participated in focus groups; authors conducted thematic analysis of focus group transcripts. Results: Differences in primary outcomes between groups, including number of attempts and time to achieve access of the renal pole, were not statistically significant. Analysis of focus group interviews revealed that the use of standardized terminology in the setting of remote training can reduce trainee confusion by clarifying ambiguity in educator feedback. Discussion: Use of standardized terminology during remote surgical skills training allows for more effective feedback to trainees.

In this study, we present a hybrid CNN-RNN approach to investigate long-term survival of subjects in a lung cancer screening study. Subjects who died of cardiovascular and respiratory causes were identified whereby the CNN model was used to capture imaging features in the CT scans and the RNN model was used to investigate time series and thus global information. To account for heterogeneity in patients' follow-up times, two different variants of LSTM models were evaluated, each incorporating different strategies to address irregularities in follow-up time. The models were trained on subjects who underwent cardiovascular and respiratory deaths and a control cohort matched to participant age, gender, and smoking history. The combined model can achieve an AUC of 0.76 which outperforms humans at cardiovascular mortality prediction. The corresponding F1 and Matthews Correlation Coefficient are 0.63 and 0.42 respectively. The generalisability of the model is further validated on an ‘external’ cohort. The same models were applied to survival analysis with the Cox Proportional Hazard model. It was demonstrated that incorporating the follow-up history can lead to improvement in survival prediction. The Cox neural network can achieve an IPCW C-index of 0.75 on the internal dataset and 0.69 on an external dataset. Delineating subjects at increased risk of cardiorespiratory mortality can alert clinicians to request further more detailed functional or imaging studies to improve the assessment of cardiorespiratory disease burden. Such strategies may uncover unsuspected and under-recognised pathologies thereby potentially reducing patient morbidity.

Emerging data suggest that post-traumatic stress disorder (PTSD) arises from disrupted brain default mode network (DMN) activity manifested by dysregulated encephalogram (EEG) alpha oscillations. Hence, we pursued the treatment of combat veterans with PTSD (n = 185) using an expanded form of repetitive transcranial magnetic stimulation (rTMS) termed personalized-rTMS (PrTMS). In this treatment methodology spectral EEG based guidance is used to iteratively optimize symptom resolution via (1) stimulation of multiple motor sensory and frontal cortical sites at reduced power, and (2) adjustments of cortical treatment loci and stimulus frequency during treatment progression based on a proprietary frequency algorithm (PeakLogic, Inc. San Diego) identifying stimulation frequency in the DMN elements of the alpha oscillatory band. Following 4 - 6 weeks of PrTMS® therapy in addition to routine PTSD therapy, veterans exhibited significant clinical improvement accompanied by increased cortical alpha center frequency and alpha oscillatory synchronization. Full resolution of PTSD symptoms was attained in over 50% of patients. These data support DMN involvement in PTSD pathophysiology and suggest a role in therapeutic outcomes. Prospective, sham controlled PrTMS® trials may be warranted to validate our clinical findings and to examine the contribution of DMN targeting for novel preventive, diagnostic, and therapeutic strategies tailored to the unique needs of individual patients with both combat and non-combat PTSD.

Psychosocial hardships associated with the COVID-19 pandemic led many individuals to suffer adverse mental health consequences, however, others show no negative effects. We hypothesized that the electroencephalographic (EEG) response to transcranial magnetic stimulation (TMS) could serve as a toy-model of an individual's capacity to resist psychological stress, in this case linked to the COVID-19 pandemic. We analyzed data from 74 participants who underwent mental health monitoring and concurrent electroencephalography with transcranial magnetic stimulation of the left dorsolateral prefrontal cortex (L-DLPFC) and left inferior parietal lobule (L-IPL). Within the following 19 months, mental health was reassessed at three timepoints during lock-down confinement and different phases of de-escalation in Spain. Compared with participants who remained stable, those who experienced increased mental distress showed, months earlier, significantly larger late EEG responses locally after L-DLPFC stimulation (but not globally nor after L-IPL stimulation). This response, together with years of formal education, was significantly predictive of mental health status during the pandemic. These findings reveal that the effect of TMS perturbation offers a predictive toy model of psychosocial stress response, as exemplified by the COVID-19 pandemic.

Summary: We present a protocol to generate an advanced ex vivo model of human placenta. We use a vibrating tissue slicer to obtain precision-cut slices representative of the entire thickness of human placenta. This approach delivers standardized cultures with a preserved microstructure and cellular composition comparable to the native tissue. We applied this system to study SARS-CoV-2 infection at the maternal-fetal interface. Moreover, this system can be used to investigate the basic functions of the human placenta in health and disease.For complete details on the use and execution of this protocol, please refer to Fahmi et al. (2021).

The Famine Early Warning Systems Network (FEWS NET) has been appraising food security in numerous countries around the world since 1985. Multiple times per year, FEWS NET reports scores for current situation assessments and future projections of food security. The scores are measured on a five-level index scale and gauged for the geographic units of livelihood zones. These zones vary in size and do not remain static, which complicates comparison of food security within and across countries and over time. To facilitate such analysis and interoperability with other sources, we transformed available raw data to the units of geospatial grid-cells that have a uniform, static resolution of 0.5° × 0.5°, a common format of data used in research across diverse disciplines. FEWS NET provides public online access to shapefiles reflecting reports back to 2009. Separate shapefiles capture assessments and projections, with further delineation by the index score. Each shapefile can comprise a complex (multi)polygon, without clear differentiation among livelihood zones. Overlaying a geospatial grid allows disaggregation of the (multi)polygons to standard units. We performed the transformation to grid-cells on the shapefiles for all 25 countries (including Yemen) that FEWS NET tracked within regional groupings of East, Southern, and West Africa from July 2009–October 2020. For each report cycle, each grid-cell was assigned scores of the assessment and near-term and medium-term projections, based on the raw data for the corresponding livelihood zone. In addition, we calculated a value of bias in medium-term projections relative to subsequent assessments, which can be used as a metric for validation of accuracy. This article provides access to the grid-cell data on assessment and projection scores and bias values. In addition, we present time-lapse animated maps as tools to visualize historical patterns and trends in these indicators across Africa. Our related research article employed the grid-cell data to evaluate the accuracy of FEWS NET projections, including as a function of variation in humanitarian assistance, climate conditions, and violent conflict (Backer and Billing [1]). Researchers can likewise use the grid-cell data to conduct further validation of food security projections and to examine the relationship of assessments and projections to potential drivers and consequences. The data and animations are also valuable to stakeholders throughout the international community seeking to learn and disseminate knowledge about the tendencies of food security projections on a broad scale.

Inflammatory responses to the novel coronavirus SARS-CoV-2, which causes COVID-19, range from asymptomatic to severe. Here we present a follow-up analysis of a longitudinal study characterizing COVID-19 immune responses from a father and son with distinctly different clinical courses. The father required a lengthy hospital stay for severe symptoms, whereas his son had mild symptoms and no fever yet tested positive for SARS-CoV-2 for 29 days. Father and son, as well as another unrelated COVID-19 patient, displayed a robust increase of SERPING1, the transcript encoding C1 esterase inhibitor (C1–INH). We further bolstered this finding by incorporating a serum proteomics dataset and found that serum C1–INH was consistently increased in COVID-19 patients. C1–INH is a central regulator of the contact and complement systems, potentially linking COVID-19 to complement hyperactivation, fibrin clot formation, and immune depression. Furthermore, despite distinct clinical cases, significant parallels were observed in transcripts involved in interferon and B cell signaling. As symptoms were resolving, widespread decreases were seen in immune-related transcripts to levels below those of healthy controls. Our study provides insight into the immune responses of likely millions of people with extremely mild symptoms who may not be aware of their infection with SARS-CoV-2 and implies a potential for long-lasting consequences that could contribute to reinfection risk.

Somatic mutations of the estrogen receptor 1 gene (ESR1) is an emerging mechanism of acquired resistance to endocrine therapy in hormonal breast cancers. Hotspot point mutations in the ligand- binding domain of estrogen receptor α (ER) and genomic rearrangements producing ESR1 fusion genes are the two major types of mutations that are associated with endocrine resistance. The crosstalk between X-box binding protein 1 (XBP1), a key transcription factor of the unfolded protein response (UPR) and ER signalling creates a positive feedback loop that results in increased expression of XBP1 in ER-positive breast cancer. Here we report that XBP1 co-operated with point mutants (Y537S, D538G) and fusion mutants (ESR1-YAP1, ESR1-DAB2) of ESR1 to increase their transcriptional activity. XBP1 was required for optimal expression of estrogen-regulated genes, and up to 40% of XBP1-dependent genes were estrogen-responsive genes. Knockdown of XBP1 in genome-edited MCF7 cells expressing Y537S mutant reduced their growth, re-sensitized them to anti-estrogens and attenuated the constitutive and estrogen-stimulated expression of estrogen-regulated genes. Our study provides a rationale for overcoming endocrine resistance in breast cancers expressing ESR1 mutation by combining the XBP1 targeting agents with anti-estrogen agents.

Background: Paediatric sepsis remains a major public health problem with significant morbidity and mortality especially in developing countries. Clinical symptoms associated with sepsis are unreliable and laboratory parameters unspecific, making an early diagnosis of paediatric sepsis difficult. The lack of definitive biomarker(s) for early diagnosis of sepsis further leads to the misuse of antibiotics. Diagnosis based on a single biomarker does not provide adequate accuracy. Subsequently, combining multiple biomarkers into a single score will help clinicians make a better diagnostic judgment. Aims: This study for the first time evaluated the individual and combined diagnostic accuracy of procalcitonin (PCT), presepsin (sCD14-ST) and high sensitive C-reactive protein (hs-CRP) using a Bioscore model. Materials and methods: In a case control study conducted at the Paediatric Emergency Unit (PEU) and the Mother and Baby Unit (MBU) of Komfo Anokye Teaching Hospital (KATH), sixty (60) paediatric subjects aged zero to six (0–6) years, were diagnosed with sepsis using case-definition by the national neonatal bloodstream infection surveillance and Pediatric Sepsis Consensus Congress. Thirty (30) other paediatric subjects, aged and sex matched without sepsis or inflammatory conditions were used as controls. One-time blood sample was taken at the time of admission for blood culture and measurement of PCT, hs-CRP, and presepsin by ELISA. The Statistical Package for Social Sciences (SPSS release 20.0, Copyright ©SPSS Inc.) was used for analysis. Results: Out of the sixty septic paediatric subjects, 14 patients (23.3%) had positive blood cultures (LCS) and 46 (76%) had negative for blood cultures (CS). Klebsiella spp. recorded the highest median levels of PCT, and hs-CRP while Pseudo. Aeruginasa recorded the highest of sCD14-ST levels. Significant elevations in PCT, sCD14-ST and hs-CRP levels were observed among septic cases in comparison to controls (p < 0.0001). Individually, PCT showed better accuracy (AUC = 78.7%) followed by hs-CRP (AUC = 78.4%) and sCD14-ST (AUC = 74.8%). Combination of PCT + hs-CRP had the highest accuracy (AUC = 80.1%) followed by hs-CRP + sCD14-ST (AUC = 77.2%), PCT + sCD14-ST + hs-CRP (AUC = 77.0%) and PCT + sCD14-ST (AUC = 75.9%).Conclusion: hs-CRP, PCT, and sCD14-ST are independent predictors of paediatric sepsis due to their high prognostic values. Moreover, Bioscore combination of these biomarkers was significantly associated with increased odds for sepsis. The incorporation of these biomarkers into routine diagnostic tests will aid in prompt diagnosis of paediatric sepsis.

This article aims to analyze the causes of pathological manifestations in a residential complex. This in situ investigation investigated and identified the types of pathologies found in the concrete structure as well as cataloging the main manifestations in specific rooms of the complex's central residence. From this, an appropriate treatment was determined for each room, meeting the specifications of ABNT technical standards for the recovery and maintenance of the structure. The manifestations found were: cracks, cracks, repression, stains, shedding of the paint on the walls and ceiling, leaching, efflorescence, carbonation, corrosion and exposure of the armor. These manifestations appeared in a very short period of the useful life of the structure after the completion of the building, around 7 years, which revealed many errors in architectural design, materials without technological control and with inferior functionality and quality, among others.

A script was developed to perform homogenous radiolysis calculations. It was used specifically to calculate radiolysis products under various neutron and gamma flux environments [1]. The routine may be used to calculate a single radiolysis condition, multiple independent conditions, or multiple conditions computed in series (the final concentration set of run i is the initial concentration of run i+1). While designed for radiolysis of water, the routine is easily adapted to a variety of aqueous reaction systems and may even be altered with minimal effort for more general homogenous chemical analysis. In the present article, the Python routine is explained along with various outputs and inputs. It and the relevant input and output text files are included as supplementary materials. They are the raw data used for calculation of figures in the associated journal article.

This article has as its central scope to capture the challenges faced by service providers for delivery applications and urban mobility on demand such as Uber, 99POP, iFood, Rappi, among others, a profession that has emerged with innovations in technology and Industry 4.0, which with the Brazilian economic crisis, a mass of workers changed their careers out of necessity and faced new challenges, with a category that is not recognized by law, there are flaws in terms of job security, and the study will also analyze the main diseases and injuries acquired while working. In addition to highlighting other risks faced by this new category of workers, such as urban violence in large cities. For this, a descriptive research was carried out with qualitative and quantitative analysis of data using books, articles, dissertations, newspapers and magazines to support the analysis of the content extracted from the interviews that took place from January/2020 to March/2020, where it was possible to know and describe the routine, the difficulties, as well as the activities that directly affect the health and safety of this service provider's work.

El desarrollo, departamento al mismo de El tiempo Quiché que forma posee parte importantes de un corredor remanentes seco, de el arquitectura cual limita sus residencial capacidades tradicional agrícolas rural y de adobe y teja asociados al paisaje del altiplano con elementos representativos del bosque seco y especies endémicas. Estos remanentes han ido desapareciendo y ya son escasos en el país. El presente estudio determinó la vulnerabilidad paisajística desde un enfoque multidisciplinario, por medio de una investigación práctica explicativa. El resultado obtenido fue conocer la vulnerabilidad paisajística del municipio de Sacapulas recabada en cartografía georreferenciada, como una herramienta relevante para la toma de decisiones para proteger y/o potenciar el uso del paisaje con un enfoque de valoración patrimonial y de desarrollo sostenible. Se utilizó para análisis de paisaje la determinación de unidades de características homogéneas y áreas de visibilidad asociada al relieve desde un eje ubicado en la carretera principal, el método de análisis se organizó en tres niveles: (1) elementos primarios de la percepción, (2) de la percepción elaborados para el diagnóstico y (3) de la percepción para la toma de decisión. Dicho proceso utiliza como base cartografía digital georreferenciada. Se obtuvo un mapeo de vulnerabilidad visual y paisajística. El principal resultado es la cartografía que indica las áreas con mayor vulnerabilidad paisajística la cual permite a instituciones y tomadores de decisiones tomar en cuenta el valor paisajístico que esta puede tener en cuanto a ser intervenida en cualquier momento.

This work is scoped to perform field work in Ecoart Structure and Production company to identify the factors that contribute to stress at work, and way to solve it. In this context the study notes that occupational stress can be caused by several factors present daily in organizations, damaging the working environment, productivity and so the company's profit. Stress index refers to the control of absences at times when workers are the scheduled time of the workday. The concept can also be better understood by the sum of the periods in which employees of a given organization absent from the work, including delays within their normal working hours. The method adopted for the realization of the research was descriptive. The typology of the adopted research covered three aspects: on the objectives treated is a deductive research; as the problem of approach was qualitative and quantitative; on the technical procedures, was literature. Through the survey it was observed that the valuation of intellectual capital can be a proposal for the reduction of occupational stress, as the successful application of this theory for the treatment of stress is to assimilate possible decision-making for managers of the resource area humans. At the end of this research are addressed recommendations that may be in guidelines for the management of people in organizations for the effective management of the causes and consequences of occupational stress, through the enhancement of intellectual capital.

The escape route is used to indicate the emergency exit, leading to the exit, stairs, fire doors and not obstructing them. In all companies there is a use of signs that indicate an escape route in emergencies. These plates are made of special materials that allow the visualization of the same case of power failure. The batteries contain a special ink or film that is being charged by ambient light. The values are varied from material to material and should be analyzed according to a demand definition.

This work of completion aimed to demonstrate the importance of the use of PPE in construction with awareness and guiding the use of personal protective equipment at the construction site area. It is estimated that the construction activity is responsible for many accidents, by requiring its employees to expose themselves to environmental hazards, such as: physical, chemical, biological, ergonomic and accidents. Considering that the Personal Protective Equipment PPE are important security items from working, since, in construction using the same becomes sporadic or non-existent on the part of service providers and employees, even if they have knowledge of the law and standards. During the study we can observe and note that the use of PPE is very important and essential in reducing the risks of accidents during the execution of the activities and their functionality, because the protection of the physical integrity and health of the employee is not isolated behavior, and these must have training and technical guidance on the appropriate use of personal protective equipment. It is understood that the lack of planning of a competent security system can cause occurrences of accidents, causing losses for low productivity and increased costs. Thus, it is evident the importance and prominence that has gained the use of PPE in construction, because this is a topic that has been evolving and requires continuous recycling of professionals in this area.

The lack of project management in the municipality of Presidente Figueiredo has consequences for work safety, which has been a notorious case of inapplicability of engineering sector norms, causing risk to the operation being performed as well as to all involved. Therefore, this article proposes the search to detect errors and thus improve efficiency through indicators that can be followed by companies, since it is common knowledge that management still presents itself erroneously in the civil sector.

Regarding the historic squares of the city, several have reached a stage of total degradation others have disappeared or suffer from overuse or misuse. Methodology: bibliographic and field research. Revitalization deals with a series of steps that lead a given space to have new efficiency, a new sense of usability, improving its surroundings in order to provide its residents and visitors a better living and leisure space. The proposal has a modern architecture following the standards of reforms that are currently being made in all major cities of the country, among its modifications include the implementation of outdoor gym, playground, ramps designed within accessibility standards, tactile floor installation, etc. The cost of the project will be R $ 255,837.02 plus BDI rate of 23.89%, lasting 60 days for its completion.

The purpose of this work is to develop an Automated Guided Vehicle (AGV) for the transport of microwave oven bulbs for white-line companies. In order to do so, it is proposed to project and implement a mobile reactive robot that transports light bulb boxes with of defined weights, this robot being a line follower with built in sensors to move, making use of the computational tool Autodesk Inventor for drawing and mechanical tests and the development of the software in a language based on C/C ++, called Wiring. The assembly of the robot began with the creation of the mechanical design with the intention of assisting in the management and supply of the white lines providing a simple and fluid management delivering the bulbs on the depot path to the production lines not requiring the employee to leave the working environment. avoiding losses such as time and work accident while loading the product. The results obtained in the experiments performed during the research showed that the system performed the movement in a stable and correct way, that is, following the line until finding the requested position.

The civil construction sector in Manaus is in continuous growth, just walk through the city and observe the excessive amount of construction, repairs and renovations. As a result, the development of techniques and methods to make sustainable day-to-day activities sustainable has intensified since the practice of reuse of construction waste is the worldwide trend towards mitigation of environmental problems. The reuse system is the technique that has been adopted by construction companies with the objective of lowering the environmental impact, as well as the reduction of costs with the creation of other new products of the same rhyme, which ensures the success of sales of the products in the construction market. As Manaus does not yet have a recycling and processing plant, as provided for in the COMANA Resolution since 2002 for these wastes, companies are at the mercy of the will of others that can easily lead them to places that are inappropriately used illegally. It should be noted that the survey carried out a survey of waste entering and leaving the worksite in the city of Manaus and proposed a roadmap for the implementation of a solid waste management plan to improve and correct waste disposal.

The uses of Individual Protection Equipment is fundamental to guarantee the professional safety, the objective of this work was to analyze how the small construction companies has been handling this subject in Amazonas, specifically in the Municipality of Presidente Figueiredo, where the research was carried out. A questionnaire was applied addressing topics of simple understanding for a better understanding of the interviewees. With the results of the research, comparative charts were elaborated. The research results reveal that employees have knowledge about the use of PPE, but there is a great lack of supervision and management of work safety in the participating companies.

This project intends to elaborate a computer program that will constitute the results of research and the educational difficulty level of the riverside population of Paraná, in the Municipality of Careiro da Várzea, advising the teachers and students with a regional language and easy to know, highlighting traditional learning in a participatory way. With a perception of construction management, the techniques used in the activities will be used to manage the stages based on knowledge of PMBoK v4.

This article will evaluate in the context of occupational safety. The disposition of risks within the company Via Sat élite communications LTDA. To perform the work at first, a technical visit was made to the company, a photographic report was generated and a questionnaire was answered by the workers. Afterwards, with these data, a floor plan of the site was generated and the risks were identified according to the environments, generating the risk map, taking advantage of the information and based on specific laws and regulations, was prepared the fire-fighting project. It was observed that the company has fire-fighting equipment with proper use conditions and correctly quantified and leased, also noted a greater predominance of ergonomic risk in return for the company's great concern with employee safety.

In Brazil, the state is responsible for investing 5% of its gross domestic product in public works, from various sectors, from infrastructure to health unit reforms. In theory, this investment should warm the market and ensure an adequate infrastructure, but what happens is a slow market and a high index of works not completed, abandoned or delivered in disagreement with the minimum conditions of use. This work aims, through the analysis of three budgets, to check within this limited cut, the quality and feasibility of budgets pre-arranged for the execution of works. After analyzing the cases presented, it was possible to conclude that there is a divergence between the market value and the budgeted value, due to the absence of compositions necessary for the proper execution of the service, it was also observed the absence of compensatory mechanisms of the natural lag of base prices of the budgets and the values of inputs when the work is carried out.

The Civil Construction is one of the sectors of economic activity that most absorbs accidents at work and where the risk of accidents is higher. The theme of safety and health in construction is relevant not only because it is a dangerous activity, but also, above all, because the prevention of work-related accidents requires specific focus, both by the particular nature of construction work and by the temporary character of the work centres (works). The purpose of this study is to present this topic in such a way as to highlight its contributions to the Management of Safety and Health. The data collection was made through a bibliographical review, from which it was possible to study all outstanding prominencies in NR 18, noting that this subject is highly favored in terms of providing the human well, both internally and externally to society, as acting in the project phase, providing for security measures in the post, where audits, performance indicators and contractual clauses on safety and health should be provided. I work in relation to the companies that act on the work.

There is a known shortage in the technical literature regarding fire prevention and fire fighting, which is often not even a constant subject in the curriculum of engineering courses. In Manaus, fire projects are regulated by the Fire Brigade Technical Standards, so there is often a technical deficiency in the preparation of these projects. In this context this work is inserted, aiming to provide a logical and normative roadmap for the correct design of fire prevention and fire prevention facilities. The object of study adopted is a Shed of 2,112.00 square meters, located in the West Zone of Manaus. The design determined a mixed fire fighting system between extinguishers and fire hydrants, requiring the adoption of elevated reservoir systems and fire pumps.

The use of individual protective equipment (IPE) is extremely essential for any activity that is prone to occupational hazards and / or illnesses that could threaten the safety and health of the worker. The construction market has grown abundantly in recent years, and consequently the risk of accidents in this work environment as well. There are several reasons for this growing increase in accidents at work, among them is the Contracting Company that does not provide correctly the equipment of personal protection for its employees and the lack of commitment and interest of the employees in the use of protective equipment. The objective of this study is to evaluate the use of individual protection equipment in the construction company in a given service rendering, which includes the construction of reinforced concrete wall and drainage network installation, observing the methods used for adhesion and control of the use of IPE. Although the work is short-term and the accident risk is high, in the course of the work up to the date of delivery, a satisfactory result was obtained both for the Company and for the employees involved in the activities, as it had no accident of job.

Today we have several technological management tools, but still many projects or processes do not fit in any of them, the purpose is to report how simple, easy and effective to use the PDCA Cycle and help in decision making, guiding the path to improvement continuous management of processes or projects. The aim of this paper is also to elucidate the importance of the tool applied in the professional qualification course of Residential Hydraulic Installer of SENAI Demóstenes Travessa School, showing benefits in the acquisition of inputs and consequently lower financial expenses and environmental impacts.

The study of occupational risk analysis is a technique that has been gaining ground among companies that care about the health and safety of their employees. This study has as its main objective to identify and analyze the probable risks in a trade in the Center of Manaus, in order to prevent accidents and propose improvements to make the work environment adequate for the activities. This study basically consists of three steps: visual description where it was observed through site visit; Risk identification and proposed improvements to address the problem. As a result, it was found that commerce has ergonomic and accident risks. And it was proposed safety measures and use of PPE to prevent occupational accidents.

This paper aims to highlight the importance of Internal Auditing for the Treasury sector in particular for a Construction Industry, as well as to investigate whether Internal Auditing systems can be considered as a tool in the procedures. management Due to the constant growth in the last years, the Construction Industries, linked to the existence of a specific branch of the new administration, reflected in the main objective of this work that focuses on proposing an Independent Audit work in the financial sector with the accounting sector of the company object of our study, for the purpose of ascertaining the procedures adopted organization with its customers. Regarding the methodology adopted by this research we have that the research was descriptive and bibliographic, because it was based on material published in books, newspapers, magazines, websites, among others. However, a case study carried out in the month of August/2019 in the premises of a Construction Industry that makes up the subject of this research stands out. Finally, regarding the need for transparency in the company's treasury, it was found that there are tools available to organizations for systematic use.

In many construction texts, the risk of falling becomes worrying, often overlooked and / or overlooked as an employee or employee. The MTE (Ministry of Labor and Employment) presents 30% of occupational investments that occur each year and falls from a height. In order to reduce the rate of falls, a Regulatory Standard No. 35, located for work at height, with a reference capacity for this work was created. safety. And with the expansion over the years, an increasing number of accidents have been added, and so on, increasingly frequent. This work aims to implement a Regulatory Standard - NR 35 for an improvement of the work execution process.

The pesticide has been used over time to optimize agricultural production and prevent certain types of unwanted fungi or herbs in its production with certain pesticides making it harmful to health both by consuming and especially by creating a direct contact, using as base the work safety standards imposed by federal law. 7,802, July 11, 1989 and Decree 4,074, January 4, 2002, NR15 and NR31 aiming at the correct application of pesticides and better storage using the field research methodology, photographic records and questionnaires with the rural worker, resulting in non-compliance with the same already mentioned for lack of correct use of PPE during the application and lack of MSDS (Chemical Safety Data Sheet) at the storage site, however in view of the information presented, attention is needed with the rural worker and his quality of work.

The slabs, as it is a project above 2 meters must be aligned with the NRs, so that no accidents occur with workers during the execution of the project. Given the above, this research aims to: Analyze the Work Safety Standards for Slab Execution and as specific objectives: Contextualize civil construction; To show the problems of construction with respect to safety at work; Highlight work safety standards for slab execution. It was found that the use of NRs in the Lajes construction process is important, so that no accidents occur in the work environment, as well as during the entire construction process. In the construction process as a whole. The use of IPEs is proven to be highly relevant to avoid work accidents, as well as the lectures and guidance given by professionals to civil construction workers.

Civil construction has great representation for the socioeconomic development of our country. However, it is an activity that, if not carried out within the safety standards required by our labor legislation, provides great trends for labor incidents. The present work aims to address the risks inherent to the misuse of cement in the construction industry for the health of workers, having seen, because cement is a chemical agent that can be inhaled through the respiratory tract or, due to direct contact. with the skin and mucous membranes, and also, by oral intake, provides the severe emergence of pathologies in the health of workers submitted to continuous contact with it. Initially, it will be presented characteristics of this material, as well as some examples of pathologies associated with the use of the product and, finally, emphasize the importance of the use of safety and prevention measures capable of avoiding the referred damages to the workers health. For this, we used the methodology of bibliographic research in scientific sources already consecrated referring to the theme dissertated here that allow to prove the theme treated here. Thus, with the conclusion of the subject, it is concluded that it is necessary to use all necessary safety measures to ensure the development of the activity, but especially to ensure the integrity and health of workers who are in continuous contact with the cement.

For a long time, water was considered only as a means of consumption for the survival of living beings. I was not concerned about its quality for its own consumption. But over time, due to many deaths from drinking non-potable water, there have been various adaptations and technologies have emerged for better consumption and treatment of this material. The objective of this research is to analyze the water quality of the Cachoeira Grande stream located in the São Jorge neighborhood in the city of Manaus in order to know the health and safety of the residents and the general population of the Amazonian capital. The analyzes were performed through the physical, chemical and microbiological characteristics of the water collected in three distinct points, near the margins of the stream. The results analyzed were already obvious and yet were disturbing, since there is a great neglect that concerns society in general.

Walkways are scaffolding erected to cross natural or artificial barriers and take care of the passenger's own safety. There are walkways over rivers, lakes, roads, railroads, valleys and also as connections between buildings, which aim at the physical distance between pedestrian flow and disorders that individuals are not able to cope with, such as water currents, the height of buildings and vehicles at high speed. The theme "Design of Reinforced Catwalk" aims to demonstrate how the design of a reinforced concrete walkway, showing the possible pathologies that may occur in these structures. The article followed the precepts of exploratory study, through bibliographic research, was developed from material already prepared, consisting of scientific articles. It has been found that it is important to consider the permanent load of the element. In the case of walkways, the load must be established in addition to its own weight, by variables that are part of the physical framework itself, other fixed overloads, such as: concrete slab, steel structures, paving, railing, signs, among others. . As for pathologies, it was concluded that the best option to prevent pathological conditions is prevention. Prevention is generated not only by a project or execution within the quality parameters, but mainly by a structural maintenance program. These programs play an important role in any structure, facilitating the verification of structural deterioration states and favoring the reduction of treatment costs. These procedures will certainly prevent the formation of marked and widespread pathologies.

This article is about the behavior of leaders in business management, showing the need for good leaders in today's world, their characteristics, skills and competences. This literature review seeks to find a model, a leader that best suits in different situations for the XXI century proposing that the appointment of leaders in companies be made through this analysis of criteria, not only in function of IQ or the function they occupy, but because of their true ability to influence people. Good leaders can hardly lose control, are confident, and can handle different styles of people. For leadership positions it has been proven through research that you need to have E.Q, emotional quotient, plus strategic vision.

Planning is an administrative tool that makes it possible to perceive reality, evaluate paths, build a future framework, structure the appropriate process and reassess the entire process for which it is intended. The budget derives from the management planning process. Planning is therefore the rational side of action. This research presents a study regarding budget errors due to the lack of prior planning through comparative analysis by observing case studies and identifying good procedures to be replicated, and suggesting recommendations to be adopted by organizations that are adopting or intending to adopt a process. implementation of planning and budget management of works. Among the main errors are the lack of parameterization of budget items and the failure to follow up on field activities. It is up to the engineering professional to pay attention to the correct execution of the monitoring and planning process so that he gets the success of his work.

The use of Personal Protective Equipment (PPE) is a method of preventive action against accidents at work, with a purpose to preserve the individual from the threats to his individual health and safety. The objective of this work is to elucidate the success of the methodology applied in the student body of the SENAI Demóstenes Travessa School, regarding the use of PPE in professional qualification courses, preventing and raising awareness among students seeking knowledge to apply in the labor market or in their personal lives, I try in view that, the school is focused on the follow-up of construction, one of the sectors that most accidents occur.

This article will evaluate the human resources and materials management of Via satellite communications LTDA. In business management, Materials and Personnel Resources are used to size inventory, distribute jobs and activities, define the appropriate physical structure of the enterprise, and others. Therefore, a study was conducted to evaluate the management of these resources. To perform the work, a photographic report was generated and a questionnaire was answered by the interviewee, a floor plan of the place was generated and the flow of materials from inside the store was determined, a flow chart of positions and description of activities performed was also prepared. The company has a good division of functions, material handling control, and adequate structure for the activity developed. It was suggested greater stock organization and workers' awareness of the internal material processing.

Recruiting a recruitment and selection that points the interests of companies and values the process with feedback directed to the candidate is the new practice of many companies seeking to reach the human side. The aim of this study is to discuss the importance of the Recruitment and Internal Selection process in the P&S Enterprise by using a case study as a research method to analyse the organizational results. In this way, it is concluded that the company correctly uses its career plan, giving due importance to the institution's recruitment and internal selection process. In order to enhance the knowledge of the managers who act in this process of employee review, the company could provide specific courses for their managers when they will enhance their knowledge in planning, recruiting and empowering the individual to suit the organization's organizational system.

Currently, the subject of Project Management has received great evidence in the business world due to the competition dispute and increasing competitiveness, which makes the business organizations present solutions more quickly and efficiently to external stimuli, in civil construction has been growing the concept of project management with the purpose of having term, quality, profit in the services rendered. With this vision, several tools, methodologies and even organizational entities have been developed with the purpose of ensuring that the projects achieve the expected results. Thus, with several processes and tasks, the project integration management area has high professional relevance, ranging from the elaboration of the scope, through the monitoring and control of the project, and ends in the organization of the final materials, as well as in the lessons learned. Thus, the article will present a project integration plan developed by a construction service provider, the integration plan aims to meet Project management, Time management, Cost management, Quality management and Human resources and their respective controls.