1. Intralesional vincristine use for treatment of squamous cell carcinoma in a puma (Puma concolor).
- Author
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Sandoval BJ, Amat AC, Sabri J, and Ramli MN
- Subjects
- Animals, Antineoplastic Agents administration & dosage, Carcinoma, Squamous Cell drug therapy, Injections, Intralesional veterinary, Male, Skin Neoplasms drug therapy, Vincristine administration & dosage, Antineoplastic Agents therapeutic use, Carcinoma, Squamous Cell veterinary, Puma, Skin Neoplasms veterinary, Vincristine therapeutic use
- Abstract
A 14-yr-old male puma (Puma concolor) was presented to the veterinary staff of the National Zoo in Malaysia for an auricular mass. Squamous cell carcinoma was diagnosed by histologic examination of a biopsy. Systemic administration of chemotherapy using vincristine (0.5 mg/m2 i.v. q. 7 days for six treatments) and prednisolone (2 mg/kg i.m. q. 72 hr x 7 days) caused side effects of vomiting, weight loss, and alopecia and did not improve the size or appearance of the tumor. Intralesional vincristine injections (0.2 mg q. 7 days for two treatments) and prednisolone (2 mg/kg i.m. q. 72 hr x 15 days) were administered, resulting in complete tumor regression after 14 days of treatment.
- Published
- 2013
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