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A generally acceptable method of comparing psychotomimetic compounds has apparently not been devised. A method of this type would provide the replicability not now available in the newly developed field of psycho-pharmacology. For example, the method employing the Cold Spring Harbor questionnaire devised by the writer and his co-workers has been criticized as being “too suggestible”, “too structured”, or “insufficiently cognizant of unconscious processing”. It is the purpose of this communication to show that the Cold Spring Harbor questionnaire (1, 2) provides a suitable method of study of the psychotomimetic drugs similar to d-lysergic acid diethylamide (LSD-25). The basis for this statement is the comparison made here of the results of an independent study of a series of congeners of LSD-25 made by Isbell, Miner and Logan (3) in another laboratory, in a different milieu, and on a different population sample. It has been found that the comparative effectiveness of a series of LSD congeners both at Cold Spring Harbor and at Isbell's laboratory in Lexington, Kentucky are the same when the Cold Spring Harbor questionnaire is employed.

(1955). Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance. The Journal of Psychology: Vol. 39, No. 2, pp. 465-473.

(1955). Lysergic Acid Diethylamide (Lsd-25): Xv. the Effects Produced By Substitution of a Tap Water Placebo. The Journal of Psychology: Vol. 40, No. 2, pp. 367-383.

(1960). Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin. The Journal of Psychology: Vol. 49, No. 1, pp. 151-154.

(1955). Lysergic Acid Diethylamide (Lsd-25): Xi. Content Analysis of Clinical Reactions. The Journal of Psychology: Vol. 40, No. 1, pp. 53-60.

(1956). Lysergic Acid Diethylamide (LSD-25): XII. A Preliminary Statement of its Effects Upon Interpersonal Communication. The Journal of Psychology: Vol. 41, No. 1, pp. 185-198.

(1955). Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli. The Journal of Psychology: Vol. 39, No. 2, pp. 443-454.

"Certain species of snails are at least as sensitive to lysergic acid diethylamide (LSD-25) as are the Siamese fighting fish (Betta splendens). Ambularia cuprina (Mystery Snail) responds to LSD-25 with a typical, persistent, disorganized movement of the gastropod. This movement persists many hours and markedly alters the behavior of the snail. D-1-bromlysergic acid diethylamide (BOL-148) does not show the same effect. The snail may be used to assay LSD-25 under certain conditions." (PsycINFO Database Record (c) 2005 APA, all rights reserved).

(1955). Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses. The Journal of Psychology: Vol. 39, No. 1, pp. 3-60.

The cultural spectra of homosexuality are briefly traced in Western and Eastern cultures. Special emphasis is placed on homosexuality in the male, which was a capital offense in the British Navy from 1700 to the early part of the nineteenth century when psychological and medical factors came to be considered of importance. In the American colonies the attitude toward male homosexuality and lesbianism is stated in a clear record of the views of Thomas Jefferson, who proposed in 1779 that "whoever shall be guilty of rape, polygamy or sodomy shall be punished if a man by castration, if a women by cutting through the cartilage of her nose a hole one-half inch in diameter at the least." The growing importance of Freudian theory led to research into child development and the stresses of entering the Oedipal period. Thanks to the insight of female psychoanalysts, Freud's original views were modified to patterns of boys and girls, and the relationship of these differences to the complex systems which may have produced homosexuality in may instances in both sexes. A thesis by Diane M. Greene entitled "Women Loving Women" is reviewed with special reference to the way women adapt to being in the world as lesbians. Prompted by what Bieber and Bieber wrote concerning the use of homosexual themes in males in solving problems related to achievement, e.g., creative success, salary increases, parenting, and drawing on psychoanalytic data, it is considered likely that women exercise similar mechanisms in solving analogous problems. It follows then that a few days delivery, a women could begin to doubt that she could handle this success-the need to mother. This could lead her to doubt her femininity, utilizing the same (hidden) homosexual mechanisms of problem solving in the male. An awareness of this process may assist the physician in management and therapy. Woods' paradigm for the male: I am a failure leads to I am castrated leads to I am not a man leads to I am like a women leads to I am homosexual. For the female, Mayberger and Abramson propose: I am a mother leads to I am successful leads to I cannot handle success because I lack the need to mother my infant lead to I am not a real women, I am like a man leads to I am homosexual.

Happiness: “A state of well-being characterized by relative permanence, by dominant agreeable emotion ranging in value from mere contentment to deep and intense joy in living, and by a natural desire for its continuation.” (Webster)Happiness in Marriage: Husband and wife give each other sexual pleasure. Each endeavors to reduce old anxieties in the other. Each tries to avoid developing new anxieties in the other (H.A.A.)