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Instruction cues are widely employed for research on neural mechanisms during movement preparation. However, their influence on brain connectivity during movement has not received much attention. Herein, 15 healthy subjects completed two experimental tasks including either instructed or voluntary movements; meanwhile electroencephalogram (EEG) data were synchronously recorded. Based on source analysis and related literature, six movement-related brain regions were selected, including the left/right supplementary motor area (SMA), left/right inferior frontal gyrus (iFg), and left/right postcentral gyrus (pCg). After assuming 10 a priori models of regional brain connectivity, we evaluated the optimal connectivity model between brain regions for the two scenarios using the dynamic causality model (DCM). During voluntary movement, the movement originated in the SMA, passed through the iFg of the prefrontal lobe, and then returned to the main sensory cortex of the pCg. In the instructed movement, the movement originated in the iFg, and then was transmitted to the pCg and the SMA, as well as from the pCg to the SMA. In contrast to the preparation process of voluntary movement, there were long-range information interactions between the iFg and pCg. Further, almost the same brain regions were active during movement preparation under both voluntary and instructed movement tasks, which evidences certain similarities in dynamic brain connectivity, that is, the brain has direct connections between the bilateral SMA, bilateral pCg, and bilateral SMA, indicating that the both brain hemispheres work together during the movement preparation phase. The results suggest that the network during the preparation process of instructed movements is more complex than voluntary movements.

This exploratory study investigated the association between self-reported impulsiveness and cortical gray matter volume (GMV) of the entire cortex in healthy adults. As a secondary objective and based on preliminary findings concerning the positive association between self-reported impulsiveness and the slant of the forehead degrees (SFD), we analyzed associations between SFD, GMV and impulsiveness. We obtained 48 structural magnetic resonances. The participants also completed BIS 11 and profile pictures were obtained. SFD was measured by a photographic support and a protractor. The GMV of the whole cortex was obtained for each participant through Freesurfer. Firstly, we found negative and positive correlations between fronto-temporal and occipital areas respectively and BIS. Second, we found negative correlations between SFD and GMV in right postcentral gyrus, right caudal middle frontal gyrus, right transverse temporal cortex and positive correlation in left entorhinal cortex. Third, we observed a positive correlation between SFD and BIS in all impulsiveness scores. In conclusion, variations in fronto-temporal and posterior cerebral areas are crucial for BIS in healthy adults. Furthermore, SFD was associated with BIS and correlated with GMV areas involved in self-reported impulsiveness.

Objective:\ud Studies have shown that males are more prevalence than females in Internet gaming disorder (IGD). This study was set to explore the sex difference on the effect of IGD in resting states of the brain.\ud \ud Methods:\ud Resting-state fMRI data were collected from 58 recreational Internet game users (RGU, male = 29) and 46 IGD subjects (male = 23). Regional homogeneity (ReHo) was used to calculate group difference between the subjects. A two-way ANOVA was used to explore the IGD-by-sex interactions. Correlations between addiction severity and the ReHo values were also calculated.\ud \ud Results:\ud Significant sex-by-group interactions were found associated with the brain features in the right posterior cingulate (rPCC), left middle occipital gyrus (lMOG), right middle temporal gyrus (rMTG), and right postcentral gyrus (rPG). Post-hoc analysis revealed that comparing with same-sex RGUs, male IGD showed decreased ReHo in the rPCC, and the ReHo in the rPCC was also negatively associated with Internet addiction test (IAT) scores for male subjects. Moreover, male IGDs showed increased ReHo, but female ones showed decreased ReHo, in both lMOG and rMTG, when comparing with same-sex RGUs.\ud \ud Conclusions:\ud Sex differences were observed in brain regions that are responsible for executive control, visual and auditory perception. These sex differences should be taken into consideration in future studies and the treatment of IGD.

More than 100 million people worldwide are thought to have alcohol use disorder, also known as AUD, alcohol dependence or alcoholism. People who struggle to regulate their emotions tend to consume more alcohol than others. This suggests that impaired emotion processing may increase the risk of developing the disorder. Most studies of emotion processing in people with alcohol use disorder do not distinguish between men and women. But evidence suggests that men and women process emotions in different ways. Sawyer et al. set out to explore the possible relationships between emotion processing, gender and alcoholism. Four groups of volunteers took part in the study: abstinent men and women with the disorder, and control groups of men and women without a history of alcoholism. Each group contained between 15 and 21 participants. The two abstinent alcoholic groups had not consumed alcohol for at least 21 days. The average length of abstinence was 7 years. The volunteers viewed a mixture of emotionally charged and neutral images while lying inside a brain scanner. The emotionally charged images were of happy, erotic, gruesome or aversive scenes. Sawyer et al. measured the difference in brain responses to the emotionally charged images versus the neutral ones, and compared this measure across the four groups of participants. Abstinent alcoholic men showed muted brain responses to the emotionally charged images compared to their female counterparts. This effect was seen in brain regions involved in memory, emotion processing and social processing. The same pattern occurred for all four types of emotionally charged image. Abstinent alcoholic men also showed smaller brain responses to the emotionally charged images than non-alcoholic control men. By contrast, abstinent alcoholic women showed larger brain responses to the emotionally charged images than non-alcoholic control women. This suggests that abstinent alcoholic men and women differ in the way they process emotions. Future studies should investigate whether these differences emerge over the course of abstinence. They should also examine whether these differences might contribute to, or result from, differences in alcohol use disorder between men and women.

The aim of this study is to investigate the genetic influence on the cerebral cortex, based on the analyses of heritability and genetic correlation between grey matter (GM) thickness, derived from structural MR images (sMRI), and associated white matter (WM) connections obtained from diffusion MRI (dMRI). We measured on sMRI the cortical thickness (CT) from a large twin imaging cohort using a surface-based approach (N = 308, average age 22.8 ± 2.3 SD). An ACE model was employed to compute the heritability of CT. WM connections were estimated based on probabilistic tractography using fiber orientation distributions (FOD) from dMRI. We then fitted the ACE model to estimate the heritability of CT and FOD peak measures along WM fiber tracts. The WM fiber tracts where genetic influence was detected were mapped onto the cortical surface. Bivariate genetic modeling was performed to estimate the cross-trait genetic correlation between the CT and the FOD-based connectivity of the tracts associated with the cortical regions. We found some cortical regions displaying heritable and genetically correlated GM thickness and WM connectivity, forming networks under stronger genetic influence. Significant heritability and genetic correlations between the CT and WM connectivity were found in regions including the right postcentral gyrus, left posterior cingulate gyrus, right middle temporal gyri, suggesting common genetic factors influencing both GM and WM. Hum Brain Mapp 37:2331-2347, 2016. © 2016 Wiley Periodicals, Inc.

An object’s location can be represented either relative to an observer’s body effectors (egocentric reference frame) or relative to another external object (allocentric reference frame). In non-spatial tasks, an object’s task-irrelevant egocentric position conflicts with the side of a task-relevant manual response, which defines the classical Simon effect. Growing evidence suggests that the Simon effect occurs not only based on conflicting positions within the egocentric but also within the allocentric reference frame. Although neural mechanisms underlying the egocentric Simon effect have been extensively researched, neural mechanisms underlying the allocentric Simon effect and their potential interaction with those underlying its egocentric variant remain to be explored. In this fMRI study, spatial congruency between the task-irrelevant egocentric and allocentric target positions and the task-relevant response hand was orthogonally manipulated. Behaviorally, a significant Simon effect was observed for both reference frames. Neurally, three sub-regions in the frontoparietal network were involved in different aspects of the Simon effect, depending on the source of the task-irrelevant object locations. The right precentral gyrus, extending to the right SMA, was generally activated by Simon conflicts, irrespective of the spatial reference frame involved, and showed no additive activity to Simon conflicts. In contrast, the right postcentral gyrus was specifically involved in Simon conflicts induced by task-irrelevant allocentric, rather than egocentric, representations. Furthermore, a right lateral frontoparietal network showed increased neural activity whenever the egocentric and allocentric target locations were incongruent, indicating its functional role as a mismatch detector that monitors the discrepancy concerning allocentric and egocentric object locations.

Metacognition refers to the ability to discriminate between one's own correct and incorrect decisions. The neurobiological underpinnings of metacognition have mainly been studied in perceptual decision-making. Here we investigated whether differences in brain structure predict individual variability in metacognitive sensitivity for visuomotor performance. Participants had to draw straight trajectories toward visual targets, which could unpredictably deviate around detection threshold, report such deviations when detected, and rate their confidence level for such reports. Structural brain MRI analyses revealed that larger gray-matter volume (GMV) in the left middle occipital gyrus, left medial parietal cortex, and right postcentral gyrus predicted higher deviation detection sensitivity. By contrast, larger GMV in the right prefrontal cortex but also right anterior insula and right fusiform gyrus predicted higher metacognitive sensitivity. These results extend past research by linking metacognitive sensitivity for visuomotor behavior to brain areas involved in action agency (insula), executive control (prefrontal cortex) and vision (fusiform).

Aim: Existing studies have shown that gray matter changes may be involved in the pathophysiology of major depression disorder (MDD). However, whether the severity of the disease can affect the change of gray matter was still controversial. The aim of the present study is to identify the changes of gray matter on patients with currently depressed MDD (cMDD) using metaanalysis based on the reported studies with VBM. Methods: A systematic retrieval of PubMed, Web of Science, Embase, Medline, and Science Direct was conducted to identify VBM studies that compared the gray matter differences between MDD patients (untreated or not recovered) and healthy controls. A meta-analysis was then carried out to quantitatively evaluate the gray matter changes of patients with cMDD. Results: Seventeen data sets from 14 studies were used in the present meta-analysis. The results showed reduced gray matter in the left superior temporal gyrus, right superior temporal gyrus, right insula, left median network, and left inferior parietal gyrus in patients with cMDD. It was also shown that the percentage of female patients and the mean age did not have a significant relationship with gray matter changes. Conclusion: The meta-analysis in the present study showed that the gray matter reduction not only exists in the frontal lobe and the hippocampus of patients with cMDD as reported in previous studies, but also exists in the temporal lobe, which may also be important in the pathophysiology basis of MDD.

Mild traumatic brain injury (mTBI) patients frequently experience emotion dysregulation symptoms, including post-traumatic stress. Although mTBI likely affects cortical activation and structure, resulting in cognitive symptoms after mTBI, early effects of mTBI on cortical emotion processing circuits have rarely been examined. To assess early mTBI effects on cortical functional and structural components of emotion processing, we assessed cortical activation to fearful faces within the first 2 weeks after motor vehicle collision (MVC) in survivors who did and did not experience mTBI. We also examined the thicknesses of cortical regions with altered activation. MVC survivors with mTBI (n = 21) had significantly less activation in left superior parietal gyrus (SPG) (−5.9, −81.8, 33.8; p = 10−3.623), left medial orbitofrontal gyrus (mOFG) (−4.7, 36.1, −19.3; p = 10−3.231), and left and right lateral orbitofrontal gyri (lOFG) (left: −16.0, 41.4, −16.6; p = 10−2.573; right: 18.7, 22.7, −17.7; p = 10−2.764) than MVC survivors without mTBI (n = 23). SPG activation in mTBI survivors within 2 weeks after MVC was negatively correlated with subsequent post-traumatic stress symptom severity at 3 months (r = −0.68, p = 0.03). Finally, the SPG region was thinner in the mTBI survivors than in the non-mTBI survivors (F = 11.07, p = 0.002). These results suggest that early differences in activation and structure in cortical emotion processing circuits in trauma survivors who sustain mTBI may contribute to the development of emotion-related symptoms.

Voluntary selection between response alternatives belongs to cognitive abilities controlling and regulating goal-directed behaviour. Voluntary selection processes are associated with increased neural activity, especially in medial and lateral frontal brain regions as well as the inferior parietal gyrus. However, the precise function of each brain region as well as the spatiotemporal characteristic of the brain regions involved is not yet clear. The aim of the present study was to disentangle distinct aspects of voluntary selection and their underlying neural processes. Hence, event-related potentials (ERPs) and functional MRI data were acquired simultaneously. Brain regions modulated by the task-induced amplitude variation of ERPs (N2, P3) were identified. The results showed N2-related hemodynamic responses, especially in medial and lateral frontal brain regions. Among other things, medial frontal brain regions are related to conflict monitoring, control of voluntary action and decision making. By contrast, the P3-amplitude proved to be predominantly related to increased BOLD responses in the temporo-parietal junction and lateral frontal brain regions. These brain regions are thought to play a decisive role in an attentional network involved in detecting auditory and visual stimuli. Overall, the results of the study indicated a whole network of brain regions to be associated with voluntary selection processes. In addition, at least some frontal brain regions seemed to be involved at an earlier stage than temporo-parietal regions, probably indicating a top-down process.

Prior behavioral studies suggested that global perception of compound stimuli is modulated by the way the local elements are grouped into global structures. The current work examined whether dis- tinct neural mechanisms are involved in global/local processing of compound stimuli when local elements are grouped into global shapes by proximity or by shape similarity. Functional magnetic resonance im- aging (fMRI) was used to measure neural activities associated with global/local processing of compound shapes that were presented against either a black background (Experiment 1) or a background of crosses (Experiment 2) while subjects discriminated close or open shapes at the global or local level. Global processing induced activation in the medial occipital cortex in Experiment 1 but in the right inferior temporal, superior parietal, and inferior frontal cortex, and the left inferior parietal gyrus in Experiment 2. Local processing was associated with activations in the left precentral gyrus and right superior temporal gurys in Experiment 1 but in the left posterior inferior parietal gyrus in Experiment 2. The fMRI results suggest that global perception is mediated by distinct neural substrates depending upon how local ele- ments are grouped into global structures.

This study examined brain activation in children with developmental coordination disorder (DCD) to reveal areas that may contribute to poor movement execution and/or abundant motor overflow. Using functional magnetic resonance imaging, 13 boys with DCD (mean age = 9.6 years ±0.8) and 13 typically developing controls (mean age = 9.3 years ±0.6) were scanned performing two tasks (finger sequencing and hand clenching) with their dominant hand, while a four-finger motion sensor recorded contralateral motor overflow on their non-dominant hand. Despite displaying increased motor overflow on both functional tasks during scanning, there were no obvious activation deficits in the DCD group to explain the abundant motor overflow seen. However, children with DCD were found to display decreased activation in the left superior frontal gyrus on the finger-sequencing task, an area which plays an integral role in executive and spatially oriented processing. Decreased activation was also seen in the left inferior frontal gyrus, an area typically active during the observation and imitation of hand movements. Finally, increased activation in the right postcentral gyrus was seen in children with DCD, which may reflect increased reliance on somatosensory information during the execution of complex fine motor tasks.

Whether Tai Chi Chuan (TCC) can influence the intrinsic functional architecture of the human brain remains unclear. To examine TCC-associated changes in functional connectomes, resting-state functional magnetic resonance images were acquired from 40 older individuals including 22 experienced TCC practitioners (experts) and 18 demographically matched TCC-naive healthy controls, and their local functional homogeneities across the cortical mantle were compared. Compared to the controls, the TCC experts had significantly greater and more experience-dependent functional homogeneity in the right postcentral gyrus (PosCG) and less functional homogeneity in the left anterior cingulate cortex (ACC) and the right dorsal lateral prefrontal cortex (DLPFC). Increased functional homogeneity in the PosCG was correlated with TCC experience. Intriguingly, decreases in functional homogeneity (improved functional specialization) in the left ACC and increases in functional homogeneity (improved functional integration) in the right PosCG both predicted performance gains on attention network behavior tests. These findings provide evidence for the functional plasticity of the brain’s intrinsic architecture toward optimizing locally functional organization, with great implications for understanding the effects of TCC on cognition, behavior and health in aging population.

OBJECTIVE The bulk of recent studies have tested whether video games change the brain in terms of activity and cortical volume. However, such studies are limited by several factors including cross-sectional comparisons, co-morbidity, and short-term follow-up periods. In the present study, we hypothesized that cognitive flexibility and the volume of brain cortex would be correlated with the career length of on-line pro-gamers. METHODS High-resolution magnetic resonance scans were acquired in twenty-three pro-gamers recruited from StarCraft pro-game teams. We measured cortical thickness in each individual using FreeSurfer and the cortical thickness was correlated with the career length and the performance of the pro-gamers. RESULTS CAREER LENGTH WAS POSITIVELY CORRELATED WITH CORTICAL THICKNESS IN THREE BRAIN REGIONS: right superior frontal gyrus, right superior parietal gyrus, and right precentral gyrus. Additionally, increased cortical thickness in the prefrontal cortex was correlated with winning rates of the pro-game league. Increased cortical thickness in the prefrontal and parietal cortices was also associated with higher performance of Wisconsin Card Sorting Test. CONCLUSION Our results suggest that in individuals without pathologic conditions, regular, long-term playing of on-line games is associated with volume changes in the prefrontal and parietal cortices, which are associated with cognitive flexibility.

In the present study, we used the two-pronged trident task to investigate the neural basis of impossible figures processing by using event-related functional magnetic resonance imaging (fMRI). Our fMRI results showed that there were no brain regions with significantly stronger responses to possible condition than to impossible condition. However, impossible condition showed significantly more activation in the right inferior temporal gyrus (ITG), the fusiform gyrus (FG) and the right superior parietal gyrus (SPG). The right SPG in the dorsal visual pathway might be related to spatial information processing and the right lateral occipital complex (LOC) (FG and ITG) in the ventral visual pathway (the object-selective regions) might be related to the representation of the impossible 3D structure. Therefore, our results indicated that the impossible 3D structure might be difficult to be represented by human visual system, and the impossible perception might be derived from the detecting and resolving the contradiction in the subjects’ interpretations according to different perceptions triggered by 3D cues.

We investigated changes in the behavioral performance and brain activities associated with word priming in a Word Stem Completion (WSC) task in Japanese. In the behavioral results, we found obvious facilitatory effects in subject's performance. The percentage of correct answers in word non priming (P/N) condition was 94%, while the percentage of correct answers in word priming P/Y-condition was 100%. Averaged reaction time in word P/N- condition was 1501ms, while that of word P/N-condition was 978ms and 3106ms in non word P/Y-condition respectively. In the fMRI experiment, the same tasks were performed by the block-design experimental paradigm without any overt response in MRI scanner. As the fMRI results, we found the activations in the bilateral middle and inferior frontal gyrus with right hemispheric prevalence, the superior and inferior parietal gyrus, and the supplementary motor area. The prefrontal-parietal network observed in our study is consistent with the activated areas in word stem task in English. These results suggested that the facilitatory effects observed in WSC-test include implicit memory access and the induced attention after successful retrieval.

We conducted an event-related, functional MRI investigation of 12 male's and 12 female's reasoning about conditional deontic rules, rules regulating people's behavior. We employed two different types of rules: social contracts and nonsocial, precautionary rules. Although the rules and the demands of the task were matched in terms of their logical structure, reasoning about social contracts and precautions activated a different constellation of neurological structures. The regions differentially activated by social contracts included dorsomedial PFC (BA 6/8), bilateral ventrolateral PFC (BA 47), the left angular gyrus (BA 39), and left orbitofrontal cortex (BA 10). The regions differentially activated by precautions included bilateral insula, the left lentiform nucleus, posterior cingulate (BA 29/31), anterior cingulate (BA 24) and right postcentral gyrus (BA 3). Collectively, reasoning about prescriptive rules activated the dorsomedial PFC (BA 6/8). The results reinforce the view that human reasoning is not a unified phenomenon, but is content-sensitive.

Voluntary selection between response alternatives belong to cognitive abilities controlling and regulating goal-directed behaviour. Voluntary selection processes are associated with increased neural activity, especially in medial and lateral frontal brain regions as well as the inferior parietal gyrus. However, the precise function of each brain region as well as the spatiotemporal characteristic of the brain regions involved is not yet clear. The aim of the present study was to disentangle distinct aspects of voluntary selection and their underlying neural processes. Hence, event-related potentials (ERPs) and functional MRI data were acquired simultaneously. Brain regions modulated by the task-induced amplitude variation of ERPs (N2, P3) were indentified. The results showed N2-related hemodynamic responses, especially in medial and lateral frontal brain regions. Among other things, medial frontal brain regions are related to conflict monitoring, control of voluntary action and decision making. By contrast, the P3-amplitude proved to be predominantly related to increased BOLD responses in the temporo-parietal junction [TPJ] and lateral frontal brain regions. These brain regions are thought to play a decisive role in an attentional network involved in detecting auditory and visual stimuli.Overall, the results of the study indicated a whole network of brain regions to be associated with voluntary selection processes. In addition, at least some frontal brain regions seemed to be involved at an earlier stage than temporo-parietal regions, probably indicating a top-down process.

Electrocorticogram activity and multiunit discharges were recorded simultaneously with the unit activity of pulvinar neurons in chronically implanted macaques by transcortical electrode couples. During slow wave sleep, synchronizations between pulvinar and cortical neurons occurred. They could be related to the occurrence of the slow wave pattern during which concomitant phasic decrease in unit activity took place in both structures. Such relationships were found between the parietal gyrus and the dorsolateral pulvinar and between the occipital gyrus and the ventrolateral pulvinar, in good agreement with known anatomical data. No similar synchronizations could be detected when 66 thalamic sites in other nuclei were analyzed. The results were compared to available data and the possible role of the pulvinar in slow wave sleep was discussed.