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Your search keyword '"Gorczyca M"' showing total 5 results
Start Over Author "Gorczyca M" Topic purines
5 results on '"Gorczyca M"'

1. Chemical and pharmacological properties of new tetrahydropyrimido-[2,1-f]-purines.

Author

Pawłowski M, Drabczyńska A, Gorczyca M, Malec D, and Modzelewski J

Subjects
Amphetamine antagonists & inhibitors, Amphetamine pharmacology, Animals, Anti-Anxiety Agents pharmacology, Anticonvulsants pharmacology, Antipsychotic Agents pharmacology, Body Temperature drug effects, Catalepsy chemically induced, Catalepsy prevention & control, Central Nervous System Agents pharmacology, Central Nervous System Agents toxicity, Lethal Dose 50, Magnetic Resonance Spectroscopy, Male, Mice, Motor Activity drug effects, Pentylenetetrazole, Purines pharmacology, Purines toxicity, Pyrimidines pharmacology, Pyrimidines toxicity, Rats, Rats, Wistar, Seizures chemically induced, Seizures prevention & control, Central Nervous System Agents chemical synthesis, Purines chemical synthesis, Pyrimidines chemical synthesis
Abstract

Following a research program on piperazinoalkyl-substituted tricyclic purines, a number of N-9-aryl(alkyl)-piperazinopropyl substituted tetrahydropyrimido-[2,1-f]-purines were synthesized and tested pharmacologically with respect to their influence on the central nervous system. Two of the new compounds induced hypothermia and decreased the spontaneous locomotor activity of mice.

Published
1995

2. The influence of new 9-(omega-[4-(2-pyrimidinyl)-1-piperazinyl]alkyl) pyrimidino[2,1-f]purines on the central nervous system.

Author

Malec D, Modzelewski J, Drabczyńska A, Pawłowski M, and Gorczyca M

Subjects
Animals, Male, Mice, Psychotropic Drugs adverse effects, Psychotropic Drugs chemistry, Purines adverse effects, Purines chemistry, Rats, Rats, Wistar, Structure-Activity Relationship, Brain drug effects, Psychotropic Drugs pharmacology, Purines pharmacology
Abstract

Synthesis and the results of preliminary pharmacological evaluation of four new 9-substituted pyrimidino[2,1-f]purines, containing pyrimidinyl-piperazine substituent are described. Some of these substances induced hypothermia, antagonism of amphetamine action and neurotoxic effects. All compounds had weaker activity on the central nervous system than previously studied compounds containing phenyl-piperazine substituent.

Published
1995

3. Synthesis and pharmacological screening of novel 10-substituted diazepino-[2,1-f]-purines.

Author

Pawłowski M, Drabczyńska A, Gorczyca M, Malec D, and Modzelewski J

Subjects
Animals, Central Nervous System Agents pharmacology, Central Nervous System Agents toxicity, Drug Design, Drug Interactions, Lethal Dose 50, Male, Mice, Purines chemistry, Rats, Rats, Wistar, Structure-Activity Relationship, Theophylline chemistry, Theophylline metabolism, Behavior, Animal drug effects, Central Nervous System Agents chemical synthesis, Purines metabolism, Theophylline analogs & derivatives
Abstract

Two series of N10 substituted derivatives of 1,3-dimethyl-2,4,9-trioxo-1,3,6,7,8,10-hexahydro-1,3-diazepino+ ++-[2,1-f]- purine and 1,3-dimethyl-2,4-dioxo-1,3,6,7,8,9-hexahydro-10H-1,3-dizepino- [2,1-f]-purine were synthesized and tested for CNS activity. The most active in central nervous system tests were compounds [II] and [XIV].

Published
1994

4. Synthesis and preliminary pharmacological assessment of novel 9-alkylamino substituted pyrimidino-[2,1-f]-purines.

Author

Drabczyńska A, Pawłowski M, Gorczyca M, Malec D, and Modzelewski J

Subjects
Animals, Body Temperature drug effects, Central Nervous System Depressants chemical synthesis, Central Nervous System Depressants toxicity, Drug Evaluation, Preclinical, Magnetic Resonance Spectroscopy, Male, Mice, Motor Activity drug effects, Purines chemical synthesis, Purines toxicity, Rats, Rats, Wistar, Behavior, Animal drug effects, Central Nervous System Depressants pharmacology, Purines pharmacology
Abstract

Two series of N9-alkylaminomethyl-, alkylpiperazino-, alkylpiperidino-substituted 1,3-dimethyl-(hexahydropyrimidino)- and (tetrahydropyrimidono)-[2,1-f]-purines were prepared and their physicochemical and pharmacological properties were described. The most active in central nervous system tests were the compounds with phenylpiperazinealkyl substituent i.e. 1,3-dimethyl-2,4-dioxo-9-[N1N4-(phenyl)-piperazinopropyl]-1, 3,6,7,8,9- hexahydropyrimidino-[2,1-f] purine 6a and its butyl and isobutyl homologs 9 and 12. The compounds depressed statistically significantly spontaneous locomotor and amphetamine activity and showed sedative, analgetic and hypothermizing properties.

Published
1992

5. Synthesis and preliminary pharmacological assessment of novel 9-substituted pyrimidino-[2,1-f]-purines.

Author

Pawłowski M, Drabczyńska A, Gorczyca M, Malec D, and Modzelewski J

Subjects
Amphetamine pharmacology, Animals, Anticonvulsants, Antidepressive Agents pharmacology, Apomorphine pharmacology, Body Temperature drug effects, Catalepsy chemically induced, Haloperidol pharmacology, Lethal Dose 50, Male, Mice, Motor Activity drug effects, Purines pharmacology, Purines toxicity, Pyrimidinones pharmacology, Pyrimidinones toxicity, Rats, Rats, Inbred Strains, Reserpine antagonists & inhibitors, Spectrophotometry, Infrared, Stereotyped Behavior drug effects, Purines chemical synthesis, Pyrimidinones chemical synthesis
Abstract

Synthesis, chemical properties and results of preliminary pharmacological evaluation of several new 9-substituted pyrimidino-[2,1-f]-purines are described. The most interesting was 1,3-dimethyl-2,4,8-trioxo-9-[gamma-N1-(N4-C6H5)-piperazynopropy l]-1,3,6,7-tetrahydro-9H-pyrimidino-[2,1-f]-purine (compound 4a), which exerted strong sedative, hypothermizing and cataleptogenic action and possessed some anti-amphetamine and anti-apomorphine properties.

Published
1991

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