1. Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's disease
- Author
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Vanderlip, Casey R, Lee, Michael D, and Stark, Craig EL
- Subjects
Biological Psychology ,Psychology ,Alzheimer's Disease ,Aging ,Neurodegenerative ,Clinical Research ,Dementia ,Neurosciences ,Acquired Cognitive Impairment ,Brain Disorders ,Prevention ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Behavioral and Social Science ,2.1 Biological and endogenous factors ,Neurological ,Humans ,Alzheimer Disease ,Female ,Male ,Aged ,Biomarkers ,Cognitive Dysfunction ,Amyloid beta-Peptides ,tau Proteins ,Neuropsychological Tests ,Middle Aged ,Aged ,80 and over ,Adult ,Alzheimer's disease ,cognitive modeling ,digital biomarker ,early diagnosis ,Mnemonic Similarity Task ,Clinical Sciences ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
BackgroundThe Mnemonic Similarity Task (MST) is a popular memory task designed to assess hippocampal integrity. We assessed whether analyzing MST performance using a multinomial processing tree (MPT) cognitive model could detect individuals with elevated Alzheimer's disease (AD) biomarker status prior to cognitive decline.MethodWe analyzed MST data from >200 individuals (young, cognitively healthy older adults and individuals with mild cognitive impairment [MCI]), a subset of which also had existing cerebrospinal fluid (CSF) amyloid beta (Aβ) and phosphorylated tau (pTau) data using both traditional and model-derived approaches. We assessed how well each could predict age group, memory ability, MCI status, Aβ, and pTau status using receiver operating characteristic analyses.ResultsBoth approaches predicted age group membership equally, but MPT-derived metrics exceeded traditional metrics in all other comparisons.DiscussionA MPT model of the MST can detect individuals with AD prior to cognitive decline, making it a potentially useful tool for screening and monitoring older adults during the asymptomatic phase of AD.HighlightsThe MST, along with cognitive modeling, identifies individuals with memory deficits and cognitive impairment. Cognitive modeling of the MST identifies individuals with increased AD biomarkers prior to changes in cognitive function. The MST is a digital biomarker that identifies individuals at high risk of AD.
- Published
- 2024